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TDMS Study 05114-01 Pathology Tables

NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  01/09/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X              X              X     X                          X      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +                       +     +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                           +                              |             
      Squamous Cell Carcinoma              |                                           X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Carcinoma                            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                                 |             
      Pheochromocytoma Benign              |                                     X                                    |             
      Bilateral, Pheochromocytoma Benign   |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Pars Distalis, Adenoma               | X           X  X  X           X  X  X     X           X     X     X      |             
      Pars Intermedia, Adenoma             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                                                    X   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |             X                                   X                        |             
      Sarcoma Stromal                      |                               X                                          |             
      Bilateral, Polyp Stromal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  M  M  +  +  M  +  +  M  M  +  +  M  +  M  +  +  M|             
      Leukemia Mononuclear                 |    X              X                    X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X                    X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X                    X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X                    X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X              X     X                          X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |    X              X                    X                          X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                X              X                                          |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Fibroadenoma                         | X     X        X                    X  X           X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Carcinoma, Metastatic, Zymbal's Gland|          X                                                               |             
      Leukemia Mononuclear                 |    X              X              X     X                          X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                 +     +                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
      Carcinoma                            |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X              X     X                          X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                              X                           |             
      Leukemia Mononuclear                 |          X        X  X  X              X     X     X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                       +                 +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                     X                                    |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                            +                     |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pheochromocytoma Benign              |                      X                    X                              |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X        X     X        X  X  X     X     X  X        X  X  X  X     X|             
      Pars Intermedia, Adenoma             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                       X                       X                     |             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                            X     X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                         X                                                |             
      Sarcoma Stromal                      |                                                                          |             
      Bilateral, Polyp Stromal             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X     X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X     X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X     X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                         X              X     X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X  X  X              X     X     X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenocarcinoma, Multiple             |                                                 X                        |             
      Fibroadenoma                         | X  X                                                     X     X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                      X  X              X     X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                     X                                    |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X  X  X              X     X     X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +                                                      |  10        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   3        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Leukemia Mononuclear                 |                X                                                         |          4 |
      Pheochromocytoma Benign              |    X                    X                                                |          5 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |    X  X     X  X  X     X  X                                             |         32 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Adenoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                         X                                                |          6 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma                            |       X                                                                  |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyp Stromal                        |                                                                          |          3 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Bilateral, Polyp Stromal             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  +  +  +  +  +  +                                             |  44        |
      Leukemia Mononuclear                 |                X        X                                                |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                X        X                                                |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                X        X                                                |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +                                             |  57        |
      Leukemia Mononuclear                 |                X        X                                                |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Fibroadenoma                         |       X  X        X                                                      |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |                X        X                                                |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         16 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +           +  +     +     +                    +  +  +  +  +   |             
      Hepatocellular Adenoma               |                                                          X               |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +     +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
      Carcinoma                            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +        +        +     +                                +  +  +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X  X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                 +     +                                +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +  +              +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               |    X        X  X     X  X  X  X              X     X  X  X     X  X  X   |             
      Pars Intermedia, Adenoma             |                               X                                          |             
      Pars Nervosa, Hamartoma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                 +     +                       +        +  +  +   |             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +                 +     +     +                    +  +  M  +  +   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +                 +  +  +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +        +        +     +              +                 +  +  +   |             
      Polyp Stromal                        |                X                             X                    X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +                 +     +           +                    +  +  +   |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +                 +     +  +                             +  +  +   |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                 +     +                                +  +  +   |             
      Leukemia Mononuclear                 |                         X                                      X  X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +  +  +  +     +     +        +        +     +  +  +  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Adenocarcinoma                       |                      X                                                   |             
      Fibroadenoma                         |                                     X        X        X     X  X         |             
      Fibroadenoma, Multiple               |                X  X  X                                            X     X|             
                                            __________________________________________________________________________|             
   Skin                                    |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Duct, Carcinoma                      |                               X                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                      X  X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +           +     +              +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +              +  +  +           +  +  +  +  +   |             
      Hepatocellular Adenoma               |                                                          X               |             
      Leukemia Mononuclear                 | X                 X  X  X              X     X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           +                    +     +                 +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           +                    +     +                 +  +      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +           +              +     +     +                    +  +   |             
      Carcinoma                            |                                  X                                       |             
      Leukemia Mononuclear                 | X                                            X                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +           +              M     +     +                    +  +   |             
      Leukemia Mononuclear                 | X                                            X                           |             
      Pheochromocytoma Malignant           |                                                                      X   |             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +                    +     +                    +      |             
      Adenoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +        +     +  +  +        +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X  X        X     X        X        X        X  X        X  X         |             
      Pars Intermedia, Adenoma             |                                                                          |             
      Pars Nervosa, Hamartoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +           +                    +     +              +     +      |             
      C-Cell, Adenoma                      |    X                                                              X      |             
      C-Cell, Carcinoma                    |                                                             X            |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +        +  +                    +     +        +        +  +      |             
