National Toxicology Program

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TDMS Study 05114-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                             HEXACHLOROCYCLOPENTADIENE (HCCPD)                          DATE: 09/14/94       
EXPERIMENT: 05114 TEST: 01                                                                                     TIME: 13:48:14       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1ES2800301          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 00125        
PATHOLOGIST: R. RENNE                        HAILEY, JAMES R.                                                  CAS: 77-47-4         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Northwest                             HEXACHLOROCYCLOPENTADIENE (HCCPD)                          DATE: 09/14/94      
EXPERIMENT: 05114 TEST: 01                                                                                     TIME: 13:48:14      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1ES2800301          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 00125       
PATHOLOGIST: R. RENNE                        HAILEY, JAMES R.                                                  CAS: 77-47-4        
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                             HEXACHLOROCYCLOPENTADIENE (HCCPD)                          DATE: 09/14/94       
EXPERIMENT: 05114 TEST: 01                                                                                     TIME: 13:48:14       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1ES2800301          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 00125        
PATHOLOGIST: R. RENNE                        HAILEY, JAMES R.                                                  CAS: 77-47-4         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                               IN THE ANALYSIS OF THE STUDY OF HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Lung                          Alveolar/Bronchiolar Carcinoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             Testes                        Adenoma
                             Thyroid Gland: C-Cell         Carcinoma or Adenoma
                             Thyroid Gland: Follicular Cell
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Malignant
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Thyroid Gland: C-Cell         Carcinoma
 
              ====================================================================================================
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   1
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  10/44 (23%)  11/38 (29%)  18/59 (31%) |  6/57 (11%)   2/29 (7%)    3/30 (10%)   2/60 (3%)  |
|ADJUSTED (b)           |  58.2%       100.0%       100.0%        61.3%      |  20.2%         5.1%         7.9%         5.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/18 (44%)   1/1 (100%)   1/1 (100%)   6/16 (38%) |  4/26 (15%)   0/2 (0%)     0/1 (0%)     1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   628          565          471          458 (I)   |   681          681          562          617       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.268      P=0.291      P=0.329      P=0.250    |  P=0.107N     P=0.533N     P=0.526      P=0.110N   |
|INCIDENTAL TUMOR       |  P=0.250      P=0.224      P=0.140      P=0.186    |  P=0.089N     P=0.637N     P=0.504      P=0.098N   |
|LOGISTIC REGRESSION    |  P=0.323      P=0.218      P=0.078      P=0.206    |  P=0.071N     P=0.608      P=0.270      P=0.109N   |
|COCHRAN-ARMITAGE       |  P=0.242                                           |  P=0.113N                                          |
|FISHER EXACT           |               P=0.488N     P=0.419      P=0.321    |               P=0.453N     P=0.626N     P=0.120N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/44 (2%)    1/38 (3%)    1/59 (2%)  |  0/57 (0%)    1/29 (3%)    1/30 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.9%         4.5%         2.1%         3.1%      |   0.0%        50.0%       100.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/1 (0%)     0/1 (0%)     0/16 (0%)  |  0/26 (0%)    1/2 (50%)    1/1 (100%)   0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   660          705          471          628       |   ---          730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.549N     P=0.522N     P=0.465N     P=0.528N   |  P=0.305N     P=0.048 *    P=0.007 **     (e)      |
|INCIDENTAL TUMOR       |  P=0.540N     P=0.529N     P=0.444N     P=0.548N   |  P=0.305N     P=0.048 *    P=0.007 **     (e)      |
|LOGISTIC REGRESSION    |  P=0.458N     P=0.733      P=0.660N     P=0.522N   |  P=0.305N     P=0.048 *    P=0.007 **     (e)      |
|COCHRAN-ARMITAGE       |  P=0.465N                                          |  P=0.431N                                          |
|FISHER EXACT           |               P=0.616N     P=0.667N     P=0.506N   |               P=0.337      P=0.345        (e)      |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   2
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/60 (27%)  11/44 (25%)  11/38 (29%)  19/59 (32%) |  6/57 (11%)   3/29 (10%)   4/30 (13%)   2/60 (3%)  |
|ADJUSTED (b)           |  59.6%       100.0%       100.0%        62.6%      |  20.2%        52.5%       100.0%         5.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/18 (44%)   1/1 (100%)   1/1 (100%)   6/16 (38%) |  4/26 (15%)   1/2 (50%)    1/1 (100%)   1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   628          565          471          458 (I)   |   681          681          562          617       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.260      P=0.297      P=0.428      P=0.253    |  P=0.057N     P=0.493      P=0.227      P=0.110N   |
