National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1956

TDMS Study 05114-02 Pathology Tables

NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|             
                                           | 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |       X                                         X                        |             
      Hepatocellular Adenoma               |                               X                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
      Squamous Cell Papilloma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  M  +  +     M  M  M  +  M  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                            X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|             
                                           | 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                        X                                 |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|             
                                           | 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                                        X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
      Histiocytic Sarcoma                  |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |             X                                               X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|             
                                           | 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                    X           X         |             
      Hepatocellular Adenoma               |                                        X                                X|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                          X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +     +  +        +                     |             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X           X  X     X     X                                   X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|             
                                           | 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                                           X                              |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             | X                                         X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Hemangioma                           |    X                                                                     |             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  +              +              +               |             
      Iliac, Lymphoma Malignant Mixed      |                            X              X                              |             
      Pancreatic, Lymphoma Malignant Mixed |                         X                                                |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                            X              X              X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                 X                          X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                          X              X                          X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|             
                                           | 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                              X   |             
      Alveolar/Bronchiolar Carcinoma       |                                           X                    X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +  +        +                             +|             
      Adenocarcinoma                       |                               X                                          |             
      Adenoma                              | X                                                                       X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                       X                                            X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X        X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                       X  X              X              X           X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Adenoma               | X     X  X                                                               |          6 |
      Histiocytic Sarcoma                  |             X                                                            |          1 |
      Lymphoma Malignant Mixed             |    X                    X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                                                               |   7        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Histiocytic Sarcoma                  |             X                                                            |          2 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |             X                                                            |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                 +                                                |   7        |
      Iliac, Lymphoma Malignant Mixed      |       X                                                                  |          3 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |       X                 X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Lymphoma Malignant Mixed             |       X        X        X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |       X                 X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X        X        X                                                |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X        X        X                                                |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                    X                                                |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrosarcoma                         |                            X                                             |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Alveolar/Bronchiolar Carcinoma       |                            X                                             |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   7        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                         X                                                |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Mixed             |       X        X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |             X                                                            |          4 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X  X        X        X                                                |         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangiosarcoma                      |                                                    X                     |             
      Hepatocellular Carcinoma             |                                                          X               |             
      Hepatocellular Adenoma               |                      X                       X        X           X     X|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  M     +  M  M  M  +  M  M     M        +     M  +  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X         |             
      Teratoma NOS                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                         X|             
      Hemangioma                           |                                                          X               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Endometrium, Polyp, Moderate         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +           +                 +        +         |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                         X                                                |             
      Pancreatic, Lymphoma Malignant Mixed |                         X                             X                  |             
      Renal, Lymphoma Malignant Mixed      |                         X           X                 X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  M  M  +  +  +  +     +        +     +  M  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                         X           X                 X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                    X                     |             
      Lymphoma Malignant Mixed             |                      X  X           X                 X        X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +  +  M  +  +  M  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Myxosarcoma                          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Meninges, Fibrosarcoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangiosarcoma, Metastatic, Liver   |                                                    X                     |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Squamous Cell Carcinoma      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +           +  +                       +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |       X              X                       X                           |             
      Adenoma, Two                         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                      X  X           X                 X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  M  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  M     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                   X                                                      |             
      Hepatocellular Adenoma               |             X                 X           X           X                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +     +           +           +         |             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
      Hemangiosarcoma                      |                                        X                                 |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +     +  M  +  +  M  M  +  M     M  M  +  M  +  M     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +  +|             
      Adenoma                              |                            X              X                    X         |             
      Carcinoma                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Sarcoma, Metastatic, Skin            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                    X                     |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Teratoma NOS                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Endometrium, Polyp, Moderate         |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +                                                     +   |             
