Share This:
https://ntp.niehs.nih.gov/go/3527

TDMS Study 05119-01 Pathology Tables

NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97
Route: SKIN APPLICATION                                                                                           Time: 17:20:28




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|             
                                           | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMBA/TPA                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Granuloma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |             +              +                          +                  |             
      Abscess                              |             4              4                                             |             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |             4                                         2                  |             
      Necrosis                             |                            3                          2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                  +                                       |             
      Dilatation                           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|             
                                           | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMBA/TPA                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                                          |             
      Cyst                                 |                                           X                              |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Hyperplasia                          |                      3                                                   |             
      Hyperplasia, Re Cell                 |    3                                                                     |             
      Axillary, Abscess                    |                               4                             3            |             
      Axillary, Cyst                       |                         X                                                |             
      Axillary, Depletion Lymphoid         |                               3                                          |             
      Axillary, Hyperplasia                |          4     3  4  3  4           3  4  4  4  4  3  4     4            |             
      Inguinal, Hyperplasia                |                            3                          3                  |             
      Lumbar, Hyperplasia                  |                                                                          |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +     +  +     +     +  +  +     +           +     +            |             
      Cyst                                 |                                                             X            |             
      Depletion Lymphoid                   |                               3                                          |             
      Hematopoietic Cell Proliferation     |                4                                                         |             
      Hyperplasia                          |          3        3     4        4  2     3           3     4            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +        +   |             
      Amyloid Deposition                   |             3                 3                                      2   |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     3  4  4  4  4  3  4  3  4  3  3  3  3     3  4  3  3        3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Other, Abscess                       |          4                                                               |             
      Other, Acanthosis, Focal             |                                  4                                       |             
      Other, Acanthosis                    |          2  3  2  2     2     3  2  2  2     2     3  2     3        2   |             
      Other, Edema                         |                                                                          |             
      Other, Exudate                       |          X  X  X  X     X     X  X     X     X     X  X     X        X   |             
      Other, Hyperkeratosis                |          2  2           1     2     2  2     1     1  2     2        2   |             
      Other, Inflammation, Subacute        |          3  4  4  4     4     3  4  3  4     4     3  4     4        4   |             
      Other, Ulcer                         |          2  4  4  4     4     3  3  3  4     4     4  4     4        4   |             
      Sebaceous Gland, Site of             |                                                                          |             
          Application-Mass, Hyperplasia    |                                                                          |             
      Site of Application-Mass, Abscess    |                               4                                          |             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           | 4  4                 4     4     4        4              4              3|             
      Site of Application-Mass, Acanthosis |                                                                      1   |             
      Site of Application-Mass, Exudate    |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|             
                                           | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMBA/TPA                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Site of Application-Mass,            |                                                                          |             
          Hyperkeratosis, Focal            |                                                                          |             
      Site of Application-Mass,            |                                                                          |             
          Hyperplasia, Focal, Mast Cell    |       2                                                                  |             
      Site of Application-Mass,            |                                                                          |             
          Inflammation, Subacute           |       2                                                                  |             
      Site of Application-Mass,            |                                                                          |             
          Inflammation, Suppurative        |                      4                                                   |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           | 3  2  2  3  2  2  2  3  2  3  2  2  2     3  3  2  2  3  2  2  2        3|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Exudate                              | X        X  X  X  X  X  X           X     X  X  X  X  X  X  X  X        X|             
      Hyperkeratosis                       | 1        2     2  4  2  2  2     2  2     2  2  2  2  2  2  1  2     2  2|             
      Inflammation, Subacute               | 4  1     3  2  2  4  2  4  2     1  3     3  1  3  4  2     1  3        2|             
      Ulcer                                | 4        2        4     2           4     2  2  4  4     2     4        3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                              2                           |             
      Leukocytosis                         |                3           3  2                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                3         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             1     1           2                          1               |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |    2        1                                                        2   |             
      Interstitium, Inflammation           |                                  2                       2  2           2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                       +                  |             
      Cataract                             |                                                       3                  |             
      Inflammation, Suppurative            |                                                                          |             
      Cornea, Inflammation, Chronic        |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|             
                                           | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMBA/TPA                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retrobulbar, Inflammation, Subacute  |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +                                                        +   |             
      Abscess                              |                                                                          |             
      Infiltration Cellular, Focal, Plasma |                                                                          |             
          Cell                             |             3                                                            |             
      Nephropathy                          |                                                                          |             
      Cortex, Atrophy                      |             4                                                        4   |             
      Papilla, Necrosis                    |                                                                      2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Vacuolization Cytoplasmic       |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2|            |
                             DAY ON TEST   | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7|            |
                                           | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMBA/TPA                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                  +                                       |   1        |
      Amyloid Deposition                   |                                  3                                       |      1  3.0|
      Granuloma                            |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                +           +     +        +                             +|   8        |
      Abscess                              |                1                 4                                      4|      6  3.5|
      Amyloid Deposition                   |                            3                                            4|      2  3.5|
      Angiectasis                          |                                  3                                       |      1  3.0|
      Hematopoietic Cell Proliferation     |                            3                                             |      3  3.0|
      Necrosis                             |                1                          2                             4|      6  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                                                                     |   1        |
      Abscess                              |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +                                                      |   1        |
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Necrosis                             |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +        +  +              +                                       |   4        |
      Abscess                              |                4                                                         |      1  4.0|
      Inflammation, Chronic, Focal         |       3                                                                  |      1  3.0|
      Atrium, Thrombosis                   |                   X                                                      |      1     |
      Epicardium, Inflammation, Suppurative|                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                   +     +                        |   3        |
      Abscess                              |       4                                   3     4                        |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                     +                                    |   1        |
      Cyst                                 |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2|            |
                             DAY ON TEST   | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7|            |
                                           | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMBA/TPA                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                  +                                       |   1        |
      Inflammation, Chronic                |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +     +     +        +  +  +  +  +  +     +  +  +  +  +  +  +|  35        |
      Abscess                              |                                     4                                    |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia                          |                                     3     3                 3            |      4  3.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Axillary, Abscess                    |                                                                          |      2  3.5|
      Axillary, Cyst                       |          X                                                               |      2     |
      Axillary, Depletion Lymphoid         |                                                                          |      1  3.0|
      Axillary, Hyperplasia                | 2        4  4     2     4              4  3  3        4  4  4  4  4  4   |     27  3.6|
      Inguinal, Hyperplasia                |                                                                          |      2  3.0|
      Lumbar, Hyperplasia                  |                                                 3                        |      1  3.0|
      Mediastinal, Abscess                 |                                  4                                       |      1  4.0|
      Mediastinal, Hyperplasia             |                                  4                                       |      1  4.0|
      Renal, Hyperplasia                   |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +  +           +                 +  +  +     +  +  +     +  +  +|  23        |
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia                          | 3        4  4           4                 4  4  3     3  4  4     4  4  4|     21  3.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                       +              +                       +|   4        |
      Hematopoietic Cell Proliferation     |          4                                                              4|      2  4.0|
      Hyperplasia                          |                                  4              3                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|  42        |
      Amyloid Deposition                   |       2           3        2  2     3                                   3|      9  2.6|
      Granuloma                            |                                  4                                       |      1  4.0|
      Hematopoietic Cell Proliferation     | 4  3  4  4  3  4  3  3  4  4  3  4  1  3  4     4     3  3  4  3  4  3  4|     43  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Other, Abscess                       |                                                 4                 4     4|      4  4.0|
      Other, Acanthosis, Focal             |                                                                          |      1  4.0|
      Other, Acanthosis                    | 2        2              3     2           2  2  2     2  3        3  1  3|     26  2.3|
      Other, Edema                         |                   3                                                      |      1  3.0|
      Other, Exudate                       |          X              X     X              X        X  X        X  X  X|     22     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2|            |
                             DAY ON TEST   | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7|            |
                                           | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMBA/TPA                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Other, Hyperkeratosis                | 1        1              2     2           2     2                 2     2|     19  1.7|
      Other, Inflammation, Subacute        | 4        4              4                 3  4  2     4  3        4  4  4|     25  3.7|
      Other, Ulcer                         | 4        4              4     4           3  4        4  3  4     4  4  4|     26  3.7|
      Sebaceous Gland, Site of             |                                                                          |            |
          Application-Mass, Hyperplasia    |                                                    4                     |      1  4.0|
      Site of Application-Mass, Abscess    |                                  4                                       |      2  4.0|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |       2                       3                    4                     |     11  3.6|
      Site of Application-Mass, Acanthosis |                                                                          |      1  1.0|
      Site of Application-Mass, Exudate    |                                                                          |      1     |
      Site of Application-Mass,            |                                                                          |            |
          Hyperkeratosis, Focal            |       2                                                                  |      1  2.0|
      Site of Application-Mass,            |                                                                          |            |
          Hyperplasia, Focal, Mast Cell    |                                                                          |      1  2.0|
      Site of Application-Mass,            |                                                                          |            |
          Inflammation, Subacute           |                                                                          |      1  2.0|
      Site of Application-Mass,            |                                                                          |            |
          Inflammation, Suppurative        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                                  2                                       |      1  2.0|
      Inflammation, Subacute               |                                           2              1               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                   4                                2                     |      2  3.0|
      Acanthosis                           | 1  2     2  2  2  2  2  2  2  3  2  2  3  2     2  3  3  2  2  2  2  3  2|     45  2.3|
      Cyst Epithelial Inclusion            |                                                       X                  |      1     |
      Exudate                              |          X  X  X     X              X  X           X  X  X  X  X  X  X  X|     31     |
      Hyperkeratosis                       |    1  2  1  1  2  2  2  2  1     2  3  1  2     2     2     2  1  1  2  2|     39  1.8|
      Inflammation, Subacute               |          2  4  2        2        2     4  3        3  4  4  3  4  2  4  3|     34  2.7|
      Ulcer                                |          4  4                          4           4  4  4  4  4  2  4   |     22  3.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                         2|      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2|            |
                             DAY ON TEST   | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7|            |
                                           | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMBA/TPA                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                             2            |      2  2.0|
      Leukocytosis                         |    2  2        4  3  2     4                    3                       2|     12  2.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                            3     1        1     2                        |      8  1.5|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                  1                                       |      4  1.5|
      Interstitium, Inflammation           |    3              2  3        2  2  3              2              2     3|     13  2.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   3        |
      Cataract                             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                 3                        |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
      Retrobulbar, Inflammation, Subacute  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +           +                 +        +                             +|   7        |
      Abscess                              |    4           4                                                         |      2  4.0|
      Infiltration Cellular, Focal, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Nephropathy                          |                                           2                              |      1  2.0|
      Cortex, Atrophy                      |                                                                          |      2  4.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Vacuolization Cytoplasmic       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9|             
                                           | 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/ACE                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    TONE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                       +                  |             
      Inflammation, Subacute               |                                                       3                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +                                +  +  +  +           +                  |             
      Abscess                              |                                        4              4                  |             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        3  2           4                  |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +  +               |             
      Abscess                              |                                                       4                  |             
      Fat, Necrosis, Focal                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                         +|             
      Edema                                |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                                +              +                  |             
      Abscess                              |                                        4                                 |             
      Amyloid Deposition                   |       3                                                                  |             
      Atrium, Thrombosis                   |       X                                                                  |             
      Epicardium, Inflammation, Suppurative|                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Abscess                              |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                                     |             
      Abscess                              |    4                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +                                         +        +         |             
      Dilatation                           |             2                                         4                  |             
      Fibrosis                             |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                   +  +     +     +           +     +|             
      Hyperplasia                          |                                                                          |             
      Axillary, Hyperplasia                |                                                                          |             