|INCIDENTAL TUMOR       |  P=0.237      P=0.221      P=0.220      P=0.182    |  P=0.046N*    P=0.391      P=0.167      P=0.098N   |
|LOGISTIC REGRESSION    |  P=0.328      P=0.175      P=0.112      P=0.207    |  P=0.041N*    P=0.307      P=0.075      P=0.109N   |
|COCHRAN-ARMITAGE       |  P=0.246                                           |  P=0.077N                                          |
|FISHER EXACT           |               P=0.516N     P=0.491      P=0.322    |               P=0.646N     P=0.474      P=0.120N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   2/48 (4%)    1/40 (3%)    2/58 (3%)  |  5/59 (8%)    5/32 (16%)   3/37 (8%)    4/60 (7%)  |
|ADJUSTED (b)           |  21.9%        26.7%        50.0%        12.5%      |  17.1%        34.0%        33.3%        11.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   1/4 (25%)    1/2 (50%)    2/16 (13%) |  4/28 (14%)   2/7 (29%)    3/9 (33%)    2/30 (7%)  |
|FIRST INCIDENCE (DAYS) |   464          540          730 (T)      730 (T)   |   709          654          730 (T)      569       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.166N     P=0.345N     P=0.204N     P=0.168N   |  P=0.206N     P=0.195      P=0.401      P=0.460N   |
|INCIDENTAL TUMOR       |  P=0.162N     P=0.290N     P=0.263N     P=0.163N   |  P=0.206N     P=0.113      P=0.323      P=0.461N   |
|LOGISTIC REGRESSION    |  P=0.209N     P=0.275N     P=0.225N     P=0.166N   |  P=0.182N     P=0.072      P=0.330      P=0.477N   |
|COCHRAN-ARMITAGE       |  P=0.223N                                          |  P=0.274N                                          |
|FISHER EXACT           |               P=0.220N     P=0.149N     P=0.147N   |               P=0.241      P=0.632N     P=0.489N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   3
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   2/48 (4%)    1/40 (3%)    2/58 (3%)  |  5/59 (8%)    5/32 (16%)   3/37 (8%)    4/60 (7%)  |
|ADJUSTED (b)           |  21.9%        26.7%        50.0%        12.5%      |  17.1%        34.0%        33.3%        11.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   1/4 (25%)    1/2 (50%)    2/16 (13%) |  4/28 (14%)   2/7 (29%)    3/9 (33%)    2/30 (7%)  |
|FIRST INCIDENCE (DAYS) |   464          540          730 (T)      730 (T)   |   709          654          730 (T)      569       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.166N     P=0.345N     P=0.204N     P=0.168N   |  P=0.206N     P=0.195      P=0.401      P=0.460N   |
|INCIDENTAL TUMOR       |  P=0.162N     P=0.290N     P=0.263N     P=0.163N   |  P=0.206N     P=0.113      P=0.323      P=0.461N   |
|LOGISTIC REGRESSION    |  P=0.209N     P=0.275N     P=0.225N     P=0.166N   |  P=0.182N     P=0.072      P=0.330      P=0.477N   |
|COCHRAN-ARMITAGE       |  P=0.223N                                          |  P=0.274N                                          |
|FISHER EXACT           |               P=0.220N     P=0.149N     P=0.147N   |               P=0.241      P=0.632N     P=0.489N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)   5/44 (11%)   5/39 (13%)  11/60 (18%) |  2/60 (3%)    1/28 (4%)    0/29 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  34.0%         0.0%        56.0%        44.0%      |   7.1%       100.0%         0.0%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  5/18 (28%)   0/0          1/2 (50%)    5/16 (31%) |  2/28 (7%)    1/1 (100%)   0/0          1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   458 (I)      635          611          458 (I)   |   730 (T)      730 (T)      ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.251      P=0.341      P=0.455      P=0.243    |  P=0.264N     P=0.096        (e)        P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.253      P=0.345      P=0.346      P=0.232    |  P=0.264N     P=0.096        (e)        P=0.476N   |
|LOGISTIC REGRESSION    |  P=0.261      P=0.402      P=0.435      P=0.258    |  P=0.264N     P=0.096        (e)        P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.193                                           |  P=0.443N                                          |
|FISHER EXACT           |               P=0.505N     P=0.597N     P=0.309    |               P=0.688      P=0.452N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   4
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    2/44 (5%)    1/39 (3%)    2/60 (3%)  |  0/60 (0%)    0/28 (0%)    0/29 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  15.6%         0.0%         3.3%        11.1%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    0/0          0/2 (0%)     0/16 (0%)  |  0/28 (0%)    0/1 (0%)     0/0          0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   626          544          705          723       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.432N     P=0.519N     P=0.232N     P=0.395N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.403N     P=0.483N     P=0.336N     P=0.375N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.315N     P=0.615N     P=0.470N     P=0.368N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.355N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.495N     P=0.342N     P=0.340N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/60 (20%)   7/44 (16%)   6/39 (15%)  13/60 (22%) |  2/60 (3%)    1/28 (4%)    0/29 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  45.6%         0.0%        57.4%        50.2%      |   7.1%       100.0%         0.0%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  6/18 (33%)   0/0          1/2 (50%)    5/16 (31%) |  2/28 (7%)    1/1 (100%)   0/0          1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   458 (I)      544          611          458 (I)   |   730 (T)      730 (T)      ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.362      P=0.471      P=0.478N     P=0.403    |  P=0.264N     P=0.096        (e)        P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.378      P=0.507      P=0.593      P=0.397    |  P=0.264N     P=0.096        (e)        P=0.476N   |
