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TDMS Study 05114-02 Pathology Tables

NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|             
                                           | 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                             3            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Cytoplasmic Alteration               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                     2                    2               |             
      Inflammation, Subacute               |                         3     4                       2                  |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Pigmentation                         |          3                                                               |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                       2                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  M  +  +     M  M  M  +  M  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             4                                                            |             
      Hypertrophy                          |                               2  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|             
                                           | 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Subacute               |                                  2                                       |             
      Follicular Cell, Hyperplasia         | 1                    3                          1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         2                    2                    3  4   |             
      Inflammation, Subacute               |                                                                   2      |             
      Mineralization                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia             |                      3        2           3                 2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                3                          3                 3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       4  3                                                               |             
      Hemorrhage                           |                                                 4                        |             
      Hyperplasia, Lymphoid                |                                                             2  3         |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|             
                                           | 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    3                    2     2     2        2              2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Infiltration Cellular, Lymphocyte    |                                                                   2      |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Cornea, Inflammation, Suppurative    |                                                                   1      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Casts                                |          3                                                  3            |             
      Cyst                                 |                                                    1                     |             
      Infiltration Cellular, Lymphocyte    |                                                                3         |             
      Inflammation, Subacute               |                                           2                              |             
      Nephropathy, Chronic                 |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|             
                                           | 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Cytoplasmic Alteration               |                   2                                                      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Subacute               |                               1                                3         |             
      Inflammation, Suppurative            |                                  4                                       |             
      Necrosis, Acute                      |    3                                                                     |             
      Pigmentation                         |                                                                          |             
      Centrilobular, Necrosis              |                                                                   4      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +     +  +        +                     |             
      Inflammation, Suppurative            |                                  3                                       |             
      Fat, Necrosis                        |                                        3           3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                         3     2                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hypertrophy                          |                            3           3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|             
                                           | 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3                                    |             
      Inflammation, Subacute               |                                                                          |             
      Follicular Cell, Hyperplasia         | 2        1           1              3  1                 4               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 3        3               |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    4                                                                     |             
      Inflammation, Suppurative            |                                  4                                       |             
      Endometrium, Hyperplasia             |    3              3           3              3     3                 3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  +              +              +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      3  4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        4           3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        3                 3     3         |             
      Inflammation, Suppurative            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                         2                                         3      |             
      Inflammation, Suppurative            |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|             
                                           | 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2           2                          2        2           3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     3                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1  2  1     1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +  +        +                             +|             
      Cyst                                 |                                  2                                       |             
      Inflammation, Suppurative            |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                4                                                         |             
      Casts                                |                                                                          |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                3         |             
      Inflammation, Subacute               |                                                                          |             
      Nephropathy, Chronic                 |                                                          4               |             
      Pelvis, Dilatation                   | 3                                                        3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
      Inflammation, Subacute               |                                                                          |      5  2.6|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis, Acute                      |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                                                               |   7        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Fat, Necrosis                        |          3                                                               |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |          3                                                               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |          2                                                               |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  4.0|
      Hypertrophy                          |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                3        3                                                |      8  2.9|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                                                                          |     10  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                 +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |          4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Lymphoid                |          4                                                               |      6  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.7|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |          3                                                               |      6  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Alopecia                             |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrous Osteodystrophy               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mineralization                       |                      2                                                   |     12  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                                                                          |      2  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Suppurative    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   7        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Casts                                |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 4| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2|                                            |            |
                                           | 8| 4| 9| 7| 3| 7| 7| 8| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |      1  4.0|
      Pelvis, Dilatation                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                3                                                         |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Hyperplasia, Nodular                 |                   2                                                      |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation, Chronic                |    4                                                                     |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Subacute               |                                        2                                 |             
      Mineralization                       |    4                                                                     |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                      3   |             
      Hyperplasia, Squamous                |                1                                                         |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  M     +  M  M  M  +  M  M     M        +     M  +  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2              3        3                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       1           1  2        4                    1              4  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Cyst                                 | 2                 4           2                       2  2     4  3  3  3|             
      Hemorrhage                           |                                     3                                    |             
      Inflammation, Suppurative            |                                                             4            |             
      Granulosa Cell, Hyperplasia          |                                                                         3|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +           +                 +        +         |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  M  M  +  +  +  +     +        +     +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |             4                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             4            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +  +  M  +  +  M  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                 1                        |             
      Hemorrhage, Acute                    |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|             
                                           | 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Mineralization  |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Mineralization                       |                2                                                  2     2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Hyperplasia, Macrophage              |    4                                                                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Subacute               |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1                                 |             
      Mucosa, Pigmentation                 |    1  1  1     1  1  1  1  1  2  1  1        1  1     1           1  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 |       1                                                           1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +           +  +                       +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Casts                                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy, Chronic                 |                                                             3            |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +  +  +  +  +  +     +        +     +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  M  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  M     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |             2                                                            |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |    3           2                                                         |             
      Hyperplasia, Nodular                 |                                              3                           |             
      Infiltration Cellular, Lymphocyte    |                      3                                                  2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                                       2                  |             
      Inflammation, Subacute               |          2                                                               |             
      Mineralization                       |                                                                          |             
      Necrosis, Acute                      |                                        2                       3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +     +           +           +         |             
      Fat, Necrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Serosa, Inflammation, Suppurative    |    4                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +     +  M  +  +  M  M  +  M     M  M  +  M  +  M     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                   1        2                 2              3     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                            3                    3     2  2  2           2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |    4           4                                                         |             
      Granulosa Cell, Hyperplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                         2|             
      Endometrium, Hyperplasia             |             4           3              3                             3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +                                                     +   |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Inflammation, Suppurative            |                4                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  M  +  +  +     +  +  +  +  M  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               3              4                           |             
      Thrombosis                           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +     +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |    3                                                                     |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Developmental Malformation           |                                                             3            |             
      Hematopoietic Cell Proliferation     |    4           3  3              4                    3                  |             
      Hyperplasia, Lymphoid                |                      3  3                 4                             3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +|             
      Alopecia                             |                                                                          |             
      Hemorrhage, Acute                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|             
