National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3380

TDMS Study 05114-01 Pathology Tables

NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  01/09/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      3   |             
      Basophilic Focus                     | X                                   X        X  X                    X  X|             
      Clear Cell Focus                     |       X                       X                                          |             
      Granuloma, Multifocal                |             2                                                           1|             
      Hepatodiaphragmatic Nodule           |                            X           X     X           X  X            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |                2  3              4                          2            |             
      Biliary Tract, Cyst                  |                                                                          |             
      Biliary Tract, Hyperplasia           |                   3                                                      |             
      Hepatocyte, Hyperplasia              |                                     4  4                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +                       +     +                                 |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        | 4        4                       2     3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  2           3     1        2     3  3                              |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                           +                              |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  3                          4            |             
      Hyperkeratosis                       |                                  3                          2            |             
      Inflammation, Suppurative            |                                  3                          3            |             
      Ulcer                                |                                  4                          4            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                  3                          3            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1                                2                  |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                   2              4     3                                 |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                               X              X   |             
      Pars Distalis, Hyperplasia           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     1           1           2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Hyperplasia                          |                                        3                                 |             
      Inflammation, Suppurative            |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  M  M  +  +  M  +  +  M  M  +  +  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          4                                                               |             
      Inflammation, Chronic                |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                             3            |             
      Necrosis                             |                                                                   4      |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X           X  X                          X                       X      |             
      Hemorrhage                           |                                  1                                3      |             
      Hydrocephalus                        |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                          2              2|             
      Hyperplasia                          |                                                          2               |             
      Inflammation, Chronic                |                                  2                    2                  |             
      Inflammation, Suppurative            |                                                          3              3|             
      Metaplasia, Squamous                 |       1     1                 1     1     1              2        1     2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Granuloma                            |                                     3                                    |             
      Alveolar Epithelium, Hyperplasia     |             2                             4                              |             
      Alveolus, Hemorrhage                 |                         1  1                 1     1     1     1        1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                                                    1     1               |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Artery, Mineralization               |                                                                1         |             
      Peribronchiolar, Pigmentation        | 1     1        1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2                    2                                                   |             
      Hemorrhage                           |    2                                                     1               |             
      Inflammation, Suppurative            |                                                                      2   |             
      Nasolacrimal Duct, Hemorrhage        |                                                                   2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           2                              |             
      Respiratory Epithelium, Hyperplasia  | 1                                                                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|             
                                           | 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                 +     +                                          |             
      Cataract                             |       2                 2     2                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |    4                                                                     |             
      Cornea, Inflammation                 |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Inflammation, Suppurative            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2  2           2           2                                 |             
      Nephropathy, Chronic                 | 3  2  2  2  2  4  1  3  2  2  2  2  3  2  2  2  1  1  3  1  2  1  2  2  1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X                                X                       X  X            |             
      Clear Cell Focus                     |                                                                          |             
      Granuloma, Multifocal                |    1           1                 2                    1           2      |             
      Hepatodiaphragmatic Nodule           |       X                                X                 X               |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |             1                                3                           |             
      Biliary Tract, Cyst                  |                                                                          |             
      Biliary Tract, Hyperplasia           |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                       +                 +                  |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                     X                                    |             
      Fat, Mineralization                  |                                                       3                  |             
      Fat, Necrosis                        | 1           3                                         3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            2           1  2  2                       2   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                            +                     |             
      Hyperkeratosis                       |       3                                                                  |             
      Hyperplasia                          |       3                                            2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     2                 1                  |             
      Hyperkeratosis                       |                                     2                                    |             
      Inflammation, Suppurative            |                                     1                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                     1                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1                                2                              |             
      Thrombosis                           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                2              1           3        2                     |             
      Necrosis                             |             3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Pars Distalis, Hyperplasia           |                      1                             1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1  3                       1                       1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                 3                 3      |             
      Inflammation, Suppurative            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                                2  4                 3         |             
      Hyperplasia, Reticulum Cell          | 3                                   2                    3               |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   X              X     X     X                           |             
      Hemorrhage                           |                   2                                                      |             
      Hydrocephalus                        |                   3              3                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                1                                                         |             
      Inflammation, Suppurative            | 1                                   1                    1               |             
      Metaplasia, Squamous                 |                            1                       1                    1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Granuloma                            |                                                    2                 1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage                 |    1  1  1  2           3           1              1  1     1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                                        1           1                     |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Peribronchiolar, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         3|             
      Hemorrhage                           |                                  2                                       |             
      Inflammation, Suppurative            |                         3                 2                             2|             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2                                                            |             
      Respiratory Epithelium, Hyperplasia  |             1                 2                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             1                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|             
                                           | 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2        2     2                 2              2               |             
      Nephropathy, Chronic                 |    1  1  2  1  3  2  1  2  2  3  3  1  3  4  3  1  1  2  3  2  1  2  3  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |     10     |
      Clear Cell Focus                     |                                                                          |      2     |
      Granuloma, Multifocal                |                                                                          |      7  1.4|
      Hepatodiaphragmatic Nodule           |    X     X                                                               |     10     |
      Pigmentation, Hemosiderin            |                      3                                                   |      1  3.0|
      Vacuolization Cytoplasmic            |                2                                                         |      7  2.4|
      Biliary Tract, Cyst                  |                         X                                                |      1     |
      Biliary Tract, Hyperplasia           |                                                                          |      1  3.0|
      Hepatocyte, Hyperplasia              |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +                                                      |  10        |
      Hemorrhage                           |                   4                                                      |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Fat, Mineralization                  |                                                                          |      1  3.0|
      Fat, Necrosis                        |          1        1                                                      |      9  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      | 2                 2        1                                             |     15  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   3        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |    1                 2     2                                             |      7  2.1|
      Hyperkeratosis                       |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Ulcer                                |                4                                                         |      3  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                3                                                         |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      4  1.5|
      Thrombosis                           | X                                                                        |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytomegaly                           |                3                                                         |      8  2.5|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |    2  1                                                                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |          2                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |          1     1  1        1                                             |     12  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                         X                                                |      2     |
      Hyperplasia                          |          3                                                               |      4  3.0|
      Inflammation, Suppurative            |          3                                                               |      3  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  +  +  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                      3                                                   |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +                                             |  57        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      4  3.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      4  2.8|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |       X                    X                                             |     11     |
      Hemorrhage                           |                                                                          |      3  2.0|
      Hydrocephalus                        |       3                                                                  |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |             3                                                            |      3  2.3|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |             3                                                            |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      5  1.8|
      Metaplasia, Squamous                 |                                                                          |     11  1.2|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |             4                                                            |      1  4.0|
      Granuloma                            |                                                                          |      3  2.0|
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      3  2.7|
      Alveolus, Hemorrhage                 | 1     2              1                                                   |     19  1.2|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                         2                                                |      5  1.2|
      Alveolus, Inflammation, Suppurative  |             4                                                            |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6|                                            |            |
                                           | 9| 3| 3| 3| 0| 9| 3| 6| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Artery, Mineralization               |                                                                          |      1  1.0|
      Peribronchiolar, Pigmentation        |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      3  2.3|
      Hemorrhage                           |    1                                                                     |      4  1.5|
      Inflammation, Suppurative            |             2                                                            |      5  2.2|
      Nasolacrimal Duct, Hemorrhage        | 2                          2                                             |      3  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |                      1                                                   |      4  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   5        |
      Cataract                             |                                                                          |      3  2.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Cornea, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |    2     2  2           2                                                |     13  2.0|
      Nephropathy, Chronic                 | 2  4  3  2  2     3     4  2                                             |     57  2.1|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |    3                                                                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                 +     +                                +  +  +   |             
      Mediastinum, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +           +  +     +     +                    +  +  +  +  +   |             
      Angiectasis                          |                                                                3         |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    X     X                                               X               |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma, Multifocal                |                                                                          |             
      Hepatodiaphragmatic Nodule           | X        X           X              X                       X            |             
      Vacuolization Cytoplasmic            |       4                                                        4         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +     +                                             |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                   4  4     3                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                 +     +                                +  +  +   |             
      Acinus, Atrophy                      |                         1                                                |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                 +     +                                +  +  +   |             
      Acanthosis                           |       3                       3                                   4  2   |             
      Erosion                              |                               4                                          |             
      Hyperkeratosis                       |       2                       3                                   3      |             
      Inflammation, Suppurative            |                                                                   3  2   |             
      Ulcer                                |                                                                      3   |             
      Muscularis, Hypoplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                 +     +                                +  +  +   |             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                                                   3  2   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +        +        +     +                                +  +  +   |             
      Cytomegaly                           |                4              2                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +                 +     +                                +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                 +     +                                +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +  +              +     +  +  +  +  +  +  +   |             
      Cyst                                 |                         X                    X              X     X  X   |             
      Pars Distalis, Hyperplasia           |       4                                                     3            |             
      Pars Intermedia, Hyperplasia         |                                                             4            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                 +     +                       +        +  +  +   |             
      Ultimobranchial Cyst                 |                               X                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +                 +     +     +                    +  +  M  +  +   |             
      Cyst                                 |    X                                                     X  X            |             
      Hyperplasia                          |                                                             3            |             
      Inflammation, Suppurative            |    4                                                     3               |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +                 +  +  +                                +  +  +   |             
      Cyst                                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +        +        +     +              +                 +  +  +   |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                 +     +                                +  +  +   |             
      Myelofibrosis                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +                 +     +           +                    +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                 +     +                                +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +                 +     +  +                             +  +  +   |             
      Hemorrhage                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +                 +     +                                +  +  +   |             
      Ectopic Tissue                       |                         X                                                |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                 +     +                                +  +  +   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +  +  +  +     +     +        +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |       +                 +     +                                +  +  +   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                 +     +                                +  +  +   |             
      Compression                          |                         X     X                                X         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |    1                 1     1        1                 1  2  1  1         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage                 | 1        1  1              1     1  1  1  1     1           1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |          1                                   2                       2   |             
      Artery, Mineralization               |                                  1                                       |             
      Bronchiole, Pigmentation             |          1           1                       1     1  1  1  1           1|             
      Peribronchiolar, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Suppurative            |                                                          4              1|             
