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TDMS Study 05114-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)


NTP Experiment-Test: 05114-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dead                                              10            8            8           13                                     
    Moribund                                           8           10           11           15                                     
    Accident                                           1                         1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           30           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (49)         (50)         (59)                                   
   Intestine Large, Cecum                             (59)         (50)         (50)         (59)                                   
   Intestine Small, Duodenum                          (59)         (50)         (50)         (59)                                   
   Intestine Small, Jejunum                           (59)         (50)         (50)         (59)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Intestine Small, Ileum                             (59)         (50)         (50)         (59)                                   
   Liver                                              (59)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         4 (7%)       2 (3%)       4 (7%)       1 (2%)                                
      Hepatocellular Adenoma                           6 (10%)     10 (17%)      6 (10%)      6 (10%)                               
      Hepatocellular Adenoma, Two                                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Mesentery                                          (7)          (4)          (6)          (3)                                    
      Fibrosarcoma, Metastatic, Skin                                1 (25%)                                                         
      Hemangiosarcoma                                               1 (25%)                                                         
      Histiocytic Sarcoma                              1 (14%)                                                                      
   Pancreas                                           (59)         (50)         (50)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Salivary Glands                                    (59)         (50)         (50)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)       2 (3%)                                
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (50)         (50)         (60)                                   
      Carcinoma                                        1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Adrenal Medulla                                    (58)         (50)         (50)         (59)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (50)         (49)         (60)                                   
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (59)         (49)         (48)         (60)                                   
      Adenoma                                          8 (14%)      3 (6%)       5 (10%)      3 (5%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (59)         (50)         (50)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Sarcoma, Metastatic, Skin                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (52)         (52)         (60)                                   
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Cystadenoma                                                   1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Teratoma NOS                                                  1 (2%)                                                          
   Uterus                                             (59)         (50)         (51)         (60)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Hemangioma, Mild                                                           1 (2%)                                             
      Histiocytic Sarcoma                              3 (5%)       1 (2%)                                                          
      Endometrium, Polyp, Moderate                                  1 (2%)                                                          
      Endometrium, Polyp Stromal, Moderate                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (7)          (8)          (5)          (5)                                    
   Lymph Node, Bronchial                              (57)         (60)         (60)         (60)                                   
   Lymph Node, Mandibular                             (50)         (44)         (47)         (57)                                   
   Lymph Node, Mesenteric                             (59)         (49)         (48)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mediastinal                            (59)         (48)         (48)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (59)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                               2 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (58)         (48)         (48)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (47)         (44)         (53)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Skin                                               (59)         (50)         (49)         (59)                                   
      Fibrosarcoma                                     1 (2%)       1 (2%)                    1 (2%)                                
      Myxosarcoma                                                   1 (2%)                                                          
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (50)         (50)         (60)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)          (2)                                    
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (50)         (50)         (60)                                   
      Meninges, Fibrosarcoma                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Adenoma                     4 (7%)       3 (5%)       4 (7%)       5 (8%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Liver                            1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Nose                                               (59)         (60)         (60)         (57)                                   
      Mucosa, Squamous Cell Carcinoma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (7)          (6)          (4)          (2)                                    
      Adenocarcinoma                                   1 (14%)                                                                      
      Adenoma                                          4 (57%)      5 (83%)      4 (100%)     2 (100%)                              
      Adenoma, Two                                                  1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (50)         (50)         (60)                                   
   Urinary Bladder                                    (58)         (50)         (50)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              4 (7%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                2 (3%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Mixed                        12 (20%)      9 (15%)      5 (8%)       8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          37          34          22                                       
     Total Primary Neoplasms                           56          56          46          32                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          22          25          15                                       
     Total Benign Neoplasms                            28          27          33          18                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          22          11          12                                       
     Total Malignant Neoplasms                         28          28          13          14                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           1                                                   
     Total Metastatic Neoplasm                          1          13           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          90           60           60           60           80           50           
  Scheduled Sacrifice                                 40           10           10           10           30                        
  Early Deaths                                                                                                                      
    Moribund                                           8            6            3            9            7            6           
    Dead                                               6            9            5            7            7           10           
    Accident                                           1            2                                      1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           33           42           34           35           33           
  Animals Examined Microscopically                    90           60           60           60           80           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (80)         (17)         (8)          (59)         (20)                      
   Intestine Small, Jejunum                           (80)         (18)         (9)          (60)         (20)                      
      Adenocarcinoma                                   1 (1%)                                 1 (2%)                                
   Intestine Small, Ileum                             (79)         (19)         (9)          (60)         (20)                      
   Liver                                              (80)         (42)         (47)         (60)         (21)                      
      Hemangiosarcoma                                               1 (2%)                    2 (3%)                                
      Hepatocellular Carcinoma                         9 (11%)      7 (17%)     10 (21%)      9 (15%)      1 (5%)                   
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Carcinoma, Two                                                           1 (2%)                                
      Hepatocellular Adenoma                          23 (29%)     15 (36%)     21 (45%)     11 (18%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Hepatocellular Adenoma, Two                                                2 (4%)       1 (2%)                                
   Mesentery                                          (4)          (5)          (2)          (2)                                    
   Pancreas                                           (79)         (18)         (8)          (60)         (20)                      