                                           | 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Mineralization                       |                                                       2                 2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                      4  3     3                                          |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 3                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Pigmentation                 |             1     1  1  1  1  2  1  1     2  1  1  1  1     2  1  1  2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 |             2                 1                                   1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Atrophy                              |                                                             3            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                 +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Casts                                |                                                       3           2      |             
      Infiltration Cellular, Lymphocyte    |                         3                                                |             
      Inflammation, Subacute               |                   2                                                      |             
      Metaplasia, Osseous                  |                                                             2            |             
      Nephropathy, Chronic                 |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                  4                             3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                                             |  50        |
      Peyer's Patch, Hyperplasia, Lymphoid |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytoplasmic Alteration               |                                                                          |      2  2.5|
      Focal Cellular Change                |          2                                                               |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Hyperplasia, Nodular                 |                                                                          |      2  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Necrosis, Acute                      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  M  +  +  M     +                                             |  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hyperplasia                          |       2                                                                  |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                                             |  50        |
      Follicular Cell, Hyperplasia         |       2  3                                                               |     14  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +     +                                             |  52        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |       2  2        3                                                      |     18  2.6|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  4.0|
      Granulosa Cell, Hyperplasia          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |          2     4                                                         |      7  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                                             |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |   8        |
      Renal, Congestion                    |                      4                                                   |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +     +                                             |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |             3                                                            |      3  3.3|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +     +                                             |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Developmental Malformation           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      6  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +     +                                             |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
      Alopecia                             |                                                                          |      1  1.0|
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Subcutaneous Tissue, Mineralization  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
      Mineralization                       |       2           2        2                                             |      8  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Macrophage              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |             3                                                            |      4  3.3|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mucosa, Pigmentation                 | 1  1  1  1  1  1  1  1     1                                             |     44  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Pigmentation                 |                   1                                                      |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 6| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3|                                            |            |
                                           | 7| 5| 7| 7| 7| 9| 7| 8| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.01 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
      Casts                                |                                                                          |      2  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |      1  3.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|             
                                           | 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Arteriole, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            |                                              4                           |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hyperplasia, Nodular                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                            +        +   |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                3                                            4        3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                2                                         2               |             
      Necrosis                             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Arteriole, Inflammation, Subacute    |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  M  M  +              M  M  +  +  +  +  M  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|             
                                           | 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |    3                          2                                   3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Follicular Cell, Hyperplasia         |          1                    3                       1        1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Cyst                                 | 2                    4              2                    2        3      |             
      Inflammation, Suppurative            |                4           2                 4                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                            2                 3                           |             
      Endometrium, Hyperplasia             | 4           3                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +              +                       +                     |             
      Iliac, Hyperplasia, Lymphoid         |                            3                                             |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3        3                                             |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +              +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  M  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +              +  +  M  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Suppurative            |                3                             2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                3           3                 3                           |             
      Hyperplasia, Lymphoid                | 3                                                                    3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  M  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +              +  +  +  +  +  +  M  +  +   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Alopecia                             |                                                                2         |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|             
                                           | 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Developmental Malformation           |                                                                          |             
      Fracture                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Compression                          |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mucosa, Pigmentation                 | 1  1  2  2           1        1     1     1     1     2  1  1     1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Pigmentation                 | 4  3  4  3  3  3  3  4     3  3  2  2  2  2  2  3  2  3  4  3  2  3  3  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  2  2  2  2  1  2  2     1  2  2  2  1  1     2     2  2  2  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Cornea, Edema                        |                                  1                                       |             
      Cornea, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
      Casts                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               | 2                 3                                                      |             
      Metaplasia, Osseous                  |                                                       3                  |             
      Mineralization                       |                                                                   3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|             
                                           | 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Arteriole, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                  3                                       |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Hyperplasia, Nodular                 |                                                             3            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Subacute               |                                                             3  2         |             
      Necrosis, Acute                      |       2                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            4                                             |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Arteriole, Inflammation, Subacute    |                         3                                                |             
      Atrium, Thrombosis                   |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +     M  +  M  M  +  +  +  +  +     +     +  +  +     +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|             
                                           | 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     M  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Hyperplasia                          | 3                                      3                 3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Follicular Cell, Hyperplasia         |    1        1                       3  1  2              2        1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Cyst                                 |          2                    3        3                    4            |             
      Inflammation, Suppurative            |                         4                             4                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Hemorrhage                           |       4                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia             |             4  2                    1        2                    3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                +                                 |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           3                             3|             
      Hyperplasia, Plasma Cell             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +  +  M  +  +  +  +  +     +     +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                       3                  |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                         3                             3                 3|             
      Hyperplasia, Lymphoid                |       4                                   4                 4            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +     +  +  +  +  +  M  +  +  +     +     +  +  +     +  +  M|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Alopecia                             |                                                                          |             
      Inflammation, Suppurative            |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|             
                                           | 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fracture                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Compression                          |                                  4                                       |             
      Mineralization                       |             2           2        2                                       |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                      3   |             
      Inflammation, Subacute               |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Mucosa, Pigmentation                 | 1  1  1  1  1                 1     1  1        2        2  2  1  2     1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                         2|             
      Inflammation, Suppurative            |                                        1                    2            |             
      Mucosa, Pigmentation                 | 3  3  1  2  4  1  2  1  2     3  3  2  2  4  1  3  2  2  3  3  3  2  3  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  1  1  2  2  1  1     1     2  1  2  1  1  1  2  2     2  1  1  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Edema                        |                                                                          |             
      Cornea, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
      Amyloid Deposition                   |                   4                                                      |             
      Casts                                |                                           3                              |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Arteriole, Inflammation, Subacute    |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia, Lymphoid |             3  3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Peyer's Patch, Hyperplasia, Lymphoid |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                |                3                                                         |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Nodular                 |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |             3                                                            |      1  3.0|
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Necrosis, Acute                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                       +                                                |   6        |
      Inflammation, Suppurative            |                         4                                                |      1  4.0|
      Fat, Necrosis                        | 3                                                                        |      5  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                         4                                                |      1  4.0|
      Inflammation, Subacute               |                         3                                                |      1  3.0|
      Inflammation, Suppurative            |                         4                                                |      2  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Arteriole, Inflammation, Subacute    |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +                                             |  48        |
      Hyperplasia                          |                   3                                                      |      7  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Follicular Cell, Hyperplasia         | 2     4     1     2                                                      |     16  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Cyst                                 |    2              4  2  3                                                |     13  2.8|
      Inflammation, Suppurative            |                         2                                                |      6  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                4                                                         |      2  4.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Endometrium, Hyperplasia             |                                                                          |      7  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      4  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M                                             |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Hyperplasia, Lymphoid                |    3        3  3                                                         |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +                                             |  48        |
      Hyperplasia, Lymphoid                | 4                                                                        |      2  3.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                3                                                         |      7  3.0|