      Pigmentation                         |          1  1  1  1  1     1  1  1  1  1  1  1  1  1  1     1     1  1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2  2                       2                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                          2              1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|             
                                           | 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         2                          2           2  2  2   |             
      Nephropathy, Chronic                 | 2  3  3  1  3  3  3  2  2  4  3  2  2  1  2  3  1  3  3  3  4  3  2  1  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                 +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +           +     +              +     +                    +      |             
      Mediastinum, Inflammation,           |                                                                          |             
          Granulomatous                    |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +              +  +  +           +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X                                   X                                 |             
      Clear Cell Focus                     |                                                                      X   |             
      Eosinophilic Focus                   |                                              X                           |             
      Granuloma, Multifocal                |    2                                                                     |             
      Hepatodiaphragmatic Nodule           | X           X                             X                 X  X         |             
      Vacuolization Cytoplasmic            |       3                                                           3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Inflammation, Granulomatous          |                                                                3         |             
      Fat, Necrosis                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +           +                    +     +                    +      |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation                 |       3                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           +                    +     +                 +  +  +   |             
      Acanthosis                           |       3                                                        4         |             
      Erosion                              |       4                                                                  |             
      Hyperkeratosis                       |       3                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                4         |             
      Muscularis, Hypoplasia               |                                                                      4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           +                    +     +                 +  +      |             
      Erosion                              |                   4                                                      |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                4         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +           +                    +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +           +              +     +     +                    +  +   |             
      Cytomegaly                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis                             | 4                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +           +              M     +     +                    +  +   |             
      Hyperplasia                          |       2                                                           2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +           +                    +     +                    +      |             
      Hyperplasia                          |       2                                2                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +        +     +  +  +        +  +  +      |             
      Cyst                                 |                X     X  X  X                                             |             
      Pars Distalis, Hyperplasia           | 2                 3                                               4      |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +           +                    +     +              +     +      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2              1                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +        +  +                    +     +        +        +  +      |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +           +                    +     +                    +      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +           +  +           +     +     +                    +  +   |             
      Endometrium, Hyperplasia             |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +           +                    +     +                    +      |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Renal, Hyperplasia, Lymphoid         |                            4                                             |             
      Renal, Pigmentation                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +           +                    +     +                    +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +           +                    +     +                    +      |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +           +  +  +              +     +     +              +  +   |             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +           +                    +     +                    +      |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +        +           +     +     +           +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +           +                    +     +                    +      |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +           +                    +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +           +  +                 +     +                    +      |             
      Compression                          |    X                                                                     |             
      Hemorrhage                           | 1                    3                                                   |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                         2                                                |             
      Inflammation, Suppurative            |    2                                                                     |             
      Metaplasia, Squamous                 |             1  1        3     1  1     1              1     1        2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                            3                                2     1      |             
      Alveolus, Hemorrhage                 |    1     1                       2  2     1           1  1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                            2  1                                          |             
      Artery, Mineralization               |                                                                1         |             
      Bronchiole, Pigmentation             | 1           1  1     1  1  1  1        1        1  1  1     1  1     1  1|             
      Peribronchiolar, Pigmentation        |                               1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                            4                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                            3                                2        4   |             
      Pigmentation                         | 1  1     1  2  1     1  1  1     1        1     1  1     1     1     1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2  2     2  2                             2                  |             
      Respiratory Epithelium, Hyperplasia  |                            4                                2        3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|             
                                           | 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.01 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  2                          2        1                          1      |             
      Nephropathy, Chronic                 | 2  2  4  2  2  2  1  2  2  2  2  2  1  2  2  2  3  3  3  2  4  4  3  3  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +           +                    +     +                    +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |      A     |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +  +                                                      |  18        |
      Mediastinum, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +                                                   |  34        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      4     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Granuloma, Multifocal                |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |     11     |
      Vacuolization Cytoplasmic            |                   2                                                      |      5  3.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +     +                                             |   6        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Fat, Necrosis                        |                      3     3                                             |      6  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +  +                                                      |  17        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +  +                                                      |  18        |
      Acanthosis                           |       4           4                                                      |      8  3.4|
      Erosion                              |       4                                                                  |      3  4.0|
      Hyperkeratosis                       |       4           4                                                      |      6  3.2|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Ulcer                                |                   4                                                      |      3  3.7|
      Muscularis, Hypoplasia               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +  +                                                      |  17        |
      Erosion                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +  +                                                      |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |      A     |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +     +  +  +                                                      |  21        |
      Cytomegaly                           |    4        3  3                                                         |      5  3.2|
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +     +  +  +                                                      |  19        |
      Hyperplasia                          |                3                                                         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +  +                                                      |  17        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +  +  +  +     +                                             |  39        |
      Cyst                                 |                                                                          |      9     |
      Pars Distalis, Hyperplasia           |                4                                                         |      6  3.3|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +  +                                                      |  19        |
      Ultimobranchial Cyst                 |       X                                                                  |      2     |
      C-Cell, Hyperplasia                  |       1                                                                  |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +     M  +  +                                                      |  22        |
      Cyst                                 |                                                                          |      3     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +     +  +  +                                                      |  18        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +     +  +  +                                                      |  22        |
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +  +                                                      |  17        |
      Myelofibrosis                        |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   2        |
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +     +  +  +                                                      |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |      A     |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +  +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +  +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +     +  +  +                                                      |  18        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +  +                                                      |  21        |
      Ectopic Tissue                       |                                                                          |      1     |
      Fibrosis                             |             3  3                                                         |      3  3.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +  +  +                                                      |  17        |
      Cyst                                 |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +  +  +                                                      |  17        |
      Ulcer                                |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +  +                                                      |  17        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +  +                                                      |  18        |
      Compression                          |       X           X                                                      |      6     |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         1                                                |      2  1.5|
      Inflammation, Suppurative            |             2                                                            |      2  2.0|
      Metaplasia, Squamous                 | 1  1        1           1                                                |     21  1.2|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Alveolus, Hemorrhage                 |                         1                                                |     18  1.1|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |       2                 2                                                |      7  1.7|
      Artery, Mineralization               |                                                                          |      2  1.0|
      Bronchiole, Pigmentation             |       1  1        1                                                      |     26  1.0|
      Peribronchiolar, Pigmentation        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 4| 5| 4| 2| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                            |      A     |
    0.01 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      5  2.8|
      Pigmentation                         | 1  1     1     1     1  1  1                                             |     42  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       2              2                                                   |     10  2.0|
      Respiratory Epithelium, Hyperplasia  | 2                                                                        |      6  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       | 2              1     2  2                                                |     14  1.7|
      Nephropathy, Chronic                 | 2  3  4  3  2     4  3  1  4                                             |     59  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +  +  +                                                      |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  +              +  +     +     +        +                 A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +              +  +     +     +        +                 A  +      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +        +  +     +  +  +  +     +  +        +     +  +      |             
      Angiectasis                          |    3                                                           3  4      |             
      Basophilic Focus                     |                                     X                             X      |             
      Clear Cell Focus                     |                               X                                          |             
      Granuloma, Multifocal                |                                        3                                 |             
      Hepatodiaphragmatic Nodule           |       X                                         X                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Hepatocyte, Hyperplasia              |             4                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +                           |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                               4              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +              +  +     +     +        +                 +  +      |             
      Acinus, Atrophy                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                               +                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +     +  +     +     +        +                 +  +     +|             
      Acanthosis                           |    2                                         1                 2  2      |             
      Hyperkeratosis                       |    3                          2                                   2      |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                              4                    4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +     +  +     +     +        +                 +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
      Muscularis, Hypoplasia               |                4                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +              +  +     +     +        +                 +  +      |             
      Cardiomyopathy                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +              +  +     +     +        +                 +  +      |             
      Cytomegaly                           |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                              3                           |             
      Bilateral, Hyperplasia               |                                                                   3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +              +  +     +     +        +                 +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +           +  +  +  +  +  +  +        +           +     +  +     +|             
      Cyst                                 |                                     X                                   X|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2           3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +              +  +     +     +        +                 +  +      |             
      C-Cell, Hyperplasia                  |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +           +  +  +  +  +     +     +  +        +  +     +  +      |             
      Cyst                                 |                                           X                              |             
      Hyperplasia                          |    3              3                 3                 3                  |             
      Inflammation, Suppurative            |                                     4                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +              +  +     +     +  +     +        +        +  +      |             
      Cyst                                 |    X                                   X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia             |                                                                   2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +              +  +     +     +        +                 +  +      |             
      Hyperplasia, Reticulum Cell          |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +              +  +     M     +        +                 +  +      |             
      Hemorrhage                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +              +  +     +     +        +                 +  +      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |       3                       2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +              +  +           +        +                 +  +      |             
      Hemorrhage                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  M              +  +     +     +        +                 +  +      |             
      Hemorrhage                           |                               1                                          |             
      Pigmentation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +              +  +     +  +  +  +     +     +  +  +     +  +      |             
      Ectopic Tissue                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                  3                       3               |             
      Hyperplasia, Reticulum Cell          |                         4                                                |             
      Necrosis                             |                                  4           3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +  +     +  +     +  +  +  +  +  +                 +  +      |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +              +  +     +     +        +                 +  +      |             
      Compression                          |                      X                                         X  X      |             
      Hemorrhage                           |    2                                1        3                 4         |             
      Hydrocephalus                        |                      4                                         4         |             
      Necrosis                             |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                             2        2   |             
      Inflammation, Chronic                |    1                                         1        2                  |             
      Inflammation, Suppurative            |                                                             2            |             
      Metaplasia, Squamous                 |                   1     1        1        1           1        1  2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                4         |             
      Granuloma                            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              3                           |             
      Alveolus, Hemorrhage                 | 1     1  1     2                       2  1  2  2  1  2     1        1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |       2                    1                    2                        |             
      Artery, Mineralization               |          1                                                               |             
      Bronchiole, Pigmentation             | 1  1     1  1     1  1  1  1  1  1  2  1  1  1  2  1  1  1        1  1  1|             
      Peribronchiolar, Pigmentation        |          1        1                       1                              |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         2                             2     3            |             
      Hemorrhage                           |                                     1                 2                  |             
      Inflammation, Suppurative            |    2                                                        3            |             
      Pigmentation                         | 1  1  1  1  2  1  2  1     2  1  2     2  2  2  2  2  2  2  1  1  1  1  2|             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2        2        2              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|             
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|             
                                           | 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                     1                       2            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +        +                       +     +     +      |             
