National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3384

TDMS Study 05119-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 DIETHYLPHTHALATE/DIMETHYLPHTHALATE


NTP Experiment-Test: 05119-01                                                                                     Report: PEIRPT03
Study Type: INIT/PROMOT                                                                                           Date: 05/20/95
Route: SKIN APPLICATION                                                                                           Time: 02:35:33




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21            4            5            7           32            6           
    Natural Death                                     11            6            2            7            6            6           
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                                     1                        
    Terminal Sacrifice                                18           38           40           35           10           38           
    Natural Death                                                   1            2            1                                     
  Missing                                                                        1                         1                        
  Animals Examined Microscopically                    50           50           49           50           49           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                                                  (46)         (42)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
   Intestine Large                                                              (49)         (50)                                   
      Mucosa, Necrosis                                                                        1 (2%)                                
   Intestine Large, Cecum                                                       (46)         (46)                                   
      Amyloid Deposition                                                         2 (4%)       1 (2%)                                
      Edema                                                                      2 (4%)       1 (2%)                                
   Intestine Large, Colon                                                       (45)         (49)                                   
      Edema                                                                      2 (4%)       1 (2%)                                
   Intestine Small                                    (2)                       (49)         (50)         (1)          (1)          
      Cortex, Amyloid Deposition                                                 1 (2%)                                             
   Intestine Small, Duodenum                          (2)                       (48)         (48)                      (1)          
      Amyloid Deposition                                                        17 (35%)     16 (33%)                               
      Inflammation, Subacute                                                                                            1 (100%)    
   Intestine Small, Ileum                             (1)                       (48)         (47)         (1)                       
      Amyloid Deposition                                                        28 (58%)     29 (62%)      1 (100%)                 
      Granuloma                                                                                            1 (100%)                 
      Hemorrhage                                                                 1 (2%)                                             
   Intestine Small, Jejunum                           (1)                       (48)         (44)                                   
      Amyloid Deposition                                                        20 (42%)     19 (43%)                               
   Liver                                              (10)         (11)         (49)         (50)         (8)          (10)         
      Abscess                                          6 (60%)      2 (18%)                   3 (6%)       5 (63%)      3 (30%)     
      Amyloid Deposition                               3 (30%)      3 (27%)     16 (33%)     13 (26%)      2 (25%)      1 (10%)     
      Angiectasis                                                                                          1 (13%)                  
      Basophilic Focus                                                           2 (4%)                                             
      Clear Cell Focus                                 1 (10%)      2 (18%)                                                         
      Cyst                                                          1 (9%)                                                          
      Cyst Multilocular                                                                       1 (2%)                                
      Eosinophilic Focus                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (20%)      3 (27%)      1 (2%)       9 (18%)      3 (38%)      5 (50%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic, Focal                                  3 (27%)     28 (57%)     26 (52%)                   1 (10%)     
      Karyomegaly                                                                1 (2%)       1 (2%)                                
      Necrosis                                         7 (70%)      3 (27%)      3 (6%)       4 (8%)       5 (63%)                  
      Regeneration, Focal                                                                     1 (2%)                                
      Vacuolization Cytoplasmic                                     2 (18%)      1 (2%)       1 (2%)                                
      Vacuolization Nuclear                                                      4 (8%)                                             
      Centrilobular, Cytomegaly                                                               1 (2%)                                
      Hepatocyte, Hyperplasia                                                    2 (4%)                                             
   Mesentery                                                       (1)                                                 (2)          
      Abscess                                                                                                           1 (50%)     
      Necrosis                                                      1 (100%)                                                        
      Fat, Necrosis, Focal                                                                                              1 (50%)     
   Pancreas                                                        (1)          (49)         (50)         (1)          (1)          