|LOGISTIC REGRESSION    |  P=0.436      P=0.473      P=0.581      P=0.431    |  P=0.264N     P=0.096        (e)        P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.336                                           |  P=0.443N                                          |
|FISHER EXACT           |               P=0.394N     P=0.381N     P=0.500    |               P=0.688      P=0.452N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   5
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/49 (2%)    1/46 (2%)    3/60 (5%)  |  1/60 (2%)    2/41 (5%)    0/42 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.3%         3.2%         4.3%        12.0%      |   2.9%         8.9%         0.0%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/5 (0%)     0/9 (0%)     0/16 (0%)  |  0/28 (0%)    1/14 (7%)    0/13 (0%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   712          639          724          617       |   683          459 (I)      ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.133      P=0.745      P=0.731N     P=0.281    |  P=0.514N     P=0.438      P=0.506N     P=0.750N   |
|INCIDENTAL TUMOR       |  P=0.146      P=0.752      P=0.748N     P=0.275    |  P=0.529N     P=0.405      P=0.705N     P=0.732    |
|LOGISTIC REGRESSION    |  P=0.208      P=0.668      P=0.668      P=0.282    |  P=0.515N     P=0.374      P=0.618N     P=0.758N   |
|COCHRAN-ARMITAGE       |  P=0.197                                           |  P=0.521N                                          |
|FISHER EXACT           |               P=0.699      P=0.682      P=0.309    |               P=0.359      P=0.588N     P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/49 (2%)    1/46 (2%)    3/60 (5%)  |  1/60 (2%)    2/41 (5%)    1/42 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.3%         3.2%         4.3%        12.0%      |   2.9%         8.9%         7.7%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/5 (0%)     0/9 (0%)     0/16 (0%)  |  0/28 (0%)    1/14 (7%)    1/13 (8%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   712          639          724          617       |   683          459 (I)      730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.133      P=0.745      P=0.731N     P=0.281    |  P=0.451N     P=0.438      P=0.675      P=0.750N   |
|INCIDENTAL TUMOR       |  P=0.146      P=0.752      P=0.748N     P=0.275    |  P=0.464N     P=0.405      P=0.550      P=0.732    |
|LOGISTIC REGRESSION    |  P=0.208      P=0.668      P=0.668      P=0.282    |  P=0.458N     P=0.374      P=0.601      P=0.758N   |
|COCHRAN-ARMITAGE       |  P=0.197                                           |  P=0.474N                                          |
|FISHER EXACT           |               P=0.699      P=0.682      P=0.309    |               P=0.359      P=0.656      P=0.752N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   6
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/49 (2%)    1/46 (2%)    3/60 (5%)  |  1/60 (2%)    2/41 (5%)    1/42 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.3%         3.2%         4.3%        12.0%      |   2.9%         8.9%         7.7%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/5 (0%)     0/9 (0%)     0/16 (0%)  |  0/28 (0%)    1/14 (7%)    1/13 (8%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   712          639          724          617       |   683          459 (I)      730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.133      P=0.745      P=0.731N     P=0.281    |  P=0.451N     P=0.438      P=0.675      P=0.750N   |
|INCIDENTAL TUMOR       |  P=0.146      P=0.752      P=0.748N     P=0.275    |  P=0.464N     P=0.405      P=0.550      P=0.732    |
|LOGISTIC REGRESSION    |  P=0.208      P=0.668      P=0.668      P=0.282    |  P=0.458N     P=0.374      P=0.601      P=0.758N   |
|COCHRAN-ARMITAGE       |  P=0.197                                           |  P=0.474N                                          |
|FISHER EXACT           |               P=0.699      P=0.682      P=0.309    |               P=0.359      P=0.656      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    2/60 (3%)    2/60 (3%)    3/60 (5%)  |  1/60 (2%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  23.5%        12.5%         9.1%        15.4%      |   3.4%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/18 (17%)   2/16 (13%)   2/22 (9%)    2/16 (13%) |  0/28 (0%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   694          730 (T)      730 (T)      639       |   726          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.577N     P=0.258N     P=0.145N     P=0.413N   |  P=0.542N     P=0.474N     P=0.493N     P=0.480N   |
|INCIDENTAL TUMOR       |  P=0.573N     P=0.248N     P=0.154N     P=0.414N   |  P=0.583N     P=0.531N     P=0.705N     P=0.567N   |
|LOGISTIC REGRESSION    |  P=0.569N     P=0.233N     P=0.150N     P=0.397N   |  P=0.549N     P=0.475N     P=0.506N     P=0.489N   |
|COCHRAN-ARMITAGE       |  P=0.522N                                          |  P=0.549N                                          |
|FISHER EXACT           |               P=0.219N     P=0.219N     P=0.359N   |               P=0.500N     P=0.504N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   7
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    1/59 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        11.8%      |   0.0%         0.0%         2.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/16 (0%)    0/22 (0%)    1/16 (6%)  |  0/28 (0%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          724       |   ---          ---          597          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.030 *      (e)          (e)        P=0.210    |  P=0.770N       (e)        P=0.467        (e)      |
|INCIDENTAL TUMOR       |  P=0.033 *      (e)          (e)        P=0.218    |  P=0.710N       (e)        P=0.701        (e)      |
|LOGISTIC REGRESSION    |  P=0.030 *      (e)          (e)        P=0.212    |  P=0.779N       (e)        P=0.505        (e)      |
|COCHRAN-ARMITAGE       |  P=0.042 *                                         |  P=0.773N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |                 (e)        P=0.496        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    2/60 (3%)    2/60 (3%)    5/60 (8%)  |  1/60 (2%)    0/60 (0%)    1/59 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  23.5%        12.5%         9.1%        26.1%      |   3.4%         0.0%         2.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/18 (17%)   2/16 (13%)   2/22 (9%)    3/16 (19%) |  0/28 (0%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   694          730 (T)      730 (T)      639       |   726          ---          597          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.258      P=0.258N     P=0.145N     P=0.561    |  P=0.478N     P=0.474N     P=0.746      P=0.480N   |
|INCIDENTAL TUMOR       |  P=0.265      P=0.248N     P=0.154N     P=0.566    |  P=0.452N     P=0.531N     P=0.787      P=0.567N   |
|LOGISTIC REGRESSION    |  P=0.266      P=0.233N     P=0.150N     P=0.583    |  P=0.482N     P=0.475N     P=0.755      P=0.489N   |
|COCHRAN-ARMITAGE       |  P=0.321                                           |  P=0.482N                                          |
|FISHER EXACT           |               P=0.219N     P=0.219N     P=0.628N   |               P=0.500N     P=0.748      P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   8
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  3/60 (5%)    1/60 (2%)    4/60 (7%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   9.6%         3.0%        12.8%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/16 (0%)    0/22 (0%)    0/16 (0%)  |  2/28 (7%)    1/33 (3%)    3/30 (10%)   0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   680          730 (T)      709          626       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.342N     P=0.257N     P=0.521      P=0.304N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.337N     P=0.276N     P=0.377      P=0.264N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.337N     P=0.273N     P=0.462      P=0.299N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.336N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.309N     P=0.500      P=0.309N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  | 13/60 (22%)  20/60 (33%)  14/60 (23%)  13/60 (22%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  38.5%        52.8%        36.9%        34.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   1/10 (10%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/16 (0%)    0/22 (0%)    0/16 (0%)  |  9/28 (32%)  16/33 (48%)   8/30 (27%)   8/30 (27%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   459 (I)      459 (I)      459 (I)      528       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.287N     P=0.219      P=0.528      P=0.534N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.263N     P=0.144      P=0.495      P=0.552N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.265N     P=0.141      P=0.441      P=0.571N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.273N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.110      P=0.500      P=0.588N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE   9
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  | 15/60 (25%)  20/60 (33%)  16/60 (27%)  14/60 (23%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  44.9%        52.8%        42.6%        36.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   1/10 (10%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/16 (0%)    0/22 (0%)    0/16 (0%)  | 11/28 (39%)  16/33 (48%)  10/30 (33%)   8/30 (27%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   459 (I)      459 (I)      459 (I)      528       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.278N     P=0.375      P=0.539      P=0.446N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.243N     P=0.277      P=0.508      P=0.428N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.255N     P=0.265      P=0.425      P=0.480N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.263N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.211      P=0.500      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  1/60 (2%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.3%         3.8%      |   3.4%         0.0%         2.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/16 (0%)    0/22 (0%)    0/16 (0%)  |  0/28 (0%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          680          681       |   726          ---          569          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.390        (e)        P=0.288      P=0.485    |  P=0.474N     P=0.474N     P=0.754      P=0.480N   |
|INCIDENTAL TUMOR       |  P=0.385        (e)        P=0.252      P=0.484    |  P=0.452N     P=0.531N     P=0.787      P=0.567N   |
|LOGISTIC REGRESSION    |  P=0.398        (e)        P=0.248      P=0.489    |  P=0.482N     P=0.475N     P=0.760      P=0.489N   |
|COCHRAN-ARMITAGE       |  P=0.414                                           |  P=0.482N                                          |
|FISHER EXACT           |                 (e)        P=0.248      P=0.500    |               P=0.500N     P=0.752N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  10
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/60 (45%)  23/49 (47%)  23/48 (48%)  36/60 (60%) | 32/60 (53%)  30/49 (61%)  25/43 (58%)  40/60 (67%) |
|ADJUSTED (b)           |  69.0%       100.0%        84.5%        94.2%      |  73.6%        89.7%       100.0%        86.4%      |
|INTERIM SACRIFICE 1 (c)|  4/10 (40%)   0/10 (0%)    0/10 (0%)    3/10 (30%) |  1/10 (10%)   0/10 (0%)    2/10 (20%)   2/10 (20%) |
|TERMINAL (d)           |  8/18 (44%)   5/5 (100%)   9/12 (75%)  14/16 (88%) | 17/28 (61%)  19/22 (86%)  14/14 (100%) 24/30 (80%) |
|FIRST INCIDENCE (DAYS) |   458 (I)      355          547          458 (I)   |   459 (I)      521          366          459 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.048 *    P=0.316      P=0.415N     P=0.061    |  P=0.190      P=0.493      P=0.269      P=0.199    |
|INCIDENTAL TUMOR       |  P=0.032 *    P=0.393      P=0.348      P=0.036 *  |  P=0.130      P=0.176      P=0.119      P=0.124    |
|LOGISTIC REGRESSION    |  P=0.034 *    P=0.288      P=0.342      P=0.040 *  |  P=0.158      P=0.217      P=0.069      P=0.122    |
|COCHRAN-ARMITAGE       |  P=0.047 *                                         |  P=0.120                                           |
|FISHER EXACT           |               P=0.496      P=0.457      P=0.072    |               P=0.264      P=0.389      P=0.096    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/49 (0%)    0/48 (0%)    0/60 (0%)  |  2/60 (3%)    1/49 (2%)    0/43 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   6.2%         2.5%         0.0%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/5 (0%)     0/12 (0%)    0/16 (0%)  |  1/28 (4%)    0/22 (0%)    0/14 (0%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   681          683          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.525N     P=0.500N     P=0.325N     P=0.487N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.552N     P=0.564N     P=0.441N     P=0.523N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.502N     P=0.573N     P=0.385N     P=0.492N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.521N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.576N     P=0.337N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  11
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    2/60 (3%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.8%         6.3%         8.5%        16.7%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/16 (6%)    1/22 (5%)    2/16 (13%) |  0/28 (0%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   536          730 (T)      723          709       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.261      P=0.524N     P=0.656N     P=0.454    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.272      P=0.475N     P=0.631N     P=0.494    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.273      P=0.510N     P=0.687N     P=0.473    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.303                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/60 (0%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.6%         3.6%         0.0%         8.4%      |   0.0%         0.0%         3.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    0/16 (0%)    0/22 (0%)    1/16 (6%)  |  0/28 (0%)    0/33 (0%)    1/30 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   730 (T)      662          ---          534       |   ---          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.292      P=0.747      P=0.460N     P=0.465    |  P=0.775N       (e)        P=0.514        (e)      |
|INCIDENTAL TUMOR       |  P=0.306      P=0.747      P=0.460N     P=0.511    |  P=0.775N       (e)        P=0.514        (e)      |
|LOGISTIC REGRESSION    |  P=0.307      P=0.753      P=0.460N     P=0.484    |  P=0.775N       (e)        P=0.514        (e)      |
|COCHRAN-ARMITAGE       |  P=0.319                                           |  P=0.773N                                          |
|FISHER EXACT           |               P=0.752N     P=0.500N     P=0.500    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  12
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/60 (0%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.6%         3.6%         0.0%        14.5%      |   0.0%         0.0%         3.3%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    0/16 (0%)    0/22 (0%)    2/16 (13%) |  0/28 (0%)    0/33 (0%)    1/30 (3%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   730 (T)      662          ---          534       |   ---          ---          730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.097      P=0.747      P=0.460N     P=0.268    |  P=0.343        (e)        P=0.514      P=0.514    |
|INCIDENTAL TUMOR       |  P=0.104      P=0.747      P=0.460N     P=0.302    |  P=0.343        (e)        P=0.514      P=0.514    |
|LOGISTIC REGRESSION    |  P=0.107      P=0.753      P=0.460N     P=0.284    |  P=0.343        (e)        P=0.514      P=0.514    |
|COCHRAN-ARMITAGE       |  P=0.118                                           |  P=0.345                                           |
|FISHER EXACT           |               P=0.752N     P=0.500N     P=0.309    |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/60 (78%)  36/58 (62%)  34/58 (59%)  44/60 (73%) |                                                    |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%        94.8%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  9/10 (90%)   2/10 (20%)   1/10 (10%)  10/10 (100%)|                                                    |
|TERMINAL (d)           | 18/18 (100%) 14/14 (100%) 21/21 (100%) 14/16 (88%) |                                                    |
|FIRST INCIDENCE (DAYS) |   458 (I)      355          402          458 (I)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.214      P=0.216N     P=0.004N**   P=0.533    |                                                    |
|INCIDENTAL TUMOR       |  P=0.250      P=0.061N     P=0.003N**   P=0.518N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.263      P=0.056N     P=0.012N*    P=0.395N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.349                                           |                                                    |
|FISHER EXACT           |               P=0.041N*    P=0.017N*    P=0.335N   |                                                    |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  13
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/59 (8%)    3/45 (7%)    5/42 (12%)   3/60 (5%)  |  6/60 (10%)   3/29 (10%)   1/29 (3%)    5/60 (8%)  |
|ADJUSTED (b)           |  20.2%        10.6%        76.5%        15.2%      |  19.6%         6.4%         0.0%        15.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   0/1 (0%)     3/4 (75%)    2/16 (13%) |  5/28 (18%)   0/2 (0%)     0/0          4/30 (13%) |
|FIRST INCIDENCE (DAYS) |   626          584          680          621       |   625          621          562          668       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.250N     P=0.644N     P=0.263      P=0.413N   |  P=0.351N     P=0.463      P=0.726      P=0.467N   |
|INCIDENTAL TUMOR       |  P=0.235N     P=0.627N     P=0.170      P=0.401N   |  P=0.313N     P=0.411      P=0.522N     P=0.439N   |
|LOGISTIC REGRESSION    |  P=0.240N     P=0.617      P=0.204      P=0.385N   |  P=0.370N     P=0.447      P=0.635N     P=0.485N   |
|COCHRAN-ARMITAGE       |  P=0.295N                                          |  P=0.497N                                          |
|FISHER EXACT           |               P=0.517N     P=0.404      P=0.349N   |               P=0.613      P=0.267N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    1/45 (2%)    3/42 (7%)    3/60 (5%)  |  0/60 (0%)    1/29 (3%)    3/29 (10%)   4/60 (7%)  |
|ADJUSTED (b)           |   0.0%         2.6%        28.9%        16.0%      |   0.0%        50.0%         0.0%        12.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/1 (0%)     1/4 (25%)    1/16 (6%)  |  0/28 (0%)    1/2 (50%)    0/0          3/30 (10%) |
|FIRST INCIDENCE (DAYS) |   ---          597          458 (I)      709       |   ---          730 (T)      549          726       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.186      P=0.490      P=0.061      P=0.103    |  P=0.191      P=0.041 *    P=0.118      P=0.074    |
|INCIDENTAL TUMOR       |  P=0.194      P=0.500      P=0.053      P=0.105    |  P=0.206      P=0.041 *    P=0.151      P=0.060    |
|LOGISTIC REGRESSION    |  P=0.215      P=0.451      P=0.055      P=0.103    |  P=0.201      P=0.041 *    P=0.018 *    P=0.072    |
|COCHRAN-ARMITAGE       |  P=0.194                                           |  P=0.139                                           |
|FISHER EXACT           |               P=0.433      P=0.069      P=0.125    |               P=0.326      P=0.032 *    P=0.059    |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  14
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/59 (8%)    3/45 (7%)    8/42 (19%)   6/60 (10%) |  6/60 (10%)   4/29 (14%)   4/29 (14%)   9/60 (15%) |
|ADJUSTED (b)           |  20.2%        10.6%       100.0%        29.4%      |  19.6%        53.2%         0.0%        27.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   0/1 (0%)     4/4 (100%)   3/16 (19%) |  5/28 (18%)   1/2 (50%)    0/0          7/30 (23%) |
|FIRST INCIDENCE (DAYS) |   626          584          458 (I)      621       |   625          621          549          668       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.550      P=0.644N     P=0.047 *    P=0.428    |  P=0.486      P=0.182      P=0.161      P=0.328    |
|INCIDENTAL TUMOR       |  P=0.569      P=0.627N     P=0.020 *    P=0.442    |  P=0.534      P=0.143      P=0.368      P=0.326    |
|LOGISTIC REGRESSION    |  P=0.572      P=0.617      P=0.029 *    P=0.458    |  P=0.473      P=0.218      P=0.133      P=0.302    |
|COCHRAN-ARMITAGE       |  P=0.499                                           |  P=0.317                                           |
|FISHER EXACT           |               P=0.517N     P=0.104      P=0.512    |               P=0.419      P=0.419      P=0.291    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    1/45 (2%)    0/42 (0%)    3/60 (5%)  |  1/60 (2%)    0/29 (0%)    0/29 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%       100.0%         0.0%        15.4%      |   3.6%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/1 (100%)   0/4 (0%)     2/16 (13%) |  1/28 (4%)    0/2 (0%)     0/0          0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          730 (T)      ---          639       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120      P=0.023 *      (e)        P=0.106    |  P=0.400N     P=0.959N       (e)        P=0.486N   |
|INCIDENTAL TUMOR       |  P=0.130      P=0.023 *      (e)        P=0.108    |  P=0.400N     P=0.959N       (e)        P=0.486N   |