      Cataract                             |                      2                                2                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       3  2  2  2  2  1        3                          2               |             
      Nephropathy, Chronic                 | 2     1  2  2  2  3  2  1  3  2  3  2  2  3  3  2  1  2  2  1  3  4  1  3|             
      Cortex, Renal Tubule, Cytoplasmic    |                                                                          |             
          Alteration                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +              +  +     +     +        +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +           +  +     +  +  +  +  +     +     +     +                    +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                  X                                      X|             
      Granuloma, Multifocal                |                                        4                                 |             
      Hepatodiaphragmatic Nodule           |                X     X     X  X                                          |             
      Vacuolization Cytoplasmic            | 4           4                                                            |             
      Hepatocyte, Hyperplasia              |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                                 |             
      Hemorrhage                           |             4                                                            |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +           +     +        +           +                     |             
      Acinus, Atrophy                      | 1                                                                        |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           M           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +           +     +        +           +                    +|             
      Acanthosis                           | 3                                                                        |             
      Hyperkeratosis                       | 3                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                | 4                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +           +     +        +           +                    +|             
      Inflammation, Suppurative            |                                                                          |             
      Muscularis, Hypoplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
      Inflammation, Suppurative            |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +           +     +        +           +                     |             
      Cardiomyopathy                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +           +           +     +        +           +                     |             
      Cytomegaly                           |             3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +           +           +     +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                         2                          3                     |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +           +     +        +           +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +     +  +  +  +  +  +     +     +  +  +  +     +  +  +      |             
      Cyst                                 |                                                 X  X  X        X         |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2              2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +           +     +        +           +                     |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +           +  +        +     +  +     M           +        +            |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +           +  +  +        +           +                     |             
      Cyst                                 | X     X                    X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       1              1   |             
      Infarct                              |                         4                                                |             
      Inflammation, Suppurative            |                                                    2                     |             
      Endometrium, Hyperplasia             | 2     2                                                                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +           +     +        +           +                     |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +           M           +     M        +           +                     |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           M           +     +        +           +                     |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +           +     +        +           +                     |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +           M           +     +        +           +  +                  |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +           +           +     +  +     +     +     +                     |             
      Ectopic Tissue                       |             X                          X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             | 4                                            3                           |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M           M           +     +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +           +     +        M           +     +  +            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +           +     +        M           +                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +           +     +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +           +     +        +           +                     |             
      Compression                          |                                                                          |             
      Hemorrhage                           |                         1                                                |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                       2                  |             
      Inflammation, Chronic                |                                                    1                     |             
      Inflammation, Suppurative            |                                                       2                  |             
      Metaplasia, Squamous                 |    1  1        1                 1  1           1        1               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            |                                                 3                        |             
      Alveolar Epithelium, Hyperplasia     |                                              1                           |             
      Alveolus, Hemorrhage                 |                   1           1                    3  1        2     1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                      2           3           3              1            |             
      Artery, Mineralization               |                                                                1         |             
      Bronchiole, Pigmentation             |    1  1  1  1  1  1  1  2  2     1  1  1     1  1  1     1  1  1  1  1  1|             
      Peribronchiolar, Pigmentation        |       1                             1                                    |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               2  2                                   1   |             
      Hemorrhage                           |                         3                                2        2     2|             
      Inflammation, Suppurative            |                               3                       1                  |             
      Pigmentation                         | 2  2  2  2  2  2  1  2  1  2  1  2  1  1     2  2  1  1  2  2  1  2  1  2|             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2                    2                 2        2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|             
                                           | 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 PPM                               | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                               3                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                               2                                      1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2           2  2                                2               |             
      Nephropathy, Chronic                 | 1  3  2  2  2  2  1  3  2  3  1  3  3  2     2  4  2  1  3  3  1  2  1  2|             
      Cortex, Renal Tubule, Cytoplasmic    |                                                                          |             
          Alteration                       |                                        4                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +           +     +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |      A     |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                 +  +  A                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                 +  +  A                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 +  A  A                                                |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                 +  +  A                                                |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                 +  A  A                                                |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                 +  A  A                                                |  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +     +  +  +                                                |  32        |
      Angiectasis                          |                      2                                                   |      4  3.0|
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      3     |
      Granuloma, Multifocal                |                                                                          |      2  3.5|
      Hepatodiaphragmatic Nodule           |       X     X                                                            |      8     |
      Vacuolization Cytoplasmic            | 4                       4                                                |      4  4.0|
      Hepatocyte, Hyperplasia              |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   6        |
      Hemorrhage                           |    4                                                                     |      2  4.0|
      Inflammation, Granulomatous          |    4  3                                                                  |      2  3.5|
      Fat, Necrosis                        |    3  3                                                                  |      5  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                 +  +  +                                                |  19        |
      Acinus, Atrophy                      |                      1                                                   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                 +  +  +                                                |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                 +  +  +                                                |  22        |
      Acanthosis                           |                   3     2                                                |      7  2.1|
      Hyperkeratosis                       |                   3     2                                                |      6  2.5|
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
      Ulcer                                |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +              +  +  +  +                                                |  23        |
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
      Muscularis, Hypoplasia               |                3                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                 +  +  +                                                |  19        |
      Cardiomyopathy                       |                      1                                                   |      1  1.0|
      Thrombosis                           | X                                                                        |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |      A     |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                 +  +  +                                                |  19        |
      Cytomegaly                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +        +        +  +  +                                                |  20        |
      Hyperplasia                          | 3                                                                        |      4  2.8|
      Bilateral, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                 +  +  +                                                |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +  +  +  +  +                                                |  38        |
      Cyst                                 |                X        X                                                |      8     |
      Hemorrhage                           |                      4                                                   |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                 +  +  +                                                |  19        |
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +           +  +  +                                                |  27        |
      Cyst                                 | X     X                                                                  |      3     |
      Hyperplasia                          | 3     3                                                                  |      6  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +              +  +  +                                                |  24        |
      Cyst                                 |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      2  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                 +  +  +                                                |  19        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                 +  +  +                                                |  16        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |      A     |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                 +  +  +                                                |  18        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +  +  +                                                |  18        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +                 +  +  +                                                |  18        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                 +  +  +                                                |  26        |
      Ectopic Tissue                       |                                                                          |      2     |
      Fibrosis                             | 3                                                                        |      5  3.2|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                 +  +  +                                                |  16        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +        +     +  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +  +  +                                                |  19        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                 +  +  +                                                |  19        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                 +  +  +                                                |  19        |
      Compression                          |                      X                                                   |      4     |
      Hemorrhage                           |                   3  1  2                                                |      8  2.1|
      Hydrocephalus                        |                      3                                                   |      3  3.7|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Foreign Body                         |                                                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Metaplasia, Squamous                 |       1                                                                  |     15  1.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  4.0|
      Granuloma                            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 3| 6| 5| 7|                                            |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3|                                            |            |
                                           | 9| 1| 1| 1| 1| 9| 6| 8| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|                                            |      A     |
    0.05 PPM                               | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Hemorrhage                 |       2     1  1     3                                                   |     22  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |       3                                                                  |      8  2.1|
      Artery, Mineralization               |                                                                          |      2  1.0|
      Bronchiole, Pigmentation             | 1  1  1  1  1              1                                             |     48  1.1|
      Peribronchiolar, Pigmentation        |                                                                          |      5  1.0|
      Pleura, Fibrosis                     |       3  1                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Foreign Body                         |                                                                          |      6  2.0|
      Hemorrhage                           |                                                                          |      6  2.0|
      Inflammation, Suppurative            |                                                                          |      4  2.3|
      Pigmentation                         | 1  2  1  1  2  1  2  1  1  2                                             |     57  1.5|
      Nasolacrimal Duct, Hemorrhage        |                   2                                                      |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         2                                                |      9  2.0|
      Respiratory Epithelium, Hyperplasia  |                1                                                         |      4  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
      Cataract                             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mineralization                       |                            2                                             |     13  2.1|
      Nephropathy, Chronic                 | 1  2  3  4  3  1     3  1  2                                             |     57  2.2|
      Cortex, Renal Tubule, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 +  +  +                                                |  19        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             4                                                            |             
      Basophilic Focus                     |       X                                                                  |             
      Clear Cell Focus                     |          X                       X                                       |             
      Granuloma, Multifocal                |                                                                      2   |             
      Hepatodiaphragmatic Nodule           |    X  X        X                    X              X                     |             
      Vacuolization Cytoplasmic            |                                                                         4|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Acinus, Atrophy                      |       1     1           2           1                                2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  4                       3     2  3  2  2|             
      Erosion                              |                                  4                             2  3      |             
      Hyperkeratosis                       |                                  3                                      2|             
      Inflammation, Suppurative            |                                                                      2  2|             
      Ulcer                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      2   |             
      Inflammation, Suppurative            |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
      Inflammation, Suppurative            |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                         1  1           1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           | 1                 2                 2     2                 3     2      |             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia                          |                               4                                          |             
      Necrosis                             |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                   2                        |             
      Bilateral, Hyperplasia               |    2                 3                                2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                X                                         X               |             
      C-Cell, Hyperplasia                  |    1              3     2              1              3        1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |          3                                      4                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Muscularis, Hyperplasia      | 3                                                                        |             
      Endometrium, Hyperplasia             |          4                    2                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +     +            |             
      Renal, Pigmentation                  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Ulcer                                |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X        X              X     X                             X  X  X  X|             
      Hemorrhage                           |                                                                      3  2|             
      Hydrocephalus                        |    3                       3     3                             3  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Suppurative            | 2                                      1                                 |             
      Metaplasia, Squamous                 | 1     1     1  1  1  1  1        1     1  1     2     1                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2           2           2        1           2            |             
      Alveolus, Hemorrhage                 | 2        1     1        1  2        1     1        1  3  1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |             2  2                       2                    3            |             
      Alveolus, Inflammation, Suppurative  |                                                                      1   |             
      Artery, Mineralization               |                                                                          |             
      Bronchiole, Pigmentation             | 1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  1  2  1  2  2  2  2  1|             
      Peribronchiolar, Pigmentation        | 1  1  1  1  1     1     1     1     1        2     1        1  1        1|             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   2              2                             2     1   |             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Suppurative            |                                     2                          3     1   |             
      Pigmentation                         | 2  2  2  2  2  2  2  2  2  2  2  3  2  2  1  2  2  1  2  2  2  1     1  1|             
      Nasolacrimal Duct, Hemorrhage        |                                                          2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                     1                          2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Cataract                             |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2        2                          2  2  2              2           2|             
      Nephropathy, Chronic                 | 2  4  1  2  4  3  2  3  4  2  3  3  3  3  1  1  2  2  4  2  2  3  3  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          3               |             
      Basophilic Focus                     |       X                                   X                              |             
      Clear Cell Focus                     |                                                                         X|             
