National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3535

TDMS Study 05120-04 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           BENZYL ACETATE


NTP Experiment-Test: 05120-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/16/94
Route: DOSED FEED                                                                                                 Time: 03:33:02




       Facility:  Southern Research Institute

       Chemical CAS #:  140-11-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           16            7            3                                     
    Natural Death                                      9            6            6            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           28           37           44                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (59)         (58)         (59)         (59)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (58)         (58)         (59)         (59)                                   
   Intestine Small, Jejunum                           (58)         (60)         (59)         (59)                                   
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Hepatocellular Carcinoma                         8 (13%)      8 (13%)      5 (8%)       6 (10%)                               
      Hepatocellular Carcinoma, Multiple, Two          1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma, Multiple, Five         1 (2%)                                                                       
      Hepatocellular Adenoma                           6 (10%)      8 (13%)      8 (13%)      7 (12%)                               
      Hepatocellular Adenoma, Multiple, Two            1 (2%)       2 (3%)                    1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Mesentery                                          (9)          (7)          (7)          (3)                                    
      Carcinoma, Metastatic, Pancreas                  1 (11%)                                                                      
      Carcinoma, Metastatic, Intestine Small           1 (11%)                                                                      
      Fibrous Histiocytoma                                          1 (14%)                                                         
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (14%)                                            
      Hemangioma                                       1 (11%)                                                                      
   Pancreas                                           (60)         (60)         (60)         (59)                                   
      Carcinoma                                        1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (2%)                                                          
   Pharynx                                                                      (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       1 (2%)       2 (3%)       1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Tongue                                             (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)         (60)                                   
      Capsule, Adenoma                                              2 (3%)                                                          
      Capsule, Carcinoma                                                         1 (2%)                                             
   Adrenal Gland, Medulla                             (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (59)                                   
      Adenoma                                          3 (5%)       2 (3%)       2 (3%)                                             
   Pituitary Gland                                    (57)         (56)         (60)         (59)                                   
      Pars Distalis, Adenoma                           9 (16%)     11 (20%)      4 (7%)       5 (8%)                                
      Pars Intermedia, Adenoma                                                   1 (2%)       1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Adenoma                                                            1 (2%)                                             
      Follicular Cell, Adenoma                         2 (3%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (58)         (59)         (59)                                   
      Choriocarcinoma                                               1 (2%)                                                          
      Cystadenoma                                      1 (2%)                    1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
      Teratoma Malignant                                                         1 (2%)                                             
   Uterus                                             (60)         (59)         (60)         (60)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma In Situ                                             1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leiomyosarcoma                                                1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal                                    8 (13%)      2 (3%)       1 (2%)       6 (10%)                               
      Sarcoma Stromal                                               1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangiosarcoma                                                            2 (3%)       1 (2%)                                
   Lymph Node                                         (60)         (60)         (60)         (59)                                   
      Axillary, Hepatocellular Carcinoma,                                                                                           
          Metastatic, Liver                            1 (2%)                                                                       
      Mediastinal, Carcinoma, Metastatic, Pancreas     1 (2%)                                                                       
      Mediastinal, Fibrous Histiocytoma                             1 (2%)                                                          
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (2%)                                                                       
      Pancreatic, Histiocytic Sarcoma, Metastatic,                                                                                  
           Uterus                                                   1 (2%)                                                          
      Renal, Fibrous Histiocytoma                                   1 (2%)                                                          
   Lymph Node, Mandibular                             (60)         (58)         (60)         (59)                                   
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (56)         (59)         (58)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (55)         (56)         (56)         (57)                                   
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (60)                                   
   Skin                                               (60)         (60)         (59)         (60)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (3%)       3 (5%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Fibrosarcoma                                                                            1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                             2 (3%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       5 (8%)                    5 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple, Two                                1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (4)          (2)          (1)                                    
      Adenoma                                          3 (100%)     4 (100%)     2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Fibroma                                                                    1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
                                                             Page   5                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Lymphoma Malignant Mixed                         7 (12%)      6 (10%)      6 (10%)      7 (12%)                               