|LOGISTIC REGRESSION    |  P=0.090      P=0.023 *      (e)        P=0.109    |  P=0.400N     P=0.959N       (e)        P=0.486N   |
|COCHRAN-ARMITAGE       |  P=0.066                                           |  P=0.490N                                          |
|FISHER EXACT           |               P=0.433        (e)        P=0.125    |               P=0.674N     P=0.674N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  15
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    1/45 (2%)    0/42 (0%)    3/60 (5%)  |  1/60 (2%)    1/29 (3%)    0/29 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%       100.0%         0.0%        15.4%      |   3.6%        50.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/1 (100%)   0/4 (0%)     2/16 (13%) |  1/28 (4%)    1/2 (50%)    0/0          0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          730 (T)      ---          639       |   730 (T)      730 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120      P=0.023 *      (e)        P=0.106    |  P=0.204N     P=0.145        (e)        P=0.486N   |
|INCIDENTAL TUMOR       |  P=0.130      P=0.023 *      (e)        P=0.108    |  P=0.204N     P=0.145        (e)        P=0.486N   |
|LOGISTIC REGRESSION    |  P=0.090      P=0.023 *      (e)        P=0.109    |  P=0.204N     P=0.145        (e)        P=0.486N   |
|COCHRAN-ARMITAGE       |  P=0.066                                           |  P=0.290N                                          |
|FISHER EXACT           |               P=0.433        (e)        P=0.125    |               P=0.548      P=0.674N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/60 (7%)    5/60 (8%)    5/60 (8%)    8/60 (13%) |
|ADJUSTED (b)           |                                                    |  13.3%        14.2%        13.6%        22.2%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  3/28 (11%)   4/33 (12%)   2/30 (7%)    4/30 (13%) |
|FIRST INCIDENCE (DAYS) |                                                    |   686          659          459 (I)      628       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.135      P=0.592      P=0.513      P=0.209    |
|INCIDENTAL TUMOR       |                                                    |  P=0.113      P=0.558      P=0.326      P=0.170    |
|LOGISTIC REGRESSION    |                                                    |  P=0.136      P=0.555      P=0.466      P=0.187    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.135                                           |
|FISHER EXACT           |                                                    |               P=0.500      P=0.500      P=0.181    |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  16
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  5/60 (8%)    5/60 (8%)    5/60 (8%)    8/60 (13%) |
|ADJUSTED (b)           |                                                    |  16.8%        14.2%        13.6%        22.2%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  4/28 (14%)   4/33 (12%)   2/30 (7%)    4/30 (13%) |
|FIRST INCIDENCE (DAYS) |                                                    |   686          659          459 (I)      628       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.181      P=0.533N     P=0.611N     P=0.314    |
|INCIDENTAL TUMOR       |                                                    |  P=0.156      P=0.566N     P=0.471      P=0.270    |
|LOGISTIC REGRESSION    |                                                    |  P=0.184      P=0.574N     P=0.593      P=0.288    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.183                                           |
|FISHER EXACT           |                                                    |               P=0.628N     P=0.628N     P=0.279    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    1/60 (2%)    0/60 (0%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   7.1%         5.1%         2.2%         0.0%      |   3.6%         2.1%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/16 (0%)    0/22 (0%)    0/16 (0%)  |  1/28 (4%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   548          379          506          ---       |   730 (T)      621          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.169N     P=0.673      P=0.500N     P=0.268N   |  P=0.352N     P=0.737N     P=0.486N     P=0.486N   |
|INCIDENTAL TUMOR       |  P=0.150N     P=0.670N     P=0.565N     P=0.257N   |  P=0.295N     P=0.742N     P=0.486N     P=0.486N   |
|LOGISTIC REGRESSION    |  P=0.140N     P=0.679N     P=0.494N     P=0.242N   |  P=0.345N     P=0.757N     P=0.486N     P=0.486N   |
|COCHRAN-ARMITAGE       |  P=0.155N                                          |  P=0.345N                                          |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.248N   |               P=0.752N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  17
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/60 (48%)  33/60 (55%)  26/60 (43%)  29/60 (48%) | 16/60 (27%)  14/60 (23%)  18/60 (30%)  21/60 (35%) |
|ADJUSTED (b)           |  72.6%        79.2%        65.2%        76.1%      |  40.6%        30.1%        43.4%        55.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/18 (44%)   8/16 (50%)   9/22 (41%)   8/16 (50%) |  6/28 (21%)   3/33 (9%)    8/30 (27%)  14/30 (47%) |
|FIRST INCIDENCE (DAYS) |   536          370          506          460       |   639          521          366          569       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.484      P=0.258      P=0.210N     P=0.416    |  P=0.135      P=0.306N     P=0.414      P=0.290    |
|INCIDENTAL TUMOR       |  P=0.510N     P=0.186      P=0.532N     P=0.489    |  P=0.085      P=0.509N     P=0.173      P=0.158    |