      Abscess                                                                                              1 (100%)                 
      Edema                                                         1 (100%)     7 (14%)      4 (8%)                    1 (100%)    
      Hypertrophy, Focal                                                                      1 (2%)                                
      Inflammation, Subacute                                                     1 (2%)                                             
   Salivary Glands                                                              (48)         (50)         (1)                       
      Amyloid Deposition                                                        16 (33%)     14 (28%)                               
      Hemorrhage                                                                                           1 (100%)                 
      Necrosis                                                                                             1 (100%)                 
   Stomach                                            (1)                       (48)         (50)                                   
      Mucosa, Hyperplasia                                                        2 (4%)                                             
      Mucosa, Hyperplasia, Glandular                                             1 (2%)                                             
   Stomach, Glandular                                                           (48)         (50)                                   
      Amyloid Deposition                                                         9 (19%)      7 (14%)                               
      Dilatation                                                                              1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Necrosis, Focal                                                                         1 (2%)                                
      Mucosa, Dilatation                                                         1 (2%)                                             
      Mucosa, Hyperplasia                                                        2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                                           (3)          (49)         (50)         (4)          (4)          
      Abscess                                                                    1 (2%)       1 (2%)       1 (25%)      1 (25%)     
      Amyloid Deposition                                            3 (100%)    26 (53%)     26 (52%)                   2 (50%)     
      Inflammation, Chronic, Focal                                               2 (4%)       3 (6%)       1 (25%)                  
      Atrium, Thrombosis                                            2 (67%)      3 (6%)       1 (2%)       1 (25%)      2 (50%)     
      Epicardium, Inflammation, Suppurative                                                                1 (25%)      1 (25%)     
      Ventricle, Thrombosis                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                                                (48)         (50)         (1)                       
      Pigmentation                                                                            1 (2%)                                
      Adrenal Gland, Amyloid Deposition                                          1 (2%)                                             
      Capsule, Hyperplasia                                                      22 (46%)     21 (42%)                               
   Adrenal Gland, Cortex                                                        (48)         (50)         (1)                       
      Amyloid Deposition                                                        21 (44%)     23 (46%)                               
      Hyperplasia, Focal                                                         1 (2%)       1 (2%)                                
      Hypertrophy, Focal                                                         1 (2%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
      Infiltration Cellular, Plasma Cell,                                                                                           
          Lymphocyte                                                                          1 (2%)                                
      Pigmentation                                                              26 (54%)     21 (42%)                               
   Adrenal Gland, Medulla                                                       (48)         (50)         (1)                       
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
   Parathyroid Gland                                                            (34)         (11)                                   
      Amyloid Deposition                                                        12 (35%)      2 (18%)                               
   Pituitary Gland                                                              (48)         (48)                                   
      Pars Distalis, Cyst                                                        1 (2%)                                             
      Pars Distalis, Hyperplasia                                                 1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                                          1 (2%)       1 (2%)                                
      Pars Intermedia, Cyst                                                                   1 (2%)                                
   Thyroid Gland                                                                (49)         (46)                      (1)          
      Amyloid Deposition                                                        24 (49%)     18 (39%)                   1 (100%)    
      Follicle, Dilatation                                                       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)          (3)          (3)          (3)          (3)          (5)          
      Abscess                                          2 (67%)      2 (67%)      2 (67%)      1 (33%)      3 (100%)     2 (40%)     
      Granuloma                                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                                         (1)                                    
      Abscess                                                                                 1 (100%)                              
   Epididymis                                                                   (49)         (50)         (1)                       
      Cyst                                                                                                 1 (100%)                 
      Inflammation, Subacute                                                                  1 (2%)                                
      Spermatocele                                                               1 (2%)                                             