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          40          35          35                                       
     Total Primary Neoplasms                           60          69          57          50                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          29          17          24                                       
     Total Benign Neoplasms                            40          39          26          31                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          24          25          16                                       
     Total Malignant Neoplasms                         20          30          31          19                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5           3           2                                       
     Total Metastatic Neoplasm                         13          11           3           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            3            6            7                                     
    Natural Death                                      4            4            3            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           43           41           39                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (57)         (60)         (58)         (60)                                   
   Intestine Large, Rectum                            (60)         (60)         (60)         (60)                                   
   Intestine Small, Jejunum                           (60)         (59)         (60)         (59)                                   
      Carcinoma                                        3 (5%)       1 (2%)       1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangiosarcoma                                               2 (3%)       1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma                         8 (13%)     10 (17%)      9 (15%)      5 (8%)                                
      Hepatocellular Carcinoma, Multiple, Two          1 (2%)       4 (7%)       1 (2%)       3 (5%)                                
      Hepatocellular Carcinoma, Multiple, Three        3 (5%)                                                                       
      Hepatocellular Carcinoma, Multiple, Five                                   1 (2%)                                             
      Hepatocellular Adenoma                          10 (17%)     12 (20%)      7 (12%)      2 (3%)                                
      Hepatocellular Adenoma, Multiple, Two            1 (2%)       1 (2%)       3 (5%)                                             
      Hepatocellular Adenoma, Multiple, Three                       1 (2%)                                                          
   Mesentery                                          (3)          (3)          (2)          (1)                                    
      Cholangiocarcinoma, Metastatic, Liver            1 (33%)                                                                      
   Pancreas                                           (60)         (60)         (60)         (60)                                   
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          3 (5%)       4 (7%)       1 (2%)       2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)         (60)                                   
      Adenoma                                          2 (3%)       1 (2%)       1 (2%)                                             
      Capsule, Adenoma                                 3 (5%)       2 (3%)                    1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Adenoma                                                       2 (3%)       3 (5%)                                             
   Pituitary Gland                                    (58)         (59)         (58)         (57)                                   
      Pars Distalis, Adenoma                           3 (5%)                                 1 (2%)                                
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Follicular Cell, Adenoma                         2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
   Preputial Gland                                    (38)         (42)         (35)         (25)                                   
   Prostate                                           (60)         (60)         (60)         (60)                                   
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
   Testes                                             (60)         (60)         (60)         (60)                                   
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               2 (3%)       1 (2%)       2 (3%)                                
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
   Lymph Node, Mandibular                             (58)         (56)         (60)         (59)                                   
   Lymph Node, Mesenteric                             (58)         (59)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
                                                             Page   9                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               2 (3%)       2 (3%)       1 (2%)                                
   Thymus                                             (52)         (55)         (57)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               2 (3%)                    1 (2%)                                
      Osteosarcoma                                                               1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    10 (17%)     14 (23%)      8 (13%)      6 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple, Two                   1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   5 (8%)       3 (5%)       1 (2%)       3 (5%)                                
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)                    2 (3%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (2)          (6)          (5)                                    
      Adenoma                                          4 (100%)     2 (100%)     6 (100%)     5 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
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         B6C3F1 MICE MALE                          0%           .033%        .1%          .3%                                       
                                                                                                                                    
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
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 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant Lymphocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Mixed                         1 (2%)       3 (5%)       2 (3%)                                             
      Mesothelioma Malignant                                                                  1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/16/94  
Route: DOSED FEED                                                                                                 Time: 03:33:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0%           .033%        .1%          .3%                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          41          38          25                                       
     Total Primary Neoplasms                           65          74          58          39                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          28          24          17                                       
     Total Benign Neoplasms                            38          43          33          18                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          21          20          15                                       
     Total Malignant Neoplasms                         27          31          25          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1           4                                       
     Total Metastatic Neoplasm                          3           1           1           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.