      Axillary, Lymphoma Malignant Mixed   |       X                                                                  |             
      Iliac, Lymphoma Malignant Mixed      |                                                                      X   |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |       X                                                              X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  M  +  +  +     +  +  +  +  M  +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |       X           X                                                  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +     +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |       X                                                              X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                        X                                 |             
      Lymphoma Malignant Mixed             |       X                                                              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +|             
      Fibrosarcoma                         |                                  X                                       |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Myxosarcoma                          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Meninges, Fibrosarcoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X     X                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Squamous Cell Carcinoma      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                 +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                           X                 X            |             
      Adenoma, Two                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |       X           X                                                  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                                             |  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |       X                                                                  |         10 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +                                             |  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +                                             |  50        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                                             |  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  M  +  +  M     +                                             |  22        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +                                             |  49        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                                             |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +     +                                             |  52        |
      Cystadenoma                          |                                                                          |          1 |
      Hemangioma                           | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Teratoma NOS                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Endometrium, Polyp, Moderate         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |   8        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +                                             |  44        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +     +                                             |  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +     +                                             |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +     +                                             |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
      Fibrosarcoma                         |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Myxosarcoma                          |                   X                                                      |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
      Meninges, Fibrosarcoma               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Squamous Cell Carcinoma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
      Adenoma                              |                                                                          |          5 |
      Adenoma, Two                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |          X                                                               |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|             
                                           | 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X                          X                     |             
      Hepatocellular Adenoma               |                   X                             X                        |             
      Hepatocellular Adenoma, Two          |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                            +        +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  M  M  +              M  M  +  +  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |       X              X                                                   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Follicular Cell, Adenoma             |       X                                                     X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Adenoma                              | X                                                                 X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|             
                                           | 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Hemangioma, Mild                     |                                                                          |             
      Endometrium, Polyp Stromal, Moderate |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +              +                       +                     |             
      Iliac, Lymphoma Malignant Mixed      |             X                                      X                     |             
      Renal, Lymphoma Malignant Mixed      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +              +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |             X                                      X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  M  +  +  +   |             
      Lymphoma Malignant Mixed             |             X           X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +              +  +  M  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |             X           X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |             X           X                          X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  M  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +              +  +  +  +  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Subcutaneous Tissue, Osteosarcoma,   |                                                                          |             
           Metastatic, Bone                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                   X                          X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|             
                                           | 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                 X                        |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Adenoma                              |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X           X                          X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|             
                                           | 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                   X      |             
      Hepatocellular Adenoma               |             X                             X                              |             
      Hepatocellular Adenoma, Two          | X                                                                        |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +     M  +  M  M  +  +  +  +  +     +     +  +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     M  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Adenoma                              |                                           X                             X|             
      Carcinoma                            |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Follicular Cell, Adenoma             |                   X                       X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|             
                                           | 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Adenoma                              |       X                                                                  |             
      Hemangioma, Mild                     |             X                                                            |             
      Endometrium, Polyp Stromal, Moderate |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                +                                 |             
      Iliac, Lymphoma Malignant Mixed      |                                        X                                 |             
      Renal, Lymphoma Malignant Mixed      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +  +  M  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                    X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +     +  +  +  +  +  M  +  +  +     +     +  +  +     +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Subcutaneous Tissue, Osteosarcoma,   |                                                                          |             
           Metastatic, Bone                |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Osteosarcoma                         |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|             
                                           | 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
      Adenoma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                    X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Carcinoma             |             X                                                            |          4 |
      Hepatocellular Adenoma               | X           X                                                            |          6 |
      Hepatocellular Adenoma, Two          |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                       +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +                                             |  48        |