   Penis                                                           (1)          (2)          (5)          (1)          (2)          
      Inflammation, Suppurative                                                  1 (50%)                                            
   Preputial Gland                                                 (4)          (2)          (1)          (1)          (1)          
      Abscess                                                       3 (75%)      1 (50%)                                1 (100%)    
      Dilatation                                                                                           1 (100%)                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation                                                                            1 (100%)                              
   Prostate                                                                     (48)         (47)                                   
      Abscess                                                                    1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Inflammation                                                               1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                      2 (4%)                                             
   Seminal Vesicle                                                 (9)          (49)         (50)         (1)          (5)          
      Dilatation                                                    8 (89%)      6 (12%)      8 (16%)                   4 (80%)     
      Fibrosis                                                                                1 (2%)                    1 (20%)     
      Inflammation                                                               1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                                                1 (100%)                 
      Inflammation, Subacute                                        1 (11%)                                                         
   Testes                                                                       (49)         (50)                                   
      Amyloid Deposition                                                        11 (22%)      9 (18%)                               
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             5 (10%)      3 (6%)                                
      Seminiferous Tubule, Degeneration                                         21 (43%)     18 (36%)                               
      Seminiferous Tubule, Giant Cell                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (24)         (8)          (49)         (50)         (35)         (13)         
      Abscess                                                                                              1 (3%)                   
      Congestion                                                    1 (13%)                                                         
      Cyst                                                                                                 1 (3%)                   
      Hematopoietic Cell Proliferation                                                                     1 (3%)                   
      Hyperplasia                                      1 (4%)       2 (25%)      2 (4%)                    4 (11%)      1 (8%)      
      Hyperplasia, Re Cell                                                                                 1 (3%)                   
      Axillary, Abscess                                                                                    2 (6%)                   
      Axillary, Cyst                                                                                       2 (6%)                   
      Axillary, Depletion Lymphoid                                                                         1 (3%)                   
      Axillary, Hyperplasia                           14 (58%)                   1 (2%)       1 (2%)      27 (77%)      2 (15%)     
      Bronchial, Hyperplasia                           1 (4%)                                                                       
      Iliac, Abscess                                                1 (13%)                                                         
      Iliac, Hyperplasia                                            1 (13%)                                                         
      Inguinal, Hyperplasia                            2 (8%)                                              2 (6%)                   
      Lumbar, Hyperplasia                              1 (4%)                                              1 (3%)                   
      Mediastinal, Abscess                                                                                 1 (3%)                   
      Mediastinal, Hyperplasia                                                                2 (4%)       1 (3%)       1 (8%)      
      Pancreatic, Hyperplasia                                                                 1 (2%)                                
      Renal, Abscess                                                1 (13%)                                                         
      Renal, Hyperplasia                                                                                   1 (3%)       1 (8%)      
   Lymph Node, Mandibular                             (17)         (3)          (48)         (49)         (23)         (10)         
      Abscess                                          3 (18%)                                2 (4%)                    3 (30%)     
      Amyloid Deposition                                                         1 (2%)       2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Cyst                                             1 (6%)                    2 (4%)       2 (4%)       1 (4%)                   
      Depletion Lymphoid                                                                                   1 (4%)                   
      Hematopoietic Cell Proliferation                                           2 (4%)                    1 (4%)                   
      Hyperplasia                                     15 (88%)      3 (100%)     6 (13%)     16 (33%)     21 (91%)     10 (100%)    
      Lymphocyte, Necrosis                             1 (6%)                                                                       
   Lymph Node, Mesenteric                             (2)          (3)          (47)         (43)         (4)          (3)          
      Abscess                                                                    1 (2%)       1 (2%)                                
      Amyloid Deposition                                                        11 (23%)     14 (33%)                               
      Depletion Lymphoid                                                                                                1 (33%)     