      Carcinoma                            |    X           X                                               X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +           +  +           +     +     +                    +  +   |             
      Polyp Stromal                        |                                  X                                   X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 | X                 X                          X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 | X                 X                          X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 | X                 X                          X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 | X                 X                          X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +           +  +  +              +     +     +              +  +   |             
      Leukemia Mononuclear                 | X                 X  X  X              X     X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +           +                    +     +                    +      |             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +        +           +     +     +           +  +  +  +|             
      Adenoacanthoma                       |                                        X                                 |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |    X     X                 X                       X           X     X  X|             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +           +                    +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +           +                    +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +           +  +                 +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                             X            |             
      Carcinoma, Metastatic, Adrenal Cortex|                                  X                                       |             
      Leukemia Mononuclear                 | X                 X  X  X                    X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Duct, Carcinoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
      Carcinoma                            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                          X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +           +                    +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X  X  X              X     X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |     A      |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +                                                   |  34        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |       X     X  X     X                                                   |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +     +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +  +                                                      |  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +  +                                                      |  17        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +     +  +  +                                                      |  21        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +     +  +  +                                                      |  19        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +  +                                                      |  18        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +  +  +  +     +                                             |  39        |
      Leukemia Mononuclear                 |                X     X                                                   |          3 |
      Pars Distalis, Adenoma               |    X  X     X     X  X     X                                             |         30 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
      Pars Nervosa, Hamartoma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |     A      |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +  +                                                      |  19        |
      C-Cell, Adenoma                      |                                                                          |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +     M  +  +                                                      |  22        |
      Carcinoma                            |       X           X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +     +  +  +                                                      |  22        |
      Polyp Stromal                        |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +  +                                                      |  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   2        |
      Renal, Leukemia Mononuclear          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +     +  +  +                                                      |  17        |
      Leukemia Mononuclear                 |             X  X                                                         |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +  +  +                                                      |  18        |
      Leukemia Mononuclear                 |             X  X                                                         |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +  +                                                      |  17        |
      Leukemia Mononuclear                 |             X  X                                                         |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +     +  +  +                                                      |  18        |
      Leukemia Mononuclear                 |             X  X                                                         |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +  +                                                      |  21        |
      Leukemia Mononuclear                 |       X     X  X                                                         |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +  +  +                                                      |  17        |
      Leukemia Mononuclear                 |                X                                                         |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +                                                      |  34        |
      Adenoacanthoma                       |                                                                          |          1 |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |    X     X                                                               |         14 |
      Fibroadenoma, Multiple               | X                                                                        |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |     A      |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +  +  +                                                      |  17        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +  +                                                      |  17        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +  +                                                      |  18        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X                                                   |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Duct, Carcinoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +  +  +                                                      |  17        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X     X  X     X                                                   |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  +              +  +     +     +        +                 A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +              +  +     +     +        +                 A  +      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +        +  +     +  +  +  +     +  +        +     +  +      |             
      Hepatocellular Carcinoma             |                                  X                                       |             
      Leukemia Mononuclear                 |    X        X                    X  X  X     X           X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                               +                                          |             
      Squamous Cell Carcinoma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +     +  +     +     +        +                 +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +     +  +     +     +        +                 +  +     +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +              +  +     +     +        +                 +  +      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +              +  +     +     +        +                 +  +      |             
      Leukemia Mononuclear                 |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +              +  +     +     +        +                 +  +      |             
      Leukemia Mononuclear                 |    X                                         X                           |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +           +  +  +  +  +  +  +        +           +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X              X  X     X     X           X           X     X  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +              +  +     +     +        +                 +  +      |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +           +  +  +  +  +     +     +  +        +  +     +  +      |             
      Carcinoma                            |                            X                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +              +  +     +     +  +     +        +        +  +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |    X           X                                                         |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +              +  +     M     +        +                 +  +      |             
      Leukemia Mononuclear                 |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +              +  +     +     +        +                 +  +      |             
      Leukemia Mononuclear                 |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +              +  +           +        +                 +  +      |             
      Leukemia Mononuclear                 |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  M              +  +     +     +        +                 +  +      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +              +  +     +  +  +  +     +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |    X                             X  X  X     X     X     X               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M              +  +     +     +        +                 +  +      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +  +     +  +     +  +  +  +  +  +                 +  +      |             
      Adenocarcinoma                       |                                  X  X                                    |             
      Fibroadenoma                         |    X        X  X     X                 X  X                              |             
      Fibroadenoma, Multiple               |                                     X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +              +  +     +     +        +                 +  +      |             
      Neurofibrosarcoma                    |                         X                                                |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +              +  +     +     +        +                 +  +      |             
      Mandible, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Pharynx             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |    X        X                    X     X  X  X           X               |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +        +                       +     +     +      |             
      Lids, Fibroma                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                    X  X  X  X  X     X     X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +           +  +     +  +  +  +  +     +     +     +                    +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 | X           X           X        X           X     X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           M           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +           +     +        +           +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +           +     +        +           +                    +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +           +     +        +           +                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +           +           +     +        +           +                     |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +           +           +     +        +           +                     |             
