National Toxicology Program

National Toxicology Program
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TDMS Study 05119-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 DIETHYLPHTHALATE/DIMETHYLPHTHALATE


NTP Experiment-Test: 05119-01                                                                                     Report: PEIRPT05
Study Type: INIT/PROMOT                                                                                           Date: 05/20/95
Route: SKIN APPLICATION                                                                                           Time: 02:35:33




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21            4            5            7           32            6           
    Natural Death                                     11            6            2            7            6            6           
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                                     1                        
    Terminal Sacrifice                                18           38           40           35           10           38           
    Natural Death                                                   1            2            1                                     
  Missing                                                                        1                         1                        
  Animals Examined Microscopically                    50           50           49           50           49           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (1)                       (48)         (44)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Liver                                              (10)         (11)         (49)         (50)         (8)          (10)         
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Multiple                                                                                         1 (10%)     
      Hepatocellular Carcinoma                                      1 (9%)                    2 (4%)                                
      Hepatocellular Adenoma                           1 (10%)      3 (27%)      9 (18%)      5 (10%)                   3 (30%)     
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Hepatocholangiocarcinoma                                      1 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                                                        (48)         (50)         (1)                       
      Adenoma                                                                    2 (4%)       4 (8%)                                
      Carcinoma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)          (3)          (3)          (3)          (3)          (5)          
      Lipoma                                           1 (33%)      1 (33%)      1 (33%)      1 (33%)                   3 (60%)     
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (24)         (8)          (49)         (50)         (35)         (13)         
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic                                                                                                   1 (8%)      
   Thymus                                                          (1)          (42)         (43)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Other, Hemangioma                                                          1 (2%)                                             
      Other, Squamous Cell Carcinoma                                                                       1 (2%)                   
      Sebaceous Gland, Site of Application-Mass,                                                                                    
           Adenoma                                                                                                      1 (2%)      
      Site of Application-Mass, Papilloma              4 (8%)                                              3 (6%)       1 (2%)      
      Site of Application-Mass, Papilloma, Multiple    1 (2%)                                             20 (41%)                  
      Site of Application-Mass, Squamous Cell                                                                                       
          Carcinoma                                                                                        7 (14%)      2 (4%)      
   Skin, Site of Application-No Mass                  (50)         (50)         (49)         (50)         (49)         (50)         
      Squamous Cell Carcinoma                                                                              2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Alveolar/Bronchiolar Adenoma                     4 (8%)       6 (12%)      4 (8%)       3 (6%)                    5 (10%)     
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       1 (2%)                                 2 (4%)      
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (6)          (5)          (49)         (50)         (7)          (5)          
   Urinary Bladder                                    (1)          (3)          (46)         (47)                                   
      Carcinoma                                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)        *(49)        *(50)         
      Lymphoma Malignant Lymphocytic                                2 (4%)                                                          
      Lymphoma Malignant Mixed                                                                             1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   ACETONE/     ACETONE/     ACETONE/     ACETONE/     DMBA/TPA     DMBA/ACE        
                                                   TPA          DEP          DMP          ACETONE                   TONE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            11          15          19          14          25          16               
     Total Primary Neoplasms                           12          17          23          16          34          18               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 10          10          15          12          23          13               
     Total Benign Neoplasms                            11          11          18          14          23          13               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           6           5           2           9           4               
     Total Malignant Neoplasms                          1           6           5           2          11           5               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                              1           1               
     Total Metastatic Neoplasm                                                                          1           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            4           31           10           27            5           
    Natural Death                                      4            7            4            4            9            5           
    Accidently Killed                                                                                                   1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           36           14           35           13           38           
    Natural Death                                      1            3                         1                         1           
  Missing                                                                        1                         1                        
  Animals Examined Microscopically                    50           50           49           50           49           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (6)          (7)          (9)          (10)         (14)         
      Hepatocellular Carcinoma                         1 (13%)                                                          1 (7%)      
      Hepatocellular Carcinoma, Multiple                                                      1 (11%)                               
      Hepatocellular Adenoma                           2 (25%)      2 (33%)      1 (14%)      5 (56%)      1 (10%)      4 (29%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (4)          (1)          (6)          (2)          (4)          
      Hemangioma                                                                                           1 (50%)                  
      Lipoma                                           4 (100%)     4 (100%)                  5 (83%)      1 (50%)      4 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (7)          (4)          (32)         (13)         (34)         (7)          
   Thymus                                                                                    (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Other, Papilloma                                                                        1 (2%)                                
      Site of Application-Mass, Papilloma              1 (2%)       1 (2%)       2 (4%)                    2 (4%)                   
      Site of Application-Mass, Papilloma, Multiple    1 (2%)                    1 (2%)                    1 (2%)                   
      Site of Application-Mass, Squamous Cell                                                                                       
          Carcinoma                                                                                        1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (48)         (50)         (49)         (50)         
      Alveolar/Bronchiolar Adenoma                     5 (10%)      5 (10%)      1 (2%)       2 (4%)                    3 (6%)      
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)       2 (4%)                    1 (2%)      
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)        *(49)        *(50)         
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   7                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)        *(49)        *(50)         
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05119-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 05/20/95    
Route: SKIN APPLICATION                                                                                           Time: 02:35:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         CD-1 CRL MICE OUTBRED CHARLES RIVE MALE   DMBA/DEP     DMBA/DMP     DEP/TPA      DEP/ACET     DMP/TPA      DMP/ACET        
                                                                                          ONE                       ONE             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            13          11           6          11           7          13               
     Total Primary Neoplasms                           14          12           7          17           7          13               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          11           6           9           6          12               
     Total Benign Neoplasms                            13          12           6          15           6          12               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1           2           1           1               
     Total Malignant Neoplasms                          1                       1           2           1           1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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