      Adenoma                              |       X                                                                  |          5 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Follicular Cell, Adenoma             |    X     X                                                               |          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Adenoma                              |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Adenoma                              |                X                                                         |          2 |
      Hemangioma, Mild                     |                                                                          |          1 |
      Endometrium, Polyp Stromal, Moderate |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          3 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M                                             |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +                                             |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +                                             |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  M  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Subcutaneous Tissue, Osteosarcoma,   |                                                                          |            |
           Metastatic, Bone                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Alveolar/Bronchiolar Carcinoma       |                            X                                             |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +           +                                                         |   4        |
      Adenoma                              |    X           X                                                         |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                  X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  M  M  M  M  M  +  M  +  M  +  M  +  +  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                   +                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +                                                      |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      | X                                                                        |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                  X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X           X              X                                   X|             
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                                  X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                  X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                X         |             
      Hepatocellular Adenoma               |       X                    X           X           X                     |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +              +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                   X     X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X     X              X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                   X     X              X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Adenoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                   X     X              X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |    X              X                                                      |          6 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X        X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +                                             |  59        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        +                                                         |   5        |
      Axillary, Lymphoma Malignant Mixed   |                X                                                         |          1 |
      Iliac, Lymphoma Malignant Mixed      |       X        X                                                         |          3 |
      Pancreatic, Lymphoma Malignant Mixed |                X                                                         |          1 |
      Renal, Lymphoma Malignant Mixed      |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X        X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |       X        X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |       X        X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X        X                                                         |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosarcoma                         |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   2        |
      Adenoma                              |                   X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  M  +  +                                             |  58        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X        X                                                         |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Hepatocellular Carcinoma             |       X                    X                                             |             
      Hepatocellular Adenoma               |                      X  X        X     X                    X  X        X|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                +              +         |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                                   +                    +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +                                                     +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  M  M  +     +  +  +  +     M  +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +     +  +  +  +     M  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  M     M  M  M  M     M  M  M  +  M  M  +     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X  X              X                          X     X     X|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                   +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                X                                   X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma                       |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Hepatocellular Carcinoma             |                                                 X     X                  |             
      Hepatocellular Adenoma               |                   X        X        X           X                 X      |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  M     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  M|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +     +  +              +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
      Renal, Lymphoma Malignant Mixed      |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  M  M  +  +  +  +     M  +  M     +  +  +  M  M  +     +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  +  M  M     M  M  M     M  M  +  M  M  M     M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X                                             |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hepatocellular Carcinoma             |                                                 X        X               |             
      Hepatocellular Adenoma               |          X  X  X           X  X                    X  X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  +  M  +  M  M  M  M  +  +  M  +  +  +  M  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M|             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                 +                        |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                      X  X        X              X                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +  +                    +                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |             X  X                    X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  89        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +     +  +  +  +  +  +  +  +                              |  75        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Hepatocellular Carcinoma             | X                          X        X                                    |          9 |
      Hepatocellular Adenoma               |    X     X                 X     X                                       |         23 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +     +  +  M  M  +  M  +  +                              |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M     +  +  +  +  +  +  +  +                              |  77        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  87        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   9        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  84        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +  M     +  +  +  +  +  +  M  +                              |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  78        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +                              |  81        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     M  +  +  +  +  +  +  +                              |  84        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M     M  M  M  M  M  M  M  M                              |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +                              |  89        |
      Alveolar/Bronchiolar Adenoma         |                            X           X                                 |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   7        |
      Adenoma                              |                         X                                                |          7 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  81        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +              +  +                    +  +               |             
      Lymphoma Malignant Mixed             | X                             X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +        +  +  +  +     +  +  +  +  +     +  +  +  +        +     +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                  X                    X                 X|             
      Hepatocellular Adenoma               |       X              X  X     X     X     X     X  X                     |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +           +                 +                    +  +     +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +           +  +              +     +        +  +  +  +        +      |             