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)       2 (50%)      2 (67%)     
      Hemorrhage                                                    1 (33%)                   1 (2%)                                
      Hyperplasia                                      1 (50%)      1 (33%)      2 (4%)       1 (2%)       2 (50%)                  
      Hyperplasia, Re Cell                                          1 (33%)                                                         
      Lymphocyte, Necrosis                             1 (50%)                                                                      
   Spleen                                             (28)         (9)          (49)         (50)         (42)         (17)         
      Amyloid Deposition                               7 (25%)      1 (11%)      8 (16%)     10 (20%)      9 (21%)      5 (29%)     
      Granuloma                                                                                            1 (2%)                   
      Hematopoietic Cell Proliferation                28 (100%)     9 (100%)    47 (96%)     48 (96%)     42 (100%)    16 (94%)     
      Pigmentation, Hemosiderin                                                  2 (4%)                                             
   Thymus                                                          (1)          (42)         (43)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Other, Abscess                                   3 (6%)       2 (4%)       2 (4%)       2 (4%)       4 (8%)       5 (10%)     
      Other, Acanthosis                               25 (50%)     11 (22%)      7 (14%)     15 (30%)     26 (53%)     15 (30%)     
      Other, Acanthosis, Focal                                                                             1 (2%)                   
      Other, Edema                                                  2 (4%)       3 (6%)       1 (2%)       1 (2%)       1 (2%)      
      Other, Exudate                                  17 (34%)      4 (8%)       5 (10%)     14 (28%)     22 (45%)     12 (24%)     
      Other, Hyperkeratosis                           16 (32%)      5 (10%)      2 (4%)       7 (14%)     19 (39%)      8 (16%)     
      Other, Inflammation, Subacute                   24 (48%)     11 (22%)      8 (16%)     15 (30%)     25 (51%)     14 (28%)     
      Other, Ulcer                                    26 (52%)      9 (18%)      8 (16%)     16 (32%)     26 (53%)     15 (30%)     
      Sebaceous Gland, Site of Application-Mass,                                                                                    
           Hyperplasia                                                                                     1 (2%)                   
      Site of Application-Mass, Abscess                                                                    2 (4%)                   
      Site of Application-Mass, Acanthosis                                                                 1 (2%)                   
      Site of Application-Mass, Acanthosis, Focal      1 (2%)                    1 (2%)       1 (2%)      11 (22%)      2 (4%)      
      Site of Application-Mass, Exudate                                                                    1 (2%)                   
      Site of Application-Mass, Hyperkeratosis,                                                                                     
           Focal                                                                                           1 (2%)                   
      Site of Application-Mass, Hyperplasia, Focal,                                                                                 
           Mast Cell                                                                                       1 (2%)                   
      Site of Application-Mass, Inflammation,                                                                                       
          Subacute                                                                                         1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Site of Application-Mass, Inflammation,                                                                                       
          Suppurative                                                                                      1 (2%)                   
   Skin, Control                                      (50)         (50)         (49)         (50)         (49)         (50)         
      Acanthosis                                       1 (2%)       1 (2%)       1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Exudate                                                       1 (2%)                                                          
      Hyperkeratosis                                                                                       1 (2%)                   
      Inflammation, Subacute                           1 (2%)       2 (4%)       1 (2%)                    2 (4%)                   
      Ulcer                                                         1 (2%)                                                          
   Skin, Site of Application-No Mass                  (50)         (50)         (49)         (50)         (49)         (50)         
      Abscess                                                                                              2 (4%)                   
      Acanthosis                                      47 (94%)      9 (18%)     11 (22%)      8 (16%)     45 (92%)     18 (36%)     
      Cyst Epithelial Inclusion                        1 (2%)                                              1 (2%)                   
      Edema                                                         1 (2%)                                                          
      Exudate                                         25 (50%)      8 (16%)      7 (14%)      4 (8%)      31 (63%)     10 (20%)     
      Hyperkeratosis                                  34 (68%)      6 (12%)      4 (8%)       1 (2%)      39 (80%)     13 (26%)     
      Inflammation, Subacute                          30 (60%)      4 (8%)       7 (14%)      9 (18%)     34 (69%)      8 (16%)     
      Ulcer                                           23 (46%)      5 (10%)      6 (12%)      2 (4%)      22 (45%)      7 (14%)     
      Sebaceous Gland, Hyperplasia, Focal                                                                               1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                        (49)         (49)                                   
      Thalamus, Mineralization, Focal                                            1 (2%)       9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Abscess                                          1 (2%)                                 2 (4%)                    1 (2%)      
      Amyloid Deposition                                                         1 (2%)       1 (2%)                                