      Hyperplasia, Lymphoid                |       3                                                                  |      6  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +                                             |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  M  +  +  +                                             |  44        |
      Duct, Dilatation                     |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Alopecia                             |                2                                                         |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Developmental Malformation           |                   3                                                      |      1  3.0|
      Fracture                             |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          |                                                                          |      1  4.0|
      Mineralization                       |    2                                                                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                   3                                                      |      3  2.7|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Mucosa, Pigmentation                 | 2           1     1                                                      |     31  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                2                                                         |      3  1.7|
      Mucosa, Pigmentation                 | 2  1  3  3  3  1  2  2  2  2                                             |     59  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Mucosa, Pigmentation                 | 2  1  2  2  1  1  2  2  2                                                |     53  1.6|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0|                                            |            |
                                           | 6| 0| 6| 6| 8| 0| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
      Cornea, Edema                        |                                                                          |      1  1.0|
      Cornea, Hyperplasia                  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +           +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Casts                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                4                                                         |      1  4.0|
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Subacute       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            3                                      4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    X                                                                     |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                      4  2                                                |             
      Inflammation, Subacute               |       2  2                             2                                 |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   4        3              2                              |             
      Acinar Cell, Hypoplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                       3                  |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Mineralization                       |                               3                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  M  M  M  M  M  +  M  +  M  +  M  +  +  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Suppurative            |       4                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                        1  2                 3           1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                   +                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                 2                              |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                   4  4  4  4  4  4     4  3                 4     4  4   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      1   |             
      Inflammation, Suppurative            |                            2           2                                 |             
      Endometrium, Hyperplasia             |             2                                                  4         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +                                                      |             
      Renal, Inflammation, Suppurative     |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3  4                                                               |             
      Hyperplasia, Mast Cell               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3                                            4      |             
      Inflammation, Suppurative            |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            3  3     3                                    |             
      Inflammation, Suppurative            |                   4     2                                            3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   4  4  3  4  4  4        3                 4  3  3  2   |             
      Inflammation, Suppurative            |                                                                          |             
      Capsule, Inflammation, Subacute      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    X                                                                     |             
      Inflammation, Suppurative            |       4                                                                  |             
      Mineralization                       |                                                 2  2                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    X                                                                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               2                                          |             
      Inflammation, Subacute               |                   3                                                      |             
      Inflammation, Suppurative            |                                     4           4                        |             
      Alveolar Epithelium, Hyperplasia     |    2                                                  2                  |             
      Mucosa, Pigmentation                 | 2     2  1  2  3  2  3  2  2  1  2     2  1  2     3  3  3  2  2  1  2  1|             
      Pleura, Inflammation, Suppurative    |                         2                                            3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       4  3        2  2  3  2     2  3  1  2  3  3  1     1  1  1  2  2  1|             
      Mucosa, Pigmentation                 | 2     2     3  3  2  2  2  2  1  1  2  2  1  2  1  1  3  2     2     1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     2                                    |             
      Mucosa, Pigmentation                 | 2     2     2  3  2  2  1  2  2  2     2  2  2  2  3  2  2  1  3  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    X                                                                     |             
      Casts                                |                                                                          |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|             
                             DAY ON TEST   | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|             
                                           | 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |       2              2                                                   |             
      Nephropathy, Chronic                 |                   3                                               2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Congestion                           |                      2                                                   |             
      Cytoplasmic Alteration, Focal        |          2                                      2                        |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                            3  3                                          |             
      Inflammation, Subacute               |                                  2                    2                  |             
      Serosa, Inflammation, Suppurative    |                                           4                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +              +                                          |             
      Fat, Necrosis                        |                3              4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Acinar Cell, Hypoplasia              |    4                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                   2                          3                           |             
      Hyperplasia, Squamous                |                            2                                             |             
      Serosa, Fibrosis                     |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                          3               |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                          3               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                            2                                             |             
      Hyperplasia                          |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    3                    2  1           2           2              1     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                    2        1     4  4     2   |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            | 4                          4  4           4                              |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                            2                                             |             
      Endometrium, Hyperplasia             |                         3                       2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
      Renal, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3                          3                                3      |             
      Hyperplasia, Mast Cell               |                                                                      4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3                          4  3           3                              |             
      Inflammation, Suppurative            |                               4                                          |             
      Capsule, Inflammation, Subacute      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |             1        2              2        2                          2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                2         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                   2      |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mucosa, Pigmentation                 | 2  2  2  2  3  2  1  2  2  3     2  2  2     2  2  2  2  2  2  2  2  3  2|             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2  2  4  2     3  3  2     3  2  4  2  2        3  4  3     2  1  4  2  3|             
      Mucosa, Pigmentation                 | 2  2     2  1  2     1  4  2  2  1  1  1     2  2  2  1  2  2  3  1  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1                                                   |             
      Mucosa, Pigmentation                 | 2  2  2  2  2  2     2  2  2     2  2  2     2  2  2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Casts                                |                                                                   2      |             
      Congestion                           |                                     1                                    |             
      Infiltration Cellular, Lymphocyte    |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|             
                                           | 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.2   PP                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Nephropathy, Chronic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Serosa, Inflammation, Subacute       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bacterium                            |                                                                          |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.0|
      Focal Cellular Change                | 4                                                                        |      1  4.0|
      Hematopoietic Cell Proliferation     |                   2        2                                             |      6  2.7|
      Inflammation, Subacute               |    2              2     2                                                |      8  2.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Fat, Necrosis                        |          4                                                               |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      3  3.0|
      Acinar Cell, Hypoplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |             3     4        2                                             |      5  2.8|
      Hyperplasia, Squamous                |          4                                                               |      3  3.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Necrosis                             |       2                                                                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |             2                                                            |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia         |          3  1              4                                             |     14  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | 3     3                                                                  |     10  2.7|
      Inflammation, Subacute               |                   2                                                      |      1  2.0|
      Inflammation, Suppurative            |                   4        4                                             |     17  3.9|
      Pigmentation                         |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                            2                                             |      4  2.0|
      Endometrium, Hyperplasia             |    3                                                                     |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        +                                                         |   5        |
      Renal, Inflammation, Suppurative     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |          4        4                                                      |      7  3.4|
      Hyperplasia, Mast Cell               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
      Inflammation, Suppurative            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                   3        3                                             |     17  3.4|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Capsule, Inflammation, Subacute      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Developmental Malformation           |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bacterium                            |                                                                          |      1     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      7  1.9|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Bacterium                            |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Mucosa, Pigmentation                 | 2  3  1  1  2  1  2     2  1                                             |     56  2.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +                                             |  57        |
      Inflammation, Suppurative            | 2  3  4  4  2  2  4  2     2                                             |     48  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 7| 7| 7| 0| 4| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5|                                            |            |
                                           | 6| 8| 6| 6| 6| 0| 6| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2   PP                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    M                                      | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Pigmentation                 | 2  1  2  1  2  2           2                                             |     50  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A                                             |  57        |
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Mucosa, Pigmentation                 | 2  2  2  2  2  2  2     2                                                |     52  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   2        |
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bacterium                            |                                                                          |      1     |
      Casts                                |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Nephropathy, Chronic                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  M  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |                3                                                         |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Fatty Change                         |                                                                          |             
      Focal Cellular Change                |                                                    2                     |             
      Hyperplasia, Nodular                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Subacute               |    2                                                              3      |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                +              +         |             