      Squamous Cell Papilloma              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +           +  +              +     +           +  +  +        +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +                 +                    +  +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +                 M                    +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +           +                 M                    +  +               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +                 +  +                 +  +               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +                           |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +                 +                    +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +           +                 +                    +  +               |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Renal, Lymphoma Malignant Mixed      | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +           +  +              +     +           +  +  +        +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +           +                 M                    +  +               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +              +  +                 +  +  +               |             
      Lymphoma Malignant Mixed             | X                             X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +           +                 M                    +  +               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +           +              +  +                    +  +               |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +           +                 M                    +  +               |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           M                 M                    M  M               |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +                 +        +           +  +               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    M           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    M                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +           +  +              +     +           +  +  +        +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                       X              X                          X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |             X           X                                                |             
      Alveolar/Bronchiolar Carcinoma       |                            X                                             |             
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                      +                        |             
      Adenoma                              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +                 +                    +  +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +                 +                    +  +               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                             X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|             
                                           | 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +        +        +     +     +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +        +        +           +        +     +  +            |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +     +  +  +  +        +  +     +  +  +  +  +  +     +   |             
      Hemangiosarcoma                      |                               X                                          |             
      Hepatocellular Carcinoma             |             X        X     X                       X                     |             
      Hepatocellular Adenoma               |                X                       X        X        X     X         |             
      Hepatocellular Adenoma, Multiple     |                                                                      X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +                                      +           +               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +  +  +     +  +        +  +  +               |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +     +        +  +        +  +  +               |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +        +        +           +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     M        M        M           +        +     M  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +        +        +           +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                             +                          +               |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +     +        +        +           +        +     +  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|             
                                           | 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +        +        +           +        +     +  +            |             
      Interstitial Cell, Adenoma           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                    +                              |             
      Axillary, Lymphoma Malignant Mixed   |                      X                                                   |             
      Iliac, Lymphoma Malignant Mixed      |                      X                                                   |             
      Inguinal, Lymphoma Malignant Mixed   |                      X                                                   |             
      Renal, Lymphoma Malignant Mixed      |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +  +  +        +  +     +        +  +        +  +  +  +            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       M     +        +        +           +        +     +  M            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +        +        +           +        +     +  +            |             
      Lymphoma Malignant Mixed             |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +     +        +        +           +        +     +  +            |             
      Lymphoma Malignant Mixed             |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +        +        +           +        +     +  +            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     M        +        +           +        +     +  +            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M     M        M        M           M        M     M  +            |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +        +        +           +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +  +        +  +     +        +  +        +  +  +  +            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X              X                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                      X   |             
      Alveolar/Bronchiolar Carcinoma       |          X                                      X                        |             
      Hemangiosarcoma, Metastatic, Liver   |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|             
                                           | 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +        +        +           +        +     +  +           +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +        +        +           +        +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                    X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +  +        +                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +  +        +                                                |  19        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +  +  +  +  +                                             |  42        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          7 |
      Hepatocellular Adenoma               | X                          X                                             |         15 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Mixed             |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +  +        +                                                |  18        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +  +  +  +                                                |  29        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +  +  +  +                                                |  26        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +  +        +                                                |  17        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +  +        +                                                |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +  +        +                                                |  16        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +  +  +        +                                                |  19        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Penis                                   |             +           +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +        +                                                |  18        |
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +  +        +                                                |  18        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +           +                                             |   5        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +  +  +  +  +  +                                                |  27        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +        M                                                |  13        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  M  +        +  +                                             |  22        |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |          +  +  +        +                                                |  16        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +        +                                                |  18        |
      Lymphoma Malignant Mixed             |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +  +        +                                                |  16        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M  +        M                                                |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +        +                                                |  18        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +        +                                                |  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +  +  +  +  +  +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          7 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   4        |
