TDMS Study 05120-04 Pathology Tables
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
Facility: Southern Research Institute
Chemical CAS #: 140-11-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0|
| 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + A + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Cyst | |
Hematopoietic Cell Proliferation | 4 1 4 4 1 4|
Hyperplasia, Focal | |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 1 2 2 |
Mineralization | |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | |
Hepatocyte, Cytomegaly | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 4 3 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Suppurative | 4 4|
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia, Lymphoid | 1 2 1 |
Necrosis | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 4 4 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + I + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0|
| 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3|
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Edema | 2|
Erosion | 2 2 3 |
Inflammation, Chronic | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Thrombosis | X|
Myocardium, Inflammation, Chronic | |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X |
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Focal | 2 |
Inflammation, Subacute | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + + + + + + + +|
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + M + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 1 3 1 2 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 |
Ectopic Thymus | X X |
Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0|
| 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | 1 1 3 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Ectasia | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Cyst | X X X X X X |
Hemorrhage | 3 |
Inflammation, Suppurative | 1 4 4 4 4 4|
Pigmentation | 3 |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Hydrometra | 2 |
Hyperplasia, Cystic | 3 3 3 4 3 3 3 2 4 2 3 2 1 2 4 4 3 2 4 2 2|
Inflammation, Suppurative | 3 2 3 3 4 2|
Endometrium, Pigmentation | |
Epithelium, Metaplasia, Squamous | 3 3 |
__________________________________________________________________________|
Vagina | |
Granuloma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 3 2 2 2 2 3|
Myelofibrosis | 2 2 3 1 2 2 1 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Angiectasis | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Plasma Cell | 3 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 4 |
Mediastinal, Inflammation, | |
Suppurative | |
Renal, Ectasia | 3 |
Renal, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0|
| 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 2 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | 4 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 1 2 2 2 3|
Hemorrhage | 2 2 1 2 |
Hyperplasia, Lymphoid | 3 4 |
Hyperplasia, Plasma Cell | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 4 3 2 4 2 3 2 1 4|
Hyperplasia, Reticulum Cell | |
Pigmentation, Hemosiderin | 3 3 3 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + M M + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 2 2 2 |
Cyst | X X |
Depletion Cellular | 2 2 2 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 |
Inflammation, Chronic | 2 1 1 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 |
Sarcolemmal Nuclei, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0|
| 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | |
Inflammation, Chronic | 1 |
Vacuolization Cytoplasmic | |
Glial Cell, Proliferation | 3 |
Thalamus, Mineralization | 1 2 1 1 1 3 2 2 2 2 1 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Bacterium | |
Congestion | |
Edema | |
Hemorrhage | 2|
Hyperplasia, Lymphoid | 1 2 2 1 1 |
Infiltration Cellular, Histiocyte | 1 2 |
Inflammation, Suppurative | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Hypertrophy | 1 |
Bronchiole, Foreign Body | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X |
Glands, Hyperplasia, Cystic | 1 1 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1|
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Casts Protein | 1 1 1 1 1 1 1 1 1 2 1 1 2 2 2 1 1 |
Cyst | X |
Glomerulosclerosis | 3 2 |
Hyperplasia, Lymphoid | 1 2 1 1 1 2 1 1 1 3 |
Inflammation, Suppurative | 3 2 4|
Interstitial Tissue, Pigmentation | 2 |
Renal Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0|
| 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | 2 2|
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 2 2 1 1 1 2 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | 1 1 1 1 1 1 3 1 2 1 |
Inflammation, Chronic | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2|
| 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Clear Cell Focus | X |
Cyst | X |
Hematopoietic Cell Proliferation | 3 4 4 3 2 1|
Hyperplasia, Focal | 2|
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Subacute | 1 1 1 1 1 1 |
Mineralization | 4 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 3 2 |
Hepatocyte, Cytomegaly | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 4 2 |
Kupffer Cell, Hyperplasia | 3 3 2 3 3 |
Kupffer Cell, Pigmentation | 2 2 |
Lobules, Necrosis | 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 2 |
Hyperplasia, Lymphoid | 2 |
Necrosis | |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Subacute | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2|
| 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Edema | |
Erosion | |
Inflammation, Chronic | 2|
Inflammation, Subacute | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Thrombosis | |
Myocardium, Inflammation, Chronic | 1 |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Focal | |
Inflammation, Subacute | 1 |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 2 1 3 1 1|
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 1 1 |
Ectopic Thymus | |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2|
| 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Ectasia | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 2 |
Cyst | X X X X|
Hemorrhage | |
Inflammation, Suppurative | 4 4 4 4 4 4 3|
Pigmentation | |
Interstitial Cell, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | |
Hyperplasia, Cystic | 2 3 4 2 1 1 2 1 1 2 3 2 3 1 3 3 2 2 3 2 3 2 2 4 3|
Inflammation, Suppurative | 1 2 3 2 2 2|
Endometrium, Pigmentation | 3 |
Epithelium, Metaplasia, Squamous | 2 2 2 2 2|
__________________________________________________________________________|
Vagina | + |
Granuloma | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 3 4 4 3 2 2 3 2|
Myelofibrosis | 1 1 3 1 1|
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Angiectasis | |
Iliac, Hematopoietic Cell | |
Proliferation | 2 |
Iliac, Hyperplasia, Plasma Cell | 4 |
Lumbar, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hyperplasia, Plasma Cell| 4 3 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Renal, Ectasia | |
Renal, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2|
| 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 2 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia, Lymphoid | 2 2 2|
Hyperplasia, Plasma Cell | 2 2 2|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 3 2 2 |
Hemorrhage | 2 3 1 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 4 4 3 3 2 3 3 4 2 2|
Hyperplasia, Reticulum Cell | 1 |
Pigmentation, Hemosiderin | 3 3 3 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 3|
Red Pulp, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + M + + + + +|
Angiectasis | 3 |
Cyst | X X X |
Depletion Cellular | 2 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 1 2 |
Hyperplasia, Lobular | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1|
Sarcolemmal Nuclei, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2|
| 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | |
Inflammation, Chronic | |
Vacuolization Cytoplasmic | |
Glial Cell, Proliferation | |
Thalamus, Mineralization | 2 2 1 2 2 2 2 2 2 2 2 3 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 4 |
Bacterium | 2 |
Congestion | 2 |
Edema | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 2 3|
Infiltration Cellular, Histiocyte | 1 2 2 2 4 |
Inflammation, Suppurative | 2 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
Artery, Hypertrophy | |
Bronchiole, Foreign Body | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X |
Glands, Hyperplasia, Cystic | 1 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 2 1 |
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Mucosa, Degeneration | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Casts Protein | 1 1 1 3 2 3 1 1 1 2 2 1 1 1 1|
Cyst | |
Glomerulosclerosis | 3 2 2 |
Hyperplasia, Lymphoid | 1 2 2 1 1 1 2 3 2 1 4 3|
Inflammation, Suppurative | 1 1 |
Interstitial Tissue, Pigmentation | 2 |
Renal Tubule, Atrophy | 2 4 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2|
| 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | 3 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Regeneration | 2 4 3 2 1 2 2 1 2 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 3 1 2 2 2 2 1 1 2 1|
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | |
| 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
Dilatation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 4 |
Clear Cell Focus | X | 2 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2 | 13 2.8|
Hyperplasia, Focal | 2 | 2 2.0|
Hyperplasia, Lymphoid | 1 | 3 1.7|
Inflammation, Subacute | 3 1 | 12 1.3|
Mineralization | | 1 4.0|
Mixed Cell Focus | X | 2 |
Bile Duct, Hyperplasia | | 2 2.5|
Hepatocyte, Cytomegaly | 3 | 1 3.0|
Hepatocyte, Karyomegaly | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 3 2.7|
Kupffer Cell, Hyperplasia | | 7 3.0|
Kupffer Cell, Pigmentation | | 2 2.0|
Lobules, Necrosis | 1 3 | 7 1.9|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Inflammation, Suppurative | | 3 3.7|
Fat, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 4 3.3|
Hyperplasia, Lymphoid | | 4 1.5|
Necrosis | 3 | 2 2.5|
Acinar Cell, Cytoplasmic Alteration | 4 2 3 | 8 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | |
| 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 1 | 11 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Inflammation, Subacute | | 4 1.5|
Ulcer | | 2 2.5|
Mucosa, Hyperplasia | 2 1 | 8 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 6 |
Edema | | 1 2.0|
Erosion | 3 | 4 2.5|
Inflammation, Chronic | | 2 2.0|
Inflammation, Subacute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 1.0|
Thrombosis | | 1 |
Myocardium, Inflammation, Chronic | 1 | 2 1.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 17 |
Hematopoietic Cell Proliferation | | 3 2.3|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Subacute | | 1 1.0|
Capsule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 | 5 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | |
| 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Angiectasis | 2 2 | 5 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 1 1 2 | 18 1.6|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 1 | 10 1.4|
Ectopic Thymus | | 2 |
Inflammation, Subacute | | 1 1.0|
Follicle, Cyst | X | 5 |
Follicular Cell, Hyperplasia | 4 1 1 | 11 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Ectasia | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | 2 | 8 1.9|
Cyst | X | 11 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 13 3.7|
Pigmentation | | 1 3.0|
Interstitial Cell, Hyperplasia | | 4 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 2 1.5|
Hydrometra | | 1 2.0|
Hyperplasia, Cystic | 3 2 2 2 1 3 3 3 2 2 | 56 2.5|
Inflammation, Suppurative | 2 2 | 14 2.4|
Endometrium, Pigmentation | | 1 3.0|
Epithelium, Metaplasia, Squamous | | 7 2.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
Granuloma | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | |
| 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 3 2 | 19 2.6|
Myelofibrosis | 2 1 1 | 16 1.6|
Pigmentation, Hemosiderin | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Iliac, Angiectasis | 4 | 1 4.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 3 | 2 2.5|
Iliac, Hyperplasia, Plasma Cell | | 2 3.5|
Lumbar, Hyperplasia, Plasma Cell | | 2 3.5|
Mediastinal, Hyperplasia, Plasma Cell| | 5 3.4|
Mediastinal, Inflammation, | | |
Suppurative | | 1 3.0|
Renal, Ectasia | | 1 3.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 2 2.0|
Renal, Hyperplasia, Lymphoid | 4 | 3 3.3|
Renal, Hyperplasia, Plasma Cell | | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia, Lymphoid | | 5 2.2|
Hyperplasia, Plasma Cell | 2 | 6 2.2|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.5|
Hematopoietic Cell Proliferation | | 11 2.1|
Hemorrhage | | 7 1.9|
Hyperplasia, Lymphoid | | 3 3.3|
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 3 4 3 | 27 2.9|
Hyperplasia, Reticulum Cell | 4 | 2 2.5|
Pigmentation, Hemosiderin | 3 | 8 2.9|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | 2 | 4 2.3|
Red Pulp, Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Angiectasis | | 4 2.3|
Cyst | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | |
| 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Cellular | 2 2 3 | 8 2.3|
Ectopic Parathyroid Gland | X | 2 |
Hyperplasia, Lymphoid | | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | | 5 1.6|
Hyperplasia, Lobular | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 2 1.5|
Inflammation, Chronic | | 3 1.3|
Subcutaneous Tissue, Edema | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 3 | 7 1.9|
Sarcolemmal Nuclei, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X | 3 |
Hydrocephalus | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
Glial Cell, Proliferation | | 1 3.0|
Thalamus, Mineralization | 2 1 3 3 2 1 1 2 | 38 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Adenomatosis | | 1 4.0|
Bacterium | | 1 2.0|
Congestion | | 1 2.0|
Edema | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 9 1.7|
Infiltration Cellular, Histiocyte | | 7 2.0|
Inflammation, Suppurative | | 2 2.0|
Thrombosis | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | |
| 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Hypertrophy | | 1 1.0|
Bronchiole, Foreign Body | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X | 15 |
Glands, Hyperplasia, Cystic | 2 1 1 1 2 1 1 | 47 1.2|
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 | 46 1.0|
Mucosa, Degeneration | 1 1 1 1 1 1 1 1 1 | 58 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Casts Protein | 1 2 1 1 1 1 2 | 39 1.3|
Cyst | X | 2 |
Glomerulosclerosis | 1 1 | 7 2.0|
Hyperplasia, Lymphoid | 2 3 1 1 1 2 | 28 1.7|
Inflammation, Suppurative | | 5 2.2|
Interstitial Tissue, Pigmentation | | 2 2.0|
Renal Tubule, Atrophy | | 2 3.0|
Renal Tubule, Dilatation | 3 1 | 6 2.2|
Renal Tubule, Necrosis | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Regeneration | 1 1 2 1 2 | 22 1.7|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 1 1 1 3 | 24 1.5|
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3|
| 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Cyst | |
Hematopoietic Cell Proliferation | 2 4 2 1 |
Hyperplasia, Focal | |
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | 1 1 |
Mixed Cell Focus | |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 3 3 3 2 |
Lobules, Necrosis | 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Suppurative | 4 3 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Mucosa, Hyperplasia | 2 1 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3|
| 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Subacute | 2 |
Ulcer | |
Mucosa, Dysplasia | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X|
Hematopoietic Cell Proliferation | |
Hyperplasia, Diffuse | 2 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | |
Capsule, Hyperplasia | 1 |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Hyperplasia | 2 1 3 2 2 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 3 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + M + + + + + + I + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Cyst | X X X X X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3|
| 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Suppurative | 4 4 4 |
Thrombosis | 2 |
__________________________________________________________________________|
Uterus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 3 |
Hyperplasia, Cystic | 2 4 3 3 2 3 2 3 1 2 3 1 3 2 2 2 1 1 2 2 1 2|
Inflammation, Suppurative | 3 2 1|
Epithelium, Metaplasia, Squamous | 2 1 3 2 3 2|
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 4 3 2 2 |
Myelofibrosis | 2 1 1 1 2|
Necrosis | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 4 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Plasma Cell | 4 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + + + + + + + + + + + + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4 3 3 3 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 4 3 1 3 1 2 2 |
Pigmentation, Hemosiderin | 2 2 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 3 |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | X|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3|
| 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Cellular | 2 3 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Sarcolemmal Nuclei, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Cyst | X |
Thalamus, Mineralization | 3 1 2 1 2 2 2 2 1 2 1 2 2 2 2 3 2 1 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | 2 2 1 |
Infiltration Cellular, Histiocyte | 2 3 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | |
Artery, Hypertrophy | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X |
Glands, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Atrophy | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 2 1 1 2 1 1|
Mucosa, Degeneration | 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 2 1 1 2 1 1|
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3|
| 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 3 |
Casts Protein | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Cyst | X |
Hyperplasia, Lymphoid | 1 1 2 3 1 1 1 1 2 |
Metaplasia, Osseous | |
Mineralization | |
Renal Tubule, Atrophy | 2 |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 4 |
Renal Tubule, Regeneration | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 3 2 1 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5|
| 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X |
Cyst | X |
Hematopoietic Cell Proliferation | 1 3 |
Hyperplasia, Focal | 3 2 |
Hyperplasia, Lymphoid | 1 1 |
Inflammation, Subacute | 3 |
Mixed Cell Focus | X X |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 3 |
Lobules, Necrosis | 2 3 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 2 |
Acinar Cell, Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Erosion | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5|
| 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Subacute | |
Ulcer | 2 |
Mucosa, Dysplasia | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Diffuse | |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Capsule, Hyperplasia | |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Cyst | X X X X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5|
| 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Suppurative | 4 3 |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | |
Hyperplasia, Cystic | 3 1 2 2 2 3 3 1 3 3 3 2 3 2 3 2 2 3 2 2 2 1 2|
Inflammation, Suppurative | 2 2 |
Epithelium, Metaplasia, Squamous | 3 |
Myometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 2 2 2 |
Myelofibrosis | 2 2 3 1 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 1 |
Hyperplasia, Lymphoid | 2 4 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 4 3 2 4 3 |
Pigmentation, Hemosiderin | 3 3 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 2 3 |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + M + + + +|
Angiectasis | |
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5|
| 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Cellular | 2 2 4 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | 1 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Sarcolemmal Nuclei, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Cyst | |
Thalamus, Mineralization | 3 2 3 2 2 1 2 2 1 2 2 1 2 1 2 2 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 3 |
Hemorrhage | 2 3 1 |
Hyperplasia, Lymphoid | 1 2 2 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Hypertrophy | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X |
Glands, Hyperplasia, Cystic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Atrophy | 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1|
Mucosa, Degeneration | 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1|
Mucosa, Pigmentation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5|
| 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Casts Protein | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Cyst | |
Hyperplasia, Lymphoid | 1 2 2 1 2 1 2 1 1 1 1 1 1|
Metaplasia, Osseous | 2 1 |
Mineralization | 1 1 |
Renal Tubule, Atrophy | |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Regeneration | 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 1 3 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | |
| 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + | 58 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | I + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 2 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 3 | 7 2.3|
Hyperplasia, Focal | | 2 2.5|
Hyperplasia, Lymphoid | 1 4 | 5 1.6|
Inflammation, Subacute | 1 | 4 1.5|
Mixed Cell Focus | | 2 |
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Kupffer Cell, Hyperplasia | 3 | 6 2.8|
Lobules, Necrosis | 4 | 8 1.9|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Inflammation, Suppurative | 4 | 3 3.7|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Cyst | | 1 |
Hyperplasia, Lymphoid | | 2 2.0|
Acinar Cell, Cytoplasmic Alteration | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 2 | 13 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | |
| 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Diverticulum | | 2 2.5|
Mucosa, Hyperplasia | 1 | 6 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 3 |
Erosion | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Ulcer | | 1 2.0|
Mucosa, Dysplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 3 1.3|
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Myocardium, Inflammation, Chronic | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 6 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia, Diffuse | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Capsule, Hyperplasia | | 1 1.0|
X-Zone, Degeneration, Fatty | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
Ectopic Thymus | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + M + + + | 56 |
Pars Distalis, Angiectasis | 2 | 4 2.0|
Pars Distalis, Hyperplasia | 2 | 14 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 9 1.6|
Follicle, Cyst | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | |
| 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 3 1 1 | 10 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Angiectasis | 2 2 | 8 2.0|
Cyst | X X X X | 14 |
Hemorrhage | 4 2 | 2 3.0|
Inflammation, Suppurative | 4 4 | 7 3.9|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | 3 | 2 2.5|
Hydrometra | 3 | 3 3.0|
Hyperplasia, Cystic | 2 2 2 2 3 2 2 2 2 2 | 55 2.2|
Inflammation, Suppurative | 2 | 6 2.0|
Epithelium, Metaplasia, Squamous | 2 | 8 2.3|
Myometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 4 | 11 2.5|
Myelofibrosis | 2 2 1 | 12 1.7|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Iliac, Hyperplasia, Lymphoid | 3 | 2 2.5|
Iliac, Hyperplasia, Plasma Cell | 3 | 3 2.7|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 4 3.3|
Mediastinal, Inflammation, | | |
Suppurative | | 2 3.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hyperplasia, Plasma Cell | 3 | 5 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 5 3.2|
Hyperplasia, Plasma Cell | 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | |
| 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + + + + + + + | 56 |
Hematopoietic Cell Proliferation | 2 2 | 5 2.0|
Hemorrhage | 3 | 3 1.7|
Hyperplasia, Lymphoid | | 3 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 3 2 3 3 | 24 2.6|
Pigmentation, Hemosiderin | 2 2 | 7 2.3|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | 3 3 | 6 2.8|
Red Pulp, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Angiectasis | | 2 2.0|
Cyst | X | 3 |
Depletion Cellular | 3 3 | 9 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia, Cystic | | 4 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Subcutaneous Tissue, Edema | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 1.5|
Sarcolemmal Nuclei, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 3 |
Cyst | | 1 |
Thalamus, Mineralization | 2 1 2 2 3 1 2 3 2 | 53 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | |
| 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Bacterium | | 1 3.0|
Hemorrhage | 3 | 6 2.2|
Hyperplasia, Lymphoid | 1 | 7 1.6|
Infiltration Cellular, Histiocyte | 1 | 4 2.3|
Inflammation, Subacute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X X | 26 |
Glands, Hyperplasia, Cystic | 1 1 1 1 1 1 2 1 1 1 | 54 1.1|
Mucosa, Atrophy | 1 1 1 2 1 1 1 1 1 | 57 1.2|
Mucosa, Degeneration | 1 1 1 2 1 1 1 1 1 1 | 57 1.2|
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 53 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Bacterium | | 1 3.0|
Casts Protein | 1 1 1 1 1 1 | 39 1.1|
Cyst | X | 2 |
Hyperplasia, Lymphoid | 1 1 1 1 2 | 27 1.3|
Metaplasia, Osseous | | 2 1.5|
Mineralization | | 2 1.0|
Renal Tubule, Atrophy | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration | | 1 3.0|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 2 2.5|
Renal Tubule, Regeneration | 1 2 | 9 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Edema | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 2 1 | 15 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5|
| 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + I + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Clear Cell Focus | X |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | 1 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | 2 1 |
Metaplasia, Osseous | |
Mineralization | |
Nuclear Alteration | |
Kupffer Cell, Hyperplasia | 2 2 2 2 3 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 3 3 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 2 1 1 2 |
Acinar Cell, Cytoplasmic Alteration | 4 4 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 3 1 1 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Subacute | 2 2 3 2 |
Mucosa, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5|
| 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cyst | |
Erosion | |
Inflammation, Subacute | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X |
Angiectasis | 2 |
Cyst | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Diffuse | 2 |
Hyperplasia, Focal | |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + M|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 1 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 2 1 1 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 3 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 1 2 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5|
| 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X X |
Hemorrhage | |
Inflammation, Suppurative | 4 4 2 |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Granuloma | 2 |
Hemorrhage | 4 |
Hydrometra | 3 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 3 1 3 3 2 1 2 3 3 2 3 2 2 2 2 2|
Inflammation, Suppurative | 3 2 2 2 3 2 |
Necrosis | |
Endometrium, Pigmentation | |
Epithelium, Metaplasia, Squamous | 3 3 2 2 1 3 2 2 |
Myometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 4 3 2 3 2 2 |
Myelofibrosis | 3 2 3 1 1 |
Pigmentation, Hemosiderin | 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Hemorrhage | 3 |
Renal, Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 2 2 |
Hyperplasia, Plasma Cell | |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | 3 1 1 1 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 4 4 2 4 3 2 2 |
Pigmentation, Hemosiderin | 2 2 3 2 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5|
| 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | X X X X |
Depletion Cellular | 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 1 |
Inflammation, Chronic | 1 1 |
Ulcer | |
Subcutaneous Tissue, Edema | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 1 1 1 |
Sarcolemmal Nuclei, Hyperplasia | 2 2 |
Sarcoplasm, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Vacuolization Cytoplasmic | |
Thalamus, Mineralization | 2 1 1 3 2 3 2 2 1 1 2 2 2 1 1 1 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Foreign Body | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X |
Glands, Hyperplasia, Cystic | 1 1 3 2 1 1 2 1 1 2 1 2 1 1 1 3 1 1 1 1 1 1 1 1 1|
Mucosa, Atrophy | 3 2 3 3 3 2 2 3 2 3 2 3 2 2 2 3 3 3 2 3 2 3 1 2 1|
Mucosa, Degeneration | 3 2 3 3 3 2 2 3 2 3 2 3 2 2 2 3 3 3 2 3 2 3 1 2 1|
Mucosa, Pigmentation | 1 2 2 1 1 1 1 2 2 2 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5|
| 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Casts Protein | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Glomerulosclerosis | 1 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 1 1 1 1 1 1 1 3 1|
Metaplasia, Osseous | |
Mineralization | 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Regeneration | 1 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 2 2 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5|
| 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 2 4 4 1 3 |
Hemorrhage | |
Hyperplasia, Focal | |
Hyperplasia, Lymphoid | 3 1 1|
Inflammation, Subacute | 1 1 3 1|
Metaplasia, Osseous | 2 |
Mineralization | 2|
Nuclear Alteration | 2 2 |
Kupffer Cell, Hyperplasia | 2 3 3 2 3 |
Kupffer Cell, Pigmentation | 1 1 2 |
Lobules, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | 4 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 2 1 |
Cyst | X |
Focal Cellular Change | X X |
Hyperplasia, Lymphoid | 2 1 |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Subacute | 2 2|
Mucosa, Hyperplasia | 1 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5|
| 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cyst | X X X |
Erosion | 1 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X |
Angiectasis | |
Cyst | X |
Hematopoietic Cell Proliferation | 2 2 3 1 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 2 1 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 3 2 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5|
| 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X X |
Hemorrhage | |
Inflammation, Suppurative | 4 4 4 2 4 |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Granuloma | |
Hemorrhage | |
Hydrometra | |
Hyperplasia, Cystic | 3 1 2 1 1 2 2 2 3 2 1 3 3 3 2 3 3 2 2 2 2 3 1 2|
Inflammation, Suppurative | 2 2 2 |
Necrosis | |
Endometrium, Pigmentation | 2 |
Epithelium, Metaplasia, Squamous | 2 3 2 2 |
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 4 3 4 4 2 2 2 2 4 |
Myelofibrosis | 2 1 2 3 1 1 1 1 |
Pigmentation, Hemosiderin | 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 4 |
Renal, Hematopoietic Cell | |
Proliferation | 4 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 3 4 3 4 4 4 2 4 3 3 |
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 3 2|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5|
| 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + + + + + + + + M + + +|
Cyst | X X X X X X X |
Depletion Cellular | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + I + + + + + + + + + +|
Acanthosis | 3 3 |
Inflammation, Chronic | 3 |
Ulcer | 3 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 1 1 1 2 |
Sarcolemmal Nuclei, Hyperplasia | 2 1 |
Sarcoplasm, Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Vacuolization Cytoplasmic | 2 |
Thalamus, Mineralization | 1 2 1 1 2 2 1 3 1 2 3 3 1 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hemorrhage | 1 1 1 |
Hyperplasia, Lymphoid | 1 2 2 1 |
Infiltration Cellular, Histiocyte | 4 2 |
Inflammation, Subacute | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Foreign Body | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X X X X X X |
Glands, Hyperplasia, Cystic | 1 1 1 2 1 1 1 1 1 1 2 2 2 1 2 1 1 2 2 1 2 2 1 1|
Mucosa, Atrophy | 2 2 3 3 2 2 3 2 2 3 3 1 2 3 3 3 3 3 3 1 3 1 1 2|
Mucosa, Degeneration | 2 2 3 3 2 2 3 2 2 1 3 3 1 2 3 3 3 3 3 3 1 3 1 1 2|
Mucosa, Pigmentation | 1 2 2 1 1 1 1 2 1 1 1 1 2 2 2 1 1 1 2 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5|
| 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Casts Protein | 2 1 1 2 2 1 1 1 1 1 2 1 2 1 1 1 1|
Glomerulosclerosis | 2 1 2 2 |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 1 2 1 1 1 2 1 1 |
Metaplasia, Osseous | 1 2 |
Mineralization | |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Regeneration | 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 1 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 | 2 2.0|
Clear Cell Focus | X | 2 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 10 2.4|
Hemorrhage | | 1 1.0|
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Lymphoid | 2 | 5 1.6|
Inflammation, Subacute | 1 | 7 1.4|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 1 2.0|
Nuclear Alteration | 2 | 3 2.0|
Kupffer Cell, Hyperplasia | 2 | 11 2.4|
Kupffer Cell, Pigmentation | 1 | 5 1.4|
Lobules, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Inflammation, Suppurative | 2 | 4 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 5 2.6|
Cyst | X X | 4 |
Focal Cellular Change | | 2 |
Hyperplasia, Lymphoid | 1 1 | 8 1.4|
Acinar Cell, Cytoplasmic Alteration | | 3 3.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 2 2 | 13 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | 2 2 | 2 2.0|
Inflammation, Subacute | 2 | 7 2.1|
Mucosa, Hyperplasia | 3 1 | 9 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 3 |
Erosion | | 1 1.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 14 |
Angiectasis | | 1 2.0|
Cyst | | 2 |
Hematopoietic Cell Proliferation | | 4 2.0|
Hyperplasia, Diffuse | | 1 2.0|
Hyperplasia, Focal | | 1 1.0|
Capsule, Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 5 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Cyst | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 | 6 1.8|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 | 15 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 1 1 2 | 14 1.6|
Follicle, Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 1 2 1 | 12 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 9 2.2|
Cyst | X X X X | 16 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 4 4 | 10 3.6|
Interstitial Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | 3 | 3 2.0|
Granuloma | | 1 2.0|
Hemorrhage | | 1 4.0|
Hydrometra | 4 4 4 | 4 3.8|
Hyperplasia, Cystic | 2 2 1 2 1 3 2 1 3 3 | 58 2.1|
Inflammation, Suppurative | 2 | 10 2.2|
Necrosis | 3 | 1 3.0|
Endometrium, Pigmentation | | 1 2.0|
Epithelium, Metaplasia, Squamous | 4 4 2 | 15 2.5|
Myometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 3 4 | 20 2.9|
Myelofibrosis | 1 | 14 1.6|
Pigmentation, Hemosiderin | 3 | 7 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 2 3.5|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Renal, Hemorrhage | | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | 2 | 5 2.4|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 4 2.0|
Hemorrhage | | 5 1.6|
Hyperplasia, Lymphoid | 2 | 3 2.3|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 1 1 2 3 | 27 2.8|
Pigmentation, Hemosiderin | 2 | 6 2.2|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | 3 | 6 2.5|
Red Pulp, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Cyst | | 11 |
Depletion Cellular | | 6 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Acanthosis | | 4 2.5|
Inflammation, Chronic | | 3 1.7|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Edema | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | | 7 1.1|
Sarcolemmal Nuclei, Hyperplasia | | 4 1.8|
Sarcoplasm, Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | | 1 2.0|
Thalamus, Mineralization | 1 1 1 2 3 1 3 2 | 47 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Hemorrhage | | 4 1.0|
Hyperplasia, Lymphoid | | 10 1.2|
Infiltration Cellular, Histiocyte | | 3 3.0|
Inflammation, Subacute | 1 | 3 1.3|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Bronchiole, Foreign Body | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X X X | 36 |
Glands, Hyperplasia, Cystic | 1 2 1 1 1 2 1 2 1 1 | 59 1.3|
Mucosa, Atrophy | 2 3 3 3 1 3 1 3 1 2 | 59 2.3|
Mucosa, Degeneration | 2 3 3 3 1 3 1 3 1 2 | 60 2.3|
Mucosa, Pigmentation | 1 2 1 1 1 1 1 1 1 1 | 58 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Bacterium | | 1 1.0|
Casts Protein | 1 1 1 1 1 1 1 | 38 1.1|
Glomerulosclerosis | | 5 1.6|
Hydronephrosis | | 1 2.0|
Hyperplasia, Lymphoid | 1 1 1 1 | 22 1.2|
Metaplasia, Osseous | | 2 1.5|
Mineralization | | 1 1.0|
Renal Tubule, Dilatation | | 2 1.5|
Renal Tubule, Regeneration | 1 1 1 | 15 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 1 2 1 | 22 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4|
DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5|
| 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 1 2 1 |
Mixed Cell Focus | |
Kupffer Cell, Hyperplasia | 3 2 2 3 2 |
Kupffer Cell, Pigmentation | 2 1 |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 3 |
Capillary, Fat, Congestion | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X |
Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 1 2 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Edema | |
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Edema | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4|
DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5|
| 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 2 2 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X |
Angiectasis | 2 |
Cyst | X X |
Developmental Malformation | |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Capsule, Hyperplasia | 3 2 3 |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Thymus | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 |
Ectopic Thymus | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | X X X X X X|
Hemorrhage | 2 |
Inflammation, Suppurative | 4 4 4 4 |
Pigmentation | 3 |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Granuloma | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4|
DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5|
| 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hydrometra | 4 |
Hyperplasia, Cystic | 3 3 4 3 2 4 3 4 3 3 3 2 2 3 4 4 3 3 2 2 3 4 3 2|
Inflammation, Suppurative | 4 2 1 2 |
Necrosis | 4 |
Epithelium, Metaplasia, Squamous | 2 1 2 1 |
Myometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 2 3 2 |
Myelofibrosis | 2 1 2 3 1 |
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | 4 |
Renal, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 1 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 4 2 2 2 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Hyperplasia | 2 2 2 |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X |
Depletion Cellular | 3 3 |
Hyperplasia, Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | 1 1 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4|
DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5|
| 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Inflammation, Chronic | |
Thalamus, Mineralization | 3 2 2 2 1 3 1 2 2 2 2 3 1 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 2 2 2 1 1 1 |
Infiltration Cellular, Histiocyte | |
Bronchiole, Foreign Body | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X X X X X X X |
Glands, Cyst | X |
Glands, Hyperplasia, Cystic | 2 3 2 2 1 2 2 1 2 2 3 2 4 2 2 2 2 2 2 2 2 1 2 2 2|
Mucosa, Atrophy | 2 3 3 3 2 2 3 3 3 2 3 3 3 3 3 3 3 3 3 1 3 3 3 3 3|
Mucosa, Degeneration | 3 3 3 3 2 2 3 3 3 2 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3|
Mucosa, Pigmentation | 1 2 2 2 1 1 1 2 2 2 2 2 2 2 2 2 1 1 2 2 2 1 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 2 1 1 2 1 1 2 2|
Cyst | |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 1 1 1 1 2 1 1 2 |
Mineralization | 1 |
Renal Tubule, Atrophy | |
Renal Tubule, Regeneration | 2 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3|
| 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 1 1 1 1 2 |
Mixed Cell Focus | X |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 1 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | |
Capillary, Fat, Congestion | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cyst | |
Hyperplasia, Lymphoid | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Edema | 2 |
Inflammation, Subacute | 1 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Edema | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3|
| 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X |
Angiectasis | |
Cyst | |
Developmental Malformation | X |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Capsule, Hyperplasia | 2 |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + M + + + + + + + + + +|
Cyst | |
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 2 1 1|
Ectopic Thymus | X |
Follicle, Cyst | X X X X |
Follicular Cell, Hyperplasia | 2 1 2 1 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | X X X X X |
Hemorrhage | |
Inflammation, Suppurative | |
Pigmentation | |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Granuloma | 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3|
| 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hydrometra | 3 |
Hyperplasia, Cystic | 4 2 3 2 3 3 2 3 3 3 2 3 3 3 1 2 2 4 2 3 3 2 1 1 1|
Inflammation, Suppurative | 1 |
Necrosis | 3 |
Epithelium, Metaplasia, Squamous | 2 |
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Myelofibrosis | 2 1 1 2 2 2 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + A + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +|
Ectasia | 2|
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 1 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 2 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Hyperplasia | 2 |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X X X X X|
Depletion Cellular | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3|
| 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Inflammation, Chronic | 1 |
Thalamus, Mineralization | 3 2 2 1 3 1 1 1 3 2 3 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | 1 2 1 1 3 |
Infiltration Cellular, Histiocyte | 1 |
Bronchiole, Foreign Body | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X X X|
Glands, Cyst | |
Glands, Hyperplasia, Cystic | 2 1 2 1 2 2 2 2 1 2 2 2 2 1 2 2 2 1 1 1 2 2 2 3 2|
Mucosa, Atrophy | 3 1 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3|
Mucosa, Degeneration | 3 1 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3|
Mucosa, Pigmentation | 2 1 3 1 2 2 2 1 2 2 1 1 1 2 1 2 2 1 1 1 2 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 1 1 1 1 1 1 1 |
Cyst | |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 1 3 1 1 3 1 1 2 1 1|
Mineralization | 1 1 |
Renal Tubule, Atrophy | |