      Leukemia Mononuclear                 |                         X                                                |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +     +  +  +  +  +  +     +     +  +  +  +     +  +  +      |             
      Leukemia Mononuclear                 |                         X                                                |             
      Pars Distalis, Adenoma               | X        X  X     X  X     X     X           X  X           X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +           +     +        +           +                     |             
      C-Cell, Adenoma                      |                                                    X                     |             
      C-Cell, Carcinoma                    | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +           +  +        +     +  +     M           +        +            |             
      Carcinoma                            |                X                 X                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +           +  +  +        +           +                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                      X  X                    X                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +           M           +     M        +           +                     |             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           M           +     +        +           +                     |             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +           +     +        +           +                     |             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +           M           +     +        +           +  +                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +           +           +     +  +     +     +     +                     |             
      Leukemia Mononuclear                 | X           X           X        X           X     X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M           M           +     +        +           +                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Leukemia Mononuclear                 |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +           +     +        M           +     +  +            |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |          X                                               X  X            |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +           +     +        M           +                     |             
      Neurofibrosarcoma                    |                                                                          |             
      Squamous Cell Papilloma              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +           +     +        +           +                     |             
      Mandible, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Pharynx             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +           +     +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Leukemia Mononuclear                 | X           X           X        X           X     X                     |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Lids, Fibroma                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X                    X     X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +           +     +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X           X        X           X     X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |     A      |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                 +  +  A                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                 +  +  A                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 +  A  A                                                |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                 +  +  A                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                 +  A  A                                                |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                 +  A  A                                                |  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +     +  +  +                                                |  32        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 | X                 X     X                                                |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                 +  +  +                                                |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                 +  +  +                                                |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +              +  +  +  +                                                |  23        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Pharynx                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                 +  +  +                                                |  19        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                 +  +  +                                                |  19        |
      Leukemia Mononuclear                 | X                 X     X                                                |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +        +        +  +  +                                                |  20        |
      Leukemia Mononuclear                 | X                 X     X                                                |          6 |
      Pheochromocytoma Malignant           |          X                                                               |          1 |
      Pheochromocytoma Benign              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +  +  +  +  +                                                |  38        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |     A      |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |             X     X  X                                                   |         25 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                 +  +  +                                                |  19        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      C-Cell, Carcinoma                    | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +           +  +  +                                                |  27        |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +              +  +  +                                                |  24        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Polyp Stromal                        |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                 +  +  +                                                |  16        |
      Leukemia Mononuclear                 | X                 X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                 +  +  +                                                |  18        |
      Leukemia Mononuclear                 | X                 X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +  +  +                                                |  18        |
      Leukemia Mononuclear                 | X                 X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +                 +  +  +                                                |  18        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 | X                 X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                 +  +  +                                                |  26        |
      Leukemia Mononuclear                 | X                 X     X                                                |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                 +  +  +                                                |  16        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +        +     +  +  +  +                                             |  29        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |     A      |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma                       |    X        X                                                            |          4 |
      Fibroadenoma                         | X  X                    X  X                                             |         13 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +  +  +                                                |  19        |
      Neurofibrosarcoma                    |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                 +  +  +                                                |  19        |
      Mandible, Squamous Cell Carcinoma,   |                                                                          |            |
           Metastatic, Pharynx             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                 +  +  +                                                |  19        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 | X                 X                                                      |         15 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic                       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
      Lids, Fibroma                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                   X     X                                                |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 +  +  +                                                |  19        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 | X                 X     X                                                |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                               X                                          |             
      Leukemia Mononuclear                 |       X     X        X        X     X           X     X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Pars Distalis, Adenoma               | X  X  X  X  X  X  X     X  X  X  X  X  X  X     X  X  X        X  X  X  X|             
      Pars Intermedia, Adenoma             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X                                   X                           |             
      C-Cell, Carcinoma                    |             X     X                 X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                            X              X                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Thecoma Malignant                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                            X                                             |             
      Polyp Stromal                        |          X                 X           X                             X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +     +            |             
      Axillary, Leukemia Mononuclear       |                                                             X            |             
      Iliac, Leukemia Mononuclear          |                                                             X            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X        X        X     X           X     X     X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |       X  X                 X                                   X  X      |             
      Fibroadenoma, Multiple               |                                        X                                 |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                      X                                                   |             
      Subcutaneous Tissue, Sarcoma         |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X        X        X     X           X     X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 | X     X  X              X     X     X                 X     X        X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                                                |             
      Pheochromocytoma Benign              |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |          X  X  X        X        X  X  X  X  X     X  X  X              X|             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X                       X                                      X|             
      C-Cell, Carcinoma                    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |       X                                   X                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Thecoma Malignant                    |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Polyp Stromal                        |                                     X     X                 X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
      Leukemia Mononuclear                 |          X              X                             X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
      Leukemia Mononuclear                 |          X              X                             X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |          X              X                             X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                             X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X     X     X                 X     X        X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                                               X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |             X                                                            |             
