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TDMS Study 05114-02 Pathology Tables

NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:56

                                                42 WEEK STOP EXPOSURE EVALUATION




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    25005 Interval Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 012    0.5  PPMSE42


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 4| 4| 2| 4| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 9| 9| 5| 9| 5| 5| 9| 9| 9| 9| 5| 9| 5| 5| 9| 5| 5| 9| 5|              |            |
                                           | 8| 5| 5| 8| 5| 8| 8| 5| 5| 5| 5| 8| 5| 8| 8| 5| 8| 8| 5| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |     A      |
    0.5  PPM                               | 2| 2| 2| 2| 3| 3| 3| 4| 6| 7| 8| 0| 1| 1| 2| 2| 3| 4| 5| 5|              |     L      |
    SE42                                   | 1| 2| 3| 5| 1| 2| 4| 3| 5| 5| 4| 1| 1| 5| 2| 5| 2| 4| 1| 4|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +        +  +  +  +     +        +        +                  |  10        |
      Hepatocellular Adenoma               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +     +        +  +  +  M     +        M        +                  |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +               |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +     +        +  +  +  +     +        M        +                  |   9        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05114-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/19/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 4| 4| 2| 4| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 9| 9| 5| 9| 5| 5| 9| 9| 9| 9| 5| 9| 5| 5| 9| 5| 5| 9| 5|              |            |
                                           | 8| 5| 5| 8| 5| 8| 8| 5| 5| 5| 5| 8| 5| 8| 8| 5| 8| 8| 5| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |     A      |
    0.5  PPM                               | 2| 2| 2| 2| 3| 3| 3| 4| 6| 7| 8| 0| 1| 1| 2| 2| 3| 4| 5| 5|              |     L      |
    SE42                                   | 1| 2| 3| 5| 1| 2| 4| 3| 5| 5| 4| 1| 1| 5| 2| 5| 2| 4| 1| 4|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M     M        M  M  M  M     M        M        +                  |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +        +  +  +  +     +        +        +                  |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +        +  +  +  +     +        +        +                  |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

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