|LOGISTIC REGRESSION    |  P=0.482N     P=0.194      P=0.507      P=0.476    |  P=0.138      P=0.422N     P=0.356      P=0.220    |
|COCHRAN-ARMITAGE       |  P=0.436N                                          |  P=0.113                                           |
|FISHER EXACT           |               P=0.292      P=0.357N     P=0.572N   |               P=0.417N     P=0.420      P=0.215    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    5/60 (8%)    0/60 (0%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.3%        20.6%         0.0%         5.9%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/16 (6%)    0/22 (0%)    0/16 (0%)  |  0/28 (0%)    0/33 (0%)    0/30 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   712          597          ---          542       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.546N     P=0.093      P=0.476N     P=0.466    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.530N     P=0.094      P=0.485N     P=0.520    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.525N     P=0.093      P=0.478N     P=0.493    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.509N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.103      P=0.500N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  18
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 56/60 (93%)  47/60 (78%)  47/60 (78%)  57/60 (95%) | 46/60 (77%)  44/60 (73%)  39/60 (65%)  48/60 (80%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  92.0%        93.5%        80.9%        95.9%      |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%)  2/10 (20%)   1/10 (10%)  10/10 (100%)|  2/10 (20%)   2/10 (20%)   3/10 (30%)   2/10 (20%) |
|TERMINAL (d)           | 18/18 (100%) 16/16 (100%) 22/22 (100%) 16/16 (100%)| 24/28 (86%)  30/33 (91%)  21/30 (70%)  28/30 (93%) |
|FIRST INCIDENCE (DAYS) |   458 (I)      355          402          458 (I)   |   459 (I)      459 (I)      366          459 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.091      P=0.268N     P=0.030N*    P=0.292    |  P=0.272      P=0.140N     P=0.195N     P=0.554    |
|INCIDENTAL TUMOR       |  P=0.007 **   P=0.016N*    P=0.013N*    P=0.148    |  P=0.189      P=0.321N     P=0.159N     P=0.476    |
|LOGISTIC REGRESSION    |  P=0.007 **   P=0.018N*    P=0.018N*    P=0.266    |  P=0.291      P=0.209N     P=0.145N     P=0.618    |
|COCHRAN-ARMITAGE       |  P=0.053                                           |  P=0.227                                           |
|FISHER EXACT           |               P=0.017N*    P=0.017N*    P=0.500    |               P=0.417N     P=0.114N     P=0.412    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 36/60 (60%)  38/60 (63%)  33/60 (55%)  34/60 (57%) | 29/60 (48%)  26/60 (43%)  27/60 (45%)  28/60 (47%) |
|ADJUSTED (b)           |  79.0%        83.9%        75.3%        79.4%      |  65.3%        52.7%        60.4%        67.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    2/10 (20%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  9/18 (50%)   9/16 (56%)  12/22 (55%)   8/16 (50%) | 13/28 (46%)  10/33 (30%)  13/30 (43%)  17/30 (57%) |
|FIRST INCIDENCE (DAYS) |   373          370          458 (I)      180       |   376          521          366          569       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.530N     P=0.347      P=0.213N     P=0.506    |  P=0.496      P=0.214N     P=0.451N     P=0.415N   |
|INCIDENTAL TUMOR       |  P=0.350N     P=0.364      P=0.516N     P=0.422N   |  P=0.501      P=0.472N     P=0.584N     P=0.559    |
|LOGISTIC REGRESSION    |  P=0.400N     P=0.321      P=0.567N     P=0.506N   |  P=0.497N     P=0.301N     P=0.503N     P=0.459N   |
|COCHRAN-ARMITAGE       |  P=0.335N                                          |  P=0.510                                           |
|FISHER EXACT           |               P=0.426      P=0.356N     P=0.427N   |               P=0.357N     P=0.427N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/15/94                     EXPERIMENT: 05114 TEST: 01                                                 PAGE  19
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.01 PPM     0.05 PPM     0.2       |   CONTROL      0.01 PPM     0.05 PPM     0.2       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 60/60 (100%) 51/60 (85%)  51/60 (85%)  59/60 (98%) | 49/60 (82%)  50/60 (83%)  44/60 (73%)  51/60 (85%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  96.0%        96.1%        87.9%        98.1%      |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%)  2/10 (20%)   3/10 (30%)  10/10 (100%)|  2/10 (20%)   2/10 (20%)   3/10 (30%)   2/10 (20%) |
|TERMINAL (d)           | 18/18 (100%) 16/16 (100%) 22/22 (100%) 16/16 (100%)| 26/28 (93%)  31/33 (94%)  24/30 (80%)  29/30 (97%) |
|FIRST INCIDENCE (DAYS) |   373          355          402          180       |   376          459 (I)      366          459 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.161      P=0.286N     P=0.037N*    P=0.385    |  P=0.367      P=0.258N     P=0.278N     P=0.548N   |
|INCIDENTAL TUMOR       |  P=0.028 *    P<0.001N**   P=0.003N**     (e)      |  P=0.314      P=0.539      P=0.190N     P=0.387    |
|LOGISTIC REGRESSION    |  P=0.022 *    P=0.003N**   P=0.003N**   P=0.996N   |  P=0.474      P=0.488N     P=0.311N     P=0.565    |
|COCHRAN-ARMITAGE       |  P=0.105                                           |  P=0.330                                           |
|FISHER EXACT           |               P=0.001N**   P=0.001N**   P=0.500N   |               P=0.500      P=0.191N     P=0.404    |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   458
          Female interim sacrifices(days): 459
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.