      Atelectasis                                                                             1 (2%)                                
      Congestion                                       3 (6%)       1 (2%)       5 (10%)      3 (6%)       1 (2%)       1 (2%)      
      Hemorrhage                                                    3 (6%)                    1 (2%)       2 (4%)                   
      Inflammation, Chronic, Focal                                  2 (4%)                                              1 (2%)      
      Leukocytosis                                    10 (20%)      2 (4%)                    6 (12%)     12 (24%)      7 (14%)     
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (4%)       4 (8%)       2 (4%)       1 (2%)       3 (6%)      
      Alveolar Epithelium, Metaplasia, Focal,                                                                                       
          Squamous                                                                            1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte      4 (8%)       2 (4%)       4 (8%)       4 (8%)       8 (16%)      3 (6%)      
      Bronchiole, Hyperplasia                                                                                           1 (2%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Bronchiole, Inflammation, Suppurative                                                                             1 (2%)      
      Bronchiole, Inflammation, Proliferative                                                 1 (2%)                                
      Bronchiole, Metaplasia                                                                                            1 (2%)      
      Interstitium, Inflammation                       9 (18%)      5 (10%)      4 (8%)       9 (18%)     13 (27%)      8 (16%)     
      Interstitium, Inflammation, Chronic, Focal                    9 (18%)      9 (18%)      6 (12%)      4 (8%)       4 (8%)      
      Pleura, Fibrosis, Focal                                                                 1 (2%)                                
      Pleura, Inflammation, Suppurative                                                       1 (2%)                    2 (4%)      
   Nose                                                                         (49)         (50)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)                       (1)          (2)          (3)          (1)          
      Cataract                                                                                             1 (33%)                  
      Inflammation, Suppurative                        1 (25%)                                             1 (33%)                  
      Cornea, Hyperplasia, Chronic                     1 (25%)                                                                      
      Cornea, Hyperplasia, Focal                       1 (25%)                                                                      
      Cornea, Inflammation, Chronic                    1 (25%)                                2 (100%)     1 (33%)      1 (100%)    
      Retrobulbar, Inflammation, Subacute                                                                  1 (33%)                  
   Harderian Gland                                                                           (1)                                    
      Inflammation, Chronic                                                                   1 (100%)                              
   Zymbal's Gland                                     (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (6)          (5)          (49)         (50)         (7)          (5)          
      Abscess                                          1 (17%)      1 (20%)      1 (2%)       3 (6%)       2 (29%)      1 (20%)     
      Amyloid Deposition                               3 (50%)      4 (80%)     23 (47%)     27 (54%)                   2 (40%)     
      Hematopoietic Cell Proliferation                 1 (17%)      1 (20%)                                                         
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Focal, Plasma Cell                                                            1 (14%)                  
      Infiltration Cellular, Plasma Cell                                                      3 (6%)                    1 (20%)     
      Infiltration Cellular, Lymphocyte                                                                                 1 (20%)     
      Nephropathy                                                               15 (31%)     14 (28%)      1 (14%)      1 (20%)     
      Cortex, Atrophy                                  2 (33%)                                             2 (29%)      1 (20%)     
      Cortex, Cyst                                                               9 (18%)      5 (10%)                               
      Papilla, Necrosis                                                                                    1 (14%)                  
      Pelvis, Dilatation                               2 (33%)      3 (60%)     13 (27%)     11 (22%)                   2 (40%)     
      Proximal Convoluted Renal Tubule,                                                                                             
          Vacuolization Cytoplasmic                                                                        1 (14%)                  
   Urinary Bladder                                    (1)          (3)          (46)         (47)                                   
      Calculus Micro Observation Only                                            6 (13%)                                            
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic                                         1 (33%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia                                                        1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            4           31           10           27            5           
    Natural Death                                      4            7            4            4            9            5           
    Accidently Killed                                                                                                   1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           36           14           35           13           38           
    Natural Death                                      1            3                         1                         1           
  Missing                                                                        1                         1                        
  Animals Examined Microscopically                    50           50           49           50           49           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                                          (2)                                                              