      Adenoma                              | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +        +                                                |  22        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +  +        +                                                |  18        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |          X                                                               |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +                                +                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                                +                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +     +     +  +        +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |       X     X                                            X  X            |             
      Hepatocellular Adenoma               |    X        X  X     X           X           X  X              X     X  X|             
      Hepatocellular Adenoma, Two          |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                                +                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    M                                +                                    |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                 +  +  +        +                 +     +            |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                 +     +        +                 +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +                                +                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +                                +                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M                                +                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +                                +           +           +            |             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                                +                                    |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +                                                  +            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +                    +                                    |             
                                            __________________________________________________________________________|             
   Testes                                  |    +                                +                       +            |             
      Interstitial Cell, Adenoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +                 +     +        +                 +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M                                M                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                                +                       +            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +                                +                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +           +           +                       +            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M                                M                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                       +        +                                    |             
      Fibrosarcoma                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +                 +     +        +                 +                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                X        X                 X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                        X                    X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +                    +                 +                        |             
      Adenoma                              |          X                    X                 X                        |             
      Adenoma, Two                         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +                       +     +           +  +                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|             
                                           | 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +                                                  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +                                +                 +         |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +     +                                            +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |             X           X     X              X              X            |             
      Hepatocellular Adenoma               |       X        X     X  X  X     X                                X     X|             
      Hepatocellular Adenoma, Two          |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +                                                  +         |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +     +                    +           +  +  +     +  +  +   |             
      Squamous Cell Papilloma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +                                      +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +                                                  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +     +                                                  +         |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +     +                                                  +         |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M     +                                                  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +                             +                    +         |             
      Follicular Cell, Adenoma             |             X                             X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +                                                  +         |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|             
                                           | 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Testes                                  |       +     +                                                  +         |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                       +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                X         |             
      Renal, Lymphoma Malignant Mixed      |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +     +                                      +  +  +     +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +                                                  M         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +                          +     +  +           +  +         |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +     +                                                  +         |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +                             +     +              +         |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M     M                                                  M         |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     M  +                                +              +         |             
      Fibrosarcoma                         |                X                                                         |             
      Hemangiosarcoma                      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +                                                  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +                                                  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +     +                                      +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X  X     X                                                     X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                     X  X  X  X                           |             
      Lymphoma Malignant Mixed             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|             
                                           | 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +        +     +                                          |             
      Adenoma                              |                X        X                                                |             
      Adenoma, Two                         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +                    +              +           +  +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +                                               +  +         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                              X                 X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3|                                            |            |
                                           | 2| 2| 9| 2| 7| 0| 9| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +     M  +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +                                                         |   8        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +                                                         |   9        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +     +  +  +  +  +                                                |  47        |
      Hepatocellular Carcinoma             |                X                                                         |         10 |
      Hepatocellular Adenoma               |             X        X  X                                                |         21 |
      Hepatocellular Adenoma, Two          |                                                                          |          2 |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +                                                         |   8        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +  +                                                      |  22        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +                                                         |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +     +  +                                                         |   8        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +     +  +                                                         |   8        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +                                                         |  12        |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3|                                            |            |
                                           | 2| 2| 9| 2| 7| 0| 9| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +  +                                                         |   8        |