      Fibroadenoma                         |       X                                                           X      |             
      Fibroadenoma, Multiple               | X                                X                                       |             
      Sarcoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
      Leukemia Mononuclear                 |          X              X           X                 X              X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                        +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X     X     X                 X     X        X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X                                                               |         21 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |       X  X  X  X  X     X                                                |         40 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Granulosa Cell Tumor Benign          |                      X                                                   |          1 |
      Thecoma Malignant                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma                       |                                                                          |          1 |
      Polyp Stromal                        |          X                                                               |          8 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   3        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +                                             |  51        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |       X  X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +                                             |  54        |
      Leukemia Mononuclear                 |       X  X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X  X                                                               |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  +  M  +  +  +                                             |  55        |
      Leukemia Mononuclear                 |          X                                                               |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |             X                                                            |          8 |
      Fibroadenoma, Multiple               |    X     X                                                               |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X  X                                                               |         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Mucinous             |                                              X                           |             
      Fibroma                              |                                                                          |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X  X        X  X     X  X     X                    X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                                         +   |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X           X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +        +  +               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X           X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Leukemia Mononuclear                 |                         X  X                                      X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X                                      X      |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |             X  X  X        X                                X            |             
      Pheochromocytoma Benign, Multiple    |                                                       X                  |             
      Bilateral, Pheochromocytoma Benign   |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                          X  X                          X   |             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               | X                 X  X  X                 X     X              X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                  X                             X         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X           X     X  X        X                    X  X        X  X|             
      Interstitial Cell, Adenoma           |          X  X  X                 X        X                       X      |             
      Interstitial Cell, Adenoma, Multiple |                               X        X        X  X  X        X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                       +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                     X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                         X|             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X        X  X                          X           X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X        X  X                          X           X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X        X  X                          X           X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X        X  X                          X           X     X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X  X     X  X     X                    X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                          X           X     X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                   X     X|             
      Fibrosarcoma                         |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |       X        X  X     X  X                          X     X     X     X|             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +        +                                    |             
      Carcinoma                            |                            X        X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                           X     X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X  X     X  X     X                    X     X  X  X     X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Adenocarcinoma, Mucinous             |                                                                          |             
      Fibroma                              |                                                       X                  |             
      Peyer's Patch, Leukemia Mononuclear  |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |       X                                                                  |             
      Leukemia Mononuclear                 |       X     X     X  X  X  X     X     X     X  X              X  X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                          +                 +     +     +   |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                     +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X                       X              X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                   X     X  X           X        X              X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X  X           X        X              X         |             
      Pheochromocytoma Malignant           |                                                       X                  |             
      Pheochromocytoma Benign              |          X           X        X                 X              X         |             
      Pheochromocytoma Benign, Multiple    |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                 X      |             
      Carcinoma                            | X     X                                   X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                   X        X                                             |             
      Pars Distalis, Adenoma               | X  X  X  X     X     X  X           X  X  X     X        X     X  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                               X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Mesothelioma Malignant    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                      X                                                   |             
      Bilateral, Interstitial Cell, Adenoma|             X                 X     X  X              X           X  X  X|             
      Interstitial Cell, Adenoma           |       X  X           X           X                 X           X         |             
      Interstitial Cell, Adenoma, Multiple | X  X                                                        X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X  X           X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                                      |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                   X                                                      |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X  X     X     X                       X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X  X     X     X                       X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X  X     X     X     X                 X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X  X     X     X                       X  X     X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X  X  X     X     X     X  X              X  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X        X     X                       X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                        X                                 |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X  X                                      X              X         |             
      Leukemia Mononuclear                 |                   X     X  X     X     X     X  X              X  X     X|             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +     +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Papilloma                            |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X  X  X     X     X     X  X              X  X     X|             
      Mesothelioma Malignant               |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  56        |
      Adenocarcinoma, Mucinous             |                                                                          |          1 |
      Fibroma                              |                                                                          |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X  X        X                                                   |         29 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +  +                                                   |  12        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                                                                        |          8 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          9 |
      Pheochromocytoma Malignant           |                      X                                                   |          2 |
      Pheochromocytoma Benign              |          X           X                                                   |         12 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              | X              X                                                         |          8 |
      Carcinoma                            |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pars Distalis, Adenoma               |    X           X  X  X  X  X                                             |         27 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Adenoma                      |                X     X                                                   |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Mesothelioma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                X  X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X        X  X  X                                                         |         23 |
      Interstitial Cell, Adenoma           |       X                 X                                                |         14 |
      Interstitial Cell, Adenoma, Multiple |    X                                                                     |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   3        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  +                                             |  51        |
      Leukemia Mononuclear                 | X           X                                                            |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 | X           X                                                            |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X           X                                                            |         19 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 | X           X                                                            |         18 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X        X  X        X                                                   |         29 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Leukemia Mononuclear                 |                                                                          |          9 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibroma                              |                                                                          |          2 |