      Edema                                                         2 (100%)                                                        
      Inflammation, Chronic                                         1 (50%)                                                         
      Necrosis                                                      1 (50%)                                                         
   Intestine Small, Duodenum                                       (1)                                                              
      Amyloid Deposition                                            1 (100%)                                                        
   Intestine Small, Ileum                             (1)          (3)                                                              
      Amyloid Deposition                                            2 (67%)                                                         
      Granuloma                                        1 (100%)                                                                     
   Intestine Small, Jejunum                                        (2)                       (1)                                    
      Amyloid Deposition                                            1 (50%)                   1 (100%)                              
   Liver                                              (8)          (6)          (7)          (9)          (10)         (14)         
      Abscess                                                       1 (17%)      5 (71%)      1 (11%)      3 (30%)      1 (7%)      
      Amyloid Deposition                               1 (13%)      1 (17%)      1 (14%)      2 (22%)      3 (30%)      5 (36%)     
      Basophilic Focus                                 1 (13%)                                                                      
      Clear Cell Focus, Multiple                                    1 (17%)                                                         
      Cytomegaly                                                    1 (17%)                                                         
      Hematopoietic Cell Proliferation                 2 (25%)                   4 (57%)                   2 (20%)      3 (21%)     
      Inflammation, Chronic, Focal                     1 (13%)      4 (67%)      1 (14%)      3 (33%)      2 (20%)      6 (43%)     
      Necrosis                                         1 (13%)                   3 (43%)      1 (11%)      2 (20%)      1 (7%)      
      Necrosis, Focal                                                                                      1 (10%)                  
      Vacuolization Cytoplasmic                        1 (13%)                                1 (11%)                               
      Centrilobular, Cytomegaly                        1 (13%)                                                                      
   Mesentery                                          (1)                       (1)                                                 
      Inflammation, Chronic                            1 (100%)                                                                     
      Fat, Necrosis, Focal                                                       1 (100%)                                           
   Pancreas                                           (1)          (3)          (1)                                    (1)          
      Edema                                            1 (100%)     3 (100%)     1 (100%)                                           
   Tongue                                                                                                 (1)                       
      Abscess                                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                                           (3)          (2)          (1)                       (1)          
      Abscess                                                                    1 (50%)      1 (100%)                              
      Amyloid Deposition                                            3 (100%)     1 (50%)                                1 (100%)    
      Atrium, Thrombosis                                            2 (67%)      1 (50%)                                1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                                                                                     (1)          
      Cyst                                                                                                              1 (100%)    
   Thyroid Gland                                                   (1)                       (1)                                    
      Amyloid Deposition                                            1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (4)          (1)          (6)          (2)          (4)          
      Abscess                                                                    1 (100%)     1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (1)                                                                           
      Inflammation                                     1 (100%)                                                                     
      Spermatocele                                     1 (100%)                                                                     
   Penis                                              (1)          (1)          (3)          (1)          (3)          (2)          
      Abscess                                                                                              2 (67%)                  
      Edema                                            1 (100%)                                                         1 (50%)     
   Preputial Gland                                    (2)          (1)          (2)          (2)          (2)          (2)          
      Abscess                                          1 (50%)      1 (100%)     2 (100%)     1 (50%)      2 (100%)     1 (50%)     
      Dilatation                                       1 (50%)      1 (100%)                  1 (50%)                   1 (50%)     
      Inflammation, Chronic                            1 (50%)                                                                      
   Prostate                                                        (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
   Seminal Vesicle                                    (6)          (3)          (4)          (6)                       (7)          
      Abscess                                                                    1 (25%)                                            
      Dilatation                                       6 (100%)     3 (100%)     3 (75%)      5 (83%)                   6 (86%)     
      Fibrosis                                         1 (17%)                                                                      
      Inflammation                                                                            2 (33%)                               