      Fibrosarcoma                         |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +  +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +  +                                                         |   9        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +     M  M  +                                                      |  16        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     M  M                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +                                                         |  13        |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +     +  +                                                         |   8        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +                                                         |  13        |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +  +                                                         |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M     M  M                                                         |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +  +        +                                                |  11        |
      Fibrosarcoma                         |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +           +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +                                                         |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3|                                            |            |
                                           | 2| 2| 9| 2| 7| 0| 9| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          9 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   7        |
      Adenoma                              |                                                                          |          5 |
      Adenoma, Two                         |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +  +                                                         |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +     +                                                |  17        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|             
                                           | 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                   X                                                      |             
      Hepatocellular Carcinoma             |                                     X                    X               |             
      Hepatocellular Carcinoma, Multiple   |                               X                                          |             
      Hepatocellular Carcinoma, Two        |       X                                                                  |             
      Hepatocellular Adenoma               | X     X                 X        X     X                                 |             
      Hepatocellular Adenoma, Two          |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                                   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma NOS                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                            X                    X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|             
                                           | 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +              +              +               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  M  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Papilloma                            | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|             
                                           | 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                       X        X                 X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                   X                                                      |             
      Alveolar/Bronchiolar Carcinoma       |          X                                         X                     |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                       X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +     +                                          |             
      Adenoma                              |                         X     X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|             
                                           | 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X                                      X     X                 X     X  X|             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Carcinoma, Two        |                                                                          |             
      Hepatocellular Adenoma               |    X  X        X                       X           X              X      |             
      Hepatocellular Adenoma, Two          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                         +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma NOS                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|             
                                           | 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Renal, Lymphoma Malignant Mixed      |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X           X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|             
                                           | 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X  X              X              X                          X  X  X  X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X           X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     A      |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                         X                                                |          2 |
      Hepatocellular Carcinoma             |                            X                                             |          9 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Carcinoma, Two        |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |         11 |
      Hepatocellular Adenoma, Two          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pheochromocytoma NOS                 |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  78                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     A      |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  M  +  +  M  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   2        |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +                                             |  56        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     A      |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Papilloma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |         12 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |          X           X                                                   |          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|             
                             DAY ON TEST   | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|             
                                           | 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      +     +        +        M  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   |                      +     +        +        +  +     +  +  +        +   |             
      Hepatocellular Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  M     +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Prostate                                |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Testes                                  |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +     +  +     +  +     +  +     +  +  +  +  +  +     +  +  +|             
      Mast Cell Tumor NOS                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|             
                             DAY ON TEST   | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|             
                                           | 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M  M  +  M  M     M  M  +  M  M     M  +  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +     +  +     +  +     +  +     +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X              X  X        X                                             |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|             
                                           | 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +              +                 M                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +              +                 +                       +  +      |             
      Hepatocellular Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +              +                 +                       +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +     +  +     +  +  +  M  +     +  +     +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +              +                 +                       +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +     +  +     +  +  +  +        +        +  +  +  +  +  +|             
      Mast Cell Tumor NOS                  |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     M              +                 +                       +  M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|             
                                           | 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +     +     +  +     +  +  +  +        +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M     M     M  M     M  M  M  M        M  M     M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +     +  +     +  +  +  +        +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +              +                 +                       +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X              X     X               |             
      Alveolar/Bronchiolar Carcinoma       |                X                                                        X|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +              +                 +                       +  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|             
                                           | 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +                    +  +     +                                       |             
      Hepatocellular Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +                    +  +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +  +  M  +  +  +  +  +     +  +  M  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +                    +  +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +   |             
      Mast Cell Tumor NOS                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +                    M  +     M                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|             