      Granuloma, Multifocal                |                            2     1     2                                 |             
      Hepatodiaphragmatic Nodule           |                                           X        X           X     X  X|             
      Vacuolization Cytoplasmic            |                                           2  3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |             3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             2            |             
      Acinus, Atrophy                      |                                              2        2     2        2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              2                           |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                              2                           |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                             2     2      |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Pars Distalis, Hyperplasia           |                            2  3                                3     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       1                 1                             4                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Muscularis, Hyperplasia      |                                                                      3   |             
      Endometrium, Hyperplasia             |    2                                                  3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2                       3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                           4                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           4                              |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X           X        X        X        X                     |             
      Hemorrhage                           |             2                                                            |             
      Hydrocephalus                        |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         2        2           4              1            |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |             1                 1           2        2        2     2     2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   4      |             
      Foreign Body                         |                                              4                           |             
      Alveolar Epithelium, Hyperplasia     | 2                                                  2                     |             
      Alveolus, Hemorrhage                 |    1        1     2  2     1        2  1        1           2  2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          | 2                       2     2     2              2                     |             
      Alveolus, Inflammation, Suppurative  |                               1              4                           |             
      Artery, Mineralization               |                   1                                                      |             
      Bronchiole, Pigmentation             | 2  2  1  1  2  1  2  1  1  1  1  2  2  2  2  1  1  2  2  2  1  2  1  2  2|             
      Peribronchiolar, Pigmentation        |    1        1  1  1  1     1     1     1        1  1  1        1        1|             
      Pleura, Fibrosis                     |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                            2                 2                           |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |             1              2        3  3  3  3        2        1         |             
      Pigmentation                         | 2  1  2  2  1  1  1  2  2  1  1  1  2  1  1  2  1  1  2  1  1  2  1  2  2|             
      Nasolacrimal Duct, Hemorrhage        |                                                 2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                                                              2         |             
      Respiratory Epithelium, Hyperplasia  |             2           1  1        2  2  2  2        2                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                     2  2     2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|             
                                           | 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2_PPM                                | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                        +   |             
      Cataract                             |             2                                                        2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2                          2        2        2           2         |             
      Nephropathy, Chronic                 | 3  2  2  3  2  3  1  2  3  2  1  3  3  2  4  3  1  3  2  3  1  3  2  1  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |      A     |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  3.5|
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |                                                                          |      3     |
      Granuloma, Multifocal                |                2     2                                                   |      6  1.8|
      Hepatodiaphragmatic Nodule           |    X              X                                                      |     12     |
      Vacuolization Cytoplasmic            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Hemorrhage                           |          4                                                               |      1  4.0|
      Fat, Necrosis                        |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      9  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                         3                                                |      8  2.6|
      Erosion                              |                                                                          |      3  3.0|
      Hyperkeratosis                       |                         3                                                |      4  2.5|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |          4                                                               |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |      A     |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytomegaly                           |          3                                                               |      7  2.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      3  2.7|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                   3                                                      |      4  2.3|
      Bilateral, Hyperplasia               |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |                   3        2                                             |     12  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |          3                                                               |      1  3.0|
      Inflammation, Suppurative            |          2                                                               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cervix, Muscularis, Hyperplasia      |                                                                          |      2  3.0|
      Endometrium, Hyperplasia             |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   3        |
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |      A     |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +                                             |  54        |
      Pigmentation                         |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  +  M  +  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |          X     X        X                                                |     16     |
      Hemorrhage                           |          2     1        2                                                |      6  2.0|
      Hydrocephalus                        |                3        2                                                |     10  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      5  2.2|
      Inflammation, Suppurative            |                      3  1                                                |      4  1.8|
      Metaplasia, Squamous                 |       1  1        2  2  1                                                |     24  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                4        4                                                |      3  4.0|
      Foreign Body                         |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                   3  1                                                   |      9  1.9|
      Alveolus, Hemorrhage                 | 1     2                    1                                             |     23  1.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                   2                                                      |     10  2.1|
      Alveolus, Inflammation, Suppurative  |                                                                          |      3  2.0|
      Artery, Mineralization               |                                                                          |      1  1.0|
      Bronchiole, Pigmentation             | 2  2  2  2  2  2  2  2  2  2                                             |     60  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 5| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5|                                            |            |
                                           | 9| 0| 0| 8| 0| 8| 0| 0| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |      A     |
    0.2_PPM                                | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Peribronchiolar, Pigmentation        |    1  1     1  1  1  1  1  1                                             |     35  1.0|
      Pleura, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                      3                                                   |      7  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                      3                                                   |     12  2.3|
      Pigmentation                         | 1  2  1  1  2  1  3     1                                                |     57  1.6|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         2                                                |      3  2.0|
      Respiratory Epithelium, Hyperplasia  |          1           2                                                   |     12  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   4        |
      Cataract                             |    2                                                                     |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |       2           2                                                      |     14  2.0|
      Nephropathy, Chronic                 | 2  2  3  2  3  3  4  2  3  2                                             |     60  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          3               |             
      Ulcer                                |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Basophilic Focus                     |          X  X                 X  X        X        3                 X   |             
      Clear Cell Focus                     |                            X     X                                       |             
      Granuloma, Multifocal                |                                        1                                 |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hepatodiaphragmatic Nodule           |                                                          X               |             
      Infarct                              |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Biliary Tract, Hyperplasia           |                         3  3                                2            |             
      Hepatocyte, Hyperplasia              |                                                             4            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                                         +   |             
      Hemorrhage                           |                                                                      4   |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                 2                        |             
      Acinus, Atrophy                      |    1        1           2  3  2        2     1  1  1        3            |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       3                  |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                          3               |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                       3                  |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                          4               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +        +  +               |             
      Atherosclerosis, Diffuse             |                                                                          |             
      Mineralization                       |                                                          3               |             
      Thrombosis                           |                                              X                           |             
      Aorta, Atherosclerosis               |                                              X                           |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2        2     2  1                 2  1     1        4  1  1         |             
      Mineralization                       |                                                          4               |             
      Thrombosis                           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |       2                    3                                            4|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                 3     2                                   3            |             
      Bilateral, Hyperplasia               |       2        3                                                     3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Hyperplasia                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Pars Distalis, Hyperplasia           |       3  3  2  2           3                                   3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                      X                                                   |             
      C-Cell, Hyperplasia                  |    1                                                        1            |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X  X                 X                          X            |             
      Hyperplasia                          |                                     4                                    |             
      Inflammation, Suppurative            |             2                       4     4           3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3  2  2     1  2                                            3           2|             
      Epithelium, Hyperplasia              |    1                    2  2                                2        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1           2     2     2  2        1                             2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation              |                   3              4                                       |             
      Interstitial Cell, Hyperplasia       |          2                                2                              |             
      Seminiferous Tubule, Atrophy         |          4  4  4                 4           2              4  3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                       +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                              2                           |             
      Myelofibrosis                        |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |             4                                                            |             
      Pigmentation                         |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                              2                           |             
      Pigmentation                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                              3                           |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |             4                                                            |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Hyperkeratosis                       |             4                                                            |             
      Ulcer                                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                          X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                            1                                      4     2|             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         2                                                |             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Chronic                |                               2  1                                       |             
      Inflammation, Suppurative            |       2                 1                                1        2      |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                          2               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                       3                  |             
      Alveolar Epithelium, Hyperplasia     | 2                                      2           1  3                  |             
      Alveolus, Hemorrhage                 | 3                    2        2        1  1  2  2  2     1           1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          | 2                                      2           2        4           3|             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Artery, Mineralization               |                                                          4               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 3                 2                                                      |             
      Hemorrhage                           |    2              2                 2                                    |             
      Inflammation, Suppurative            | 1                 2        3     1                 1     4              3|             
      Pigmentation                         |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                      2        2        2        2  2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2                 2        1     1                 1                    3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|             
                                           | 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                          3               |             
      Choroid, Iris, Inflammation, Chronic |                                                                          |             
      Cornea, Inflammation                 |                                                          3               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +        +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Mineralization                       |                                              X                           |             
      Nephropathy, Chronic                 | 3  3  2  2  2  3  3  3  3  4  2  3  2  2  3        3  3  4  3  2     3  4|             
      Cortex, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                     X                    X           X   |             
      Clear Cell Focus                     |                               X                                          |             
      Granuloma, Multifocal                | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Infarct                              |                                                             4            |             
      Vacuolization Cytoplasmic            |                                           3                              |             
      Biliary Tract, Hyperplasia           |                   3  2           3           3                          2|             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                          +                 +     +     +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                4         |             
      Fat, Necrosis                        |          3  4                          4                 3           3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3        4                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |    2  3  3  2  3     3  2        2  1  2  2  2     1  2        2        2|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      3  2              3  1                              |             
      Hyperkeratosis                       |                         2                 1                              |             
      Inflammation, Suppurative            |                2     3                                                   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                      4                 4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hemorrhage                           |                         4                                                |             
      Inflammation, Suppurative            |                2     3                                                   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Inflammation, Suppurative            |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                     +   |             
      Atherosclerosis, Diffuse             |                                                                      X   |             
      Mineralization                       |                1                                                         |             
      Thrombosis                           |                                                                          |             
      Aorta, Atherosclerosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2                       2  2                          2            |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |       2        2           2  3           3                              |             
      Hyperplasia                          |                   2           2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2              3  2        2                       2      |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              1                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      4                                                   |             
      Necrosis                             |                      4                                                   |             
      Pars Distalis, Hyperplasia           |                                  3                                      3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    1                                      1  1                           |             
      Follicular Cell, Cyst                |    2                                                                     |             
      Follicular Cell, Hyperplasia         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X        X                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                 3                 3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2     2  3                       3     2        2     2         |             
      Epithelium, Hyperplasia              |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2  2                                                     3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation              |                3                                                         |             
      Interstitial Cell, Hyperplasia       |                      2  2                                                |             
      Seminiferous Tubule, Atrophy         |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                                      |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         4                                                |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |       X                                                                  |             
      Fibrosis                             |             3  4                 4                             4         |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Necrosis                             |                            4                 3  4                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |                      4                                                   |             
      Cyst Epithelial Inclusion            |    X     X  X                                                        X   |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X        X  X                             X        X               |             
      Gliosis                              |                         3                                                |             
      Hemorrhage                           |                   3                    4                          4      |             