   Testes                                             (2)          (1)                       (1)          (1)                       
      Amyloid Deposition                                            1 (100%)                                                        
      Seminiferous Tubule, Atrophy                     2 (100%)     1 (100%)                                                        
      Tunic, Fibrosis                                                                         1 (100%)                              
      Tunic, Inflammation                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (6)          (2)          (35)         (18)         (29)         (8)          
      Abscess                                                                                 1 (6%)       1 (3%)                   
      Cyst                                                                       1 (3%)       1 (6%)                                
      Hematopoietic Cell Proliferation                              1 (50%)                                                         
      Hyperplasia                                                                5 (14%)      1 (6%)       5 (17%)      2 (25%)     
      Axillary, Hematopoietic Cell Proliferation                                                           1 (3%)                   
      Axillary, Hyperplasia                                         1 (50%)     19 (54%)      4 (22%)     21 (72%)                  
      Axillary, Hyperplasia, Focal, Lymphoid                                     1 (3%)                                             
      Axillary, Hyperplasia, Plasma Cell                                         1 (3%)                                             
      Inguinal, Hyperplasia                                                                                2 (7%)                   
      Mediastinal, Hyperplasia                                                                             1 (3%)                   
      Pancreatic, Hematopoietic Cell Proliferation                  1 (50%)                                                         
   Lymph Node, Mandibular                             (4)          (1)          (22)         (16)         (22)         (6)          
      Abscess                                          2 (50%)                   2 (9%)       1 (6%)       3 (14%)                  
      Amyloid Deposition                                                         1 (5%)                                             
      Cyst                                                          1 (100%)                                            1 (17%)     
      Hematopoietic Cell Proliferation                 1 (25%)                   2 (9%)                                             
      Hyperplasia                                      2 (50%)      1 (100%)    18 (82%)     14 (88%)     22 (100%)     5 (83%)     
      Hyperplasia, Plasma Cell                                                   2 (9%)                    1 (5%)                   
      Lymphatic, Dilatation                                                                   1 (6%)                                
   Lymph Node, Mesenteric                             (2)          (1)          (5)          (2)          (1)          (1)          
      Amyloid Deposition                                                                      1 (50%)                               
      Cyst                                                          1 (100%)                                                        
      Hematopoietic Cell Proliferation                                           4 (80%)      1 (50%)                   1 (100%)    
      Hemorrhage                                       1 (50%)                                                          1 (100%)    
      Hyperplasia                                                                1 (20%)      1 (50%)      1 (100%)                 
      Infarct                                          1 (50%)                                                                      
   Spleen                                             (7)          (4)          (32)         (13)         (34)         (7)          
      Amyloid Deposition                               2 (29%)                   3 (9%)       2 (15%)      9 (26%)      1 (14%)     
      Congestion                                                                                                        1 (14%)     
      Hematopoietic Cell Proliferation                 7 (100%)     4 (100%)    32 (100%)    12 (92%)     33 (97%)      7 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Amyloid Deposition                                                         1 (2%)                                             
      Other, Abscess                                   1 (2%)                    4 (8%)       1 (2%)       2 (4%)       2 (4%)      
      Other, Acanthosis                                5 (10%)      4 (8%)      27 (55%)     18 (36%)     21 (43%)     11 (22%)     
      Other, Edema                                     2 (4%)       5 (10%)                   4 (8%)                    4 (8%)      
      Other, Exudate                                   3 (6%)       4 (8%)      23 (47%)     14 (28%)     13 (27%)      9 (18%)     
      Other, Hyperkeratosis                            1 (2%)       1 (2%)      18 (37%)      6 (12%)     11 (22%)      4 (8%)      
      Other, Inflammation, Subacute                    5 (10%)      4 (8%)      25 (51%)     16 (32%)     19 (39%)      8 (16%)     
      Other, Ulcer                                     5 (10%)      3 (6%)      26 (53%)     18 (36%)     20 (41%)     12 (24%)     
      Sebaceous Gland, Site of Application-Mass,                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
           Hyperplasia                                 1 (2%)                                                                       
      Site of Application-Mass, Acanthosis                                       1 (2%)                                             
      Site of Application-Mass, Acanthosis, Focal                                1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Other, Exudate, Focal                                              1 (2%)                                
   Skin, Control                                      (50)         (50)         (49)         (50)         (49)         (50)         
      Acanthosis                                                                              1 (2%)       1 (2%)                   
      Edema                                                         3 (6%)                    1 (2%)                    1 (2%)      
      Exudate                                                                    1 (2%)                    1 (2%)                   
      Hyperkeratosis                                                                                       2 (4%)                   
      Inflammation, Subacute                           1 (2%)                    2 (4%)                                 2 (4%)      
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Skin, Site of Application-No Mass                  (50)         (50)         (49)         (49)         (49)         (50)         
      Abscess                                                                                              2 (4%)                   
      Acanthosis                                       6 (12%)      7 (14%)     42 (86%)     14 (29%)     47 (96%)      9 (18%)     
      Edema                                                         1 (2%)                                                          
      Exudate                                          5 (10%)      2 (4%)      32 (65%)     11 (22%)     30 (61%)      5 (10%)     
      Hyperkeratosis                                   5 (10%)      2 (4%)      31 (63%)      8 (16%)     34 (69%)      1 (2%)      
      Hyperplasia, Focal, Mast Cell                    1 (2%)                                                                       
      Inflammation, Subacute                           4 (8%)       3 (6%)      37 (76%)      7 (14%)     38 (78%)      3 (6%)      
      Ulcer                                            5 (10%)      3 (6%)      25 (51%)      6 (12%)     27 (55%)      3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (48)         (50)         (49)         (50)         
      Abscess                                                                    1 (2%)       1 (2%)                    1 (2%)      
      Atelectasis                                                   1 (2%)                                 1 (2%)                   
      Congestion                                       2 (4%)       6 (12%)      2 (4%)       1 (2%)       2 (4%)       4 (8%)      
      Fibrosis, Focal                                               1 (2%)                                              1 (2%)      
      Foreign Body                                                                                                      1 (2%)      
      Granuloma                                                                               1 (2%)                                
      Hemorrhage                                       3 (6%)       9 (18%)                   5 (10%)      1 (2%)       3 (6%)      
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Leukocytosis                                     2 (4%)                    6 (13%)      6 (12%)      5 (10%)      2 (4%)      
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (2%)                    2 (4%)       2 (4%)       1 (2%)      
      Alveolus, Infiltration Cellular, Histiocyte      3 (6%)       5 (10%)      4 (8%)       8 (16%)      3 (6%)       4 (8%)      
      Interstitium, Inflammation                       5 (10%)     11 (22%)      8 (17%)     10 (20%)      2 (4%)       4 (8%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05119-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Interstitium, Inflammation, Chronic, Focal      11 (22%)      7 (14%)      5 (10%)      8 (16%)      1 (2%)       8 (16%)     
      Pleura, Inflammation, Suppurative                                                                                 1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)          (2)          (5)          (2)          
      Cornea, Hyperplasia                                                                                  1 (20%)                  
      Cornea, Inflammation, Chronic                    1 (100%)                               2 (100%)     2 (40%)      1 (50%)     
      Cornea, Inflammation, Subacute                                                                                    1 (50%)     
      Lids, Inflammation, Chronic                                                1 (100%)                                           
      Lids, Cornea, Inflammation, Subacute                                                                 1 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (7)          (10)         (6)          (5)          (4)          (8)          
      Abscess                                                                                              1 (25%)      1 (13%)     
      Amyloid Deposition                               5 (71%)      7 (70%)      3 (50%)      4 (80%)      2 (50%)      5 (63%)     
      Infarct                                                       1 (10%)                                                         
      Nephropathy                                                   1 (10%)                                                         
      Cortex, Atrophy                                                            1 (17%)      2 (40%)      1 (25%)                  
      Cortex, Cyst                                     1 (14%)      3 (30%)      1 (17%)      1 (20%)                               
      Cortex, Infiltration Cellular, Plasma Cell                                                           1 (25%)                  
      Papilla, Mineralization                                                                              1 (25%)                  
      Papilla, Necrosis                                                                                    1 (25%)                  
      Pelvis, Dilatation                               4 (57%)      4 (40%)      2 (33%)      2 (40%)      1 (25%)      4 (50%)     
      Proximal Convoluted Renal Tubule, Necrosis                                                           1 (25%)                  
      Proximal Convoluted Renal Tubule,                                                                                             
          Vacuolization Cytoplasmic                                                           1 (20%)      1 (25%)                  
   Urethra                                                         (1)          (1)                                                 
      Inflammation, Acute                                                        1 (100%)                                           
   Urinary Bladder                                    (1)          (2)          (6)                       (1)          (3)          
      Amyloid Deposition                                                         1 (17%)                                            
      Calculus Micro Observation Only                                                                                   1 (33%)     
      Congestion                                                                                                        1 (33%)     
      Hemorrhage                                                    1 (50%)      1 (17%)                                            
      Submucosa, Hemorrhage                                                      1 (17%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.