                                           | 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +        +  M  +  +  +  +  +  +  +  +  +     M  +  +  M  M  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M        M  M  M  M  M  M  M  +  M  M  M     M  M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +                    +  +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                X   |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                            +  +                  |             
      Adenoma                              |       X                                            X  X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +                    +  +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6|                                                           |            |
                             DAY ON TEST   | 3| 4| 3| 3| 4|                                                           |            |
                                           | 1| 2| 4| 1| 1|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    0.2  PPM                               | 8| 8| 8| 8| 8|                                                           |     L      |
    SE33                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  69        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +                                                                  |  21        |
      Hepatocellular Carcinoma             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  20        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  67        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  20        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  87                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6|                                                           |            |
                             DAY ON TEST   | 3| 4| 3| 3| 4|                                                           |            |
                                           | 1| 2| 4| 1| 1|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    0.2  PPM                               | 8| 8| 8| 8| 8|                                                           |     L      |
    SE33                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +                                                               |  59        |
      Mast Cell Tumor NOS                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |  78        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  64        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  68        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M                                                            |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  68        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +                                                               |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  20        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  80        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  78        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |         10 |
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  80        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  80        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
      Adenoma                              |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |  80        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  88                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6|                                                           |            |
                             DAY ON TEST   | 3| 4| 3| 3| 4|                                                           |            |
                                           | 1| 2| 4| 1| 1|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    0.2  PPM                               | 8| 8| 8| 8| 8|                                                           |     L      |
    SE33                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  89                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 6| 3| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 5| 3| 3| 3| 2| 5| 3| 2| 3| 3| 3| 3| 3| 5| 5| 4| 2| 2| 3|             
                                           | 0| 0| 0| 6| 0| 0| 2| 0| 0| 0| 3| 5| 0| 6| 0| 0| 0| 0| 0| 6| 4| 7| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4|             
    SE65                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +     +  +  +  +     +  +  +  +  +  +  +  M  M  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +        +     +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Mixed             |                                                          X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                          X     X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M     M  M  M        M     M  M  M  M  M  M  M  M  +     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +        +     +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         | X  X        X           X                 X           X           X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 6| 3| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 5| 3| 3| 3| 2| 5| 3| 2| 3| 3| 3| 3| 3| 5| 5| 4| 2| 2| 3|             
                                           | 0| 0| 0| 6| 0| 0| 2| 0| 0| 0| 3| 5| 0| 6| 0| 0| 0| 0| 0| 6| 4| 7| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4|             
    SE65                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                          X     X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                      +            |             
      Adenoma                              |                      X                                      X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                          X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 1| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 5| 3| 3|            |
                                           | 0| 3| 0| 0| 0| 0| 8| 4| 0| 0| 0| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 7| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    0.2  PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0|     L      |
    SE65                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  M  M  M  M  +  +  M  +  M  M     M  M  +  +  +  +  M|  30        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|  45        |
      Follicular Cell, Adenoma             |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +     +  +  +  +     +  +  +  +  +        +  +  +     +  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
      Lymphoma Malignant Mixed             |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M     M  M  M  M  M     M  M  M  M  +  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +     +  +  +  +     +  +  +  +  +        +  +  +     +  +|  35        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 1| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 5| 3| 3|            |
                                           | 0| 3| 0| 0| 0| 0| 8| 4| 0| 0| 0| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 7| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    0.2  PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0|     L      |
    SE65                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                X        X           X  X  X  X                          X|         14 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                      X                                                   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   3        |
      Adenoma                              |                         X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  93                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 2| 7| 7| 2| 2| 7| 7| 7| 7| 1| 1| 2| 2| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 8| 9| 2| 2| 9| 9| 0| 2| 2| 2| 8| 8| 3| 3| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 5| 9| 1| 5| 9| 9| 5| 5| 3| 9| 9| 9| 3| 3| 2| 2| 9| 9| 9| 9| 5| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5  PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
    SE26                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                M        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                M        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                M        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Liver                                   |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +        +  +                    +  +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     +  M  M  +  +  +  M  M  M  +  +  M  +  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +        +  +                    M  +                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Prostate                                |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Testes                                  |                +        +  +                    +  +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +        M  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +        +  M                    +  +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 2| 7| 7| 2| 2| 7| 7| 7| 7| 1| 1| 2| 2| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 8| 9| 2| 2| 9| 9| 0| 2| 2| 2| 8| 8| 3| 3| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 5| 9| 1| 5| 9| 9| 5| 5| 3| 9| 9| 9| 3| 3| 2| 2| 9| 9| 9| 9| 5| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5  PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
    SE26                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M     M  M  M  M  M  M  M  M  M        M  M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +        +  +                    +  +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X        X                                   X                 X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                       X  X               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +        +  +                    +  +                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 4| 4| 7| 2| 7| 1| 7| 1| 7| 7| 2| 2| 2| 4| 2| 4| 7| 4| 4| 1| 7|             
                             DAY ON TEST   | 2| 9| 8| 2| 5| 5| 2| 3| 2| 8| 2| 8| 2| 2| 9| 3| 9| 9| 3| 5| 2| 5| 5| 8| 2|             
                                           | 9| 5| 3| 9| 8| 8| 9| 2| 9| 3| 9| 3| 9| 9| 5| 2| 5| 4| 2| 8| 9| 8| 8| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