      Fibrosarcoma                         |                                                                          |          1 |
      Squamous Cell Papilloma              |          X                                                               |          1 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
      Rhabdomyosarcoma                     |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          5 |
      Leukemia Mononuclear                 | X           X        X                                                   |         22 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Medulla      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X        X  X        X                                                   |         29 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +              +  +  +     +  +  +  +      |             
      Hepatocellular Adenoma               | X                                                                        |             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X     X                    X  X     X  X  X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +           +                                             |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 | X                                                  X                     |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 | X  X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +                 +  +        +  +  +  +      |             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +           +     +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 |    X                                                        X            |             
      Pheochromocytoma Malignant           |                                                             X            |             
      Pheochromocytoma Benign              |       X              X                 X                                 |             
      Bilateral, Pheochromocytoma Benign   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Adenoma                              |       X              X                                                   |             
      Carcinoma                            |                X                             X                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +     +                 +  +  +     +  +  +  M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +        +        +  +  +     +  +  +  +      |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X        X  X  X              X           X        X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      C-Cell, Adenoma                      |    X                                                                     |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +     +        +        +  +  +     +  +  +  +      |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                      X        X     X  X  X        X  X     X            |             
      Interstitial Cell, Adenoma           | X                                            X  X        X     X         |             
      Interstitial Cell, Adenoma, Multiple |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 |    X                                                              X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                      +                        |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |          X                                      X                        |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 | X  X     X                                      X  X        X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +                 +  +  +     M  +  +  +      |             
      Leukemia Mononuclear                 | X  X     X                                      X  X        X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 | X  X     X                                      X  X        X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 | X  X     X                                      X  X        X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +        +  +     +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X     X        X  X        X  X     X  X  X  X      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +     +                 +  +  +     +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X  X                                            X  X        X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +        +  +     +  +  +     +  +  +  +      |             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                              X                           |             
      Squamous Cell Papilloma              |                                                                   X      |             
      Sebaceous Gland, Carcinoma           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 | X  X     X  X        X              X  X        X  X     X  X     X      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                     +        +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Duct, Carcinoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 |             X                                            X  X     X      |             
      Nephroblastoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X     X        X  X        X  X     X  X  X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +     +  +     +     A     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +     +  +     +     A     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +        +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X        X  X     X     X        X  X           X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                +                     |             
      Leukemia Mononuclear                 |                   X                                X                     |             
      Mesothelioma Malignant               |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X                                X                     |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +     +  +  +     +     +  +              +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X                                X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X                       X        X              X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X                       X        X              X  X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |             X                       X                             X     X|             
      Bilateral, Pheochromocytoma Benign   |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Adenoma                              |                   X                 X                                    |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +     +     M     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +     +     +     +  +  +  +  +     +  +        +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|          X                                                               |             
      Leukemia Mononuclear                 |                   X                                X                    X|             
      Pars Distalis, Adenoma               |    X        X     X     X        X     X  X     X           X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +     +  +  +  +  +     +     +  +              +  +  +|             
      C-Cell, Adenoma                      |                                                    X                     |             
      C-Cell, Carcinoma                    |                                                    X                     |             
      Follicular Cell, Adenoma             |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                      X   |             
      Bilateral, Mesothelioma Malignant    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +     +     +  +  +     +     +  +  +           +  +  +|             
      Carcinoma                            |    X                                                  X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +     +     +     +  +  +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                    X                 X   |             
      Bilateral, Interstitial Cell, Adenoma|    X           X     X     X  X     X                 X     X            |             
      Interstitial Cell, Adenoma           |       X                 X        X                 X     X        X     X|             
      Interstitial Cell, Adenoma, Multiple |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X                                               X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +        +              +                     |             
      Axillary, Leukemia Mononuclear       |                                                    X                     |             
      Pancreatic, Leukemia Mononuclear     |                            X        X              X                     |             
      Renal, Leukemia Mononuclear          |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     M  +     +     +     +  +  +     +     +  +              +  M  +|             
      Leukemia Mononuclear                 |                   X           X     X     X        X              X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +     +     +     +  +  +  +  +     +  +              +     +|             
      Leukemia Mononuclear                 |                   X           X     X     X        X              X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X           X     X     X        X              X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X           X     X     X        X              X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +  +  +     +     +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X        X  X     X     X        X        X     X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                   X           X                    X              X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +     +  +  +  +  +     +  +              +  +  +|             
      Fibroma                              |       X                                                                  |             
      Fibrosarcoma                         |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +     +  +  +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Carcinoma, Metastatic, Zymbal's Gland|          X                                                           X   |             
      Leukemia Mononuclear                 |       X           X        X  X     X     X        X  X     X     X  X  X|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
      Duct, Carcinoma                      |                                                                      X   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                           +   |             
      Carcinoma                            |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +     +     +  +  +     +     +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                X                     |             
      Nephroblastoma                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X        X  X     X     X        X  X     X     X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                    X                 X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +                                                      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +           +                                                      |  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +                                                      |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +           +     +                                                |  42        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |         27 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +     +  +  +  +                                                   |  11        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |    X        X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +                                                      |  34        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +           +                                                      |  36        |
      Mesothelioma Malignant               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +           +                                                      |  35        |
      Mesothelioma Malignant               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +                                                      |  34        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +           +                                                      |  33        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    M  +           +                                                      |  34        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          7 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +                                                      |  34        |
      Adenoma                              |                   X                                                      |          5 |
      Carcinoma                            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +           +                                                      |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +     +                                                      |  39        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pars Distalis, Adenoma               |       X     X     X                                                      |         23 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +                                                      |  35        |
      C-Cell, Adenoma                      |                   X                                                      |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +     +                                                      |  35        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
      Bilateral, Mesothelioma Malignant    |    X        X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +        +  +                                                      |  38        |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +           +                                                      |  36        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +        +  +                                                      |  35        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +                                                   |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                   X                                                      |          1 |
      Bilateral, Mesothelioma Malignant    |    X        X                                                            |          4 |
      Bilateral, Interstitial Cell, Adenoma|    X  X     X  X     X                                                   |         21 |
      Interstitial Cell, Adenoma           |          X                                                               |         13 |
      Interstitial Cell, Adenoma, Multiple |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +                                                      |  34        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   6        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                X                                                         |          6 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +     +     +                                                      |  32        |
      Leukemia Mononuclear                 |    X  X                                                                  |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +           M                                                      |  32        |
      Leukemia Mononuclear                 |    X  X                                                                  |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           +  +                                                   |  35        |
      Leukemia Mononuclear                 |    X  X              X                                                   |         16 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +           M                                                      |  32        |
      Leukemia Mononuclear                 |    X  X                                                                  |         15 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +           +  +                                                   |  41        |
      Leukemia Mononuclear                 |    X  X              X                                                   |         31 |
      Mesothelioma Malignant               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           M                                                      |  32        |
      Leukemia Mononuclear                 |       X                                                                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +           +                                                      |  38        |
      Fibroma                              |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +                                                      |  34        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +                                                      |  35        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          2 |
      Leukemia Mononuclear                 |       X        X     X                                                   |         27 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Duct, Carcinoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +     +                                                      |  38        |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Nephroblastoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +                                                      |  34        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X        X     X                                                   |         33 |
      Mesothelioma Malignant               |    X        X     X                                                      |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +        +        +        +  I     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +     +        +  +     +  +  +  +     +            |             
      Hepatocellular Adenoma               |                                                       X                  |             
      Leukemia Mononuclear                 |    X  X  X     X  X  X     X        X           X     X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +                             +                  |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +        +        +  +  +  +     +  +     +            |             
      Leukemia Mononuclear                 |                X                          X           X                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                      +                                                   |             
      Papilloma                            |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +        +        +        +  +     +     +  +     +            |             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |    X                                X                 X                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |    X                                X                 X                  |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |       X     X     X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +        +        +  +     +  +  +  +     +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                 X                        |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +        +        +        +  +     +     M  +     +            |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +        +        +  I  +  +  +  +  +     +            |             
      Leukemia Mononuclear                 |             X                                         X                  |             
      Pars Distalis, Adenoma               |       X  X  X  X  X                             X     X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +     +  +        +        +  +     +     +  +     +            |             
      C-Cell, Adenoma                      |                X                                                         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +        +  +     +        +  +     +     +  +     +            |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +        +  +  +  +  +  +  +     +            |             
      Bilateral, Interstitial Cell, Adenoma|                X  X  X  X           X     X                              |             
      Interstitial Cell, Adenoma           |    X                                   X        X     X                  |             
      Interstitial Cell, Adenoma, Multiple | X                                                           X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |    X                                X                 X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +  +                                +                  |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |             X     X  X                                X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |    X     X        X        X        X                 X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |    X     X        X        X        X                 X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +        +        +        +  +  +  +     +  +     +            |             
      Leukemia Mononuclear                 |    X     X        X        X        X     X           X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +  +        +        +        +  +     +     +  +     +            |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |    X     X        X        X        X                 X     X            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +  +     +        +  +  +  +  +  +  +     +            |             
      Leukemia Mononuclear                 |    X  X  X     X  X  X     X        X     X     X     X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +        +        +        +  +     +     +  +     +            |             
      Leukemia Mononuclear                 |    X              X        X                          X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +        +        +        +  +     +  +  +  +     +            |             
      Fibroma                              |       X                                                                  |             
      Neurofibrosarcoma                    |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +              +   |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Sarcoma                              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Granular Cell Tumor Malignant        |                                                                          |             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |             X                                                            |             
      Leukemia Mononuclear                 |    X     X  X  X  X        X        X     X     X     X     X            |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
      Carcinoma                            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +     +  +        +  +  +  +     +  +     +            |             
      Leukemia Mononuclear                 |    X              X                                   X                  |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +        +        +        +  +     +     +  +     +            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X     X        X     X     X     X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +           +  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  A           A  +  +     +  +     +     +  +           A   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  A           A  +  +     +  +     +     +  +           A   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  A           A  +  +     +  +     +     +  +           A   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  A           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  A           A  +  +     +  +     +     +  +           A   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  A           A  +  +     +  +     +     +  +           A   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +        A  +  +     +  +     +     +  +  +        +   |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X     X           X           X  X     X        X     X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +           +                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                  +                                       |             
      Papilloma                            |                                  X                                       |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                               X        X        X     X                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                               X        X        X     X                  |             
      Pheochromocytoma Malignant           |                                                                      X   |             
      Pheochromocytoma Benign              | X                                      X  X           X              X   |             
      Bilateral, Pheochromocytoma Benign   |             X                    X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +           A  +  +     +  +     +     +  +           +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                           X     X        X               |             
      Carcinoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M           +  +           M  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +           A  +  +     +  +  +  +  +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pars Distalis, Adenoma               | X  X        X  X              X           X  X  X  X  X           X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +  +           +  +  +     +  +     +  +  +  +  +  +     +  +|             
      C-Cell, Adenoma                      |                                  X              X  X        X            |             
      C-Cell, Carcinoma                    | X                                                              X        X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +           +  +  +  +  +  +     +     +  +           +   |             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +           A  +  +     +  +  +  +  +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +           +  +           A  +  +     +  +     +  +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X           X              X  X        X     X        X     X      |             
      Interstitial Cell, Adenoma           |          X              X              X        X                       X|             
      Interstitial Cell, Adenoma, Multiple |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |                                        X              X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                          +  +           +           +      |             
      Deep Cervical, Leukemia Mononuclear  |                                                       X                  |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
      Renal, Leukemia Mononuclear          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +     +  +           A  +  +     +  +     +     +  +  +        +   |             
      Leukemia Mononuclear                 |       X                       X        X        X     X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +  +        +  A  +  +     +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |       X                       X        X        X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +  +           A  +  +  +  +  +     +     +  +           +   |             
      Leukemia Mononuclear                 |       X                       X        X        X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +     +     +  +           A  +  +     +  +     +     +  +           +   |             
      Carcinoma, Metastatic, Thyroid Gland | X                                                                        |             
      Leukemia Mononuclear                 |       X                       X  X     X        X     X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        A  +  +     +  +     +     +  +  +        +  +|             
      Leukemia Mononuclear                 | X     X           X           X  X     X        X     X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +           +  +           A  +  +     +  +     +     +  +  +        +   |             
      Leukemia Mononuclear                 |                               X        X              X     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +           +  +  +  +  +  +     +     +  +  +        +   |             
      Fibroma                              |                                                                          |             
      Neurofibrosarcoma                    |    X                                                                     |             
      Sarcoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +           A  +  +     +  +     +  +  +  +           +   |             
      Granular Cell Tumor Malignant        |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                         X|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
      Leukemia Mononuclear                 |       X                       X        X        X     X     X            |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                       +           +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +        +  A  +  +     +  +  +  +  +  +  +        +  +  +|             
      Leukemia Mononuclear                 |                                        X              X                  |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
   Urinary Bladder                         | +           +  +           A  +  +     +  +     +     +  +           +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X           X  X     X        X     X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +  +        +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +  +        +                                                |  25        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +  +  +        +                                                |  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A        +  +  +        +                                                |  23        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +  +        +                                                |  26        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A        +  +  +        +                                                |  23        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +  +  +        +                                                |  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +        +  +                                             |  36        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X  X           X                                             |         24 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   8        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +  +  +     +                                                |  30        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |             +                                                            |   3        |
      Papilloma                            |                                                                          |          1 |
      Squamous Cell Carcinoma              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +  +  +        +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +  +        +  +                                             |  30        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +  +        +  +                                             |  30        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +  +        +                                                |  27        |
      Leukemia Mononuclear                 |             X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +  +  +        +                                                |  27        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |             X                                                            |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +        +  +  +        +                                                |  28        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                                            |          8 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                X                                                         |          6 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +        +                                                |  29        |
      Adenoma                              |                         X                                                |          5 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  +  +        +                                                |  25        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +                                                |  38        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pars Distalis, Adenoma               |       X     X  X  X     X                                                |         23 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +  +  +        +                                                |  33        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +  +  +        +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +  +  +        +                                                |  30        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +  +  +        +                                                |  30        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +        +  +  +        +                                                |  29        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Bilateral, Interstitial Cell, Adenoma|    X     X  X     X                                                      |         19 |
      Interstitial Cell, Adenoma           | X     X              X     X                                             |         13 |
      Interstitial Cell, Adenoma, Multiple |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +  +        +                                                |  27        |
      Leukemia Mononuclear                 |             X  X                                                         |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +                                                         |  11        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                X                                                         |          2 |
      Renal, Leukemia Mononuclear          |             X                                                            |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M        +  +  +        +                                                |  28        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X  X  X                                                         |         16 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +  +  +        +  +                                             |  30        |
      Leukemia Mononuclear                 |          X  X  X           X                                             |         16 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +  +  +        +  +                                             |  31        |
      Leukemia Mononuclear                 |          X  X  X           X                                             |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +        +  +  +        +                                                |  28        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X  X                                                         |         16 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +        +  +                                             |  37        |
      Leukemia Mononuclear                 |          X  X  X           X                                             |         25 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +  +        +                                                |  28        |
      Leukemia Mononuclear                 |          X     X                                                         |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  +  +        +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +  +     +  +                                                |  34        |
      Fibroma                              |                      X                                                   |          2 |
      Neurofibrosarcoma                    |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +  +        +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +  +        +                                                |  29        |
      Granular Cell Tumor Malignant        |                                                                          |          1 |
      Leukemia Mononuclear                 |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X  X           X                                             |         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +        +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +  +        +  +                                             |  36        |