      Mediastinal, Hyperplasia             |                                                       3                  |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                                   +  +           +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9|             
                                           | 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/ACE                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    TONE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |    4                                   2  4                              |             
      Hyperplasia                          |    4                                   3  4           3           4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                         +|             
      Depletion Lymphoid                   |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +                 +  +           +  +  +        +  +                 +|             
      Amyloid Deposition                   |    3                                               2                     |             
      Hematopoietic Cell Proliferation     |    4                 1  3           3  4  3        3  4                 3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |    3                                      2                              |             
      Other, Acanthosis                    |    2                                2  2  3     2     2           3      |             
      Other, Edema                         |       3                                                                  |             
      Other, Exudate                       |    X                                X  X  X                       X      |             
      Other, Hyperkeratosis                |    3                                2  2  4           2           1      |             
      Other, Inflammation, Subacute        |    4                                3  4  4     3     3           3      |             
      Other, Ulcer                         |    4                                4  4  4     4                 3      |             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2  2  1              3                 2  1        3           3  1     2|             
      Exudate                              |                      X                 X           X           X        X|             
      Hyperkeratosis                       | 2  2  2              2                 2  1        2           2  1     2|             
      Inflammation, Subacute               |    2                 3                 2           4                    2|             
      Ulcer                                |                      2                             4                    2|             
      Sebaceous Gland, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 4                        |             
      Congestion                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Leukocytosis                         |                                        4  2           3           1      |             
      Alveolar Epithelium, Hyperplasia     |    2                                3           4                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       2                             3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9|             
                                           | 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/ACE                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    TONE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bronchiole, Hyperplasia              |                                                 4                        |             
      Bronchiole, Inflammation, Suppurative|                                                 4                        |             
      Bronchiole, Metaplasia               |                                                 4                        |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |       2                                      1                    2      |             
      Interstitium, Inflammation           |    2                             2              4  2                    3|             
      Pleura, Inflammation, Suppurative    |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cornea, Inflammation, Chronic        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                        +  +                              |             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                           4                              |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Nephropathy                          |                                           3                              |             
      Cortex, Atrophy                      |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9|            |
                                           | 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/ACE                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    TONE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   1        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |       +           +                                +     +               |  10        |
      Abscess                              |                   4                                                      |      3  4.0|
      Amyloid Deposition                   |       3                                                                  |      1  3.0|
      Hematopoietic Cell Proliferation     |       3           3                                                      |      5  3.0|
      Inflammation, Chronic, Focal         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   1        |
      Edema                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                                                            |   4        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   |             3                                                            |      2  3.0|
      Atrium, Thrombosis                   |             X                                                            |      2     |
      Epicardium, Inflammation, Suppurative|                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +                                                            |   1        |
      Amyloid Deposition                   |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                              +  +     +           +      |   5        |
      Abscess                              |                                                 4                        |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                +                        |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                  +                             +         |   5        |
      Dilatation                           |                                  4                             2         |      4  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +     +                       +        +                        |  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9|            |
                                           | 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/ACE                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    TONE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                        3                                 |      1  3.0|
      Axillary, Hyperplasia                |    4  3                                                                  |      2  3.5|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Renal, Hyperplasia                   |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     +     +                       +        +                        |  10        |
      Abscess                              |                                                                          |      3  3.3|
      Hyperplasia                          |    3     3     4                       3        4                        |     10  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +        +                                                         |   3        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       3        4                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +     +  +                    +        +           +            |  17        |
      Amyloid Deposition                   |       2                                3        2                        |      5  2.4|
      Hematopoietic Cell Proliferation     |    4  3  3     4  4                             3           3            |     16  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |                   3     4                                   3            |      5  3.0|
      Other, Acanthosis                    |    2     2     3  2     3        3              3           3            |     15  2.5|
      Other, Edema                         |                                                                          |      1  3.0|
      Other, Exudate                       |    X           X  X     X        X              X           X            |     12     |
      Other, Hyperkeratosis                |    1                                                        1            |      8  2.0|
      Other, Inflammation, Subacute        |          4     4  4     4        3              4           4            |     14  3.6|
      Other, Ulcer                         |    4     4     4  4        3     4     4        4           4            |     15  3.9|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |    4           3                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    3  2        1           2     1                 1  2     2            |     19  1.9|
      Exudate                              |    X  X        X           X                                X            |     10     |
      Hyperkeratosis                       |    1  2                                                     2            |     13  1.8|
      Inflammation, Subacute               |    1  2                                                     3            |      8  2.4|
      Ulcer                                |       3                    1                       1        2            |      7  2.1|
      Sebaceous Gland, Hyperplasia, Focal  |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9|            |
                                           | 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/ACE                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    TONE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  4.0|
      Congestion                           |                3                                                         |      1  3.0|
      Inflammation, Chronic, Focal         |                                        2                                 |      1  2.0|
      Leukocytosis                         |       2           3                             3                        |      7  2.6|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                        2                                 |      3  2.3|
      Bronchiole, Hyperplasia              |                                                                          |      1  4.0|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  4.0|
      Bronchiole, Metaplasia               |                                                                          |      1  4.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |             4                                                            |      4  2.3|
      Interstitium, Inflammation           |          3                                            1              1   |      8  2.3|
      Pleura, Inflammation, Suppurative    |                   2                                                      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +     +     +                                 |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +           +                    +                                 |   5        |
      Abscess                              |                   3                                                      |      1  3.0|
      Amyloid Deposition                   |       2           2                                                      |      2  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                        4                                 |      1  4.0|
      Nephropathy                          |                                                                          |      1  3.0|
      Cortex, Atrophy                      |       3                                                                  |      1  3.0|
      Pelvis, Dilatation                   |       2                                3                                 |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9|             
                                           | 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    TPA                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                  +  +     +  +                           |             
      Abscess                              |                                     4        4                           |             
      Amyloid Deposition                   |                                  3        1                              |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  3  3                                    |             
      Necrosis                             |                                     4     2  4                           |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +                 +  +        +  +     +  +  +     +  +   |             
      Hyperplasia                          |                                                                      2   |             
      Axillary, Hyperplasia                |    4     4     4                                3     4  3        4      |             
      Bronchial, Hyperplasia               |                                                                          |             
      Inguinal, Hyperplasia                |    4                                                                     |             
      Lumbar, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +                 +  +        +        +     +     +      |             
      Abscess                              |                4                    4                                    |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 4  3     4     4                 3           4        4     4     4      |             
      Lymphocyte, Necrosis                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Hyperplasia                          |                                                                          |             
      Lymphocyte, Necrosis                 |                                                             3            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +        +  +     +  +        +  +  +  +     +  +     +   |             
      Amyloid Deposition                   |                                  3  3                          2         |             
      Hematopoietic Cell Proliferation     | 3  3  3  3     4        4  4     4  4        4  2  3  3     2  3     3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9|             
                                           | 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    TPA                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                     4                                    |             
      Other, Acanthosis                    | 3  2  2  3              2  3     2  2     2  2           3  3     3  2   |             
      Other, Exudate                       | X  X     X              X  X     X        X  X           X  X     X  X   |             
      Other, Hyperkeratosis                | 3     2  2              2        2  2                    2        2      |             
      Other, Inflammation, Subacute        | 4  3  2  2              4  4     4        4  4           3  4     4  4   |             
      Other, Ulcer                         | 4  4  4  2              4  4     4  4     4  4        3  3  4     4  4   |             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                2         |             
      Inflammation, Subacute               |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2  4  2  3  2  3  2  2     2     2  2  2  2  2  3  2  2  2  4  2  2  2  3|             
      Cyst Epithelial Inclusion            | X                                                                        |             
      Exudate                              |    X     X     X           X              X  X  X  X  X     X  X  X  X   |             
      Hyperkeratosis                       | 2  2  3  2     2  2     2  2     2  2     2  2  2  2  2     2     2     2|             
      Inflammation, Subacute               | 2  4     4  1  4           3                       3  4     4  4  2  3  3|             
      Ulcer                                |    4  4  4     4     3     3           3     2  4  4  4     1  4  2  3  3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Congestion                           |                                     2     2              2               |             
      Leukocytosis                         | X                       3        2  4        2                 2         |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                      1                 2                             1   |             
      Interstitium, Inflammation           |       3        2        2        3  3     2     2                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +     +           +        +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +  +        +           +               |             
      Inflammation, Suppurative            |                                     3                                    |             
      Cornea, Hyperplasia, Chronic         |                                              3                           |             
      Cornea, Hyperplasia, Focal           |                                                          2               |             
      Cornea, Inflammation, Chronic        |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3|             
                             DAY ON TEST   | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9|             
                                           | 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    TPA                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
      Dilatation                           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                  +                             +         |             
      Abscess                              |                                                                3         |             
      Amyloid Deposition                   |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Cortex, Atrophy                      |                                                                3         |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1|            |
                             DAY ON TEST   | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4|            |
                                           | 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    TPA                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                   +  +     +  +                 +              +         |  10        |
      Abscess                              |                      4     4                    3              3         |      6  3.7|
      Amyloid Deposition                   |                      4                                                   |      3  2.7|
      Clear Cell Focus                     |                               X                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Necrosis                             |                      4     3                    4              3         |      7  3.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                +|   3        |
      Abscess                              |                                        4                                4|      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +        +  +     +  +  +     +  +                 +     +|  24        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Axillary, Hyperplasia                |          4     4                 4  4  3                          4     4|     14  3.8|
      Bronchial, Hyperplasia               |                                                                         4|      1  4.0|
      Inguinal, Hyperplasia                |                                        3                                 |      2  3.5|
      Lumbar, Hyperplasia                  |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +              +        +  +  +        +                       +|  17        |
      Abscess                              |                                        4                                 |      3  4.0|
      Cyst                                 |                                  X                                       |      1     |
      Hyperplasia                          |          4              3        4  4           3                       4|     15  3.7|
      Lymphocyte, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +                                             |   2        |
      Hyperplasia                          |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1|            |
                             DAY ON TEST   | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4|            |
                                           | 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    TPA                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphocyte, Necrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +                 +  +  +     +  +  +     +  +              +  +     +|  28        |
      Amyloid Deposition                   |                      3  3                       3              2         |      7  2.7|
      Hematopoietic Cell Proliferation     |    4                 3  3  4     3  3  4     3  3              3  3     3|     28  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |                      3                 3                                 |      3  3.3|
      Other, Acanthosis                    |    3     2           2  3  3     2  2  2        2              3        3|     25  2.4|
      Other, Exudate                       |    X                             X  X  X                                X|     17     |
      Other, Hyperkeratosis                |    2     1           2  2        1  1  1                                2|     16  1.8|
      Other, Inflammation, Subacute        |    3     3           4  2  2     4  4  4        3              4        4|     24  3.5|
      Other, Ulcer                         |    4     4           4     3     4  4  4        3  3           4        4|     26  3.7|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 2  3  2  2  1  2  3  2  2  2     1  2  2  3  2  2  2  3  2  1  3  3  2  1|     47  2.2|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Exudate                              | X  X     X     X        X           X     X  X        X        X  X  X   |     25     |
      Hyperkeratosis                       | 2  2     1     2  2  2  2  2     1  2        1        2  2     2  1  3   |     34  1.9|
      Inflammation, Subacute               |    3     2     4  2     3           2  2  2  3  3     2  2  2  2  4  4  2|     30  2.8|
      Ulcer                                |    4     2     4                    2        4  4                 4      |     23  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                         4|      1  4.0|
      Congestion                           |                                                                          |      3  2.0|
      Leukocytosis                         |                         3                       3              3     4   |     10  2.9|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1|            |
                             DAY ON TEST   | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4|            |
                                           | 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    TPA                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      |                                                       2                  |      4  1.5|
      Interstitium, Inflammation           |    3                       4                                             |      9  2.7|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   5        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Cornea, Hyperplasia, Chronic         |                                                                          |      1  3.0|
      Cornea, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                      +                          +  +  +                  |   6        |
      Abscess                              |                                                                          |      1  3.0|
      Amyloid Deposition                   |                      3                          2                        |      3  2.3|
      Hematopoietic Cell Proliferation     |                      3                                                   |      1  3.0|
      Cortex, Atrophy                      |                      3                                                   |      2  3.0|
      Pelvis, Dilatation                   |                                                    2  2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                    +                     |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1|             
                             DAY ON TEST   | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4|             
                                           | 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DEP/TPA                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                         +                                                |             
      Abscess                              |                         4                                                |             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                         3                                                |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Necrosis                             |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Fat, Necrosis, Focal                 |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +              +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                                                     +   |             
      Abscess                              |                4                                                     4   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +                                      +              +   |             
      Abscess                              |                4                                                         |             
      Dilatation                           |                4                                      3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +     +  +  +     +  +     +  +  +        +  +     +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             3     2     3     4                                          |             
      Axillary, Hyperplasia, Focal,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Axillary, Hyperplasia                | 4                             3              4  3  4        3  4        4|             
      Axillary, Hyperplasia, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +  +        +  +        +  +     +     +        +        +   |             
      Abscess                              |             4                                                            |             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1|             
                             DAY ON TEST   | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4|             
                                           | 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DEP/TPA                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 3  4        4  3        3  4           3     4     4                 4   |             
      Hyperplasia, Plasma Cell             |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                                         +                       +   |             
      Hematopoietic Cell Proliferation     |    3                                         3                       3   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +           +  +  +  +  +     +     +  +     +  +  +           +     +  +|             
      Amyloid Deposition                   |             2                          3                                 |             
      Hematopoietic Cell Proliferation     | 3           3  4  3  3  3     3     3  3     3  3  3           4     4  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Other, Abscess                       |                2                                                        3|             
      Other, Acanthosis                    | 2  3        2  3        3  3        2  2     2     3                 3  3|             
      Other, Exudate                       |    X        X  X        X  X        X  X     X     X                 X  X|             
      Other, Hyperkeratosis                | 1  2        2  2        2  2        1  2           2                     |             
      Other, Inflammation, Subacute        | 4  4        4  4        4  4        3  4     4     4                 4   |             
      Other, Ulcer                         | 4  4        4  4        4  4        4  3     4     4                 4  4|             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           |                                                                4         |             
      Site of Application-Mass, Acanthosis |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Inflammation, Subacute               |                3                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 3  3        2  3  2  3  2  2  2  2     2  2  3  2  2  3  2  3  2  2  3  2|             
      Exudate                              | X              X  X  X  X        X           X  X  X  X     X  X  X  X  X|             
      Hyperkeratosis                       | 2  3        2  2  2  2  2     2  2     2     2  2  1  2     2  2     2  2|             
      Inflammation, Subacute               | 4  2        1  3  2  2  2  2  3  2     3  2  3  4  2  1  2  3  4  2  2  3|             
      Ulcer                                | 4  2              4  3     2  4           2  3  4           4  4  2      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Congestion                           |                                                                         3|             
      Leukocytosis                         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1|             
                             DAY ON TEST   | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4|             
                                           | 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DEP/TPA                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              1                       2   |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           | 1           2           2                                                |             
      Interstitium, Inflammation           |                            2        2           3              2     1   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                       +                                 |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lids, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                        +                                 |             
      Amyloid Deposition                   |                                        2                                 |             
      Cortex, Atrophy                      |                                        3                                 |             
      Cortex, Cyst                         |                                        X                                 |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +                                                     +   |             
      Amyloid Deposition                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Submucosa, Hemorrhage                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2|            |
                             DAY ON TEST   | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6|            |
                                           | 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DEP/TPA                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +                 +  +        +              +           +|   7        |
      Abscess                              |                4                 4  4                       4            |      5  4.0|
      Amyloid Deposition                   |                                              2                           |      1  2.0|
      Hematopoietic Cell Proliferation     |                3                 2                          1            |      4  2.3|
      Inflammation, Chronic, Focal         |                                                             2            |      1  2.0|
      Necrosis                             |                                  4                                      3|      3  3.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                              +                           |   1        |
      Edema                                |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                     +        +                           |   2        |
      Abscess                              |                                     4                                    |      1  4.0|
      Amyloid Deposition                   |                                              2                           |      1  2.0|
      Atrium, Thrombosis                   |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   1        |
      Abscess                              |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
      Abscess                              |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                                                         |   4        |
      Abscess                              |                                                                          |      1  4.0|
      Dilatation                           |                4                                                         |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +     +  +  +     +  +  +  +        +  +  +     +  +|  35        |
      Cyst                                 |                                                             X            |      1     |
      Hyperplasia                          |    1                                                                     |      5  2.6|
      Axillary, Hyperplasia, Focal,        |                                                                          |            |
          Lymphoid                         |                                                          3               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2|            |
                             DAY ON TEST   | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6|            |
                                           | 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DEP/TPA                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Axillary, Hyperplasia                | 4  4  3        3  4  4     4           4        4        4     3         |     19  3.7|
      Axillary, Hyperplasia, Plasma Cell   |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +                    +  +  +     +  +  +                       +  +|  22        |
      Abscess                              |                                           4                              |      2  4.0|
      Amyloid Deposition                   |                                              2                           |      1  2.0|
      Hematopoietic Cell Proliferation     |                                  4                                      3|      2  3.5|
      Hyperplasia                          | 4     4                    4           4  4  3                       3  3|     18  3.6|
      Hyperplasia, Plasma Cell             |                               4                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +                                                     +   |   5        |
      Hematopoietic Cell Proliferation     |                                                                      4   |      4  3.3|
      Hyperplasia                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +        +  +  +  +     +        +  +  +     +  +|  32        |
      Amyloid Deposition                   |                2                                                         |      3  2.3|
      Hematopoietic Cell Proliferation     | 4  3  3        4  4  3  2        4  4  3  3     4        3  3  3     3  4|     32  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |             2                                                            |      1  2.0|
      Other, Abscess                       |                                              4                          4|      4  3.3|
      Other, Acanthosis                    | 3     3        3  2        3  4  3  3  2  2  3           2     2     3  3|     27  2.7|
      Other, Exudate                       | X     X        X           X  X  X  X  X     X           X           X  X|     23     |
      Other, Hyperkeratosis                | 2     2           2           2     2                    2     2     3  2|     18  1.9|
      Other, Inflammation, Subacute        | 4     4        4           4  3  4  3  4  4  4           2     2     3  4|     26  3.7|
      Other, Ulcer                         | 4     4        4  2        4  4  4  4  4  4  2           2     2        4|     26  3.7|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
      Site of Application-Mass, Acanthosis |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Exudate                              |          X                                                               |      1     |
      Inflammation, Subacute               |          4                                                               |      2  3.5|
      Ulcer                                |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |    2  2  3  2  2  3  3  2  2  3     2  2  2     3  2     2  2  3  2  2   |     43  2.4|
      Exudate                              |    X  X  X     X  X  X  X  X  X     X  X        X        X  X  X  X  X   |     32     |
      Hyperkeratosis                       |       1     2  2  3  2     2  2        2  2     2        3  1  2         |     31  2.0|
      Inflammation, Subacute               |    4     2     4  2  4  2  2  2        3  2     4        4     4  2  2   |     38  2.7|
      Ulcer                                |    4  2        4  4  4  4  2  2        1        2        4     4     3   |     25  3.1|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2|            |
                             DAY ON TEST   | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6|            |
                                           | 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DEP/TPA                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  48        |
      Abscess                              | 4                                                                        |      1  4.0|
      Congestion                           |                         2                                                |      2  2.5|
      Leukocytosis                         |          1              4        3                          1           1|      6  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                              3              1            |      4  1.8|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           | 2                                            3                           |      5  2.0|
      Interstitium, Inflammation           |             2                    2  2                                    |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                         +|   1        |
      Lids, Inflammation, Chronic          |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +                    +                                +  +  +|   6        |
      Amyloid Deposition                   |             1                                                     3      |      3  2.0|
      Cortex, Atrophy                      |                                                                          |      1  3.0|
      Cortex, Cyst                         |                                                                          |      1     |
      Pelvis, Dilatation                   |                                                                   3  3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |          +                                                               |   1        |
      Inflammation, Acute                  |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +                    +                                       |   6        |
      Amyloid Deposition                   | 4                                                                        |      1  4.0|
      Hemorrhage                           |          3                                                               |      1  3.0|
      Submucosa, Hemorrhage                |             4                                                            |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3|             
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8|             
                                           | 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DEP/ACET                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                      +   |             
      Amyloid Deposition                   |                                                                      2   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +                       +           +                    +     +   |             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                2     2   |             
      Inflammation, Chronic, Focal         |       2                                                                  |             
      Necrosis                             |       2                                                                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                                                                        |             
      Abscess                              | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +                                                            |             
      Amyloid Deposition                   |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                        +                                 |             
      Abscess                              |                                        4                                 |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +                                +                              |             
      Dilatation                           |          3                                4                              |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                                             +            |             
      Tunic, Fibrosis                      |                                                             3            |             
      Tunic, Inflammation                  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +           +     +  +     +           +                 +     +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Axillary, Hyperplasia                |                                                 4                 4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +           +     M  +     +           +                 +     +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          | 2        3           3        3     4           4                 3     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3|             
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8|             
                                           | 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DEP/ACET                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphatic, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                                                                        |             
      Amyloid Deposition                   | 2                                                                        |             
      Hematopoietic Cell Proliferation     | 4                                                                        |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                                   +  +                                +|             
      Amyloid Deposition                   |                                        3                                 |             
      Hematopoietic Cell Proliferation     | 3                                   4  3                                3|             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                                                          |             
      Other, Acanthosis                    | 2        3           3     3  2     3  2        3              3        2|             
      Other, Edema                         |                3        2                                            3   |             
      Other, Exudate                       | X        X           X     X  X     X                          X        X|             
      Other, Hyperkeratosis                | 2                                   2           2              2         |             
      Other, Inflammation, Subacute        | 4        2           4     2  3     4           4              3        4|             
      Other, Ulcer                         | 4        2           3     1  4     4  4        4              3        4|             
      Subcutaneous Tissue, Other, Exudate, |                                                                          |             
           Focal                           |                                     4                                    |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        2                                 |             
      Edema                                |                2                                                         |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          1     2     1  2           1           1              2  2     2|             
      Exudate                              | X              X     X  X                       X                 X  X  X|             
      Hyperkeratosis                       | 2              2     2  2                       2                    2  2|             
      Inflammation, Subacute               |                      1           2              3                 3      |             
      Ulcer                                |                                  2     2        4                 4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4                                                                        |             
      Congestion                           |                                                       2                  |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                         3  2                                      1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3|             
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8|             
                                           | 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DEP/ACET                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                             2            |             
      Leukocytosis                         |                3  3                 2  3                       2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                3        2        2     2  3              1               |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                      2                    3                          3   |             
      Interstitium, Inflammation           |       1                 3  2           2              2  1               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                   +                                    |             
      Cornea, Inflammation, Chronic        | 1                                   2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +                       +                                 |             
      Amyloid Deposition                   |                4                       2                                 |             
      Cortex, Atrophy                      |                                        3                                 |             
      Cortex, Cyst                         |                                        X                                 |             
      Pelvis, Dilatation                   |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Vacuolization Cytoplasmic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9|            |
                                           | 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DEP/ACET                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                            +                    +                 +      |   9        |
      Abscess                              |                                                 4                        |      1  4.0|
      Amyloid Deposition                   |                                                                          |      2  2.0|
      Inflammation, Chronic, Focal         |                            1                                      2      |      3  1.7|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                         M                                                |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   1        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +           +              +  +              +  +                        |   6        |
      Abscess                              |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                  +                                       |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Dilatation                           |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                          +                 +           +               |   6        |
      Dilatation                           | 3                          3                 3                           |      5  3.2|
      Inflammation                         |                                              2           2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |   1        |
      Tunic, Fibrosis                      |                                                                          |      1  3.0|
      Tunic, Inflammation                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +              +  +              +  +        +  +     +           +   |  18        |
      Abscess                              |                                                 4                        |      1  4.0|
      Cyst                                 |                                     X                                    |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9|            |
                                           | 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DEP/ACET                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                     3                                    |      1  3.0|
      Axillary, Hyperplasia                |                   4                    4                                 |      4  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +  +              +  +        +  +     +           +   |  16        |
      Abscess                              |                                                 4                        |      1  4.0|
      Hyperplasia                          |                   4  3              4  4                 4           3   |     14  3.4|
      Lymphatic, Dilatation                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                                                     |   2        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +     +  +  +              +  +        +        +           +   |  13        |
      Amyloid Deposition                   |          3                                                               |      2  3.0|
      Hematopoietic Cell Proliferation     |          3        4  3              3  3        4        4           3   |     12  3.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |                                                 4                        |      1  4.0|
      Other, Acanthosis                    |                   3  2              3  3        2  2     2           2   |     18  2.5|
      Other, Edema                         |                                           3                              |      4  2.8|
      Other, Exudate                       |                   X  X                          X  X     X           X   |     14     |
      Other, Hyperkeratosis                |                   2                    1                                 |      6  1.8|
      Other, Inflammation, Subacute        |                   4  4              4  4        4        4           3   |     16  3.6|
      Other, Ulcer                         |                   4  4              4  4        4  3     3           3   |     18  3.4|
      Subcutaneous Tissue, Other, Exudate, |                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                      2           2  2  2                    2            |     14  1.7|
      Exudate                              |                      X              X  X                                 |     11     |
      Hyperkeratosis                       |                                     1                                    |      8  1.9|
      Inflammation, Subacute               |                      2              2  2                                 |      7  2.1|
      Ulcer                                |                                        3                    2            |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9|            |
                                           | 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DEP/ACET                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      1  2.0|
      Granuloma                            |                                                 2                        |      1  2.0|
      Hemorrhage                           |                         2                 1                              |      5  1.8|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Leukocytosis                         |                                                 2                        |      6  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                2         |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             1                                                  2         |      8  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                  2        2     2        1        2      |      8  2.1|
      Interstitium, Inflammation           | 2                       2  2              3                              |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +  +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +                    +                       +                        |   5        |
      Amyloid Deposition                   |    3                    4                                                |      4  3.3|
      Cortex, Atrophy                      |                                                 3                        |      2  3.0|
      Cortex, Cyst                         |                                                                          |      1     |
      Pelvis, Dilatation                   |    2                    2                                                |      2  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Vacuolization Cytoplasmic       |                                                 4                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/DEP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
      Granuloma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |          +                 +        +  +                       +  +      |             
      Amyloid Deposition                   |          3                                                               |             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |          3                                                        2      |             
      Inflammation, Chronic, Focal         |                                                                2         |             
      Necrosis                             |          2                                                               |             
      Vacuolization Cytoplasmic            |                                     2                                    |             
      Centrilobular, Cytomegaly            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                           +                              |             
      Edema                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                          +         |             
      Abscess                              |                                     4                                    |             
      Dilatation                           |                                                                2         |             
      Inflammation, Chronic                |                                                                3         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +           +     +                                       |             
      Dilatation                           |                2           3     4                                       |             
      Fibrosis                             |                            2                                             |             
                                            __________________________________________________________________________|             
   Testes                                  |                                           +                              |             
      Seminiferous Tubule, Atrophy         |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                             +  +                       +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +                             +                          +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/DEP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |          4                                                        4      |             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Hyperplasia                          |          4                                                        3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                           +                              |             
      Hemorrhage                           |                                           3                              |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +                    +  +  +  +              +           +      |             
      Amyloid Deposition                   |          2                                                        2      |             
      Hematopoietic Cell Proliferation     |          3                    3  2  3  3              2           3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                                                          |             
      Other, Acanthosis                    |          1                    3        3                          3      |             
      Other, Edema                         |                                                          3               |             
      Other, Exudate                       |          X                             X                          X      |             
      Other, Hyperkeratosis                |                                                                   2      |             
      Other, Inflammation, Subacute        |          3                    4        4                          2      |             
      Other, Ulcer                         |          3                    4        3                          4      |             
      Sebaceous Gland, Site of             |                                                                          |             
          Application-Mass, Hyperplasia    |                                                 4                        |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                   2      |             
      Ulcer                                |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3  2  3     2                              |             
      Exudate                              |                               X  X  X                                    |             
      Hyperkeratosis                       |                               2  2  2     2                              |             
      Hyperplasia, Focal, Mast Cell        |                                                       2                  |             
      Inflammation, Subacute               |                               2  4                                       |             
      Ulcer                                |                               2  4  1                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                  2        2                              |             
      Leukocytosis                         |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                   2                          2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/DEP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                          2               |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |       1                                2  3  2                           |             
      Interstitium, Inflammation           |                   2                                   3  3               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cornea, Inflammation, Chronic        |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +              +                 +                    +     +   |             
      Amyloid Deposition                   |          2              4                 3                          3   |             
      Cortex, Cyst                         |                                                                      X   |             
      Pelvis, Dilatation                   |                         2                                      3     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8|            |
                                           | 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/DEP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +                                                      |   1        |
      Granuloma                            |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                             +  +         |   8        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                             X            |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                               +                                          |   1        |
      Edema                                |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                         +              +|   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +                                                            |   1        |
      Inflammation                         |             2                                                            |      1  2.0|
      Spermatocele                         |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +     +                                            +      |   6        |
      Dilatation                           |                3     3                                            3      |      6  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |             +                                                            |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8|            |
                                           | 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/DEP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Atrophy         |             3                                                            |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +        +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                            +                                             |   4        |
      Abscess                              |                                                                          |      2  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                     +                                    |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |   7        |
      Amyloid Deposition                   |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      7  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |                            4                                             |      1  4.0|
      Other, Acanthosis                    |                            2                                             |      6  2.3|
      Other, Edema                         |                                     2                                    |      2  2.5|
      Other, Exudate                       |                                                                          |      3     |
      Other, Hyperkeratosis                |                                                                          |      1  2.0|
      Other, Inflammation, Subacute        |                            3                                             |      5  3.2|
      Other, Ulcer                         |                            4                                             |      6  3.7|
      Sebaceous Gland, Site of             |                                                                          |            |
          Application-Mass, Hyperplasia    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |             3                 3                                          |      6  2.7|
      Exudate                              |             X                 X                                          |      5     |
      Hyperkeratosis                       |             2                                                            |      5  2.0|
      Hyperplasia, Focal, Mast Cell        |                                                                          |      1  2.0|
      Inflammation, Subacute               |             2                 3                                          |      4  2.8|
      Ulcer                                |             2                 4                                          |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8|            |
                                           | 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/DEP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    2                                      3                              |      2  2.5|
      Hemorrhage                           |                   3                                                      |      3  2.3|
      Leukocytosis                         |                                                                2         |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                2                          2                              |      3  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                3  2           2     3  2     1              2            |     11  2.1|
      Interstitium, Inflammation           |                                  2     2                                 |      5  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                     +                             +      |   7        |
      Amyloid Deposition                   |                                     4                                    |      5  3.2|
      Cortex, Cyst                         |                                                                          |      1     |
      Pelvis, Dilatation                   |                                                                   2      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DEP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +              +     +                 +     +              +      |             
      Abscess                              |                            4                                      4      |             
      Amyloid Deposition                   |       2                                                                  |             
      Clear Cell Focus                     |                                              X     X                     |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                      3      |             
      Inflammation, Chronic, Focal         |                            3                 2     2                     |             
      Necrosis                             |                                              2                    4      |             
      Vacuolization Cytoplasmic            |                                              2     2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Necrosis                             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                                                            |             
      Edema                                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +              +                                             |             
      Amyloid Deposition                   |             2              1                                             |             
      Atrium, Thrombosis                   |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                          +                                    |             
      Abscess                              |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +           +                                             |             
      Abscess                              |                4                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +  +                    +                                    |             
      Dilatation                           |             2  2                    3                                    |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                    +                                   +     +|             
      Congestion                           |                                                                   4      |             
      Hyperplasia                          |                                                                   4      |             
      Iliac, Abscess                       |          4                                                               |             
      Iliac, Hyperplasia                   |          4                                                               |             
      Renal, Abscess                       |                                                                   4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +                    +                                          |             
      Hyperplasia                          |          4                    3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                   +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DEP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                   4      |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +                                   +                    +     +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |       3  4                                   3                    4     3|             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                                                   4      |             
      Other, Acanthosis                    |          2           3        3           3                       3      |             
      Other, Edema                         |    2                       3                                             |             
      Other, Exudate                       |          X                                X                              |             
      Other, Hyperkeratosis                |                      2        2           3                              |             
      Other, Inflammation, Subacute        |          3           3     2  3           4                       4      |             
      Other, Ulcer                         |                      4                    4                       4      |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Edema                                |                            3                                             |             
      Exudate                              |          X                                                               |             
      Inflammation, Subacute               |          3                 2                                             |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      1        2  2     2              2              1   |             
      Edema                                |                            3                                             |             
      Exudate                              |          X           X        X  X                    X                  |             
      Hyperkeratosis                       |          2                                            2           2      |             
      Inflammation, Subacute               |                            2  2                       4                  |             
      Ulcer                                |             1                 1                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                                               |             
      Hemorrhage                           |                                     1                             3      |             
      Inflammation, Chronic, Focal         |                                                          2               |             
      Leukocytosis                         |                                                                   4      |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DEP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     2     3                              |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |             4     1  3                                2                  |             
      Interstitium, Inflammation           |       2                    3                                      3      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +                                                              +      |             
      Abscess                              |                                                                   4      |             
      Amyloid Deposition                   |    3                                                              3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +                                                               |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3|            |
                             DAY ON TEST   | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9|            |
                                           | 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DEP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +                    +     +                          +         |  11        |
      Abscess                              |                                                                          |      2  4.0|
      Amyloid Deposition                   | 2                             2                                          |      3  2.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Cyst                                 |                                                                X         |      1     |
      Hematopoietic Cell Proliferation     |          4                                                               |      3  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      3  2.3|
      Necrosis                             |          4                                                               |      3  3.3|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   1        |
      Edema                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                  +                                       |   3        |
      Amyloid Deposition                   |                                  2                                       |      3  1.7|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |          +                                                               |   3        |
      Abscess                              |          4                                                               |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                             +                     |   4        |
      Abscess                              |                      3                             4                     |      3  3.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +                       +     +     +                       +|   9        |
      Dilatation                           |             2                       4     3     3                       2|      8  2.6|
      Inflammation, Subacute               |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +                                                  +   |   8        |
      Congestion                           |                                                                          |      1  4.0|
      Hyperplasia                          |    3                                                                     |      2  3.5|
      Iliac, Abscess                       |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3|            |
                             DAY ON TEST   | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9|            |
                                           | 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DEP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Hyperplasia                   |                                                                          |      1  4.0|
      Renal, Abscess                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                                                                  |   3        |
      Hyperplasia                          |       4                                                                  |      3  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   3        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |                   2                                                      |      1  2.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +     +                                                         |   9        |
      Amyloid Deposition                   |    2                                                                     |      1  2.0|
      Hematopoietic Cell Proliferation     |    3  3  3     3                                                         |      9  3.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |          4                                                               |      2  4.0|
      Other, Acanthosis                    |    2  3  2                    3                    2  2                  |     11  2.5|
      Other, Edema                         |                                                                          |      2  2.5|
      Other, Exudate                       |    X                                               X                     |      4     |
      Other, Hyperkeratosis                |    2                                               2                     |      5  2.2|
      Other, Inflammation, Subacute        |    3  4                       3                    4  4                  |     11  3.4|
      Other, Ulcer                         |    2  4  2                    3                    4  4                  |      9  3.4|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                      1   |      1  1.0|
      Edema                                |                                                                          |      1  3.0|
      Exudate                              |                                                                          |      1     |
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    3        2                 2                                          |      9  1.9|
      Edema                                |                                                                          |      1  3.0|
      Exudate                              |    X     X                    X                                          |      8     |
      Hyperkeratosis                       |    2  2  2                                                               |      6  2.0|
      Inflammation, Subacute               |    4                                                                     |      4  3.0|
      Ulcer                                |    4                          2                                          |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3|            |
                             DAY ON TEST   | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9|            |
                                           | 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DEP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                   3      |      3  2.3|
      Inflammation, Chronic, Focal         | 2                                                                        |      2  2.0|
      Leukocytosis                         |          4                                                               |      2  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                2         |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.5|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |    2  2        1     2                                         2         |      9  2.1|
      Interstitium, Inflammation           |                                        2                    3            |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +                                                            |   5        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   | 3           2                                                            |      4  2.8|
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Pelvis, Dilatation                   | 2        3  2                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                   +                           |   3        |
      Inflammation, Chronic                |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2|             
                             DAY ON TEST   | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9|             
                                           | 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMP/TPA                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                               +                 +           +     +      |             
      Abscess                              |                               4                 4                        |             
      Amyloid Deposition                   |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Necrosis, Focal                      |                                                                   3      |             
      Necrosis                             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Abscess                              |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +     +                          +               |             
      Abscess                              |                         3                                4               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +                                      +      |             
      Abscess                              |                            4                                      4      |             
                                            __________________________________________________________________________|             
   Testes                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +     +        +  +     +  +  +     +        +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |                                              3                    4      |             
      Axillary, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                          |             
      Axillary, Hyperplasia                |          4     4  4              4  4     3           3        3  4  4  4|             
      Inguinal, Hyperplasia                |                                                                          |             
      Mediastinal, Hyperplasia             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +  +  +     +                 +  +                 +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |    4     4  4  4  4     4                 4  4                 3  4  4  4|             
      Hyperplasia, Plasma Cell             |                                              4                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2|             
                             DAY ON TEST   | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9|             
                                           | 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMP/TPA                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +     +     +  +  +     +  +  +        +  +  +  +  +  +|             
      Amyloid Deposition                   |                         2                       2           3  2         |             
      Hematopoietic Cell Proliferation     |    3     3  3  3  3     4     3  3  4     3  3  4        3  3  3  4  3  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                                                          |             
      Other, Acanthosis                    |          3  2  3  1     2     3     2                    3     2  2  2  2|             
      Other, Exudate                       |             X  X        X     X                          X     X     X  X|             
      Other, Hyperkeratosis                |          1  2  2        2                                2     2     1  1|             
      Other, Inflammation, Subacute        |          4  4  4  2     4           3                    4     3  4  4  4|             
      Other, Ulcer                         |          4  4  4        4     4     4                    4     3  4  4  4|             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                             2            |             
      Exudate                              |                                                 X                        |             
      Hyperkeratosis                       |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                             4            |             
      Acanthosis                           | 3  3  2  2  3  2  4  3  2  2     2  2  3  3  3  2  3  3  3  2  2  2  2  2|             
      Exudate                              | X  X  X  X  X     X  X           X  X  X  X  X     X  X  X  X     X  X   |             
      Hyperkeratosis                       | 2  2     2  1     1  3  2  1  3  3  2  2  2  2  2  2  2     2        1  2|             
      Inflammation, Subacute               | 2  4  2  4  3  2  4  4           4  4  2  3  4  2  2  3  3  4     4  2  2|             
      Ulcer                                | 3  4        4     4  4           4  4     3  4        4  4  4     4  2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                      3                                      3            |             
      Hemorrhage                           |                                     2                                    |             
      Leukocytosis                         |                         2                       2                        |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2                 2                    1                              |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                              2                           |             
      Interstitium, Inflammation           | 2     3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2|             
                             DAY ON TEST   | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9|             
                                           | 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMP/TPA                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                       +   |             
      Cornea, Hyperplasia                  |                                                                          |             
      Cornea, Inflammation, Chronic        |                                              3                           |             
      Lids, Cornea, Inflammation, Subacute |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                 +                        |             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Cortex, Atrophy                      |                                                                          |             
      Cortex, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                 3                        |             
      Papilla, Mineralization              |                                                 2                        |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                                                 2                        |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Vacuolization Cytoplasmic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3|            |
                             DAY ON TEST   | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9|            |
                                           | 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMP/TPA                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +                       +                    +  +               |  10        |
      Abscess                              |          4                                                               |      3  4.0|
      Amyloid Deposition                   |    2                             3                                       |      3  2.3|
      Hematopoietic Cell Proliferation     |          2                                                               |      2  2.5|
      Inflammation, Chronic, Focal         |                                  2                       2               |      2  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Necrosis                             |          4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +  +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
      Abscess                              |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
      Abscess                              |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +  +     +  +        +        +  +           +  +  +  +   |  29        |
      Abscess                              |             4                                                            |      1  4.0|
      Hyperplasia                          |             4                                   4           4            |      5  3.8|
      Axillary, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                                3         |      1  3.0|
      Axillary, Hyperplasia                |       3        4  4     4  4                 4              4  4  4  4   |     21  3.8|
      Inguinal, Hyperplasia                |       3           3                                                      |      2  3.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +     +     +  +        +        +              +  +  +      |  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3|            |
                             DAY ON TEST   | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9|            |
                                           | 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMP/TPA                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              |             4     4                 4                                    |      3  4.0|
      Hyperplasia                          |       4     4     4     3  4        3        3              4  4  4      |     22  3.8|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                         +                                                |   1        |
      Hyperplasia                          |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +        +     +  +     +  +  +     +     +  +  +  +   |  34        |
      Amyloid Deposition                   |          1  2                    3  3     2                              |      9  2.2|
      Hematopoietic Cell Proliferation     |       3  4  4  3  4        3        4     3  3  3     4     3  3  3  3   |     33  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Other, Abscess                       |       4                             4                                    |      2  4.0|
      Other, Acanthosis                    |       3     3     3        2     3  3                 2        3  2      |     21  2.4|
      Other, Exudate                       |       X           X        X        X                             X      |     13     |
      Other, Hyperkeratosis                |                   1        2                                      3      |     11  1.7|
      Other, Inflammation, Subacute        |       4     4     4        4        4                 2        4  4      |     19  3.7|
      Other, Ulcer                         |       4     4     4        4     3  4                 3        4  4      |     20  3.9|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      1  2.0|
      Exudate                              |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |    2                                                                     |      2  3.0|
      Acanthosis                           | 2  2  2  1  2  3  1     2  2  2  2  2     2  2  2  3  3  2  3  3  2  2  2|     47  2.3|
      Exudate                              | X              X        X                 X  X  X     X  X  X  X  X  X   |     30     |
      Hyperkeratosis                       | 1  2  2  2  3  2  2     2  1  2     2              2           3     2   |     35  2.0|
      Inflammation, Subacute               | 3     2     2  4        3  2  2           4  4  3  3  4  2  4  2  2  4   |     38  3.0|
      Ulcer                                | 3              4        4  2        2     4  4  4  3  4  4  4        4   |     27  3.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                  +                    +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3|            |
                             DAY ON TEST   | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9|            |
                                           | 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMP/TPA                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Atelectasis                          |                                                          4               |      1  4.0|
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Leukocytosis                         |                                  2  2                 3                  |      5  2.2|
      Alveolar Epithelium, Hyperplasia     |                                                 3                        |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.7|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Interstitium, Inflammation           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +                                               +                  |   5        |
      Cornea, Hyperplasia                  |       3                                                                  |      1  3.0|
      Cornea, Inflammation, Chronic        |       3                                                                  |      2  3.0|
      Lids, Cornea, Inflammation, Subacute |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +                          +              +                     |   4        |
      Abscess                              |          3                                                               |      1  3.0|
      Amyloid Deposition                   |                                     2              2                     |      2  2.0|
      Cortex, Atrophy                      |                                                    4                     |      1  4.0|
      Cortex, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  3.0|
      Papilla, Mineralization              |                                                                          |      1  2.0|
      Papilla, Necrosis                    |                                                    3                     |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis                        |          3                                                               |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Vacuolization Cytoplasmic       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8|             
                                           | 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMP/ACET                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +              +  +                          +  +  +               |             
      Abscess                              |                                                    4                     |             
      Amyloid Deposition                   |                      1  2                             2                  |             
      Hematopoietic Cell Proliferation     |                                                    4  3                  |             
      Inflammation, Chronic, Focal         |       2                                                                  |             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                 +                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                     +                                    |             
      Amyloid Deposition                   |                                     3                                    |             
      Atrium, Thrombosis                   |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                      +   |             
      Cyst                                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                          +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                                                |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                       +  +               |             
      Abscess                              |                                                          4               |             
      Dilatation                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                              M              +     +     +|             
      Dilatation                           |                                                             2     3     3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +     +  +  +        +         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                           +     +  +  +        +         |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                 4  3  4        3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                       +                  |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Hemorrhage                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +                                         +  +  +        +         |             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |       3                                                                  |             
      Hematopoietic Cell Proliferation     |       3                                         3  3  4        3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8|             
                                           | 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMP/ACET                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                                       4                  |             
      Other, Acanthosis                    |       3                 2                    3  3  2  2        3         |             
      Other, Edema                         |                      3  3                                                |             
      Other, Exudate                       |       X                                      X  X  X           X         |             
      Other, Hyperkeratosis                |                         2                    2                 3         |             
      Other, Inflammation, Subacute        |       3                                      3  4  3           4         |             
      Other, Ulcer                         |       3           3                          3  4  3  3        4         |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                    |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2              3     2                 1  2                 3         |             
      Exudate                              |                   X     X                                      X         |             
      Hyperkeratosis                       |                                                                3         |             
      Inflammation, Subacute               |                   2                                                      |             
      Ulcer                                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Congestion                           |                                              2                           |             
      Fibrosis, Focal                      |                                                                          |             
      Foreign Body                         |                                              3                           |             
      Hemorrhage                           |                                        3              2                  |             
      Leukocytosis                         |       3                                                                  |             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   1           2                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           | 1        1        2        1        3                          2  1      |             
      Interstitium, Inflammation           |    2                    2                       2     3                  |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                                            +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8|             
                                           | 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    DMP/ACET                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                       +                        |             
      Cornea, Inflammation, Chronic        |                         3                                                |             
      Cornea, Inflammation, Subacute       |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +  +     +     +                 +     +            |             
      Abscess                              |                                                       4                  |             
      Amyloid Deposition                   |                      3  3           4                 3                  |             
      Pelvis, Dilatation                   |                               3                             2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                         +|             
      Calculus Micro Observation Only      |                                                                         X|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9|            |
                                           | 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMP/ACET                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +     +  +        +           +              +     +            |  14        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   |                   2                    1                                 |      5  1.6|
      Hematopoietic Cell Proliferation     |                                                       4                  |      3  3.7|
      Inflammation, Chronic, Focal         |          1     2  2        2           2                                 |      6  1.8|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   1        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                      +                              |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                    +                     |   2        |
      Edema                                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +              +     +                 +                              |   7        |
      Dilatation                           |    3              2     2                                                |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                   +     +                  |   8        |
      Hyperplasia                          |                                                 2     3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +                                                            |   6        |
      Cyst                                 |             X                                                            |      1     |
      Hyperplasia                          |             3                                                            |      5  3.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9|            |
                                           | 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMP/ACET                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                     A                 +           +      |   7        |
      Amyloid Deposition                   |                                                       2                  |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                       4           3      |      7  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |                                                       4                  |      2  4.0|
      Other, Acanthosis                    |             3                                   3     2           2      |     11  2.5|
      Other, Edema                         |          3                             3                                 |      4  3.0|
      Other, Exudate                       |             X                                   X     X           X      |      9     |
      Other, Hyperkeratosis                |             2                                                            |      4  2.3|
      Other, Inflammation, Subacute        |             2                                         4           3      |      8  3.3|
      Other, Ulcer                         |             3                    4              3     4           2      |     12  3.3|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                       2           2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    1        2                    2                                       |      9  2.0|
      Exudate                              |             X                    X                                       |      5     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Subacute               |             2                                                     2      |      3  2.0|
      Ulcer                                |    2        2                                                            |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                   4      |      1  4.0|
      Congestion                           |                         2              2                             2   |      4  2.0|
      Fibrosis, Focal                      |       2                                                                  |      1  2.0|
      Foreign Body                         |                                                                          |      1  3.0|
      Hemorrhage                           |                               2                                          |      3  2.3|
      Leukocytosis                         |                                     3                                    |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9|            |
                                           | 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    DMP/ACET                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ONE                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                        2     2                           |      4  1.8|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                       1                  |      8  1.5|
      Interstitium, Inflammation           |                                                                          |      4  2.3|
      Pleura, Inflammation, Suppurative    |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                    +              +                        |   5        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
      Cornea, Inflammation, Subacute       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                         +                          +                     |   8        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   |                                                    2                     |      5  3.0|
      Pelvis, Dilatation                   |                         2                          1                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                             A                 +                  |   3        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Congestion                           |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                             DAY ON TEST   | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5|             
                                           | 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/DMP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                  A                                       |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +                          +                          +        +  +   |             
      Abscess                              |                               4                                          |             
      Amyloid Deposition                   |    2                                                                     |             
      Clear Cell Focus, Multiple           |                                                          4               |             
      Cytomegaly                           |                                                          3               |             
      Inflammation, Chronic, Focal         |                               3                                   2  2   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                             +            |             
      Edema                                |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                  +                                   +   |             
      Amyloid Deposition                   |                                  2                                   3   |             
      Atrium, Thrombosis                   |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                       +                  |             
      Amyloid Deposition                   |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +     +     +                                            +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Abscess                              |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                                         +|             
      Hemorrhage                           |                                                                         4|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +                                          |             
      Dilatation                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                                             +            |             
      Amyloid Deposition                   |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                             DAY ON TEST   | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5|             
                                           | 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/DMP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Axillary, Hyperplasia                |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +     +                                    |             
      Hematopoietic Cell Proliferation     |                               3     3                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Acanthosis                    |                                                                      2   |             
      Other, Edema                         |    3                             2           3              2            |             
      Other, Exudate                       |                                                                      X   |             
      Other, Hyperkeratosis                |                                                                          |             
      Other, Inflammation, Subacute        |                                                                      2   |             
      Other, Ulcer                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                             3                       2   |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1     1              1  2              2                              |             
      Edema                                |                                                                          |             
      Exudate                              |                                           X                              |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Subacute               |                                           2                              |             
      Ulcer                                |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                             DAY ON TEST   | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5|             
                                           | 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    DMBA/DMP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |    2     3                 3                                             |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |    3  2                    2        2              2     2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    3     3              2                             2                  |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |       2                          4  1  2     2                           |             
      Interstitium, Inflammation           |       2  3     2        2                          2  3                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +  +                             +  +        +  +            |             
      Amyloid Deposition                   |    3           4                             4  3           3            |             
      Infarct                              |                                              3                           |             
      Nephropathy                          |                                                          2               |             
      Cortex, Cyst                         |                                                 X           X            |             
      Pelvis, Dilatation                   |    2        3                                            3               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                       +                  |             
      Hemorrhage                           |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9|            |
                                           | 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/DMP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                         +           +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                         +           +                                    |   2        |
      Edema                                |                         3           3                                    |      2  3.0|
      Inflammation, Chronic                |                         3                                                |      1  3.0|
      Necrosis                             |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                      +              +              +                     |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                     +                                    |   1        |
      Amyloid Deposition                   |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                      +              +              +                     |   3        |
      Amyloid Deposition                   |                      4              4                                    |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                     +              +                     |   2        |
      Amyloid Deposition                   |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                         +|   6        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Clear Cell Focus, Multiple           |                                                                          |      1  4.0|
      Cytomegaly                           |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                         1|      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                         +           +                                    |   3        |
      Edema                                |                         3           2                                    |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                         +                                                |   3        |
      Amyloid Deposition                   |                         2                                                |      3  2.3|
      Atrium, Thrombosis                   |                         X                                                |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   1        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                  +                                       |   1        |
      Abscess                              |                                  3                                       |      1  3.0|
      Dilatation                           |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9|            |
                                           | 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/DMP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +                                                                  |   3        |
      Dilatation                           |    2  2                                                                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |   1        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +        +      |   2        |
      Hematopoietic Cell Proliferation     |                                                                   4      |      1  4.0|
      Axillary, Hyperplasia                |                                                                   4      |      1  4.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                   +      |   1        |
      Cyst                                 |                                                                   X      |      1     |
      Hyperplasia                          |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                          +               |   1        |
      Cyst                                 |                                                          X               |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                               +                                   +      |   4        |
      Hematopoietic Cell Proliferation     |                               3                                   3      |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Acanthosis                    |    2                          3                                   3      |      4  2.5|
      Other, Edema                         |                                     3                                    |      5  2.6|
      Other, Exudate                       |    X                          X                                   X      |      4     |
      Other, Hyperkeratosis                |                                                                   2      |      1  2.0|
      Other, Inflammation, Subacute        |    3                          4                                   4      |      4  3.3|
      Other, Ulcer                         |    3                          4                                   4      |      3  3.7|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      3  2.3|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |       2                                                           3      |      7  1.7|
      Edema                                |                                     3                                    |      1  3.0|
      Exudate                              |                                                                   X      |      2     |
      Hyperkeratosis                       |       1                                                           1      |      2  1.0|
      Inflammation, Subacute               |       1                                                           2      |      3  1.7|
      Ulcer                                |                               2                                      2   |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3|            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9|            |
                                           | 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    DMBA/DMP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                                              4                           |      1  4.0|
      Congestion                           |                   2  3                             2                     |      6  2.5|
      Fibrosis, Focal                      |                                                       2                  |      1  2.0|
      Hemorrhage                           |    2        2                                               2            |      9  2.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   3                                                      |      5  2.6|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                         3     1                                          |      7  2.1|
      Interstitium, Inflammation           |                   2        2                 2           2              3|     11  2.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                 +           +                                    |  10        |
      Amyloid Deposition                   |                         3           3                                    |      7  3.3|
      Infarct                              |                                                                          |      1  3.0|
      Nephropathy                          |                                                                          |      1  2.0|
      Cortex, Cyst                         |                                     X                                    |      3     |
      Pelvis, Dilatation                   |       2                                                                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +                                                      |   2        |
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|             
                                           | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  A  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                        2     1                           |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Amyloid Deposition           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            1  2  1     1     1  1     2  2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3                 3  4  4  4  3  4  4  4  4     4  4               |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2  3  2     2     2  2     3  3               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2  3  2     2     2        2  2               |             
      Basophilic Focus                     |                         X                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                 3                        |             
      Inflammation, Chronic, Focal         |    2  2                    2  2  2     1     2  2  2  2        2  2      |             
      Karyomegaly                          |                                                                          |             
      Necrosis                             |                                                 2                        |             
      Vacuolization Cytoplasmic            |                   2                                                      |             
      Vacuolization Nuclear                |                                                 3                 3      |             
      Hepatocyte, Hyperplasia              |                                                          2               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        2     2        2  2               |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             2              2  3  3     2        2     3  2               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Glandular       |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2  2        2                                 |             
      Inflammation, Chronic                |                            2                                             |             
      Mucosa, Dilatation                   |                                  2                                       |             
      Mucosa, Hyperplasia                  |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|             
                                           | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                       2                  |             
      Amyloid Deposition                   |    1        3           1  2  3  3     2  2  1  2        2               |             
      Inflammation, Chronic, Focal         |                                                                         1|             
      Atrium, Thrombosis                   |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adrenal Gland, Amyloid Deposition    |                                              4                           |             
      Capsule, Hyperplasia                 |             2  1              2        2     2     2        2        2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             3              2  3  3     4        2     3  4               |             
      Hyperplasia, Focal                   |    2                                                                     |             
      Hypertrophy, Focal                   |                                                                          |             
      Pigmentation                         |    2     2     2  2  2        2  3           3  2  1  2     2     2  3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +|             
      Amyloid Deposition                   |                               2  2     2        1                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                    X                     |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2        3              1  2  3     2     2  2     2  1               |             
      Follicle, Dilatation                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                 +                                                |             
      Abscess                              |       4                 4                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                    |             
      Abscess                              |                                     4                                    |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                          3               |             
      Inflammation, Chronic                |                                        2                                 |             
      Inflammation                         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|             
                                           | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   2        2     1                                   4   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            4           4  2  3  2        1               |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Interstitial Cell, Hyperplasia       |          2           3        2                                          |             
      Seminiferous Tubule, Degeneration    |          4           3     4  3        3  2  3  2        1  1            |             
      Seminiferous Tubule, Giant Cell      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                                 |             
      Axillary, Hyperplasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Cyst                                 |                                           X                              |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hyperplasia                          |    4                                   3  3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                               2  3     2  2  2  2     2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2                                                  2               |             
      Hematopoietic Cell Proliferation     |    3  3  2  3  2  2  1  4  2  2  2  3  2  3  2  2  1  2  2  2  2  2  2  2|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  +  +  M  +  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |    4                    4                                                |             
      Other, Acanthosis                    |    3                             2        2                              |             
      Other, Edema                         |                                                                          |             
      Other, Exudate                       |    X                    X                 X                              |             
      Other, Hyperkeratosis                |                                                                          |             
      Other, Inflammation, Subacute        |    4                    4        2        4                              |             
      Other, Ulcer                         |    4                    4        1        4                              |             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|             
                                           | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2        1                    2     2        2                    1  2|             
      Exudate                              |                                  X     X        X                       X|             
      Hyperkeratosis                       |                                        2        2                       2|             
      Inflammation, Subacute               |    2                             2     2        2                    1  2|             
      Ulcer                                |    2                                   2                                2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |                                  2                                      2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2        3                       2                                    |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |       2                 2              1     2        3                  |             
      Interstitium, Inflammation           |             3              2                                3            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |    2        4              3  3  3     4     3  2     2  4               |             
      Infarct                              |             3                                                            |             
      Nephropathy                          |                   2     2                          1           2  2  2  1|             
      Cortex, Cyst                         |                X  X                                                      |             
      Pelvis, Dilatation                   |                   2  2  2     2  3                          2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|             
                                           | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Calculus Micro Observation Only      |                   X                    X                 X               |             
      Inflammation                         |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8|            |
                                           | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|  46        |
      Amyloid Deposition                   |                                                                          |      2  1.5|
      Edema                                |                                                       3        3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|  45        |
      Edema                                |             3                                         3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cortex, Amyloid Deposition           |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   | 1           2           1  2     1                    2     2  2        2|     17  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   | 3           4        2  4  4     4  4  3     4  3  4  4     4  4     3  3|     28  3.6|
      Hemorrhage                           |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   | 2           3           2  2     2  2        2     4  2     2  2        2|     20  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   | 2           2           2  2                 2  2  2  2                 2|     16  2.1|
      Basophilic Focus                     |                                                             X            |      2     |
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 2  2  2        2  2        2        2  1  2  2     1     2  1  1  2  1   |     28  1.8|
      Karyomegaly                          |                                                                      3   |      1  3.0|
      Necrosis                             |                3                    3                                    |      3  2.7|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Vacuolization Nuclear                |                                                             4        3   |      4  3.3|
      Hepatocyte, Hyperplasia              |                                                             2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                              3        3        2         |      7  2.3|
      Inflammation, Subacute               |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   | 2                                2     2        2  3  4        2        3|     16  2.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mucosa, Hyperplasia, Glandular       |                   3                                                      |      1  3.0|
      Mucosa, Hyperplasia                  |    3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8|            |
                                           | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   |             2                       3        2     2           2        2|      9  2.1|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mucosa, Dilatation                   |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                               3                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      1  2.0|
      Amyloid Deposition                   | 1           2     2     2  2     1  1  2     3  2  3  3     2  3        2|     26  2.0|
      Inflammation, Chronic, Focal         |                1                                                         |      2  1.0|
      Atrium, Thrombosis                   |                                              X        X                  |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Adrenal Gland, Amyloid Deposition    |                                                                          |      1  4.0|
      Capsule, Hyperplasia                 | 1        2     2  2     2           1     2  2  2        1     2     1  1|     22  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   | 3           4     2     3  2     2     2     4  3     3     2  3        3|     21  2.9|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                          2               |      1  2.0|
      Pigmentation                         | 2  2     3        2     2     3        2  2     3        3  1     2      |     26  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  M  M  +  +  M  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M|  34        |
      Amyloid Deposition                   | 2           2           2                       2  3  3     1        1   |     12  1.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   | 1           3           2  1     1  3        2  2  3  2     2  2     2  3|     24  2.0|
      Follicle, Dilatation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                     +                                    |   3        |
      Abscess                              |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8|            |
                                           | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Spermatocele                         |                                                             X            |      1     |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                      +                  |   2        |
      Inflammation, Suppurative            |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                              +                           |   2        |
      Abscess                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                2                                                         |      2  2.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |             3                       3                                    |      6  2.5|
      Inflammation                         |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   | 2                                      3     4                 1        4|     11  2.7|
      Fibrosis                             |                4                                                         |      1  4.0|
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                 3                       3|      5  2.6|
      Seminiferous Tubule, Degeneration    | 3                    3  1              2     4  3           2  2  2  2  4|     21  2.6|
      Seminiferous Tubule, Giant Cell      |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                      3   |      2  3.0|
      Axillary, Hyperplasia                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   |                                                    2                     |      1  2.0|
      Cyst                                 |                                                                      X   |      2     |
      Hematopoietic Cell Proliferation     |                   3                                                      |      2  2.5|
      Hyperplasia                          |       3                                      3                       4   |      6  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Abscess                              | 3                                                                        |      1  3.0|
      Amyloid Deposition                   |                                     1  2              4     2            |     11  2.2|
      Hematopoietic Cell Proliferation     |                                                                2         |      1  2.0|
      Hyperplasia                          |                                        3                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   | 2                          1                 2     2  4              2   |      8  2.1|
      Hematopoietic Cell Proliferation     |    2  3  1  1  4  2  3  2  2  2  2  2  1  1  2  2  2     1  2  2  2  4  2|     47  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8|            |
                                           | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                 1                       2|      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  M  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M|   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Other, Abscess                       |                                                                          |      2  4.0|
      Other, Acanthosis                    |       2           2                          2                       3   |      7  2.3|
      Other, Edema                         |             2                                         3                 3|      3  2.7|
      Other, Exudate                       |       X                                      X                           |      5     |
      Other, Hyperkeratosis                |       1                                                              2   |      2  1.5|
      Other, Inflammation, Subacute        |       4           3                          4                       4   |      8  3.6|
      Other, Ulcer                         |       4           3                          4                       4   |      8  3.5|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                  1                                       |      1  1.0|
      Inflammation, Subacute               |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |       2           2              1              1                        |     11  1.6|
      Exudate                              |       X           X                          X                           |      7     |
      Hyperkeratosis                       |       1                                                                  |      4  1.8|
      Inflammation, Subacute               |       3                                                                  |      7  2.0|
      Ulcer                                |       4           2                          2                           |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thalamus, Mineralization, Focal      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                         2                                                |      1  2.0|
      Congestion                           | 2  2                          3                                3         |      5  2.4|
      Alveolar Epithelium, Hyperplasia     |                         2                    3                           |      4  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                 1                        |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                             DAY ON TEST   | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8|            |
                                           | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    DMP                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |    2                                         4        3        3         |      9  2.4|
      Interstitium, Inflammation           |                                                                   3      |      4  2.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                4                                                         |      1  4.0|
      Amyloid Deposition                   | 3           3     3     2  2     3           4  3  3  3     2  3        3|     23  2.9|
      Infarct                              |                                                                          |      1  3.0|
      Nephropathy                          |    2     2           2        2     2                    1        2  4   |     15  1.9|
      Cortex, Cyst                         |                X  X              X  X           X     X  X               |      9     |
      Pelvis, Dilatation                   | 2        2     3  2              2                             2        3|     13  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Calculus Micro Observation Only      |                                     X        X                       X   |      6     |
      Inflammation                         |                2                                                         |      1  2.0|
      Mucosa, Hyperplasia                  |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|             
                                           | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  M  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Necrosis                     | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Amyloid Deposition                   |       1                          2  1  1  1        2     3     2     1  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Amyloid Deposition                   | 3     4     3        3  3     3  3  3  3  4  4     4           3     3  4|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  A  A  +  +  +  +|             
      Amyloid Deposition                   | 2     2     1        2  2     2  2  1              2           3     2  1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |       2        2                 2        2        2     2           2  2|             
      Cyst Multilocular                    |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |             3           4                                                |             
      Inflammation, Chronic, Focal         | 2  1  1           1  2     1  2     2  2  1     1     2     2     2  1  1|             
      Karyomegaly                          |                                                                          |             
      Necrosis                             | 2                                1                                       |             
      Regeneration, Focal                  |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Centrilobular, Cytomegaly            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2     2           3                     |             
      Hypertrophy, Focal                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2     2        2                 2  2     2              4  4  2     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                  2           2     2        1           1|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|             
                                           | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   | 2     2     2  1     2  2        2  1  1  2  2     2     3  2  2     2  2|             
      Inflammation, Chronic, Focal         |    2                                                     2               |             
      Atrium, Thrombosis                   |                                                                          |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                         2                                                |             
      Capsule, Hyperplasia                 | 2                 1  3     2           3  2        2  2     2     2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3     3        2     2  2     2  4  2     3        3     3  3  2     3  3|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Plasma Cell,  |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Pigmentation                         | 2     2  2        1        1              1  2     2  2     1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  +  +  M  M  M|             
      Amyloid Deposition                   |                                                             1            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Intermedia, Cyst                |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2     2     1        2  2     2  2     1     2     3     3     2     2  1|             
      Follicle, Dilatation                 |                                     3                       3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
      Granuloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |             +                                                            |             
      Abscess                              |             4                                                            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             +           +                                   +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                         +|             
      Inflammation                         |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|             
                                           | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       3           3                                               4     3|             
      Fibrosis                             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3     1                       2  3                                   3   |             
      Interstitial Cell, Hyperplasia       |          1                                2                    1         |             
      Seminiferous Tubule, Degeneration    | 3     2           1        1  2  3        1  3     2        1        3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia                |                                                 3                        |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |             4                                                            |             
      Amyloid Deposition                   |                               2                                          |             
      Cyst                                 |    X                                                                     |             
      Hyperplasia                          |    3     3  3           4                       4        3           4  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  A  A  +  +  M  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |       2              2        2     2     2                    3         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                3                                                         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         2                 1        2     2  2           3|             
      Hematopoietic Cell Proliferation     | 2  4  2  2  3     2  3  4  2  2  1  2  1  2  1  3  3  1  3  3  2  2  3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  +  M  M  M  +  M  M  +  M  M  +  M  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Abscess                       |                                                                          |             
      Other, Acanthosis                    |    3        2           3                       3        2  2        2  2|             
      Other, Edema                         |                                                                          |             
      Other, Exudate                       |    X                    X                       X        X  X        X  X|             
      Other, Hyperkeratosis                |    2                                            2           2        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|             
                                           | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Other, Inflammation, Subacute        |    4        2           4                                3  4        4  4|             
      Other, Ulcer                         |    4     4  3           4                       4        4  4        4  4|             
      Site of Application-Mass, Acanthosis,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3  1           2                       2  1                 2   |             
      Exudate                              |          X                                      X                    X   |             
      Hyperkeratosis                       |          2                                                               |             
      Inflammation, Subacute               |          3  1           2                       2  1              1  1   |             
      Ulcer                                |          2              3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Thalamus, Mineralization, Focal      |          1                                   1        1                 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                      2                                                   |             
      Atelectasis                          |                                                                          |             
      Congestion                           |                3                                                         |             
      Hemorrhage                           |                                                                          |             
      Leukocytosis                         |             4           3                             2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Focal, Squamous                 |          2                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                 1                        |             
      Bronchiole, Inflammation,            |                                                                          |             
          Proliferative                    |                                                    3                     |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                    4                     |             
      Interstitium, Inflammation           | 2                                         3           3                  |             
      Pleura, Fibrosis, Focal              |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|             
                                           | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    ACETONE/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |             4                                               3            |             
      Amyloid Deposition                   | 3     3     2  3     2  2     2  4  2  2  3  2     4     4     2        3|             
      Infiltration Cellular, Plasma Cell   |                                                 3                        |             
      Nephropathy                          |          2        2                                   2           2  3   |             
      Cortex, Cyst                         |                      X                    X     X                        |             
      Pelvis, Dilatation                   |                      2           3                 2           2        2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9|            |
                                           | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  A  +  +  +  +  +|  42        |
      Inflammation, Chronic                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Necrosis                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Amyloid Deposition                   |          2                                                               |      1  2.0|
      Edema                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   |    1     2  1                 2                    3     3               |     16  1.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Amyloid Deposition                   |    3     2  3  3     3        4     3  2  3     4  4  4  3        2      |     29  3.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +|  44        |
      Amyloid Deposition                   |    2     2  2  2              3                 2  3                     |     19  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                            4  4        4                                 |      3  4.0|
      Amyloid Deposition                   |          2     4                                2  2     3               |     13  2.2|
      Cyst Multilocular                    |                                        X                                 |      1     |
      Eosinophilic Focus                   |                                           X                              |      1     |
      Hematopoietic Cell Proliferation     |                3           3  4        2  2              2        2      |      9  2.8|
      Inflammation, Chronic, Focal         | 2     2     2           2        2           2  2     2        2        2|     26  1.7|
      Karyomegaly                          |                   3                                                      |      1  3.0|
      Necrosis                             |                   2        4                                             |      4  2.3|
      Regeneration, Focal                  |                            2                                             |      1  2.0|
      Vacuolization Cytoplasmic            |                         3                                                |      1  3.0|
      Centrilobular, Cytomegaly            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                    2                     |      4  2.3|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |    2     2  3                 4                                          |     14  2.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |          2                    2                                          |      7  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9|            |
                                           | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                  2                                       |      1  2.0|
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
      Necrosis, Focal                      |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                               3                                          |      1  3.0|
      Amyloid Deposition                   |    2     1  2  1              3     2           1  3     1               |     26  1.8|
      Inflammation, Chronic, Focal         |                                        3                                 |      3  2.3|
      Atrium, Thrombosis                   |                                                    X                     |      1     |
      Ventricle, Thrombosis                |                               4                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |       2  3  1           2                 2        1           2     2  2|     21  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |    2     2     3              4     3           3  3     1               |     23  2.7|
      Hyperplasia, Focal                   |                                           2                              |      1  2.0|
      Hypertrophy, Focal                   |                                                             2            |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                        2                                 |      1  2.0|
      Infiltration Cellular, Plasma Cell,  |                                                                          |            |
           Lymphocyte                      |                            4                                             |      1  4.0|
      Pigmentation                         |    2        2     3        2              2           2  1  2  2     2  2|     21  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  M  M  M  M  M  +  +  M  +  M  +  +  M  M  M  M  M  M  +  M  +|  11        |
      Amyloid Deposition                   |                               2                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Amyloid Deposition                   |    2        2                 4                    2                     |     18  2.1|
      Follicle, Dilatation                 |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +           +     +            |   3        |
      Abscess                              |                                                       4                  |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9|            |
                                           | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
      Granuloma                            |                                           4                              |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                           +           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Inflammation                         |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |    2     3                    3                       3                  |      8  3.0|
      Fibrosis                             |                               2                                          |      1  2.0|
      Inflammation                         |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |          2  2        1        3                                          |      9  2.2|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.3|
      Seminiferous Tubule, Degeneration    |    1     2  2        1        3              1           2               |     18  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia                |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia             |                            4  3                                          |      2  3.5|
      Pancreatic, Hyperplasia              |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                3                                                         |      2  3.5|
      Amyloid Deposition                   |    2                                                                     |      2  2.0|
      Cyst                                 |                                                                   X      |      2     |
      Hyperplasia                          |             3  3                    3  4  3           3  3        4      |     16  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Abscess                              |                                                    3                     |      1  3.0|
      Amyloid Deposition                   |    2     2  2  2                    2           2  2     1               |     14  2.0|
      Hematopoietic Cell Proliferation     |                   3                                                      |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9|            |
                                           | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                2                    2           2        2               |     10  2.0|
      Hematopoietic Cell Proliferation     | 2  2  1  2  3  4  2  1  2  4  4  2  3  4  3  2  2  1  3  3  2  2  4  2  2|     48  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M|  43        |
      Cyst                                 |                                           X                              |      1     |
      Hyperplasia                          |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  M  M  M  +  +  M  +  M  M  M  M  M  M  M  M  M  +  M  +  M  M|  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Other, Abscess                       |                            4                             4               |      2  4.0|
      Other, Acanthosis                    |             2  3              3     2  3                 3        2      |     15  2.5|
      Other, Edema                         |                                                    3                     |      1  3.0|
      Other, Exudate                       |             X  X              X     X  X                 X        X      |     14     |
      Other, Hyperkeratosis                |                2                       2                 2               |      7  2.0|
      Other, Inflammation, Subacute        |             3  3           3  4     4  4                 4        3      |     15  3.5|
      Other, Ulcer                         |             4  4              4     3  3                 4        4      |     16  3.8|
      Site of Application-Mass, Acanthosis,|                                                                          |            |
           Focal                           |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 1                          2                                             |      8  1.8|
      Exudate                              | X                                                                        |      4     |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Subacute               | 1                          2                                             |      9  1.6|
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thalamus, Mineralization, Focal      |          1     1        1        2              1                        |      9  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                               4                    4                     |      2  4.0|
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Atelectasis                          |                                  3                                       |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05119-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: INIT/PROMOT                             DIETHYLPHTHALATE/DIMETHYLPHTHALATE                            Date: 04/24/97    
Route: SKIN APPLICATION                                                                                           Time: 17:20:28    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9|            |
                                           | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   CD-1 CRL MICE OUTBRED CHARLES  MALE     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    ACETONE/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    ACETONE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                               2                          2               |      3  2.3|
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Leukocytosis                         |                               4        3                          3      |      6  3.2|
      Alveolar Epithelium, Hyperplasia     |                         2                                            3   |      2  2.5|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Focal, Squamous                 |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                            2           2                             2   |      4  1.8|
      Bronchiole, Inflammation,            |                                                                          |            |
          Proliferative                    |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |          1  2  2                             1     3                     |      6  2.2|
      Interstitium, Inflammation           |                            3        2              3  2  3        2      |      9  2.6|
      Pleura, Fibrosis, Focal              |                                                       2                  |      1  2.0|
      Pleura, Inflammation, Suppurative    |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                    +               |   2        |
      Cornea, Inflammation, Chronic        |                                     2                    2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   1        |
      Inflammation, Chronic                |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                    3                     |      3  3.3|
      Amyloid Deposition                   |    2     2  2  3              3        1  2  2  2  3     2               |     27  2.5|
      Infiltration Cellular, Plasma Cell   |                            3           3                                 |      3  3.0|
      Nephropathy                          | 2     2           2     2                    3        1     1  1        1|     14  1.9|
      Cortex, Cyst                         |                                              X                          X|      5     |
      Pelvis, Dilatation                   |    2     3              2           2        2                 2         |     11  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------