   Stomach, Forestomach                               (80)         (29)         (22)         (60)         (20)                      
      Squamous Cell Papilloma                                       1 (3%)       1 (5%)       1 (2%)                                
   Stomach, Glandular                                 (79)         (26)         (18)         (60)         (20)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (17)         (8)          (60)         (20)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (79)         (17)         (8)          (60)         (20)                      
   Adrenal Medulla                                    (79)         (17)         (8)          (60)         (20)                      
      Pheochromocytoma NOS                                                                    1 (2%)                                
   Islets, Pancreatic                                 (79)         (17)         (8)          (60)         (20)                      
                                                             Page   7                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                          1 (1%)                                                                       
   Pituitary Gland                                    (77)         (16)         (8)          (59)         (20)                      
      Carcinoma                                        1 (1%)                                                                       
   Thyroid Gland                                      (87)         (19)         (12)         (60)         (67)         (45)         
      Follicular Cell, Adenoma                         1 (1%)                    3 (25%)      2 (3%)       2 (3%)       2 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (79)         (17)         (8)          (60)         (20)                      
      Fibrosarcoma                                                               1 (13%)                                            
   Testes                                             (80)         (18)         (9)          (60)         (20)                      
      Interstitial Cell, Adenoma                                    1 (6%)       1 (11%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (80)         (17)         (8)          (60)         (59)         (35)         
      Mast Cell Tumor NOS                                                                                  1 (2%)                   
   Lymph Node                                         (1)          (5)          (3)          (2)                                    
   Lymph Node, Bronchial                              (84)         (27)         (16)         (56)         (78)         (48)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                                         1 (2%)      
   Lymph Node, Mandibular                             (60)         (13)         (3)          (52)         (15)                      
   Lymph Node, Mesenteric                             (78)         (22)         (13)         (59)         (20)                      
   Lymph Node, Mediastinal                            (81)         (16)         (8)          (60)         (64)         (44)         
   Spleen                                             (80)         (18)         (13)         (60)         (20)                      
   Thymus                                             (84)         (16)         (7)          (60)         (68)         (46)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (80)         (18)         (11)         (60)         (68)         (46)         
      Fibrosarcoma                                                               1 (9%)                                             
      Hemangiosarcoma                                                            1 (9%)                                             
      Papilloma                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (90)         (27)         (18)         (60)         (80)         (49)         
   Lung                                               (89)         (60)         (60)         (60)         (78)         (49)         
      Alveolar/Bronchiolar Adenoma                    13 (15%)      7 (12%)      9 (15%)     12 (20%)     10 (13%)     14 (29%)     
      Alveolar/Bronchiolar Adenoma, Multiple                        3 (5%)       2 (3%)       4 (7%)                    1 (2%)      
      Alveolar/Bronchiolar Carcinoma                                3 (5%)       4 (7%)       2 (3%)       4 (5%)       1 (2%)      
      Alveolar/Bronchiolar Carcinoma, Multiple                                                                          1 (2%)      
      Hemangiosarcoma, Metastatic, Liver                            1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (3%)       1 (2%)                    3 (5%)       2 (3%)                   
   Nose                                               (90)         (60)         (60)         (60)         (80)         (49)         
   Trachea                                            (90)         (60)         (60)         (60)         (80)         (49)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (7)          (4)          (7)          (2)          (4)          (3)          
      Adenoma                                          7 (100%)     3 (75%)      5 (71%)      2 (100%)     4 (100%)     3 (100%)    
      Adenoma, Two                                                               2 (29%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (81)         (22)         (12)         (60)         (20)                      
   Urinary Bladder                                    (80)         (18)         (17)         (60)         (20)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(90)        *(60)        *(60)        *(60)        *(80)        *(50)         
      Lymphoma Malignant Histiocytic                                             1 (2%)       2 (3%)       1 (1%)       1 (2%)      
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                         2 (2%)       5 (8%)       4 (7%)       2 (3%)                    3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          35          43          36          21          24               
     Total Primary Neoplasms                           58          47          68          57          23          26               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          25          34          27          15          18               
     Total Benign Neoplasms                            45          31          46          35          16          20               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          15          20          18           6           6               
     Total Malignant Neoplasms                         13          16          22          21           6           6               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2                       3           2           1               
     Total Metastatic Neoplasm                          3           2                       3           2           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1           1                           
     Total Uncertain Neoplasms                                                              1           1                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          90           70                                                               
  Scheduled Sacrifice                                 40           20                                                               
  Early Deaths                                                                                                                      
    Dead                                               4            7                                                               
    Moribund                                           5           10                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           33                                                               
  Animals Examined Microscopically                    90           70                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (20)         (10)                                                             
      Hepatocellular Adenoma                                        1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (79)         (50)                                                             
      Follicular Cell, Adenoma                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (87)         (66)                                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Lymph Node, Mediastinal                            (75)         (53)                                                             
                                                             Page  11                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (89)         (70)                                                             
      Alveolar/Bronchiolar Adenoma                    11 (12%)     10 (14%)                                                         
      Alveolar/Bronchiolar Adenoma, Multiple           1 (1%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   5 (6%)       7 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (3)                                                              
      Adenoma                                          4 (100%)     1 (33%)                                                         
      Carcinoma                                                     1 (33%)                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(90)        *(70)                                                             
      Lymphoma Malignant Histiocytic                   1 (1%)                                                                       
      Lymphoma Malignant Mixed                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            20          17                                                               
     Total Primary Neoplasms                           24          20                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          12                                                               
     Total Benign Neoplasms                            17          12                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               6           8                                                               
     Total Malignant Neoplasms                          7           8                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1                                                               
     Total Metastatic Neoplasm                                      2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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