      Hydrocephalus                        |       1                                         1        3     1         |             
      Necrosis                             |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Inflammation, Suppurative            |                               2              2                    2      |             
      Metaplasia, Squamous                 |                                           1                              |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                                   3                                   2|             
      Alveolus, Hemorrhage                 | 3  1                                               2        2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |          3                          3                                    |             
      Alveolus, Inflammation, Suppurative  |                                     2                                    |             
      Artery, Mineralization               |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                      2                                      2        2   |             
      Inflammation, Suppurative            | 3                                   1                             2      |             
      Pigmentation                         |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 1                             1                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +     +   |             
      Atrophy                              |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|             
                                           | 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                                      2   |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Choroid, Iris, Inflammation, Chronic |                                                                      2   |             
      Cornea, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 3  2  3  3  2  4  3  4  2     4  2  3  2  4  2  4  2  4  3  2  3  2  3  2|             
      Cortex, Necrosis                     |                         4                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                4                                                         |             
      Transitional Epithelium, Hyperplasia |                2                                1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |     10  3.0|
      Clear Cell Focus                     |    X                                                                     |      4     |
      Granuloma, Multifocal                |    2                                                                     |      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                X                                                         |      3     |
      Infarct                              |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Biliary Tract, Hyperplasia           |             3                                                            |      9  2.7|
      Hepatocyte, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +  +                                                   |  12        |
      Hemorrhage                           |          4                                                               |      2  4.0|
      Inflammation, Granulomatous          |                      4                                                   |      2  4.0|
      Fat, Necrosis                        |          3        2  4                                                   |      9  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                2     2  3                                                |     29  2.0|
      Artery, Inflammation                 |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |          3                                                               |      6  2.5|
      Hyperkeratosis                       |          3                                                               |      3  2.0|
      Inflammation, Suppurative            |          4                                                               |      3  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |          4                                                               |      3  3.0|
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   5        |
      Atherosclerosis, Diffuse             |                                                                          |      1     |
      Mineralization                       |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
      Aorta, Atherosclerosis               |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |          1  2  1                                                         |     17  1.7|
      Mineralization                       |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytomegaly                           |                3                                                         |      9  2.7|
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                3                                                         |     10  2.5|
      Bilateral, Hyperplasia               |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                         3                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 2        3                                                               |     10  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |             1           3                                                |      7  1.3|
      Follicular Cell, Cyst                |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |             X                                                            |      7     |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      6  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            | 1                                                                        |     15  2.1|
      Epithelium, Hyperplasia              |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                            3                                             |     11  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Arteriole, Inflammation              |                      4                                                   |      4  3.5|
      Interstitial Cell, Hyperplasia       |                   2                                                      |      5  2.0|
      Seminiferous Tubule, Atrophy         |          4                                                               |      9  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   3        |
      Renal, Hemorrhage                    |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  +                                             |  51        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation                         |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         | 3                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |                                                                          |      1     |
      Fibrosis                             | 3                                                                        |      5  3.6|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      3  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                   1                                                      |      1  1.0|
      Acanthosis                           |                                                                          |      2  4.0|
      Cyst Epithelial Inclusion            |                                                                          |      5     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Ulcer                                |                   3                                                      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                   X                                                      |      6     |
      Gliosis                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      6  3.0|
      Hydrocephalus                        |                                                                          |      4  1.5|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      7  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 2                       2                                                |      9  2.1|
      Alveolus, Hemorrhage                 |    1  2           1     1                                                |     18  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          | 3     2              2                                                   |     10  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 6| 7| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8|                                            |            |
                                           | 3| 8| 8| 3| 7| 3| 4| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Foreign Body                         |                                                                          |      2  2.5|
      Hemorrhage                           |                      3                                                   |      7  2.1|
      Inflammation, Suppurative            |                                                                          |     10  2.1|
      Pigmentation                         |          1                                                               |      1  1.0|
      Nasolacrimal Duct, Hemorrhage        |    2                                                                     |      6  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 2                                                                        |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      8  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   4        |
      Atrophy                              |                                                                          |      1  4.0|
      Cataract                             |                   2                                                      |      2  2.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Choroid, Iris, Inflammation, Chronic |                   2                                                      |      2  2.0|
      Cornea, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Mineralization                       |                                                                          |      1     |
      Nephropathy, Chronic                 | 4  2  1  3  2  4  3  4  3  2                                             |     56  2.8|
      Cortex, Necrosis                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Inflammation, Suppurative            |                            3                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +              +  +  +     +  +  +  +      |             
      Basophilic Focus                     |                   X           X              X                           |             
      Clear Cell Focus                     |                               X                                          |             
      Eosinophilic Focus                   |                                                             X            |             
      Hepatodiaphragmatic Nodule           |                X        X                                         X      |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            |          2                                               4               |             
      Biliary Tract, Hyperplasia           |                                                    4                     |             
      Hepatocyte, Hyperplasia              |                                                          4               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +           +                                             |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |    3           3           4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Acinus, Atrophy                      |       2  2     3  3        1                 4     4                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Acanthosis                           |       1  4                                               2        2      |             
      Hyperkeratosis                       |          3                                               2        1      |             
      Inflammation, Suppurative            |       2                                                                  |             
      Ulcer                                |          3                                                               |             
      Muscularis, Hypoplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Erosion                              |    3     3                                                               |             
      Inflammation, Suppurative            |       2                                                                  |             
      Mineralization                       |       3                    4                                             |             
      Necrosis                             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
      Mineralization, Diffuse              |                            3                                             |             
      Polyarteritis, Diffuse               |                                                                          |             
      Mesenteric Artery, Developmental     |                                                                          |             
          Malformation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |       3              2     4                                1            |             
      Mineralization                       |       3                    4                                             |             
      Thrombosis                           |                                                                   X      |             
      Myocardium, Hemorrhage               |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +                 +  +        +  +  +  +      |             
      Cytomegaly                           | 2                                               3        4               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                   3                                      3               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +           +     +  +  +     +  +  +  +      |             
      Hyperplasia                          |       2           2  3                       1  2        4               |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +     +                 +  +  +     +  +  +  M      |             
      Hyperplasia                          |       2                    3                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +        +        +  +  +     +  +  +  +      |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Ultimobranchial Cyst                 |       X                                                           X      |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +     +        +        +  +  +     +  +  +  +      |             
      Cyst                                 |                                                 X                        |             
      Hyperplasia                          |                                     3                                    |             
      Inflammation, Suppurative            |                                                          2               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Inflammation, Suppurative            |       4        3  3                             2              2  2      |             
      Epithelium, Hyperplasia              | 2     2                                                        2         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Inflammation, Suppurative            |       3  2                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
      Interstitial Cell, Hyperplasia       | 4           3              3                 2  3        3     2         |             
      Seminiferous Tubule, Atrophy         |    4                                                        4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Myelofibrosis                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                      +                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +                 +  +  +     M  +  +  +      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +     +                 +  +  +     +  +  +  +      |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +        +  +     +  +  +     +  +  +  +      |             
      Fibrosis                             |                4  4                                                      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +     +                 +  +  +     +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +        +  +     +  +  +     +  +  +  +      |             
      Abscess                              |                                                                          |             
      Acanthosis                           |                                     4  4                                 |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Hyperkeratosis                       |    3                                                              2      |             
      Ulcer                                |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Compression                          |                X  X                                            X         |             
      Hemorrhage                           |    4     4     2                                                         |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                   3                                            2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  2                                       |             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Suppurative            |    2                             2                                       |             
      Metaplasia, Squamous                 |                         1                                1     1     1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|             
                                           | 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            3                          1                  |             
      Alveolus, Hemorrhage                 |          1     3  4     1     2  1        2           1              1  1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |             3                             3           2                  |             
      Alveolus, Inflammation, Suppurative  |       2           1                                                      |             
      Artery, Mineralization               |       3                                                                 1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 3                                                  2                     |             
      Hemorrhage                           |                                                       2     2            |             
      Inflammation, Suppurative            | 2                          2              1        1                     |             
      Pigmentation                         |    1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  2  1  1|             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 1     1                                            1                     |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                     +        +   |             
      Cataract                             |                                                             2        2   |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Mineralization                       |       4                    4                                             |             
      Nephropathy, Chronic                 | 2  2  3     2  4  4  3     4                 2  2  2     3  2  4  3      |             
      Papilla, Necrosis                    |       3                                                                  |             
      Pelvis, Dilatation                   |       4                    3                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +                 +  +  +     +  +  +  +      |             
      Inflammation, Suppurative            |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +     +  +     +     A     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +     +  +     +     A     +  +  +     +     +  +              +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +        +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                                X     X        X      |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Biliary Tract, Hyperplasia           |                            4                                             |             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                +                     |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Acinus, Atrophy                      |          1        2           3  1        2                          2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +     +  +  +     +     +  +              +  +  +|             
      Acanthosis                           |       3           3                                                      |             
      Hyperkeratosis                       |          2                                                               |             
      Inflammation, Suppurative            |                   3                                                      |             
      Ulcer                                |       4           4                                                      |             
      Muscularis, Hypoplasia               |                      4                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                   3                                                      |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +     +|             
      Mineralization, Diffuse              |                                                                          |             
      Polyarteritis, Diffuse               |                                                                         4|             
      Mesenteric Artery, Developmental     |                                                                          |             
          Malformation                     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    1        2                 2           3                              |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Myocardium, Hemorrhage               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Cytomegaly                           |                   4                                                      |             
      Hemorrhage                           |                                  1                                       |             
      Hyperplasia                          |                                     1                                    |             
      Necrosis                             |    1                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Hyperplasia                          |                                     3                                   3|             
      Bilateral, Hyperplasia               |                   3           3                 3                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +     +     M     +  +  +     +     +  +              +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +     +     +     +  +  +  +  +     +  +        +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Hemorrhage                           | 3                                                                       4|             
      Pars Distalis, Hyperplasia           |                               3                                   3  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +     +  +  +  +  +     +     +  +              +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +     +     +  +  +     +     +  +  +           +  +  +|             
      Cyst                                 |       X                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +     +     +     +  +  +     +     +  +     +  +     +  +  +|             
      Inflammation, Suppurative            |                                     1     3        2        4     3     3|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Inflammation, Suppurative            |          1                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +|             
      Interstitial Cell, Hyperplasia       | 3           2                             1        3              4      |             
      Seminiferous Tubule, Atrophy         |       4                 3  3        4              4                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Myelofibrosis                        |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +        +              +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     M  +     +     +     +  +  +     +     +  +              +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +     +     +     +  +  +  +  +     +  +              +     +|             
      Hemorrhage                           | 3                                                                        |             
      Hyperplasia, Lymphoid                |          1                             3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Hemorrhage                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Hemorrhage                           |                                  2                                       |             
      Pigmentation                         |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +  +  +     +     +  +        +  +  +  +  +|             
      Fibrosis                             |                   2     3                                   3  4        3|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Galactocele                          |                         X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +     +  +  +  +  +     +  +              +  +  +|             
      Abscess                              |       3                                                                  |             
      Acanthosis                           |                                        4                                 |             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Hyperkeratosis                       |                                        4                                 |             
      Ulcer                                |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +     +  +  +  +  +     +     +  +              +  +  +|             
      Compression                          |                   X                                                      |             
      Hemorrhage                           |          3                 3                                             |             
      Hemorrhage, Multifocal               | 3                                                                        |             
      Hydrocephalus                        |                   4                             4                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            | 1                                                                        |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|             
                                           | 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.01 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                         4                                                |             
      Alveolar Epithelium, Hyperplasia     |             3        1                 2  2                              |             
      Alveolus, Hemorrhage                 | 2              1                 2        2  2           1        1  2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                      3                 3  3              2               |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Artery, Mineralization               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             3                       2                                    |             
      Hemorrhage                           |    2  2                                                     1        2   |             
      Inflammation, Suppurative            |                               2                                         2|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1     1  1  2  1  1  1  1  1  1  1  1  1     1|             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     2                                    |             
      Respiratory Epithelium, Hyperplasia  |             3                 3     1                                2  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             3                                                        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                           +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +     +     +  +  +     +     +  +        +  +  +  +  +|             
      Mineralization                       |          1                                                               |             
      Nephropathy, Chronic                 | 2  2     1  3     3     3     3  1  3     4     3  3        3  4  2  3  3|             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +     +     +  +  +     +     +  +              +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +                                                      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +           +                                                      |  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +                                                      |  32        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +           +     +                                                |  42        |
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |       X                 X                                                |      4     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Necrosis, Focal                      |    4                                                                     |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  3.0|
      Biliary Tract, Hyperplasia           |                                                                          |      2  4.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +     +  +  +  +                                                   |  11        |
      Inflammation, Granulomatous          |                   4                                                      |      1  4.0|
      Fat, Necrosis                        |       3        4     4                                                   |      7  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +                                                      |  34        |
      Acinus, Atrophy                      |                                                                          |     13  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +           +                                                      |  36        |
      Acanthosis                           |                                                                          |      6  2.5|
      Hyperkeratosis                       |                                                                          |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      3  3.7|
      Muscularis, Hypoplasia               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +           +                                                      |  35        |
      Erosion                              |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      2  3.5|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Inflammation, Suppurative            |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Diffuse              |                                                                          |      1  3.0|
      Polyarteritis, Diffuse               |                                                                          |      1  4.0|
      Mesenteric Artery, Developmental     |                                                                          |            |
          Malformation                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +                                                      |  34        |
      Cardiomyopathy                       |    2                                                                     |      9  2.2|
      Mineralization                       |                                                                          |      2  3.5|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Hemorrhage               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +           +                                                      |  33        |
      Cytomegaly                           |                                                                          |      4  3.3|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      3  2.3|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    M  +           +                                                      |  34        |
      Hyperplasia                          |                                                                          |      8  2.5|
      Bilateral, Hyperplasia               |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +                                                      |  34        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +           +                                                      |  30        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +     +                                                      |  39        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia           |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +                                                      |  35        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +     +                                                      |  35        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +        +  +                                                      |  38        |
      Cyst                                 |                X                                                         |      3     |
      Hyperplasia                          |                4                                                         |      2  3.5|
      Inflammation, Suppurative            |                4                                                         |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +           +                                                      |  36        |
      Inflammation, Suppurative            |                   2                                                      |     13  2.6|
      Epithelium, Hyperplasia              |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +        +  +                                                      |  35        |
      Inflammation, Suppurative            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +                                                   |  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |     12  2.8|
      Seminiferous Tubule, Atrophy         |                      4                                                   |      8  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +                                                      |  34        |
      Myelofibrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +     +     +                                                      |  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +           M                                                      |  32        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           +  +                                                   |  35        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +           M                                                      |  32        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation                         |    4                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +           +  +                                                   |  41        |
      Fibrosis                             |    4                 3                                                   |      9  3.3|
      Necrosis                             |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           M                                                      |  32        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +                                                      |  34        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +           +                                                      |  38        |
      Abscess                              |                                                                          |      1  3.0|
      Acanthosis                           |                                                                          |      3  4.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hyperkeratosis                       |                                                                          |      3  3.0|
      Ulcer                                |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +                                                      |  34        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +                                                      |  35        |
      Compression                          |                   X                                                      |      5     |
      Hemorrhage                           |       4                                                                  |      6  3.3|
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
      Hydrocephalus                        |                   4                                                      |      5  3.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |       3                                                                  |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       2                                                                  |      4  1.8|
      Metaplasia, Squamous                 |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      6  2.0|
      Alveolus, Hemorrhage                 | 1     3  1              1  2                                             |     23  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                                                                          |      7  2.7|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  1.5|
      Artery, Mineralization               |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |    2                                                                     |      5  2.4|
      Hemorrhage                           |          2              2                                                |      8  1.9|
      Inflammation, Suppurative            |    3                                                                     |      7  1.9|
      Pigmentation                         |       1  1  1  1  1  1  1                                                |     54  1.1|
      Nasolacrimal Duct, Hemorrhage        |                            2                                             |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |    2     2  1                                                            |     11  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   4        |
      Cataract                             |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 4| 7| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5|                                            |            |
                                           | 8| 4| 5| 8| 2| 2| 6| 2| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.01 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +     +                                                      |  38        |
      Mineralization                       |                                                                          |      3  3.0|
      Nephropathy, Chronic                 | 2  3  4     3     3                                                      |     37  2.8|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +                                                      |  34        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +        +        +        +  I     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +     +        +  +     +  +  +  +     +            |             
      Angiectasis                          |                                     4                                    |             
      Basophilic Focus                     |                                        X                                 |             
      Clear Cell Focus                     |                   X                                   X                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Hyperplasia           |                                                       4                  |             
      Hepatocyte, Hyperplasia              |    4                 4                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +                             +                  |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                      3  4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +        +        +  +  +  +     +  +     +            |             
      Acinus, Atrophy                      |          3     3  2                 2        2                           |             
      Acinus, Hyperplasia                  |    3                                                                     |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                      +                                                   |             
      Developmental Malformation           |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Acanthosis                           |          2  3                                                            |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |          1                                                               |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             3                                                            |             
      Muscularis, Hypoplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Polyarteritis, Diffuse               |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +        +        +        +  +     +     +  +     +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    2                                                                     |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +        +        +        +  +     +     +  +     +            |             
      Cytomegaly                           |          1                                   2                           |             
      Hyperplasia                          |                   3                                                      |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Hyperplasia                          |                                     3                 2                  |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +        +        +  +     +  +  +  +     +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +        +        +        +  +     +     M  +     +            |             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +        +        +  I  +  +  +  +  +     +            |             
      Cyst                                 |                                                 X                        |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Pars Distalis, Hyperplasia           |                                     2     3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +     +  +        +        +  +     +     +  +     +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +        +        +        +  +     +     +  +     +            |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +        +  +     +        +  +     +     +  +     +            |             
      Cyst                                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +        +        +        +  +     +     +  +     +            |             
      Inflammation, Suppurative            |    3  2  2        2        2                                             |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +        +        +        +  +     +     +  +     +            |             
      Inflammation, Suppurative            |          1                 2                                2            |             
      Epithelium, Hyperplasia              |          1                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +        +  +  +  +  +  +  +     +            |             
      Arteriole, Inflammation              |                                                                          |             
      Interstitial Cell, Hyperplasia       |       2                                2     3        3                  |             
      Seminiferous Tubule, Atrophy         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +        +        +        +  +     +     +  +     +            |             
      Myelofibrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +  +                                +                  |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +  +        +        +        +  +     +     +  +     +            |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +        +        +        +  +     +     +  +     +            |             
      Hyperplasia, Lymphoid                |                                        3           2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +        +        +        +  +  +  +     +  +     +            |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +  +     +        +  +  +  +  +  +  +     +            |             
      Ectopic Tissue                       |                            X                                             |             
      Fibrosis                             |          3                                            3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +        +        +        +  +     +     +  +     +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +        +        +        +  +     +     +  +     +            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +        +        +        +  +     +  +  +  +     +            |             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                        X        X                        |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +        +        +        +  +     +     +  +     +            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +              +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +        +        +  +     +     +  +     +            |             
      Compression                          |       X  X  X                                                            |             
      Hemorrhage                           |    4                                                                     |             
      Hydrocephalus                        |       3  2  2                          4                                 |             
      Mineralization                       |                                        3                                 |             
      Necrosis                             |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                              2                           |             
      Metaplasia, Squamous                 |                                              2                           |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|             
                             DAY ON TEST   | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|             
                                           | 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.05 PPM                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      3  3                       3              1         |             
      Alveolus, Hemorrhage                 | 1              1        1     1  1     1  1  2  2  2     2     1  1  1  1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |    3        3        4        1                       3     2  2         |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Artery, Mineralization               |                                  1                             1  1     1|             
      Bronchiole, Pigmentation             |                                                                      1   |             
      Peribronchiolar, Pigmentation        |             1                                               1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              2              2            |             
      Hemorrhage                           | 2           3     2              2                                       |             
      Inflammation, Suppurative            |                                              1                           |             
      Pigmentation                         | 1  1  1  1  2  2  1  2  2  1  1  1  1  1  2  2  2  1  1  1  2  1  1  1  1|             
      Nasolacrimal Duct, Hemorrhage        | 2                             2  2                             2     2  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2                                                            |             
      Respiratory Epithelium, Hyperplasia  |                                                                1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +                                                   |             
      Cataract                             |             2        2                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +     +  +        +  +  +  +     +  +     +            |             
      Cyst                                 |                                           X                              |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 |       3  3  4     3     4  1        3  1     1        2     2            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +        +        +        +  +     +     +  +     +            |             
      Inflammation, Suppurative            |                                                             2            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +           +  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  A           A  +  +     +  +     +     +  +           A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  A           A  +  +     +  +     +     +  +           A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  A           A  +  +     +  +     +     +  +           A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  A           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  A           A  +  +     +  +     +     +  +           A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  A           A  +  +     +  +     +     +  +           A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +        A  +  +     +  +     +     +  +  +        +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                           X                              |             
      Clear Cell Focus                     |    X                                                                     |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Hyperplasia           |                                                                          |             
      Hepatocyte, Hyperplasia              |       4                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +           +                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |             4     3           2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Acinus, Atrophy                      |                                                       2                  |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation                 |             4                                                            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                  +                                       |             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +           A  +  +     +  +     +     +  +           +   |             
      Acanthosis                           |                                           3     3                    2   |             
      Edema                                |                                                 3                        |             
      Erosion                              |                                           4                              |             
      Hyperkeratosis                       |                                                 3                        |             
      Inflammation, Suppurative            |                                                                      2   |             
      Mineralization                       |                                                          3               |             
      Ulcer                                |                                                          3               |             
      Muscularis, Hypoplasia               |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +           A  +  +     +  +     +     +  +           +   |             
      Edema                                |                                                 3                        |             
      Inflammation, Suppurative            |                                                                      2   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
      Polyarteritis, Diffuse               |             4                                                            |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +           A  +  +     +  +     +     +  +           +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |             2                                                            |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Cytomegaly                           |             4                                         2                  |             
      Hyperplasia                          |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Hyperplasia                          | 3                                         2           4                  |             
      Bilateral, Hyperplasia               |                                  3              2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M           +  +           M  +  +     +  +     +     +  +           +   |             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +           A  +  +     +  +  +  +  +  +  +  +     +  +   |             
      Cyst                                 |          X                                               X               |             
      Hemorrhage                           |                                                          4               |             
      Necrosis                             |                                                          4               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +  +           +  +  +     +  +     +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Granuloma Sperm                      |                               3                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +           +  +  +  +  +  +     +     +  +           +   |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +           A  +  +     +  +  +  +  +  +  +           +  +|             
      Inflammation, Suppurative            | 2           3  3                       2     4     4  2                  |             
      Epithelium, Hyperplasia              |             2                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +           +  +           A  +  +     +  +     +  +  +  +           +  +|             
      Inflammation, Suppurative            |                                                    4                     |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Arteriole, Inflammation              |                         4                                               4|             
      Interstitial Cell, Hyperplasia       |                                        2  3           3  2               |             
      Seminiferous Tubule, Atrophy         |    3                    4                                   4        3  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Myelofibrosis                        |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                          +  +           +           +      |             
      Pancreatic, Hemorrhage               |                                           4                              |             
      Renal, Hemorrhage                    |                                           4                              |             
      Renal, Hyperplasia, Lymphoid         |             4                                                            |             
      Renal, Pigmentation                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +     +  +           A  +  +     +  +     +     +  +  +        +   |             
      Hemorrhage                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +  +        +  A  +  +     +  +     +     +  +           +   |             
      Hyperplasia, Lymphoid                |                                  3                       3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +  +           A  +  +  +  +  +     +     +  +           +   |             
      Hemorrhage                           |             4                       3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +     +     +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        A  +  +     +  +     +     +  +  +        +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |          3  3     3                                   3                 3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +           +  +           A  +  +     +  +     +     +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +  +           A  +  +     +  +     +     +  +           +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +           +  +  +  +  +  +     +     +  +  +        +   |             
      Acanthosis                           | 4                                                                        |             
      Cyst Epithelial Inclusion            |       X                                                     X            |             
      Hyperkeratosis                       | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Inflammation, Suppurative            |                                  4                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +           A  +  +     +  +     +  +  +  +           +   |             
      Compression                          |             X  X                                   X  X  X               |             
      Hemorrhage                           | 1              3                       1                                 |             
      Hydrocephalus                        |             4  4                                   2  3  2               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          1               |             
      Inflammation, Suppurative            |                   3                                                      |             
      Metaplasia, Squamous                 |             1  1                                1  1        1            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|             
                                           | 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.05 PPM                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                4                                                         |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             1                                   1                        |             
      Alveolus, Hemorrhage                 |    1                 1                       1                 1  1  2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                                                             3            |             
      Alveolus, Inflammation, Suppurative  |                            4                                             |             
      Artery, Mineralization               |                                                                1         |             
      Bronchiole, Pigmentation             |                                                                          |             
      Peribronchiolar, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       4                          1        2              2        2      |             
      Hemorrhage                           |                         3                                         3      |             
      Inflammation, Suppurative            |       2                                   3                       2      |             
      Pigmentation                         | 1  2     2  1  2  1  1  2     1  1  1  1  1  2  1  2  1  1  2  1  2  1  2|             
      Nasolacrimal Duct, Hemorrhage        |                      2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       2                  |             
      Respiratory Epithelium, Hyperplasia  |       3     1           2        1  1     2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                       +           +                     |             
      Cataract                             |                2                                   2                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +        +  A  +  +     +  +  +  +  +  +  +        +  +  +|             
      Cyst                                 |                                           X                              |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 4           3  1        4     3  3     2  4  3  3  4  3  3        4  3  4|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +           A  +  +     +  +     +     +  +           +   |             
      Inflammation, Suppurative            |             3                                                            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +  +        +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +  +        +                                                |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +  +  +        +                                                |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A        +  +  +        +                                                |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +  +        +                                                |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A        +  +  +        +                                                |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +  +  +        +                                                |  24        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +        +  +                                             |  36        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Thrombosis                           |             X                                                            |      1     |
      Biliary Tract, Hyperplasia           |                                                                          |      1  4.0|
      Hepatocyte, Hyperplasia              |             4                                                            |      4  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   8        |
      Fat, Mineralization                  | 3                                                                        |      1  3.0|
      Fat, Necrosis                        | 4        4                                                               |      7  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +  +  +     +                                                |  30        |
      Acinus, Atrophy                      | 2        3     2                                                         |      9  2.3|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Artery, Inflammation                 |                   4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |             +                                                            |   3        |
      Developmental Malformation           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +  +  +        +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +  +        +  +                                             |  30        |
      Acanthosis                           |             2                                                            |      6  2.5|
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  4.0|
      Hyperkeratosis                       |             2                                                            |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       | 4                                                                        |      2  3.5|
      Ulcer                                |                                                                          |      2  3.0|
      Muscularis, Hypoplasia               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +  +        +  +                                             |  30        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |   2        |
      Polyarteritis, Diffuse               |                                                                          |      1  4.0|
      Aorta, Mineralization                | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +  +        +                                                |  27        |
      Cardiomyopathy                       | 3                       2                                                |      4  2.3|
      Mineralization                       | 4                                                                        |      1  4.0|
      Thrombosis                           |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +  +  +        +                                                |  27        |
      Cytomegaly                           |                                                                          |      4  2.3|
      Hyperplasia                          |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +        +  +  +        +                                                |  28        |
      Hyperplasia                          | 1                       1                                                |      7  2.3|
      Bilateral, Hyperplasia               |                3                                                         |      3  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +        +                                                |  29        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  +  +        +                                                |  25        |
      Hyperplasia                          | 4                                                                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +                                                |  38        |
      Cyst                                 |                                                                          |      3     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |          3                                                               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +  +  +        +                                                |  33        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +  +  +        +                                                |  27        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +  +  +        +                                                |  30        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +  +  +        +                                                |  30        |
      Inflammation, Suppurative            |             3           4                                                |     14  2.7|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +        +  +  +        +                                                |  29        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                         3                                                |      5  2.4|
      Epithelium, Hyperplasia              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Arteriole, Inflammation              |                                                                          |      2  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      8  2.5|
      Seminiferous Tubule, Atrophy         |    4           4     4     4                                             |     10  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +  +        +                                                |  27        |
      Myelofibrosis                        | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +                                                         |  11        |
      Pancreatic, Hemorrhage               |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M        +  +  +        +                                                |  28        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +  +  +        +  +                                             |  30        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +  +  +        +  +                                             |  31        |
      Hemorrhage                           |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +        +  +  +        +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +        +  +                                             |  37        |
      Ectopic Tissue                       |                                                                          |      1     |
      Fibrosis                             | 2           2                                                            |      9  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +  +        +                                                |  28        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  +  +        +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +  +     +  +                                                |  34        |
      Acanthosis                           |                                                                          |      1  4.0|
      Cyst Epithelial Inclusion            |                                                                          |      4     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +  +        +                                                |  27        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +  +        +                                                |  29        |
      Compression                          |                         X                                                |      9     |
      Hemorrhage                           |             3                                                            |      5  2.4|
      Hydrocephalus                        |                         1                                                |     10  2.7|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Metaplasia, Squamous                 |                                                                          |      6  1.2|
      Mineralization                       | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  4.0|
      Thrombosis                           |             X                                                            |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      6  2.0|
      Alveolus, Hemorrhage                 | 2  1              1                                                      |     24  1.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          | 2              3                                                         |     10  2.6|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  4.0|
      Artery, Mineralization               | 3              1                                                         |      7  1.3|
      Bronchiole, Pigmentation             |                                                                          |      1  1.0|
      Peribronchiolar, Pigmentation        |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Foreign Body                         | 2                                                                        |      8  2.1|
      Hemorrhage                           |                   2                                                      |      7  2.4|
      Inflammation, Suppurative            | 2                       3                                                |      6  2.2|
      Pigmentation                         | 1  2  2  1  1  1  2  2  1  2                                             |     58  1.4|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      7  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Respiratory Epithelium, Hyperplasia  | 2                       2                                                |      9  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 7| 6| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3|                                            |            |
                                           | 2| 1| 1| 5| 5| 5| 1| 1| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.05 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +        +                                                         |   7        |
      Cataract                             |       2                                                                  |      5  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +  +        +  +                                             |  36        |
      Cyst                                 |                                                                          |      2     |
      Mineralization                       | 4                                                                        |      1  4.0|
      Nephropathy, Chronic                 | 4        2  3  2        4  4                                             |     33  2.9|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                         +                                                |   1        |
      Inflammation, Suppurative            |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +  +        +                                                |  27        |
      Inflammation, Suppurative            |                         3                                                |      3  2.7|
      Transitional Epithelium, Hyperplasia |                         3                                                |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                           4                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X                 X               |             
      Clear Cell Focus                     |       X                                                                 X|             
      Granuloma, Multifocal                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            | 4              4                                                         |             
      Biliary Tract, Hyperplasia           |                                                 1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +              +     +  +  +                 +               |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |       3     4              2        3  3                 3               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