    SE26                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Liver                                   |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                 +                    +  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M        M  +  M  +  M  +  +  +  +  +  +  +  M     M        +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +|             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                 +                    +  M  +     M                  |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Testes                                  |    +                 +                    +  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +        +  +  +     +     +  +  +  +  +  +  +     +           +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 +                    M  +  M     M                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +     +        +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 4| 4| 7| 2| 7| 1| 7| 1| 7| 7| 2| 2| 2| 4| 2| 4| 7| 4| 4| 1| 7|             
                             DAY ON TEST   | 2| 9| 8| 2| 5| 5| 2| 3| 2| 8| 2| 8| 2| 2| 9| 3| 9| 9| 3| 5| 2| 5| 5| 8| 2|             
                                           | 9| 5| 3| 9| 8| 8| 9| 2| 9| 3| 9| 3| 9| 9| 5| 2| 5| 4| 2| 8| 9| 8| 8| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
    SE26                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +     +        +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M        M  M  M     M     M  M  +  M  M     M     M           M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +        +  +  +     +     +  +  +  +  +  +  +     +           +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +        +  +  +     +     +  +  +  +  +  +  +     +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                 +                    +  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X  X                 X                                    |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +                 +                    +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                 +                    +  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 7| 1| 2| 7| 7| 4| 7| 7| 4| 7| 7| 5| 4| 7| 6| 7| 1| 7| 2| 1| 2|             
                             DAY ON TEST   | 3| 9| 2| 5| 2| 8| 9| 2| 2| 5| 3| 3| 5| 3| 3| 7| 5| 3| 1| 3| 8| 3| 9| 8| 3|             
                                           | 2| 5| 9| 8| 9| 3| 5| 9| 9| 8| 0| 0| 8| 0| 0| 0| 8| 0| 2| 0| 3| 0| 5| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|             
    SE26                                   | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +     +  +     +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +              +                                               +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | M  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     +  +  +  M  M     +  +     +  +  +     M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +     +  +     +  +  +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +              +                                               +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +     +  +     +  +  +     +     +     +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +              +                                               M     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M     +  +  +  +  +     +  +     +  +  +     M  +  +  +  M  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 7| 1| 2| 7| 7| 4| 7| 7| 4| 7| 7| 5| 4| 7| 6| 7| 1| 7| 2| 1| 2|             
                             DAY ON TEST   | 3| 9| 2| 5| 2| 8| 9| 2| 2| 5| 3| 3| 5| 3| 3| 7| 5| 3| 1| 3| 8| 3| 9| 8| 3|             
                                           | 2| 5| 9| 8| 9| 3| 5| 9| 9| 8| 0| 0| 8| 0| 0| 0| 8| 0| 2| 0| 3| 0| 5| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|             
    SE26                                   | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +     +  +     +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M     +  M  M     M  M     M  M        M     M     M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +     +  +     +  +  +     +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +     +  +     +  +  +     +     +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +              +                                               +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X              X        X                     |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +              +                                               +     +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +              +                                               +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 4| 1| 7| 7| 2| 7| 7| 2| 2| 7| 7|                             |            |
                             DAY ON TEST   | 9| 3| 3| 3| 5| 8| 3| 2| 3| 0| 3| 3| 3| 3| 3|                             |            |
                                           | 5| 0| 0| 0| 8| 3| 0| 5| 2| 3| 0| 2| 2| 0| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    0.5  PPM                               | 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|                             |     L      |
    SE26                                   | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                       +        +  +                                    |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                       +        +  +                                    |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                       +        +  +                                    |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                       +        +  +                                    |  20        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                       +        +  +                                    |  19        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +     +  +  +  +  +  M  +  +  +  +                              |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                       +        +  +                                    |  19        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  79        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                       +        +  +                                    |  18        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                       +        +  +                                    |  20        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +        +  +  +  +  +  +  +  +  +                              |  67        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  87        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 100                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 4| 1| 7| 7| 2| 7| 7| 2| 2| 7| 7|                             |            |
                             DAY ON TEST   | 9| 3| 3| 3| 5| 8| 3| 2| 3| 0| 3| 3| 3| 3| 3|                             |            |
                                           | 5| 0| 0| 0| 8| 3| 0| 5| 2| 3| 0| 2| 2| 0| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    0.5  PPM                               | 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|                             |     L      |
    SE26                                   | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                       +        +  M                                    |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                       +        +  +                                    |  19        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  75        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  78        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M        M  M  M  M  M  +  M  M  M                              |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +        +  +  +  +  M  +  +  +  +                              |  68        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +        +  +  +  +  +  +  +  +  +                              |  67        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                       +        +  +                                    |  20        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |         11 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                      X        X                                          |          5 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  87        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                    +                                 |   4        |
      Adenoma                              |                   X                    X                                 |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                       +        +  +                                    |  20        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                       +        +  +                                    |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 101                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 4| 1| 7| 7| 2| 7| 7| 2| 2| 7| 7|                             |            |
                             DAY ON TEST   | 9| 3| 3| 3| 5| 8| 3| 2| 3| 0| 3| 3| 3| 3| 3|                             |            |
                                           | 5| 0| 0| 0| 8| 3| 0| 5| 2| 3| 0| 2| 2| 0| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    0.5  PPM                               | 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|                             |     L      |
    SE26                                   | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|                             |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 102                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:23:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 2| 2| 2| 4| 2| 4| 2| 4| 7| 7| 7| 2| 7| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 5| 9| 9| 7| 5| 9| 5| 4| 5| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| 2| 2| 0| 2| 2| 9|             
                                           | 8| 5| 5| 4| 8| 5| 8| 5| 8| 9| 9| 9| 5| 9| 9| 7| 6| 9| 9| 9| 9| 1| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5  PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    SE42                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +        +           +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +        +                    +                                   +|             
      Hepatocellular Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +        +                    +                                   +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +        +                    +                                   +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |