https://ntp.niehs.nih.gov/go/3537

TDMS Study 05120-04 Pathology Tables


NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  BENZYL ACETATE                                    DATE: 09/16/94       
EXPERIMENT: 05120 TEST: 04                                                                                     TIME: 03:57:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55082          ROUTE: DOSED FEED                                                                  NTP C#: 06508B       
PATHOLOGIST: JAMES HEATH                     SCOT EUSTIS                                                       CAS: 140-11-4        
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                  BENZYL ACETATE                                    DATE: 09/16/94      
EXPERIMENT: 05120 TEST: 04                                                                                     TIME: 03:57:58      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-55082          ROUTE: DOSED FEED                                                                  NTP C#: 06508B      
PATHOLOGIST: JAMES HEATH                     SCOT EUSTIS                                                       CAS: 140-11-4       
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                    ----------------
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  BENZYL ACETATE                                    DATE: 09/16/94       
EXPERIMENT: 05120 TEST: 04                                                                                     TIME: 03:57:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55082          ROUTE: DOSED FEED                                                                  NTP C#: 06508B       
PATHOLOGIST: JAMES HEATH                     SCOT EUSTIS                                                       CAS: 140-11-4        
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF BENZYL ACETATE
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             All Organs                    Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Uterus                        Polyp Stromal
                                                           Sarcoma Stromal or Polyp Stromal
                             All Organs                    Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    3/60 (5%)    1/60 (2%)    1/60 (2%)  |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.9%         7.0%         2.4%         2.6%      |   0.0%         6.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/39 (10%)   3/43 (7%)    1/41 (2%)    1/39 (3%)  |  0/29 (0%)    0/28 (0%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   457 (I)      729 (T)      729 (T)      729 (T)   |   ---          723          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.095N     P=0.312N     P=0.096N     P=0.105N   |  P=0.305N     P=0.238        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.095N     P=0.312N     P=0.096N     P=0.105N   |  P=0.897N     P=0.348        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.091N     P=0.349N     P=0.102N     P=0.104N   |  P=0.333N     P=0.247        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.090N                                          |  P=0.379N                                          |
|FISHER EXACT           |               P=0.359N     P=0.103N     P=0.103N   |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         4.2%         0.0%         2.4%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/43 (0%)    0/41 (0%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          562          ---          701       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.610      P=0.244        (e)        P=0.495    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.645      P=0.288        (e)        P=0.536    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.673      P=0.224        (e)        P=0.500    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.615                                           |    (e)                                             |
|FISHER EXACT           |               P=0.248        (e)        P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/60 (2%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         4.2%         2.0%         4.5%      |   0.0%         0.0%         5.4%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/43 (0%)    0/41 (0%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    2/37 (5%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          562          618          584       |   ---          ---          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.310      P=0.244      P=0.513      P=0.240    |  P=0.476        (e)        P=0.293      P=0.583    |
|INCIDENTAL TUMOR       |  P=0.292      P=0.288      P=0.602      P=0.260    |  P=0.476        (e)        P=0.293      P=0.583    |
|LOGISTIC REGRESSION    |  P=0.370      P=0.224      P=0.491      P=0.237    |  P=0.476        (e)        P=0.293      P=0.583    |
|COCHRAN-ARMITAGE       |  P=0.314                                           |  P=0.354                                           |
|FISHER EXACT           |               P=0.248      P=0.500      P=0.248    |                 (e)        P=0.248      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    2/60 (3%)    6/60 (10%)   5/60 (8%)  |  3/60 (5%)    4/60 (7%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   9.9%         4.7%        13.8%        11.9%      |   8.3%        13.3%         5.2%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/39 (8%)    2/43 (5%)    4/41 (10%)   2/39 (5%)  |  1/29 (3%)    2/28 (7%)    1/37 (3%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   724          729 (T)      708          683       |   600          723          723          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.288      P=0.298N     P=0.400      P=0.495    |  P=0.085N     P=0.501      P=0.400N     P=0.220N   |
|INCIDENTAL TUMOR       |  P=0.415      P=0.365N     P=0.347      P=0.553    |  P=0.259N     P=0.542      P=0.537N     P=0.467N   |
|LOGISTIC REGRESSION    |  P=0.292      P=0.314N     P=0.391      P=0.493    |  P=0.129N     P=0.514      P=0.463N     P=0.287N   |
|COCHRAN-ARMITAGE       |  P=0.313                                           |  P=0.165N                                          |
|FISHER EXACT           |               P=0.340N     P=0.372      P=0.500    |               P=0.500      P=0.500N     P=0.309N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.9%         2.3%         2.4%         0.0%      |   2.7%         2.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/43 (2%)    1/41 (2%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   458 (I)      729 (T)      729 (T)      ---       |   656          628          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120N     P=0.281N     P=0.294N     P=0.123N   |  P=0.286N     P=0.738N     P=0.452N     P=0.465N   |
|INCIDENTAL TUMOR       |  P=0.120N     P=0.281N     P=0.294N     P=0.123N   |  P=0.476N     P=0.735      P=0.436N       (e)      |
|LOGISTIC REGRESSION    |  P=0.116N     P=0.307N     P=0.308N     P=0.122N   |  P=0.308N     P=0.762      P=0.500N     P=0.499N   |
|COCHRAN-ARMITAGE       |  P=0.116N                                          |  P=0.305N                                          |
|FISHER EXACT           |               P=0.309N     P=0.309N     P=0.122N   |               P=0.752N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.9%         2.3%         2.4%         0.0%      |   2.7%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/43 (2%)    1/41 (2%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   458 (I)      729 (T)      729 (T)      ---       |   656          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120N     P=0.281N     P=0.294N     P=0.123N   |  P=0.451N     P=0.484N     P=0.452N     P=0.465N   |
|INCIDENTAL TUMOR       |  P=0.120N     P=0.281N     P=0.294N     P=0.123N   |  P=0.904N     P=0.403N     P=0.436N       (e)      |
|LOGISTIC REGRESSION    |  P=0.116N     P=0.307N     P=0.308N     P=0.122N   |  P=0.471N     P=0.500N     P=0.500N     P=0.499N   |
|COCHRAN-ARMITAGE       |  P=0.116N                                          |  P=0.472N                                          |
|FISHER EXACT           |               P=0.309N     P=0.309N     P=0.122N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    3/59 (5%)    0/60 (0%)  |  3/60 (5%)    2/60 (3%)    2/60 (3%)    0/59 (0%)  |
|ADJUSTED (b)           |   0.0%         4.7%         7.2%         0.0%      |   8.8%         7.1%         4.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    2/43 (5%)    2/40 (5%)    0/39 (0%)  |  2/29 (7%)    2/28 (7%)    1/37 (3%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      711          ---       |   533          729 (T)      702          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.399N     P=0.260      P=0.129        (e)      |  P=0.054N     P=0.517N     P=0.398N     P=0.079N   |
|INCIDENTAL TUMOR       |  P=0.362N     P=0.260      P=0.113        (e)      |  P=0.101N     P=0.529N     P=0.596N     P=0.139N   |
|LOGISTIC REGRESSION    |  P=0.395N     P=0.260      P=0.123        (e)      |  P=0.085N     P=0.492N     P=0.467N     P=0.120N   |
|COCHRAN-ARMITAGE       |  P=0.385N                                          |  P=0.101N                                          |
|FISHER EXACT           |               P=0.248      P=0.119        (e)      |               P=0.500N     P=0.500N     P=0.125N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         4.2%         2.1%         2.1%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/43 (0%)    0/41 (0%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          562          620          584       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.613      P=0.244      P=0.509      P=0.504    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.590      P=0.288      P=0.602      P=0.500    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.614      P=0.224      P=0.492      P=0.496    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.614                                           |    (e)                                             |
|FISHER EXACT           |               P=0.248      P=0.500      P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/60 (18%)  14/60 (23%)  10/60 (17%)   2/60 (3%)  |  7/60 (12%)  10/60 (17%)   8/60 (13%)   8/60 (13%) |
|ADJUSTED (b)           |  26.3%        31.5%        21.8%         4.2%      |  20.8%        28.5%        19.8%        17.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   2/10 (20%)   1/10 (10%) |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  9/39 (23%)  13/43 (30%)   7/41 (17%)   1/39 (3%)  |  5/29 (17%)   6/28 (21%)   6/37 (16%)   6/44 (14%) |
|FIRST INCIDENCE (DAYS) |   458 (I)      458 (I)      457 (I)      456 (I)   |   456 (I)      507          458 (I)      544       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003N**   P=0.418      P=0.460N     P=0.010N** |  P=0.235N     P=0.297      P=0.545N     P=0.455N   |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.378      P=0.483N     P=0.009N** |  P=0.528N     P=0.331      P=0.539N     P=0.532    |
|LOGISTIC REGRESSION    |  P=0.002N**   P=0.345      P=0.483N     P=0.009N** |  P=0.486N     P=0.304      P=0.566      P=0.553    |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.537N                                          |
|FISHER EXACT           |               P=0.327      P=0.500N     P=0.008N** |               P=0.301      P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/60 (20%)  14/60 (23%)  11/60 (18%)   8/60 (13%) | 10/60 (17%)   8/60 (13%)   6/60 (10%)   7/60 (12%) |
|ADJUSTED (b)           |  26.6%        29.6%        24.7%        18.5%      |  27.0%        20.9%        14.1%        15.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  7/39 (18%)  10/43 (23%)   8/41 (20%)   5/39 (13%) |  4/29 (14%)   3/28 (11%)   3/37 (8%)    7/44 (16%) |
|FIRST INCIDENCE (DAYS) |   508          508          618          584       |   520          507          568          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.155N     P=0.497      P=0.454N     P=0.241N   |  P=0.121N     P=0.387N     P=0.106N     P=0.107N   |
|INCIDENTAL TUMOR       |  P=0.098N     P=0.275      P=0.577      P=0.236N   |  P=0.493N     P=0.470N     P=0.338N     P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.088N     P=0.413      P=0.434N     P=0.154N   |  P=0.505N     P=0.463N     P=0.371N     P=0.220N   |
|COCHRAN-ARMITAGE       |  P=0.125N                                          |  P=0.315N                                          |
|FISHER EXACT           |               P=0.412      P=0.500N     P=0.232N   |               P=0.399N     P=0.211N     P=0.301N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/60 (38%)  23/60 (38%)  20/60 (33%)  10/60 (17%) | 15/60 (25%)  15/60 (25%)  14/60 (23%)  14/60 (23%) |
|ADJUSTED (b)           |  49.5%        47.6%        41.9%        22.2%      |  38.5%        39.6%        32.3%        30.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   2/10 (20%)   1/10 (10%) |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 16/39 (41%)  18/43 (42%)  14/41 (34%)   6/39 (15%) |  7/29 (24%)   8/28 (29%)   9/37 (24%)  12/44 (27%) |
|FIRST INCIDENCE (DAYS) |   458 (I)      458 (I)      457 (I)      456 (I)   |   456 (I)      507          458 (I)      544       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005N**   P=0.443N     P=0.302N     P=0.010N*  |  P=0.120N     P=0.567N     P=0.260N     P=0.171N   |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.490      P=0.427N     P=0.007N** |  P=0.535      P=0.546      P=0.519N     P=0.468    |
|LOGISTIC REGRESSION    |  P=0.002N**   P=0.552N     P=0.322N     P=0.004N** |  P=0.500      P=0.529      P=0.421N     P=0.412N   |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.457N                                          |
|FISHER EXACT           |               P=0.574N     P=0.352N     P=0.007N** |               P=0.583N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/60 (38%)  23/60 (38%)  20/60 (33%)  10/60 (17%) | 15/60 (25%)  15/60 (25%)  14/60 (23%)  14/60 (23%) |
|ADJUSTED (b)           |  49.5%        47.6%        41.9%        22.2%      |  38.5%        39.6%        32.3%        30.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   2/10 (20%)   1/10 (10%) |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 16/39 (41%)  18/43 (42%)  14/41 (34%)   6/39 (15%) |  7/29 (24%)   8/28 (29%)   9/37 (24%)  12/44 (27%) |
|FIRST INCIDENCE (DAYS) |   458 (I)      458 (I)      457 (I)      456 (I)   |   456 (I)      507          458 (I)      544       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005N**   P=0.443N     P=0.302N     P=0.010N*  |  P=0.120N     P=0.567N     P=0.260N     P=0.171N   |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.490      P=0.427N     P=0.007N** |  P=0.535      P=0.546      P=0.519N     P=0.468    |
|LOGISTIC REGRESSION    |  P=0.002N**   P=0.552N     P=0.322N     P=0.004N** |  P=0.500      P=0.529      P=0.421N     P=0.412N   |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.457N                                          |
|FISHER EXACT           |               P=0.574N     P=0.352N     P=0.007N** |               P=0.583N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)  15/60 (25%)   8/60 (13%)   6/60 (10%) |  1/60 (2%)    5/60 (8%)    1/60 (2%)    5/60 (8%)  |
|ADJUSTED (b)           |  23.3%        33.9%        17.6%        15.4%      |   3.4%        15.3%         2.6%        10.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  7/39 (18%)  14/43 (33%)   5/41 (12%)   6/39 (15%) |  1/29 (3%)    3/28 (11%)   0/37 (0%)    3/44 (7%)  |
|FIRST INCIDENCE (DAYS) |   458 (I)      508          457 (I)      729 (T)   |   729 (T)      628          723          456 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.074N     P=0.256      P=0.367N     P=0.214N   |  P=0.330      P=0.109      P=0.703N     P=0.185    |
|INCIDENTAL TUMOR       |  P=0.055N     P=0.159      P=0.412N     P=0.196N   |  P=0.167      P=0.085      P=0.697N     P=0.150    |
|LOGISTIC REGRESSION    |  P=0.062N     P=0.196      P=0.380N     P=0.209N   |  P=0.193      P=0.111      P=0.695N     P=0.104    |
|COCHRAN-ARMITAGE       |  P=0.061N                                          |  P=0.176                                           |
|FISHER EXACT           |               P=0.184      P=0.399N     P=0.211N   |               P=0.103      P=0.752N     P=0.103    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    3/60 (5%)    1/60 (2%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  12.1%         7.0%         2.4%         6.8%      |   0.0%         0.0%         2.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/39 (10%)   3/43 (7%)    1/41 (2%)    1/39 (3%)  |  0/29 (0%)    0/28 (0%)    1/37 (3%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   508          729 (T)      729 (T)      457 (I)   |   ---          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.419N     P=0.310N     P=0.095N     P=0.361N   |  P=0.719N       (e)        P=0.549        (e)      |
|INCIDENTAL TUMOR       |  P=0.397N     P=0.377N     P=0.165N     P=0.374N   |  P=0.719N       (e)        P=0.549        (e)      |
|LOGISTIC REGRESSION    |  P=0.402N     P=0.347N     P=0.100N     P=0.357N   |  P=0.720N       (e)        P=0.549        (e)      |
|COCHRAN-ARMITAGE       |  P=0.400N                                          |  P=0.785N                                          |
|FISHER EXACT           |               P=0.359N     P=0.103N     P=0.359N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  17/60 (28%)   9/60 (15%)   8/60 (13%) |  1/60 (2%)    5/60 (8%)    2/60 (3%)    5/60 (8%)  |
|ADJUSTED (b)           |  34.2%        38.5%        19.9%        19.1%      |   3.4%        15.3%         5.2%        10.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           | 11/39 (28%)  16/43 (37%)   6/41 (15%)   6/39 (15%) |  1/29 (3%)    3/28 (11%)   1/37 (3%)    3/44 (7%)  |
|FIRST INCIDENCE (DAYS) |   458 (I)      508          457 (I)      457 (I)   |   729 (T)      628          723          456 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.042N*    P=0.532      P=0.112N     P=0.088N   |  P=0.361      P=0.109      P=0.586      P=0.185    |
|INCIDENTAL TUMOR       |  P=0.028N*    P=0.370      P=0.173N     P=0.080N   |  P=0.197      P=0.085      P=0.593      P=0.150    |
|LOGISTIC REGRESSION    |  P=0.032N*    P=0.443      P=0.114N     P=0.080N   |  P=0.212      P=0.111      P=0.608      P=0.104    |
|COCHRAN-ARMITAGE       |  P=0.032N*                                         |  P=0.190                                           |
|FISHER EXACT           |               P=0.418      P=0.127N     P=0.082N   |               P=0.103      P=0.500      P=0.103    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/58 (5%)    0/59 (0%)    0/58 (0%)    1/57 (2%)  |  9/58 (16%)  11/56 (20%)   4/60 (7%)    5/59 (8%)  |
|ADJUSTED (b)           |   7.9%         0.0%         0.0%         2.6%      |  29.0%        36.3%        10.8%        10.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/38 (8%)    0/43 (0%)    0/39 (0%)    1/39 (3%)  |  7/29 (24%)   9/27 (33%)   4/37 (11%)   4/44 (9%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          ---          729 (T)   |   722          521          729 (T)      544       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.451N     P=0.100N     P=0.116N     P=0.296N   |  P=0.014N*    P=0.345      P=0.047N*    P=0.051N   |
|INCIDENTAL TUMOR       |  P=0.451N     P=0.100N     P=0.116N     P=0.296N   |  P=0.037N*    P=0.334      P=0.044N*    P=0.202N   |
|LOGISTIC REGRESSION    |  P=0.451N     P=0.100N     P=0.116N     P=0.296N   |  P=0.040N*    P=0.370      P=0.033N*    P=0.104N   |
|COCHRAN-ARMITAGE       |  P=0.451N                                          |  P=0.082N                                          |
|FISHER EXACT           |               P=0.119N     P=0.122N     P=0.316N   |               P=0.370      P=0.107N     P=0.187N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/58 (5%)    0/59 (0%)    1/58 (2%)    1/57 (2%)  |  9/58 (16%)  11/56 (20%)   4/60 (7%)    5/59 (8%)  |
|ADJUSTED (b)           |   7.9%         0.0%         2.0%         2.6%      |  29.0%        36.3%        10.8%        10.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/38 (8%)    0/43 (0%)    0/39 (0%)    1/39 (3%)  |  7/29 (24%)   9/27 (33%)   4/37 (11%)   4/44 (9%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          571          729 (T)   |   722          521          729 (T)      544       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.444N     P=0.100N     P=0.294N     P=0.296N   |  P=0.014N*    P=0.345      P=0.047N*    P=0.051N   |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.100N     P=0.224N     P=0.296N   |  P=0.037N*    P=0.334      P=0.044N*    P=0.202N   |
|LOGISTIC REGRESSION    |  P=0.443N     P=0.100N     P=0.301N     P=0.296N   |  P=0.040N*    P=0.370      P=0.033N*    P=0.104N   |
|COCHRAN-ARMITAGE       |  P=0.445N                                          |  P=0.082N                                          |
|FISHER EXACT           |               P=0.119N     P=0.309N     P=0.316N   |               P=0.370      P=0.107N     P=0.187N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    2/60 (3%)    3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         6.0%         7.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/43 (0%)    0/41 (0%)    0/39 (0%)  |  0/29 (0%)    1/28 (4%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          656          712          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.284N     P=0.244      P=0.182        (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.647      P=0.288      P=0.172        (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.342N     P=0.242      P=0.163        (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.385N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.248      P=0.122        (e)      |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.4%         2.1%         4.4%         0.0%      |   0.0%         0.0%         2.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/43 (0%)    1/41 (2%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   725          589          618          ---       |   ---          ---          722          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.340N     P=0.753N     P=0.516      P=0.505N   |  P=0.733N       (e)        P=0.556        (e)      |
|INCIDENTAL TUMOR       |  P=0.311N     P=0.703      P=0.538      P=0.464N   |  P=0.884        (e)        P=0.564        (e)      |
|LOGISTIC REGRESSION    |  P=0.332N     P=0.761      P=0.506      P=0.503N   |  P=0.759N       (e)        P=0.553        (e)      |
|COCHRAN-ARMITAGE       |  P=0.332N                                          |  P=0.785N                                          |
|FISHER EXACT           |               P=0.752N     P=0.500      P=0.500N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         4.2%         4.4%         2.1%      |   0.0%         0.0%         2.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/43 (0%)    1/41 (2%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    1/37 (3%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          562          618          584       |   ---          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.610      P=0.244      P=0.252      P=0.504    |  P=0.719N       (e)        P=0.549        (e)      |
|INCIDENTAL TUMOR       |  P=0.588      P=0.288      P=0.301      P=0.500    |  P=0.719N       (e)        P=0.549        (e)      |
|LOGISTIC REGRESSION    |  P=0.628N     P=0.224      P=0.239      P=0.496    |  P=0.720N       (e)        P=0.549        (e)      |
|COCHRAN-ARMITAGE       |  P=0.615                                           |  P=0.785N                                          |
|FISHER EXACT           |               P=0.248      P=0.248      P=0.500    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    1/60 (2%)    3/60 (5%)  |  0/60 (0%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   7.3%         8.8%         2.4%         6.3%      |   0.0%         3.6%         5.4%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    3/43 (7%)    1/41 (2%)    0/39 (0%)  |  0/29 (0%)    1/28 (4%)    2/37 (5%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   670          508          729 (T)      457 (I)   |   ---          729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.558N     P=0.541      P=0.292N     P=0.659    |  P=0.635      P=0.493      P=0.293      P=0.583    |
|INCIDENTAL TUMOR       |  P=0.480N     P=0.393      P=0.313N     P=0.623N   |  P=0.635      P=0.493      P=0.293      P=0.583    |
|LOGISTIC REGRESSION    |  P=0.544N     P=0.506      P=0.293N     P=0.615N   |  P=0.635      P=0.493      P=0.293      P=0.583    |
|COCHRAN-ARMITAGE       |  P=0.544N                                          |  P=0.500                                           |
|FISHER EXACT           |               P=0.500      P=0.309N     P=0.660N   |               P=0.500      P=0.248      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    1/60 (2%)    2/60 (3%)  |  0/60 (0%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   7.3%         8.8%         2.4%         4.1%      |   0.0%         3.6%         5.4%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    3/43 (7%)    1/41 (2%)    0/39 (0%)  |  0/29 (0%)    1/28 (4%)    2/37 (5%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   670          508          729 (T)      457 (I)   |   ---          729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.352N     P=0.541      P=0.292N     P=0.500N   |  P=0.635      P=0.493      P=0.293      P=0.583    |
|INCIDENTAL TUMOR       |  P=0.310N     P=0.393      P=0.313N     P=0.467N   |  P=0.635      P=0.493      P=0.293      P=0.583    |
|LOGISTIC REGRESSION    |  P=0.338N     P=0.506      P=0.293N     P=0.501N   |  P=0.635      P=0.493      P=0.293      P=0.583    |
|COCHRAN-ARMITAGE       |  P=0.338N                                          |  P=0.500                                           |
|FISHER EXACT           |               P=0.500      P=0.309N     P=0.500N   |               P=0.500      P=0.248      P=0.500    |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.1%         2.3%         4.9%         2.6%      |   5.1%         0.0%         0.0%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/43 (2%)    2/41 (5%)    1/39 (3%)  |  1/29 (3%)    0/28 (0%)    0/37 (0%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      729 (T)   |   457 (I)      ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.493N     P=0.466N     P=0.677N     P=0.500N   |  P=0.564N     P=0.244N     P=0.213N     P=0.404N   |
|INCIDENTAL TUMOR       |  P=0.493N     P=0.466N     P=0.677N     P=0.500N   |  P=0.564N     P=0.244N     P=0.213N     P=0.404N   |
|LOGISTIC REGRESSION    |  P=0.493N     P=0.466N     P=0.677N     P=0.500N   |  P=0.652N     P=0.227N     P=0.243N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.477N                                          |  P=0.646N                                          |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500N   |               P=0.248N     P=0.248N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  8/60 (13%)   2/60 (3%)    1/60 (2%)    6/60 (10%) |
|ADJUSTED (b)           |                                                    |  25.2%         7.1%         2.7%        13.6%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  6/29 (21%)   2/28 (7%)    1/37 (3%)    6/44 (14%) |
|FIRST INCIDENCE (DAYS) |                                                    |   656          729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.411N     P=0.050N     P=0.006N**   P=0.139N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.529N     P=0.036N*    P=0.006N**   P=0.319N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.547N     P=0.038N*    P=0.006N**   P=0.223N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.478                                           |
|FISHER EXACT           |                                                    |               P=0.047N*    P=0.016N*    P=0.389N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/60 (0%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         2.2%         4.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/29 (0%)    0/28 (0%)    1/37 (3%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          544          457 (I)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.469N     P=0.504      P=0.266        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.619N     P=0.464      P=0.266        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.541N     P=0.528      P=0.231        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.516N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.248        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  8/60 (13%)   3/60 (5%)    3/60 (5%)    6/60 (10%) |
|ADJUSTED (b)           |                                                    |  25.2%         9.2%         7.0%        13.6%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  6/29 (21%)   2/28 (7%)    2/37 (5%)    6/44 (14%) |
|FIRST INCIDENCE (DAYS) |                                                    |   656          544          457 (I)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.333N     P=0.106N     P=0.048N*    P=0.139N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.492N     P=0.087N     P=0.046N*    P=0.319N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.535N     P=0.090N     P=0.070N     P=0.223N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.553                                           |
|FISHER EXACT           |                                                    |               P=0.102N     P=0.102N     P=0.389N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         2.3%         0.0%         0.0%      |   6.9%         3.6%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    1/43 (2%)    0/41 (0%)    0/39 (0%)  |  2/29 (7%)    1/28 (4%)    0/37 (0%)    0/44 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      ---          ---       |   729 (T)      729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.592N     P=0.519        (e)          (e)      |  P=0.113N     P=0.512N     P=0.186N     P=0.152N   |
|INCIDENTAL TUMOR       |  P=0.592N     P=0.519        (e)          (e)      |  P=0.113N     P=0.512N     P=0.186N     P=0.152N   |
|LOGISTIC REGRESSION    |  P=0.592N     P=0.519        (e)          (e)      |  P=0.113N     P=0.512N     P=0.186N     P=0.152N   |
|COCHRAN-ARMITAGE       |  P=0.584N                                          |  P=0.169N                                          |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.500N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    5/60 (8%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    4/60 (7%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.9%         4.2%        11.1%         4.5%      |   0.0%         0.0%        10.3%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    0/43 (0%)    3/41 (7%)    0/39 (0%)  |  0/29 (0%)    0/28 (0%)    3/37 (8%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   725          562          618          584       |   ---          ---          722          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.592N     P=0.675N     P=0.242      P=0.689    |  P=0.562        (e)        P=0.101      P=0.583    |
|INCIDENTAL TUMOR       |  P=0.572N     P=0.687      P=0.276      P=0.663N   |  P=0.442        (e)        P=0.103      P=0.583    |
|LOGISTIC REGRESSION    |  P=0.492N     P=0.704N     P=0.226      P=0.694N   |  P=0.525        (e)        P=0.108      P=0.583    |
|COCHRAN-ARMITAGE       |  P=0.579N                                          |  P=0.410                                           |
|FISHER EXACT           |               P=0.691N     P=0.219      P=0.691N   |                 (e)        P=0.059      P=0.500    |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    3/60 (5%)    5/60 (8%)    2/60 (3%)  |  2/60 (3%)    1/60 (2%)    4/60 (7%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.9%         6.4%        11.1%         4.5%      |   6.9%         3.6%        10.3%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    1/43 (2%)    3/41 (7%)    0/39 (0%)  |  2/29 (7%)    1/28 (4%)    3/37 (8%)    1/44 (2%)  |
|FIRST INCIDENCE (DAYS) |   725          562          618          584       |   729 (T)      729 (T)      722          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.515N     P=0.526      P=0.242      P=0.689    |  P=0.281N     P=0.512N     P=0.457      P=0.356N   |
|INCIDENTAL TUMOR       |  P=0.489N     P=0.491      P=0.276      P=0.663N   |  P=0.354N     P=0.512N     P=0.460      P=0.356N   |
|LOGISTIC REGRESSION    |  P=0.412N     P=0.500      P=0.226      P=0.694N   |  P=0.310N     P=0.512N     P=0.485      P=0.356N   |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.459N                                          |
|FISHER EXACT           |               P=0.500      P=0.219      P=0.691N   |               P=0.500N     P=0.340      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    3/60 (5%)    2/60 (3%)    1/60 (2%)  |  8/60 (13%)   8/60 (13%)   9/60 (15%)  10/60 (17%) |
|ADJUSTED (b)           |   4.4%         7.0%         4.4%         2.6%      |  23.3%        24.9%        22.8%        21.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    3/43 (7%)    0/41 (0%)    1/39 (3%)  |  5/29 (17%)   5/28 (18%)   7/37 (19%)   8/44 (18%) |
|FIRST INCIDENCE (DAYS) |   577          729 (T)      618          729 (T)   |   494          681          716          302       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.319N     P=0.530      P=0.676N     P=0.505N   |  P=0.413N     P=0.589      P=0.512N     P=0.508N   |
|INCIDENTAL TUMOR       |  P=0.270N     P=0.474      P=0.654N     P=0.479N   |  P=0.348      P=0.544N     P=0.492      P=0.497    |
|LOGISTIC REGRESSION    |  P=0.305N     P=0.507      P=0.692      P=0.500N   |  P=0.413      P=0.588N     P=0.587N     P=0.431    |
|COCHRAN-ARMITAGE       |  P=0.303N                                          |  P=0.333                                           |
|FISHER EXACT           |               P=0.500      P=0.691N     P=0.500N   |               P=0.605N     P=0.500      P=0.399    |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  16
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    3/60 (5%)    2/60 (3%)    1/60 (2%)  |  8/60 (13%)   7/60 (12%)   9/60 (15%)   9/60 (15%) |
|ADJUSTED (b)           |   4.4%         7.0%         4.4%         2.6%      |  23.3%        22.8%        22.8%        19.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    3/43 (7%)    0/41 (0%)    1/39 (3%)  |  5/29 (17%)   5/28 (18%)   7/37 (19%)   8/44 (18%) |
|FIRST INCIDENCE (DAYS) |   577          729 (T)      618          729 (T)   |   494          691          716          302       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.319N     P=0.530      P=0.676N     P=0.505N   |  P=0.350N     P=0.521N     P=0.512N     P=0.407N   |
|INCIDENTAL TUMOR       |  P=0.270N     P=0.474      P=0.654N     P=0.479N   |  P=0.472      P=0.460N     P=0.492      P=0.590N   |
|LOGISTIC REGRESSION    |  P=0.305N     P=0.507      P=0.692      P=0.500N   |  P=0.493      P=0.479N     P=0.587N     P=0.441N   |
|COCHRAN-ARMITAGE       |  P=0.303N                                          |  P=0.399                                           |
|FISHER EXACT           |               P=0.500      P=0.691N     P=0.500N   |               P=0.500N     P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/60 (50%)  28/60 (47%)  24/60 (40%)  17/60 (28%) | 32/60 (53%)  29/60 (48%)  17/60 (28%)  24/60 (40%) |
|ADJUSTED (b)           |  66.3%        62.0%        49.4%        37.1%      |  81.1%        75.2%        39.8%        48.6%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   1/10 (10%)   3/10 (30%)   2/10 (20%) |  3/10 (30%)   0/10 (0%)    1/10 (10%)   2/10 (20%) |
|TERMINAL (d)           | 24/39 (62%)  26/43 (60%)  17/41 (41%)  11/39 (28%) | 22/29 (76%)  19/28 (68%)  12/37 (32%)  19/44 (43%) |
|FIRST INCIDENCE (DAYS) |   457 (I)      458 (I)      457 (I)      456 (I)   |   456 (I)      507          458 (I)      456 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.012N*    P=0.250N     P=0.139N     P=0.016N*  |  P=0.002N**   P=0.392N     P<0.001N**   P=0.002N** |
|INCIDENTAL TUMOR       |  P=0.003N**   P=0.403N     P=0.153N     P=0.006N** |  P=0.056N     P=0.360N     P<0.001N**   P=0.044N*  |
|LOGISTIC REGRESSION    |  P=0.006N**   P=0.376N     P=0.138N     P=0.010N** |  P=0.053N     P=0.315N     P<0.001N**   P=0.052N   |
|COCHRAN-ARMITAGE       |  P=0.007N**                                        |  P=0.112N                                          |
|FISHER EXACT           |               P=0.428N     P=0.179N     P=0.012N*  |               P=0.358N     P=0.004N**   P=0.100N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  17
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0%           .033%        .1%          .3%       |   0%           .033%        .1%          .3%       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/60 (42%)  21/60 (35%)  20/60 (33%)  15/60 (25%) | 17/60 (28%)  24/60 (40%)  25/60 (42%)  16/60 (27%) |
|ADJUSTED (b)           |  50.8%        42.8%        40.6%        31.5%      |  42.8%        56.4%        50.6%        33.7%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 15/39 (38%)  15/43 (35%)  12/41 (29%)   7/39 (18%) |  8/29 (28%)  11/28 (39%)  13/37 (35%)  13/44 (30%) |
|FIRST INCIDENCE (DAYS) |   458 (I)      508          571          457 (I)   |   494           17          114          302       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.075N     P=0.214N     P=0.202N     P=0.062N   |  P=0.025N*    P=0.163      P=0.353      P=0.163N   |
|INCIDENTAL TUMOR       |  P=0.015N*    P=0.397N     P=0.197N     P=0.023N*  |  P=0.470N     P=0.143      P=0.071      P=0.508    |
|LOGISTIC REGRESSION    |  P=0.013N*    P=0.270N     P=0.172N     P=0.016N*  |  P=0.134N     P=0.122      P=0.119      P=0.443N   |
|COCHRAN-ARMITAGE       |  P=0.042N*                                         |  P=0.212N                                          |
|FISHER EXACT           |               P=0.287N     P=0.225N     P=0.040N*  |               P=0.124      P=0.090      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 45/60 (75%)  41/60 (68%)  38/60 (63%)  25/60 (42%) | 38/60 (63%)  40/60 (67%)  35/60 (58%)  35/60 (58%) |
|ADJUSTED (b)           |  86.5%        81.9%        71.6%        50.7%      |  85.7%        86.7%        69.7%        67.1%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   1/10 (10%)   3/10 (30%)   2/10 (20%) |  3/10 (30%)   0/10 (0%)    2/10 (20%)   2/10 (20%) |
|TERMINAL (d)           | 32/39 (82%)  34/43 (79%)  26/41 (63%)  15/39 (38%) | 23/29 (79%)  22/28 (79%)  22/37 (59%)  27/44 (61%) |
|FIRST INCIDENCE (DAYS) |   457 (I)      458 (I)      457 (I)      456 (I)   |   456 (I)       17          114          302       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001N**   P=0.128N     P=0.107N     P=0.002N** |  P=0.003N**   P=0.427      P=0.060N     P=0.014N*  |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.272N     P=0.077N     P<0.001N** |  P=0.310N     P=0.526      P=0.167N     P=0.333N   |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.185N     P=0.078N     P<0.001N** |  P=0.114N     P=0.527      P=0.232N     P=0.262N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.247N                                          |
|FISHER EXACT           |               P=0.272N     P=0.118N     P<0.001N** |               P=0.424      P=0.354N     P=0.354N   |
|=================================================================================================================================|
         DATE: 09/16/94                     EXPERIMENT: 05120 TEST: 04                                                 PAGE  18
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 456
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).