National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1958

TDMS Study 05114-02 Pathology Tables

NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:01:20

                                                26 WEEK STOP EXPOSURE EVALUATION




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    25005 Interval Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 011    0.5  PPMSE26


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:01:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 1| 1| 2| 2| 2| 1| 4| 4| 2| 1| 1| 2| 2| 2| 2| 4| 4| 4| 1| 2| 2| 4|             
                             DAY ON TEST   | 9| 9| 9| 8| 8| 3| 3| 9| 8| 5| 5| 3| 8| 8| 9| 3| 9| 3| 5| 5| 5| 8| 3| 9| 5|             
                                           | 5| 5| 5| 3| 3| 2| 2| 5| 3| 8| 8| 2| 3| 3| 5| 2| 5| 2| 8| 8| 8| 3| 2| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 2| 2| 2| 4| 4| 4| 4| 7| 7| 7| 7| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3|             
    SE26                                   | 1| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 4| 1| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +           +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +        +  +  +           +        +  +  +  +              M  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +        +  +  +  +  +  +  M           +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        M  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +           +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +           +        +  M  +  M              +  +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +        +  +  +           +        M  +  M  M              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +        +  M  +  +  +  +  +           +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +        +  M  +  +  +  +  +           +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:01:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 1| 1| 2| 2| 2| 1| 4| 4| 2| 1| 1| 2| 2| 2| 2| 4| 4| 4| 1| 2| 2| 4|             
                             DAY ON TEST   | 9| 9| 9| 8| 8| 3| 3| 9| 8| 5| 5| 3| 8| 8| 9| 3| 9| 3| 5| 5| 5| 8| 3| 9| 5|             
                                           | 5| 5| 5| 3| 3| 2| 2| 5| 3| 8| 8| 2| 3| 3| 5| 2| 5| 2| 8| 8| 8| 3| 2| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 2| 2| 2| 4| 4| 4| 4| 7| 7| 7| 7| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3|             
    SE26                                   | 1| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 4| 1| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M        M  M  M           M        +  M  M  M              M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +           +        +  +  +  +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:01:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 4| 4| 4| 1| 2| 1| 2| 2| 4| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 8| 9| 5| 5| 5| 8| 9| 8| 3| 9| 5| 8| 3| 3| 3|                             |            |
                                           | 3| 5| 8| 8| 8| 3| 5| 3| 2| 5| 8| 3| 2| 2| 2|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|                             |     A      |
    0.5  PPM                               | 3| 3| 4| 5| 6| 7| 7| 7| 8| 8| 9| 9| 0| 0| 1|                             |     L      |
    SE26                                   | 4| 5| 3| 1| 3| 2| 4| 5| 1| 2| 3| 4| 2| 5| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +  +  +  +     +  +  +  +                              |  30        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +              +     +  +        +  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +              +     +  +        +  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +              +     +  +        +  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +              +     +  +        +  +  +                              |  20        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +              +     +  +        +  +  +                              |  20        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +              +     +  +        +  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +  +  +  +  M     +  +  +  +                              |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +              +     +  +        +  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +  +  +  +     +  +  +  +                              |  30        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +              +     +  +        +  +  +                              |  18        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +              +     +  +        +  +  +                              |  20        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                              |  37        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +              M     +  +        +  +  M                              |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +              +     +  +        +  +  +                              |  19        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:01:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 4| 4| 4| 1| 2| 1| 2| 2| 4| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 8| 9| 5| 5| 5| 8| 9| 8| 3| 9| 5| 8| 3| 3| 3|                             |            |
                                           | 3| 5| 8| 8| 8| 3| 5| 3| 2| 5| 8| 3| 2| 2| 2|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|                             |     A      |
    0.5  PPM                               | 3| 3| 4| 5| 6| 7| 7| 7| 8| 8| 9| 9| 0| 0| 1|                             |     L      |
    SE26                                   | 4| 5| 3| 1| 3| 2| 4| 5| 1| 2| 3| 4| 2| 5| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +           +  +  +  +  +     +  +  +  +                              |  29        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +  +  +  +  +     +  +  +  +                              |  29        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +              M     M  M        M  +  M                              |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +              +     +  +        +  +  +                              |  20        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +              +     +  +        +  +  +                              |  20        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +              +     +  +        +  +  +                              |  20        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  39        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +                              |  38        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +              +     +  +        +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +              +     +  +        +  +  +                              |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
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