      Acinus, Atrophy                      | 3                       1           2           1     3     2     3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                4                                   3  3           3      |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                    3                     |             
      Inflammation, Suppurative            |                3                                                  3      |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Muscularis, Hypoplasia               |                                                    4                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                3                                                  3      |             
      Mineralization                       |                                                                          |             
      Serosa, Fibrosis                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atherosclerosis, Diffuse             |                                                                          |             
      Mineralization, Diffuse              |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           2     2  1  2  2           2           2     2  2  2     1   |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |       3                                                              3   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4                 2     3  4        1                           |             
      Bilateral, Hyperplasia               | 3                                      4                       4         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |             1                                2           2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                       X                     |             
      Hemorrhage                           |                            4                                             |             
      Pars Distalis, Hyperplasia           |          2                       2     3                                 |             
      Pars Intermedia, Hyperplasia         |                      4                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |    X                                                        X     X      |             
      C-Cell, Hyperplasia                  |                                        2                          3      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                X         |             
      Inflammation, Suppurative            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3  2  2     2                                      3     2               |             
      Epithelium, Hyperplasia              |                                        1                       1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                 1                 1            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation              |                                                          3           4   |             
      Interstitial Cell, Hyperplasia       |                            1                 2                           |             
      Seminiferous Tubule, Atrophy         |       3                          3     4           3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         +                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                3  3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +                                            +     +         |             
      Renal, Hyperplasia, Lymphoid         |                                                          4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |             X                                      X                     |             
      Fibrosis                             |                      3     2                                            4|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                          X               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                              2                           |             
      Cyst Epithelial Inclusion            | X           X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X  X                                      X               |             
      Hemorrhage                           |    3     1        1        3                                             |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                         1|             
      Inflammation, Suppurative            |                               3           1     2                        |             
      Metaplasia, Squamous                 |                2                                                        1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |             3                                                            |             
      Alveolus, Hemorrhage                 | 1                 2     2  4  1           1     1           2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |          3              1     2                                3        3|             
      Alveolus, Inflammation, Suppurative  |          2                                                               |             
      Artery, Mineralization               |                                                                          |             
      Bronchiole, Pigmentation             | 1  1  1  2  2  1  1  1  1  1  1  1  1  2     1  1  2  2  1  1  1  2  2  1|             
      Peribronchiolar, Pigmentation        | 1           2     1  1  2              2                       3     1   |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             2                          2                                 |             
      Hemorrhage                           |                                  2              3  3     3  2        4   |             
      Inflammation, Suppurative            |          1                                                        3      |             
      Pigmentation                         | 2  2  2  2  2  1  2  2     1  2  2  2  2  1  2  2  1  2        2  2  3  1|             
      Nasolacrimal Duct, Hemorrhage        |                                                             2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2                          2               |             
      Respiratory Epithelium, Hyperplasia  |             2     1        1                       1              2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         | 1     1     1                       1                                    |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +              +           +           +                           |             
      Cataract                             |       2                                                                  |             
      Anterior Chamber, Hemorrhage         |       2                                                                  |             
      Choroid, Iris, Inflammation, Chronic |                                              3                           |             
      Cornea, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                X         |             
      Mineralization                       |                                                                1     2   |             
      Nephropathy, Chronic                 | 3  2  4  3  4  3  4  4  2  4  3  3  3  4     1  2  2  2  4  2  4  2  3  2|             
      Pelvis, Dilatation                   |                                                                2         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|             
                                           | 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.2_PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                          4     4         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                4         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                             X                                       |             
      Clear Cell Focus                     | X                                                        X               |             
      Granuloma, Multifocal                |       1                                                     2            |             
      Hepatodiaphragmatic Nodule           |                                                    X                     |             
      Hyperplasia                          | 4                                                     4                 3|             
      Vacuolization Cytoplasmic            |                                           2                              |             
      Biliary Tract, Hyperplasia           |                   3                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +                 +           +                     |             
      Inflammation, Granulomatous          |                      4                 4                                 |             
      Fat, Necrosis                        |             4        3                 4           3                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                            +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Acinus, Atrophy                      | 2  1              3  3  2  2  3              3  2                       2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Edema                                |                                                                         4|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                4         |             
      Ulcer                                |                                                                          |             
      Muscularis, Hypoplasia               | 4                       4  4                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         4|             
      Erosion                              |                                                                         4|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                4         |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Inflammation, Suppurative            |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                 +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atherosclerosis, Diffuse             |                                              X                           |             
      Mineralization, Diffuse              |                                                                4         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                 2        1        2      |             
      Mineralization                       |                                                                4         |             
      Thrombosis                           | X                                                                       X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                                           2  1  2     3        3     2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                   2        3                 2                    3      |             
      Bilateral, Hyperplasia               |                                        3           3  3                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                4         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                            2                 4                           |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                   1        1                 3        1                 1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |          X                       X                          X            |             
      Inflammation, Suppurative            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2              2              2     3  3                 4   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1     2                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation              |                               3                 3                 3      |             
      Interstitial Cell, Hyperplasia       |             1              2           2     3        2              2   |             
      Seminiferous Tubule, Atrophy         | 4              3     4                          3  3     3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1                                                              2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +              +  +|             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           3                              |             
      Hyperplasia, Lymphoid                |                            4                                             |             
      Inflammation, Chronic                |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                           2        2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                             X            |             
      Fibrosis                             |                   2           3                          1        2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                      X   |             
      Hyperplasia                          |                                           2                          3   |             
      Inflammation, Suppurative            |                                           3                          3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                     +         |             
      Mineralization                       |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      X        X           X                          X   |             
      Hemorrhage                           |             1     4                                                      |             
      Hydrocephalus                        |                      3        2           2                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             1                                                            |             
      Metaplasia, Squamous                 |             1                                         2                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     | 2  3                                         2                           |             
      Alveolus, Hemorrhage                 |    2  1  1  2  2                 1  2        3  2           2     1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          | 4        1        3     3              4     4        4        4         |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Artery, Mineralization               |    2                                                           4         |             
      Bronchiole, Pigmentation             | 1  1  1  1  2  1  1  1  1  2  2  1  1  2  2  1  2  2  2  2  1  1  2  1  1|             
      Peribronchiolar, Pigmentation        |    1  1                                   1  3  2  1     1  1     1      |             
      Pleura, Fibrosis                     |                         4                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             3                             4                          3   |             
      Hemorrhage                           |                   2                 2                                    |             
      Inflammation, Suppurative            |    1        2                 2           3  2                 3     3   |             
      Pigmentation                         | 2  1  1  1     2  2  3  2  1  2     1  2  2  2  2  2  1  2  2  1  2  1  1|             
      Nasolacrimal Duct, Hemorrhage        |    2  2                          2  2                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             4                 3     1     2                          3   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                          +                 +|             
      Cataract                             |                                                       2                  |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Choroid, Iris, Inflammation, Chronic |                                                                          |             
      Cornea, Inflammation                 |                            4                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 3  2  2  1  3  1  3  3  3  4  4  2  1  3  3  4  4  3  4  3  1  4  4  4  2|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|             
                                           | 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.2_PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Hyperplasia                     |                                                                      3   |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      2   |             
      Transitional Epithelium, Hyperplasia |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      4     |
      Clear Cell Focus                     |                X                                                         |      5     |
      Granuloma, Multifocal                |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      3  3.7|
      Vacuolization Cytoplasmic            |                                                                          |      3  3.3|
      Biliary Tract, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +     +                                                            |  14        |
      Inflammation, Granulomatous          |                                                                          |      2  4.0|
      Fat, Necrosis                        | 4     4                                                                  |     12  3.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  3.0|
      Acinus, Atrophy                      |       2        1  2  1     1                                             |     22  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |             2           3                                                |      6  3.0|
      Edema                                |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Ulcer                                |                         3                                                |      1  3.0|
      Muscularis, Hypoplasia               |                                                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  4.0|
      Erosion                              |                         3                                                |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Atherosclerosis, Diffuse             |                                                                          |      1     |
      Mineralization, Diffuse              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    1        2     2  1                                                   |     19  1.7|
      Mineralization                       |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytomegaly                           | 1                    1                                                   |     10  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          | 2     3     2     2                                                      |     13  2.5|
      Bilateral, Hyperplasia               |                                                                          |      6  3.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  56        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      3     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |             3                                                            |      6  2.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      3     |
      C-Cell, Hyperplasia                  |       3                                                                  |      8  1.9|
      Follicular Cell, Hyperplasia         |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      4     |
      Inflammation, Suppurative            | 4                                                                        |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            | 2                                                                        |     13  2.5|
      Epithelium, Hyperplasia              |             2                                                            |      3  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Arteriole, Inflammation              |                                                                          |      5  3.2|
      Interstitial Cell, Hyperplasia       |          2        3     2                                                |     11  2.0|
      Seminiferous Tubule, Atrophy         |                      4     3                                             |     12  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myelofibrosis                        |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   8        |
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  M  +  +  +  +  +                                             |  52        |
      Pigmentation                         |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                         3                                                |      3  3.3|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pigmentation                         |             3                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |                                                                          |      3     |
      Fibrosis                             |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Galactocele                          |                                                                          |      2     |
      Hyperplasia                          |                      4                                                   |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Mineralization                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                         X                                                |      8     |
      Hemorrhage                           |                                                                          |      6  2.2|
      Hydrocephalus                        |                         3                                                |      4  2.5|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      4  1.8|
      Metaplasia, Squamous                 |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.5|
      Alveolus, Hemorrhage                 |    1  1                    2                                             |     22  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |          2        4                                                      |     15  3.0|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                          |      2  3.0|
      Bronchiole, Pigmentation             | 1  2  1  1  1  2  1  2  1  2                                             |     59  1.4|
      Peribronchiolar, Pigmentation        |          2     1           1                                             |     20  1.5|
      Pleura, Fibrosis                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |       2                 3                                                |      7  2.7|
      Hemorrhage                           |                            2                                             |      9  2.6|
      Inflammation, Suppurative            | 2     3           3     2                                                |     13  2.3|
      Pigmentation                         | 2  2  2  2  1  2  1  2  1  2                                             |     55  1.7|
      Nasolacrimal Duct, Hemorrhage        |    2                                                                     |      6  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Respiratory Epithelium, Hyperplasia  | 3  1  3           2     1                                                |     15  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2     2                                                                  |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05114-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:57:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3|                                            |            |
                                           | 0| 8| 0| 0| 3| 0| 2| 0| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.2_PPM                                | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5|                                            |      L     |
                                           | 3| 4| 1| 2| 3| 4| 1| 2| 3| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pigmentation                         |                                                                          |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
      Cataract                             |                                                                          |      2  2.0|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  2.0|
      Choroid, Iris, Inflammation, Chronic |                                                                          |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Mineralization                       |                                                                          |      2  1.5|
      Nephropathy, Chronic                 | 3  2  4  2  3  4  4  3  4  3                                             |     59  2.9|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.