      Necrosis                             |                                                                2         |             
      Fat, Hemorrhage                      |                2                                                         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                                   +                    +         |             
      Inflammation, Suppurative            |                                           4                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +                                                     +         |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |          3                                                               |             
      Duct, Dilatation                     |       4                                                        4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                2         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Hyperplasia                          |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  M  M  +     +  +  +  +     M  +  +  +  M  +  +     +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +     +  +  +  +     M  +  +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  M     M  M  M  M     M  M  M  +  M  M  +     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Alopecia                             |                                                                          |             
      Inflammation, Suppurative            |          4                             3  4                              |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Compression                          |                                                                          |             
      Mineralization                       |                                                       2                 2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Bronchiole, Hyperplasia              |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                   +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Casts                                |                                                                          |             
      Cyst                                 |                                                                          |             
      Dilatation                           |                      2           2                                      2|             
      Hydronephrosis                       |                                                                          |             
      Hypertrophy                          |                                                                   2      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |       2                             3                                    |             
      Nephropathy, Chronic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|             
                                           | 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polycystic Kidney                    |                                                                   4      |             
      Pelvis, Dilatation                   |       2  2                                2                              |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                                                                  |             
      Concretion                           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
      Concretion                           |                                                                          |             
      Dilatation                           |       3  2        2                       2                    4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Fatty Change                         |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Infarct                              |                                                 4                        |             
      Inflammation, Chronic                |                                                 3                        |             
      Inflammation, Necrotizing            |                4                                                         |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                       3                  |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Necrosis                             |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  M     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  M|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                    1              2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                       +                  |             
      Inflammation, Suppurative            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +     +  +              +   |             
      Inflammation, Granulomatous          |                                                    2                     |             
      Inflammation, Suppurative            |                                                                      4   |             
      Duct, Dilatation                     |                                              4        3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  M  M  +  +  +  +     M  +  M     +  +  +  M  M  +     +  +  M|             
      Congestion                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Lymphoid                |                         2                    3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  +  M  M     M  M  M     M  M  +  M  M  M     M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Alopecia                             |                         2                             2                  |             
      Inflammation, Suppurative            |                         3                                                |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Compression                          |                                                                          |             
      Mineralization                       |       2           2                    2                    2     2      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                         2                                                |             
      Bronchiole, Hyperplasia              |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Casts                                |                                                                          |             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Hydronephrosis                       |                                                                      4   |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                         2  2        2              2                     |             
      Inflammation, Suppurative            |                                                       4                  |             
      Nephropathy, Chronic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|             
                                           | 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polycystic Kidney                    |                                                                          |             
      Pelvis, Dilatation                   |                                     2           2     3                  |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +|             
      Concretion                           |             4                                                            |             
      Dilatation                           |             4                                                        4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                  3                                       |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                            3                                             |             
      Cytoplasmic Alteration               |                         2                                                |             
      Fatty Change                         |                      3                                                   |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Subacute               |                            4                                             |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Acute                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Necrosis                             |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                         2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mineralization                       |                         2                                                |             
      Necrosis                             |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  +  M  +  M  M  M  M  +  +  M  +  +  +  M  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                 +                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Dilatation                           |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            3     3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alopecia                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Compression                          |                      2                                                   |             
      Mineralization                       |    2                 3           2           2                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Bronchiole, Hyperplasia              |                                                                          |             
      Pleura, Inflammation, Suppurative    |       4                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |       4                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +  +                    +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Casts                                |                      3                                                   |             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|             
                             DAY ON TEST   | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|             
                                           | 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polycystic Kidney                    |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Concretion                           |                                                                          |             
      Dilatation                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  89        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +     +  +  +  +  +  +  +  +                              |  75        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Fatty Change                         |                                                                          |      1  3.0|
      Focal Cellular Change                |                                                                          |      1  2.0|
      Hyperplasia, Nodular                 |                            3                                             |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Inflammation, Subacute               |                                     4                                    |      4  3.3|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Necrosis, Acute                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Necrosis                             |                                                                          |      1  2.0|
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
      Inflammation, Subacute               |    2                                                                     |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
      Hyperplasia                          |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  79        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +     +  +  M  M  +  M  +  +                              |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M     +  +  +  +  +  +  +  +                              |  77        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +     +  +  +  +  +  +  +  +                              |  87        |
      Follicular Cell, Hyperplasia         |                                                                          |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  79        |
      Inflammation, Granulomatous          |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   9        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
      Duct, Dilatation                     | 4                                                                        |      5  3.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Dilatation                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Atrophy                              |                                     4                                    |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  84        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +  M     +  +  +  +  +  +  M  +                              |  60        |
      Congestion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  78        |
      Congestion                           |                            2                                             |      1  2.0|
      Hemorrhage                           | 3                                                                        |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +                              |  81        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Hematopoietic Cell Proliferation     |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     M  +  +  +  +  +  +  +                              |  84        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M     M  M  M  M  M  M  M  M                              |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Alopecia                             |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      4  3.5|
      Prepuce, Inflammation, Suppurative   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Compression                          |                                                                          |      1  2.0|
      Mineralization                       |    3  2                 2  2  2     1                                    |     17  2.1|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +                              |  89        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2                                                                        |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Bronchiole, Hyperplasia              |                               2                                          |      1  2.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Hemorrhage, Acute                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2|                             |            |
                             DAY ON TEST   | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9|                             |            |
                                           | 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  81        |
      Casts                                |                                                                          |      1  3.0|
      Cyst                                 |                               2                                          |      1  2.0|
      Dilatation                           |                                                                          |      3  2.0|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
      Inflammation, Subacute               |                                        2                                 |      5  2.0|
      Inflammation, Suppurative            |                                                                          |      3  3.0|
      Nephropathy, Chronic                 |                            2        2                                    |      2  2.0|
      Polycystic Kidney                    |                                                                          |      1  4.0|
      Pelvis, Dilatation                   |                                                                          |      6  2.2|
      Renal Tubule, Cytoplasmic Alteration |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Concretion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +                              |  80        |
      Concretion                           |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      8  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +           +                 +                    +  +               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +              +  +                    +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +        +  +  +  +     +  +  +  +  +     +  +  +  +        +     +|             
      Angiectasis                          |                                                          4               |             
      Cyst                                 |                                     3                                    |             
      Fibrosis                             |                                                          3               |             
      Focal Cellular Change                |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                                                          3               |             
      Inflammation, Subacute               |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +           +                 +                    +  +     +         |             
      Duct, Cyst                           |                                                                4         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +           +  +              +     +        +  +  +  +        +      |             