      Leukemia Mononuclear                 |             X  X           X                                             |          8 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +  +        +                                                |  27        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X  X  X           X                                             |         26 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X  X     X  X        X           X  X  X     X     X  X        X  X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +              +     +  +  +                 +               |             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                        X      |             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                        X      |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                        X      |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |          X              X                          X                     |             
      Bilateral, Pheochromocytoma Benign   |             X                                            X           X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                   X           X   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               | X  X  X     X  X  X        X     X              X  X     X     X  X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    | X                                                              X         |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                  X                                       |             
      Bilateral, Interstitial Cell, Adenoma|             X        X        X     X  X           X  X        X        X|             
      Interstitial Cell, Adenoma           | X     X                 X        X           X  X           X            |             
      Interstitial Cell, Adenoma, Multiple |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         +                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +                                            +     +         |             
      Pancreatic, Leukemia Mononuclear     |    X                                                                     |             
      Renal, Leukemia Mononuclear          |             X                                                  X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X                    X     X     X                 X  X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X        X                 X     X                 X  X  X  X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X                          X     X                 X  X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X                          X     X                 X  X  X  X|             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X        X           X  X  X     X     X  X        X  X  X  X|             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |          X                                   X                       X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibroma                              |                                                                X         |             
      Neurofibroma                         |                                                                          |             
      Neurofibrosarcoma                    |                                                          X               |             
      Squamous Cell Carcinoma              |                                     X                                    |             
      Squamous Cell Papilloma              |                                        X                                 |             
      Sebaceous Gland, Carcinoma           |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma Malignant                     |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                            X               |             
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |             
      Leukemia Mononuclear                 |    X     X           X           X  X  X     X     X           X  X  X  X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Papillary                   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Oral Mucosa                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +              +           +           +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X        X           X  X  X     X     X  X        X  X  X  X|             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                   X  X                                                   |             
      Leukemia Mononuclear                 | X                 X  X  X     X        X     X        X              X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +                 +           +                     |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                            +                                             |             
      Squamous Cell Carcinoma              |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                             X   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                 +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                   X              X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                     X|             
      Bilateral, Adenoma                   |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                   X                                                     X|             
      Pheochromocytoma Malignant           | X                                                                        |             
      Pheochromocytoma Benign              |                   X  X     X  X           X              X     X         |             
      Bilateral, Pheochromocytoma Benign   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X  X     X  X                    X              X         |             
      Carcinoma                            |                               X                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Pars Distalis, Adenoma               |       X     X     X  X     X  X           X     X  X  X  X  X     X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                              X                           |             
      C-Cell, Carcinoma                    |                                                                      X   |             
      Follicular Cell, Adenoma             |             X                             X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                   X     X                                X     X         |             
      Interstitial Cell, Adenoma           | X     X        X           X  X        X  X  X  X  X              X     X|             
      Interstitial Cell, Adenoma, Multiple |    X                             X  X                       X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                       X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +              +  +|             
      Pancreatic, Leukemia Mononuclear     |                                                                      X  X|             
      Renal, Leukemia Mononuclear          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X     X              X     X        X              X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X  X  X     X        X     X        X              X  X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X  X  X              X     X        X              X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X     X              X     X        X              X  X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X  X  X     X        X     X        X              X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                      X   |             
      Leukemia Mononuclear                 |                   X  X                       X        X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibroma                              |                                                 X  X                     |             
      Neurofibroma                         |                                                                   X      |             
      Neurofibrosarcoma                    |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                     +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma Malignant                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                                      X   |             
      Leukemia Mononuclear                 | X                 X  X  X              X     X        X              X  X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Papillary                   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Oral Mucosa                     |                            X                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                          +                 +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                  X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X  X  X     X        X     X        X              X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                         X                                                |          3 |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         29 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +     +                                                            |  14        |
      Mesothelioma Malignant               |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Mesothelioma Malignant               |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X           X  X  X                                                |         14 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |       X              X                                                   |         11 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  56        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               | X     X     X  X  X  X  X  X                                             |         36 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |       X                                                                  |          3 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Adenoma             |       X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Mesothelioma Malignant    |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Carcinoma                            | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Mesothelioma Malignant    |             X                                                            |          2 |
      Bilateral, Interstitial Cell, Adenoma| X     X     X  X     X     X                                             |         19 |
      Interstitial Cell, Adenoma           |                   X                                                      |         20 |
      Interstitial Cell, Adenoma, Multiple |    X                                                                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                 X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   8        |
      Pancreatic, Leukemia Mononuclear     |                   X                                                      |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  M  +  +  +  +  +                                             |  52        |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         23 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         25 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         23 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         22 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         29 |
      Mesothelioma Malignant               |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Carcinoma                 |       X                                                                  |          1 |
      Fibroma                              |                                                                          |          3 |
      Neurofibroma                         |                                                                          |          1 |
      Neurofibrosarcoma                    |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Glioma Malignant                     |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05114-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:16:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |     L      |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Leukemia Mononuclear                 | X        X        X                                                      |         24 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma, Papillary                   | X                                                                        |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Oral Mucosa                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   2        |
      Adenoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                                                                        |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X     X  X        X                                                      |         29 |
      Mesothelioma Malignant               |             X                                                            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
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                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------