      Hyperkeratosis                       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +           +  +              +     +           +  +  +        +      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Developmental Malformation           |                                                 2                        |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +                 +                    +  +               |             
      Inflammation, Subacute               |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +                 M                    +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +           +                 M                    +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +                 +  +                 +  +               |             
      Follicular Cell, Hyperplasia         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +                 +                    +  +               |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +                           |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                              3                           |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +                 +                    +  +               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +                 +                    +  +               |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +           +                 +                    +  +               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
      Congestion                           |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +           +  +              +     +           +  +  +        +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +           +                 M                    +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +              +  +                 +  +  +               |             
      Congestion                           |       3                                                                  |             
      Hemorrhage                           |                                                    3                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +           +                 M                    +  +               |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +           +              +  +                    +  +               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +           +                 M                    +  +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           M                 M                    M  M               |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +                 +        +           +  +               |             
      Alopecia                             |                                           2                              |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    M           +                 +                    +  +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +                 +                    +  +               |             
      Cerebellum, Infarct                  |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    M                                                                     |             
      Hemorrhage, Acute                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +           +  +              +     +           +  +  +        +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      2   |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               3                                          |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Arteriole, Inflammation, Suppurative |                                                                          |             
      Mucosa, Pigmentation                 |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2     2  1  2  2  1  2  2  1  1  2  2  1  2  2  2  1     2  2  1     1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2        2  2           1  1  1           1  2  2        2  2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                      +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +                 +                    +  +           +   |             
      Cyst                                 |          3                                                               |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                          3               |             
      Mineralization                       |                                                                          |             
      Pelvis, Dilatation                   |                3                                                         |             
      Renal Tubule, Degeneration           |                4                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +                 +                    +  +               |             
      Concretion                           |                                                                          |             
      Dilatation                           |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|             
                                           | 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +        +        +     +     +        +     +  +            |             
      Epithelium, Hyperplasia              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +     +  +  +  +        +  +     +  +  +  +  +  +     +   |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Focal Cellular Change                |                3                                                         |             
      Infarct                              |                                                             4            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                               3                                          |             
      Necrosis, Acute                      |                               4                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +                                      +           +               |             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            |       4                                                                  |             
      Necrosis                             |                                                          3               |             
      Fat, Necrosis                        | 3                                            3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +        +        +           +        +     +  +            |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +  +  +     +  +        +  +  +               |             
      Hyperkeratosis                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +     +        +  +        +  +  +               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Developmental Malformation           |                                                                2         |             
      Inflammation, Suppurative            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +        +        +           +        +     +  +            |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     M        M        M           +        +     M  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +        +        +           +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|             
                                           | 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +        +        +           +        +     +  +            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +        +        +           +        +     +  +            |             
      Serosa, Inflammation, Suppurative    |       4                                                                  |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                    +                     |             
      Concretion                           |                                                    3                     |             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                             +                          +               |             
      Inflammation, Suppurative            |                               4                                          |             
      Duct, Dilatation                     | 4                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +        +        +           +        +     +  +            |             
      Inflammation, Suppurative            |                                                             4            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +     +        +        +           +        +     +  +           +|             
      Dilatation                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +        +        +           +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                    +                              |             
      Congestion                           |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +  +  +        +  +     +        +  +        +  +  +  +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       M     +        +        +           +        +     +  M            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +        +        +           +        +     +  +            |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +        +        +           +        +     +  +            |             
      Hematopoietic Cell Proliferation     |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     M        +        +           +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M     M        M        M           M        M     M  +            |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +        +        +           +        +     +  +            |             
      Alopecia                             |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|             
                                           | 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +        +        +           +        +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +        +        +           +        +     +  +            |             
      Cerebellum, Infarct                  |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
      Hemorrhage, Acute                    |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +  +        +  +     +        +  +        +  +  +  +            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2     2                     |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                3         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |          1                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
      Arteriole, Inflammation, Suppurative |                                                                          |             
      Mucosa, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  2  2  1  2  1  1  1     2  2  2  2     1  2  2  2  1  1     1  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  1           1  1        1  1  2  1        2  1  1     1        1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +        +        +           +        +     +  +           +|             
      Cyst                                 |                                                                         2|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                    4        4            |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +        +        +           +        +     +  +     +      |             
      Concretion                           |                                                                          |             
      Dilatation                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +  +        +                                                |  18        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +  +        +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +  +  +  +  +                                             |  42        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Focal Cellular Change                |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Necrosis, Acute                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   5        |
      Congestion                           | 3                                                                        |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +  +        +                                                |  18        |
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +  +  +  +                                                |  29        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +  +  +  +                                                |  26        |
      Necrosis                             |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +  +        +                                                |  17        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +  +        +                                                |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +  +        +                                                |  16        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +  +  +        +                                                |  19        |
      Follicular Cell, Hyperplasia         |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +  +        +                                                |  17        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |             +           +                                                |   3        |
      Concretion                           |                         3                                                |      2  3.0|
      Hemorrhage, Acute                    |             4                                                            |      1  4.0|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +                                                         |   5        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Duct, Dilatation                     |                3                                                         |      3  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +  +        +                                                |  17        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +        +                                                |  18        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +  +        +                                                |  18        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +  +        +                                                |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +           +                                             |   5        |
      Congestion                           |                            2                                             |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +  +  +  +  +  +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +        M                                                |  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  M  +        +  +                                             |  22        |
      Congestion                           |       2                                                                  |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |          +  +  +        +                                                |  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +        +                                                |  18        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +  +        +                                                |  16        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M  +        M                                                |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +        +                                                |  18        |
      Alopecia                             |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |                4                                                         |      1  4.0|
      Inflammation, Suppurative            |             3                                                            |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +        +                                                |  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +  +        +                                                |  17        |
      Cerebellum, Infarct                  |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage, Acute                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +  +  +  +  +  +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      3  2.0|
      Hemorrhage, Multifocal               |          2                                                               |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                            2                                             |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Arteriole, Inflammation, Suppurative |                         3                                                |      1  3.0|
      Mucosa, Pigmentation                 |       1                                                                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Pigmentation                 | 1  2  2  1        1  1  1  2                                             |     52  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Pigmentation                 |       1                    1                                             |     29  1.4|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 6| 4| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3|                                            |            |
                                           | 3| 3| 3| 9| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +        +                                                |  22        |
      Cyst                                 |                                                                          |      2  2.5|
      Hydronephrosis                       |             2                                                            |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Mineralization                       |          2                                                               |      1  2.0|
      Pelvis, Dilatation                   |    2           3        4                                                |      4  3.0|
      Renal Tubule, Degeneration           |                         4                                                |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +  +        +                                                |  18        |
      Concretion                           |          4                                                               |      1  4.0|
      Dilatation                           |             3  4        4                                                |      5  3.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +                                +                                    |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +     +     +  +        +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                       2                  |             
      Focal Cellular Change                |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Nodular                 | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Congestion                           |    3                                                                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    M                                +                                    |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                 +  +  +        +                 +     +            |             
      Cyst                                 |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                         4                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                 +     +        +                 +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M                                +                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +                                +           +           +            |             
      Follicular Cell, Hyperplasia         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +                                                  +            |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |    4     3                                                  3            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +                    +                                    |             
      Dilatation                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  |    +                                +                       +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
      Iliac, Hyperplasia, Lymphoid         |                                     3                                    |             
      Renal, Hyperplasia, Lymphoid         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +                 +     +        +                 +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M                                M                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                                +                       +            |             
      Congestion                           |                                                             3            |             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                     4                                    |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +                                +                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +           +           +                       +            |             
      Hematopoietic Cell Proliferation     |             2                                               3            |             
      Hyperplasia, Lymphoid                |                         3           3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M                                M                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                       +        +                                    |             
      Alopecia                             |                            2                                             |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |    4                                3                                    |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                                +                                    |             
      Arthrosis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                                +                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +                 +     +        +                 +                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Subacute               |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                       2                  |             
      Alveolar Epithelium, Inflammation,   |                                                                          |             
           Subacute                        |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
      Mucosa, Pigmentation                 | 2  1  1  2     1  2  1     1  1  2  2  2  2     1  1  1  2  1  2     1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Pigmentation                 | 4  3  3  3  3  4  2  2  3  2  3  2  3  3  2  3  2  2  2  2  2  3  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  2  2  2     2  3  1  2  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +                    +                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +                                +                                    |             
      Inflammation, Chronic                |                                                                          |             
      Pelvis, Dilatation                   |                                     3                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +                       +     +           +  +                     |             
      Dilatation                           |    3  2                       2                 3  2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|             
                                           | 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +                                +                 +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +     +                                            +         |             
      Peyer's Patch, Hyperplasia, Lymphoid |                   3                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3                                 |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                        3                                 |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Hyperplasia, Nodular                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Congestion                           |                                                                          |             
      Fat, Necrosis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +     +                    +           +  +  +     +  +  +   |             
      Cyst                                 |                   2                                                      |             
      Hyperkeratosis                       | 3                                                                        |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +                                      +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +                                                  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M     +                                                  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +                             +                    +         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|             
                                           | 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +     +                                                  +         |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |       +     +                                                  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                       +         |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +     +                                      +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +                                                  M         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +                          +     +  +           +  +         |             
      Congestion                           |                                              3              3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                        4        3                        |             
      Inflammation, Suppurative            |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +     +                                                  +         |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +                             +     +              +         |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Hyperplasia, Lymphoid                |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M     M                                                  M         |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     M  +                                +              +         |             
      Alopecia                             |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +                                                  +         |             
      Arthrosis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +                                                  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|             
                                           | 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +     +                                      +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Hemorrhage                           |                                                          2               |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2  2              2                                                      |             
      Alveolar Epithelium, Inflammation,   |                                                                          |             
           Subacute                        |                                              2                           |             
      Artery, Inflammation, Subacute       | 3                                                                        |             
      Mucosa, Pigmentation                 | 1  1     2     1  2  1  1  1  1  1  1  1  1  1  2        1  1  2  1     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    1                     |             
      Mucosa, Pigmentation                 | 3  2  2  3  2  3  3  2  2  2  3  2  3  3  3  3  3  2  2  3  3  3  3  2  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 1  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  1  1  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +        +     +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +                    +              +           +  +         |             
      Inflammation, Chronic                |                                                 3           3            |             
      Pelvis, Dilatation                   |                                  2                          3            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +                                               +  +         |             
      Dilatation                           |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3|                                            |            |
                                           | 2| 2| 9| 2| 7| 0| 9| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +     M  +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +                                                         |   9        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |       +     +  +  +  +  +                                                |  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                      3                                                   |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      2  2.5|
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Nodular                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Congestion                           |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +  +                                                      |  22        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Developmental Malformation           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +                                                         |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +                                                         |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3|                                            |            |
                                           | 2| 2| 9| 2| 7| 0| 9| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |          2                                                               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   1        |
      Inflammation, Suppurative            |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   4        |
      Inflammation, Suppurative            |                         3                                                |      1  3.0|
      Duct, Dilatation                     |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +  +                                                         |   9        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +  +                                                         |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +     M  M  +                                                      |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     M  M                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +                                                         |  13        |
      Congestion                           |                                                                          |      3  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.7|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +     +  +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +                                                         |  13        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +  +                                                         |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M     M  M                                                         |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +  +        +                                                |  11        |
      Alopecia                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3|                                            |            |
                                           | 2| 2| 9| 2| 7| 0| 9| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.05 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |             2                                                            |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
      Prepuce, Inflammation, Suppurative   |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +           +                                             |   9        |
      Arthrosis                            |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +                                                         |   8        |
      Mineralization                       |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                      3                                                   |      5  2.2|
      Alveolar Epithelium, Inflammation,   |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  3.0|
      Mucosa, Pigmentation                 | 1  2  2  2        1  2  2  2                                             |     49  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |    2                                                                     |      2  1.5|
      Mucosa, Pigmentation                 | 3  2  2  2  2  2  2  3  2  2                                             |     60  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Pigmentation                 | 1  2  2  2  2     1  2  2  2                                             |     58  1.9|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +  +                                                         |  12        |
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Pelvis, Dilatation                   |             2                                                            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +     +                                                |  17        |
      Dilatation                           | 3  4        3           3                                                |     10  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|             
                                           | 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                   2                          3                    3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                              3                           |             
      Infarct                              |                                  4                                       |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Acute                      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Necrosis                             |                                                          4               |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            3           2           2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|             
                                           | 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       2                                      1                    4      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                            4                                             |             
                                            __________________________________________________________________________|             
   Penis                                   |                                           +                              |             
      Concretion                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +              +              +               |             
      Duct, Dilatation                     |                            3              4                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Deep Cervical, Hematopoietic Cell    |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  M  +  M  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                              3           4               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Lymphoid                | 3                       2                    3                 4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|             
                                           | 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                          3               |             
      Mineralization                       | 2  2     2  2     2     2                                   3           2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Subacute               |       3                                                  3           1   |             
      Inflammation, Suppurative            |                                           4           4                  |             
      Alveolar Epithelium, Hyperplasia     |                         2                    2                           |             
      Bronchiole, Hyperplasia              |                                                                          |             
      Mucosa, Pigmentation                 | 3  2  2  1  2  2  1  2  2  2  2  2     3     2  2  2     1  3  3  2  2  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2  3  1  1     2  1        1     2     4  4  2     1  4  3  1  2     1  3|             
      Mucosa, Pigmentation                 | 1     3  2  3  2  2  2  4  2  3  3  2  3  1  1  3  2        2  2  2  2  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                       2                  |             
      Mucosa, Pigmentation                 | 3  2  3  2  2  2  2  2  2  2  2  2     3  1  2  2  2     2  2  3  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +     +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Osseous                  |                            2                                             |             
      Mineralization                       |                                                                2         |             
      Nephropathy, Chronic                 |                               4                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|             
                                           | 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                   4      |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |                                                                         3|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |          2                                         3                     |             
      Infarct                              |                                                                          |             
      Inflammation, Subacute               |          2                                                               |             
      Mineralization                       |                               2                                          |             
      Necrosis, Acute                      |       2                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Necrosis                             |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                         +                           |             
      Developmental Malformation           |    2                                         3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|             
                                           | 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                4                                         2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                                                                  |             
      Concretion                           |       4                                                                  |             
      Inflammation, Suppurative            |       4                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Deep Cervical, Hematopoietic Cell    |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |             4                                4           4               |             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2  2            |             
      Hematopoietic Cell Proliferation     |                                                                         4|             
      Hemorrhage                           |                   3                                                      |             
      Hyperplasia, Lymphoid                |                3                 3                          2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3     3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|             
                                           | 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2  PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |       3                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    2     2     2                             2        2     1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                   4                                                      |             
      Alveolar Epithelium, Hyperplasia     |                            3        2     3     3                        |             
      Bronchiole, Hyperplasia              |                                                                3         |             
      Mucosa, Pigmentation                 | 2  2  2  3  2  2     3  2  3  2  3  3  2  2  2  2  2  2  2  2  2  2     3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  2  2  4  4  2  3     2  2        3  2  3  3        2  3     2  2  2  2|             
      Mucosa, Pigmentation                 | 2  2  2  2     2     4  2  2  4  2  1  3  2  1  3  2  2  2  3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Pigmentation                 | 2  2  2  3  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2           2                          2                              |             
      Inflammation, Chronic                |                                        4                                 |             
      Inflammation, Subacute               |                         3                                2               |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                      2                                   2               |             
      Nephropathy, Chronic                 |                                                                          |             
      Pelvis, Dilatation                   |                         3                                                |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                 4        3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      A     |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                            3                                             |      1  3.0|
      Hyperplasia                          |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                            3                                             |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytoplasmic Alteration               |       2                                                                  |      4  2.5|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Acute                      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   2        |
      Necrosis                             |                                                                          |      1  4.0|
      Fat, Necrosis                        |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Arteriole, Mineralization            |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      A     |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  M  +  +  M  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia         |                                                                          |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |       4                                                                  |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +                                                |   3        |
      Concretion                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                         4                                                |      2  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   4        |
      Duct, Dilatation                     |                         4                                                |      3  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                   3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   2        |
      Deep Cervical, Hematopoietic Cell    |                                                                          |            |
          Proliferation                    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Hematopoietic Cell Proliferation     |                   3                                                      |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  3.8|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      A     |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      7  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                      2                                                   |     15  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                         3  4                                             |      2  3.5|
      Inflammation, Subacute               |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                   4                                                      |      4  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      6  2.5|
      Bronchiole, Hyperplasia              |                                                                          |      1  3.0|
      Mucosa, Pigmentation                 | 2  2  2  2  3  2  2  3  1  2                                             |     55  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            | 3  2  3  2  2  2  3  3  2                                                |     46  2.3|
      Mucosa, Pigmentation                 | 2  2  3  2  3  2     2  3  3                                             |     54  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                   4                                                      |      2  3.0|
      Mucosa, Pigmentation                 | 3  2  2  2  3  2  2  2  2  2                                             |     58  2.1|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 5| 4| 4| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6|                                            |            |
                                           | 9| 1| 9| 1| 1| 1| 5| 9| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      A     |
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |    2                                                                     |      4  2.0|
      Nephropathy, Chronic                 |                                                                          |      1  4.0|
      Pelvis, Dilatation                   |                         3                                                |      2  3.0|
      Renal Tubule, Degeneration           |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                         3                                                |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|             
                             DAY ON TEST   | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|             
                                           | 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      +     +        +        M  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   |                      +     +        +        +  +     +  +  +        +   |             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +     +        +        +  +     +  +  +        +   |             
      Congestion                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +     +        +        +  +     +  +  +        +   |             
      Congestion                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  M     +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Follicular Cell, Hyperplasia         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Prostate                                |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Testes                                  |                      +     +        +        +  +     +  +  +        +   |             
      Atrophy                              |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|             
                             DAY ON TEST   | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|             
                                           | 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +     +  +     +  +     +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +     +        +        +  +     +  +  +        +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |                      +     +        +        +  +     +  +  +        +   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M  M  +  M  M     M  M  +  M  M     M  +  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +     +  +     +  +     +  +     +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +     +        +        +  +     +  +  +        +   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2     2              2                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Pigmentation                         |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation           |          3                                                               |             
      Mucosa, Pigmentation                 | 2  2  2  2  2  1  2  2     2  2     2  2  3  2  3  2  2  3  2     2  1  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                2                             2        2  2           1   |             
      Mucosa, Pigmentation                 | 3  4  3  2  2  1  3  1  4  3  3  2  3  3  2  1  3  2  1  3  3  2  2  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  2  2  2  2  3  2  3  2  3  2  2  3  2  4  2  2  2  2  3  3  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +     +        +        +  +     +  +  +        +   |             
      Inflammation, Subacute               |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|             
                             DAY ON TEST   | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|             
                                           | 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +     +        +        +  +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|             
                                           | 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +              +                 M                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +              +                 +                       +  +      |             
      Cytoplasmic Alteration               | 2                    2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +              +                 +                       +  +      |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +              +                 +                       +  +      |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +              +                 +                       +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +     +  +     +  +  +  M  +     +  +     +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      Follicular Cell, Hyperplasia         |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +              +                 +                       +  +      |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|             
                                           | 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +     +  +     +  +  +  +        +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     M              +                 +                       +  M      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +              +                 +                       +  +      |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +     +     +  +     +  +  +  +        +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +              +                 +                       +  +      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M     M     M  M     M  M  M  M        M  M     M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +     +  +     +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +     +  +     +  +  +  +        +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +              +                 +                       +  +      |             
      Mineralization                       |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            2                             3               |             
      Interstitium, Inflammation           |                                                                          |             
      Mucosa, Pigmentation                 | 2  2  1  2  3  2  3  3  2  2  2  3  2  1  2  3  2  2  3  2  2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |       1                                2                       1         |             
      Mucosa, Pigmentation                 | 2  2  1  2  2  2  2  3  2  2  2  2  2  1  2  2  2  2  2  2  2  1  4  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 4  1  2  2  2  2  2  3  2  2  2  2  2  2  2  3  1  2  3  2  2  2  4  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +              +                 +                       +  +      |             
      Inflammation, Subacute               |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|             
                                           | 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +              +                 +                       +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|             
                                           | 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +                    +  +     +                                       |             
      Cytoplasmic Alteration               |                         2        2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                    +  +     +                                       |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +                    +  +     +                                       |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Inflammation, Suppurative            |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +                    +  +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +  +  M  +  +  +  +  +     +  +  M  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +   |             
      Cyst                                 |                                                                      2   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +                    +  +     +                                       |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|             
                                           | 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +                    M  +     M                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +                    +  +     +                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +        +  M  +  +  +  +  +  +  +  +  +     M  +  +  M  M  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +                    +  +     +                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M        M  M  M  M  M  M  M  +  M  M  M     M  M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +                    +  +     +                                       |             
      Mineralization                       |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Infiltration Cellular, Histiocyte    |                   2                                                      |             
      Inflammation, Subacute               |                                     2                                    |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   3                 2                                3   |             
      Interstitium, Inflammation           |                                                                          |             
      Mucosa, Pigmentation                 | 1  1  2  2  2  2  2  2  3  1  2  3  2  2  2  2     2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            | 1                                      3                                 |             
      Mucosa, Pigmentation                 | 1  2  2  3  3  2  2  2  4  1  3  2  2  2  2  2  3  2  2  2  2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Pigmentation                 | 2  2  2  2  3  2  2  2  4  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                            +  +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +                    +  +     +                                       |             
      Inflammation, Subacute               | 1                                                                        |             
      Renal Tubule, Cytoplasmic Alteration |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|             
                                           | 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2  PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    SE33                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +                    +  +     +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6|                                                           |            |
                             DAY ON TEST   | 3| 4| 3| 3| 4|                                                           |            |
                                           | 1| 2| 4| 1| 1|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0.2  PPM                               | 8| 8| 8| 8| 8|                                                           |      L     |
    SE33                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  69        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +                                                                  |  21        |
      Cytoplasmic Alteration               |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  20        |
      Congestion                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  20        |
      Congestion                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  20        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  67        |
      Cyst                                 |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6|                                                           |            |
                             DAY ON TEST   | 3| 4| 3| 3| 4|                                                           |            |
                                           | 1| 2| 4| 1| 1|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0.2  PPM                               | 8| 8| 8| 8| 8|                                                           |      L     |
    SE33                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  20        |
      Atrophy                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |  78        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  20        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  64        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  68        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M                                                            |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  68        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +                                                               |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  20        |
      Mineralization                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  80        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  78        |
      Congestion                           |                                                                          |      4  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Subacute               |    3                                                                     |      2  2.5|
      Pigmentation                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  2.6|
      Interstitium, Inflammation           |                                                                          |      1  3.0|
      Mucosa, Pigmentation                 | 2        2  2                                                            |     74  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  80        |
      Inflammation, Subacute               |    1                                                                     |      1  1.0|
      Inflammation, Suppurative            |                                                                          |     10  1.7|
      Mucosa, Pigmentation                 | 2  2  2  2  2                                                            |     80  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6|                                                           |            |
                             DAY ON TEST   | 3| 4| 3| 3| 4|                                                           |            |
                                           | 1| 2| 4| 1| 1|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0.2  PPM                               | 8| 8| 8| 8| 8|                                                           |      L     |
    SE33                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  80        |
      Mucosa, Pigmentation                 | 2  2  2  2  2                                                            |     80  2.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  20        |
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 6| 3| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 5| 3| 3| 3| 2| 5| 3| 2| 3| 3| 3| 3| 3| 5| 5| 4| 2| 2| 3|             
                                           | 0| 0| 0| 6| 0| 0| 2| 0| 0| 0| 3| 5| 0| 6| 0| 0| 0| 0| 0| 6| 4| 7| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4|             
    SE65                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Developmental Malformation           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +     +  +  +  +     +  +  +  +  +  +  +  M  M  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Crystals                             |                         2                                                |             
      Follicular Cell, Hyperplasia         |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +        +     +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M     M  M  M        M     M  M  M  M  M  M  M  M  +     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +        +     +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Congestion                           |                   2                                                      |             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Subacute               |       2                                                                  |             
      Alveolar Epithelium, Hyperplasia     |                                                          3               |             
      Arteriole, Bacterium                 |                                                                   4      |             
      Mucosa, Pigmentation                 | 3  2  2  2  2  2  2  2  2  2     2  2     2  1  2  3  2  1  2  2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 6| 3| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 5| 3| 3| 3| 2| 5| 3| 2| 3| 3| 3| 3| 3| 5| 5| 4| 2| 2| 3|             
                                           | 0| 0| 0| 6| 0| 0| 2| 0| 0| 0| 3| 5| 0| 6| 0| 0| 0| 0| 0| 6| 4| 7| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2  PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4|             
    SE65                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Subacute               |                   2                                                      |             
      Inflammation, Suppurative            |          1     2        2           3  2  3  2                 2        4|             
      Mucosa, Pigmentation                 | 3  2  2  3  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  3  2  1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mucosa, Pigmentation                 | 2  2  2  2  2  2  2  2  2  2     3  2  2  2  2  2  3  2  2  2  2  1     2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                      +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 1| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 5| 3| 3|            |
                                           | 0| 3| 0| 0| 0| 0| 8| 4| 0| 0| 0| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    0.2  PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0|      L     |
    SE65                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  M  M  M  M  +  +  M  +  M  M     M  M  +  +  +  +  M|  30        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|  45        |
      Crystals                             |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |       2     1                                                           2|      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +     +  +  +  +     +  +  +  +  +        +  +  +     +  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M     M  M  M  M  M     M  M  M  M  +  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +     +  +  +  +     +  +  +  +  +        +  +  +     +  +|  35        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                   4      |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 1| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 5| 3| 3|            |
                                           | 0| 3| 0| 0| 0| 0| 8| 4| 0| 0| 0| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    0.2  PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0|      L     |
    SE65                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Subacute               |                               2                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                             2            |      2  2.5|
      Arteriole, Bacterium                 |                                                                          |      1  4.0|
      Mucosa, Pigmentation                 | 2  2  2  2  2  2  2     1  2  2  1  2  2  2  2  2  1  2  2  2  2  1  2  2|     45  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Inflammation, Suppurative            |          2  2                 3  4           4     2  3  2               |     17  2.5|
      Mucosa, Pigmentation                 | 1  2  2  3  2  2  3  2  2  2  2     2  2  2     2  2  3  2  2  2  2  2  2|     46  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Pigmentation                 | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 2| 7| 7| 2| 2| 7| 7| 7| 7| 1| 1| 2| 2| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 8| 9| 2| 2| 9| 9| 0| 2| 2| 2| 8| 8| 3| 3| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 5| 9| 1| 5| 9| 9| 5| 5| 3| 9| 9| 9| 3| 3| 2| 2| 9| 9| 9| 9| 5| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5  PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
    SE26                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                M        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                M        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                M        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Liver                                   |                +        +  +                    +  +                     |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +        +  +                    +  +                     |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +        +  +                    +  +                     |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +        +  +                    +  +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     +  M  M  +  +  +  M  M  M  +  +  M  +  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +        +  +                    M  +                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       4           1                                                     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Prostate                                |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Testes                                  |                +        +  +                    +  +                     |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 2| 7| 7| 2| 2| 7| 7| 7| 7| 1| 1| 2| 2| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 8| 9| 2| 2| 9| 9| 0| 2| 2| 2| 8| 8| 3| 3| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 5| 9| 1| 5| 9| 9| 5| 5| 3| 9| 9| 9| 3| 3| 2| 2| 9| 9| 9| 9| 5| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5  PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
    SE26                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +        M  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +        +  M                    +  +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |                +        +  +                    +  +                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M     M  M  M  M  M  M  M  M  M        M  M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +        +  +                    +  +                     |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             1                                                            |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             4            |             
      Mucosa, Pigmentation                 | 2  2  1  2  2  3  1  1  2  3  2  2  2  2  2  1  2  3  2     2  2  3  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           2  4                       2   |             
      Mucosa, Pigmentation                 | 2  1  1  2     1  1  1  1  1  2  2  1  2           1  2     1  1  2  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Pigmentation                 | 2  2  1  2  2  2  2  2  2  2     2  2  2  2  3  2  2  2  2  1  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +        +  +                    +  +                     |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +        +  +                    +  +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05114-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:32:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 4| 4| 7| 2| 7| 1| 7| 1| 7| 7| 2| 2| 2| 4| 2| 4| 7| 4| 4| 1| 7|             
                             DAY ON TEST   | 2| 9| 8| 2| 5| 5| 2| 3| 2| 8| 2| 8| 2| 2| 9| 3| 9| 9| 3| 5| 2| 5| 5| 8| 2|             
                                           | 9| 5| 3| 9| 8| 8| 9| 2| 9| 3| 9| 3| 9| 9| 5| 2| 5| 4| 2| 8| 9| 8| 8| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5  PPM                               | 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
    SE26                                   | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                 +                    +  +  +     +                  |