Renal Tubule, Regeneration | 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 3 2 3 1 3 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + M + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | 2 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 5 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Subacute | 1 1 1 1 1 | 13 1.2|
Mixed Cell Focus | | 1 |
Kupffer Cell, Hyperplasia | | 5 2.4|
Kupffer Cell, Pigmentation | | 2 1.5|
Lobules, Necrosis | 1 3 | 6 1.7|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Suppurative | | 1 3.0|
Capillary, Fat, Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + | 59 |
Atrophy | | 2 1.5|
Cyst | | 1 |
Hyperplasia, Lymphoid | | 4 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 | 15 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | 2 | 2 2.0|
Edema | | 1 2.0|
Inflammation, Subacute | | 2 1.5|
Mucosa, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 2 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 5 |
Inflammation, Chronic Active | | 5 1.8|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 14 |
Angiectasis | | 1 2.0|
Cyst | | 2 |
Developmental Malformation | | 1 |
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 1 1 | 2 1.0|
Capsule, Hyperplasia | 2 | 5 2.4|
X-Zone, Degeneration, Fatty | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 55 |
Cyst | | 1 |
Ectopic Thymus | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 | 14 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 1 1 | 13 1.2|
Ectopic Thymus | | 1 |
Follicle, Cyst | X | 5 |
Follicular Cell, Hyperplasia | 1 3 2 1 | 17 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | 2 | 5 2.0|
Cyst | X X X X X X | 17 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 4 4.0|
Pigmentation | 3 | 2 3.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | 2 | 3 2.3|
Granuloma | | 1 3.0|
Hydrometra | | 2 3.5|
Hyperplasia, Cystic | 3 3 2 2 1 3 3 2 3 | 58 2.7|
Inflammation, Suppurative | 1 | 6 1.8|
Necrosis | | 2 3.5|
Epithelium, Metaplasia, Squamous | 1 1 | 7 1.4|
Myometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 2 3 | 8 2.5|
Myelofibrosis | 2 1 3 | 15 1.7|
Pigmentation, Hemosiderin | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Iliac, Hyperplasia, Plasma Cell | | 1 4.0|
Renal, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + I + + + | 58 |
Ectasia | | 2 3.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | 3 | 6 1.8|
Hyperplasia, Lymphoid | 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 2 2 2 2 | 15 2.4|
Pigmentation, Hemosiderin | 2 2 | 2 2.0|
Lymphoid Follicle, Hyperplasia | 2 2 | 6 2.0|
Red Pulp, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | X | 13 |
Depletion Cellular | | 2 3.0|
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | | 2 1.0|
Hyperplasia, Lobular | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | 2 | 3 1.3|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 2 1.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Inflammation, Chronic | | 1 1.0|
Thalamus, Mineralization | 1 1 2 2 1 3 2 2 | 42 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hemorrhage | 1 | 4 1.8|
Hyperplasia, Lymphoid | 1 2 | 14 1.5|
Infiltration Cellular, Histiocyte | | 1 1.0|
Bronchiole, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X X X X X X | 45 |
Glands, Cyst | | 1 |
Glands, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 1 2 | 60 1.9|
Mucosa, Atrophy | 3 3 3 3 3 3 3 3 3 2 | 60 2.8|
Mucosa, Degeneration | 3 3 3 3 3 3 3 3 3 2 | 60 2.9|
Mucosa, Pigmentation | 2 2 1 2 2 1 1 1 1 1 | 58 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
.3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 2 3 3 1 2 1 | 31 1.3|
Cyst | X X | 2 |
Glomerulosclerosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 3 1 1 1 | 23 1.4|
Mineralization | | 3 1.0|
Renal Tubule, Atrophy | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 1 3 3 | 14 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 2 1 1 | 17 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0|
| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + M + M +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + A M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X |
Nuclear Alteration | 2 |
Centrilobular, Necrosis | 4 |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2|
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 3 4 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Focal Cellular Change | X |
Acinar Cell, Cytoplasmic Alteration | 3 3|
__________________________________________________________________________|
Pharynx | + |
Ulcer | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
Mucosa, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Erosion | 1 1 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0|
| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X |
Angiectasis | |
Cyst | X |
Hyperplasia, Focal | 1 2 2 2 |
Hypertrophy, Focal | 2 2 1 1 3 1 2 1 2 2 2 |
Vacuolization Cytoplasmic, Focal | 2 1 1 |
Capsule, Hyperplasia | 3 3 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 2 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1|
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | 1 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Atrophy | |
Ectasia | 4 3 3 4 4 3 3 3 4 3 3 2 4 3 4 3 |
Inflammation, Chronic | 2 1 2 3 2 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0|
| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Chronic | 2|
Inflammation, Suppurative | 2 |
Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 3|
Necrosis | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M M + + + +|
Depletion Cellular | 2|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +|
Depletion Cellular | 2|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 2 1 3 2 1 3 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 2 |
Hyperplasia, Reticulum Cell | 3 |
Necrosis | |
Lymphoid Follicle, Atrophy | 3|
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + M M M + + + +|
Cyst | X X X X X X X|
Depletion Cellular | 2 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0|
| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcolemmal Nuclei, Hyperplasia | 2 |
Sarcoplasm, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 3 2 1 2 2 1 2 3 2 2 2 1 3 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 4 3 4 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Exudate | X X X X |
Glands, Hyperplasia, Cystic | 1 1 1 2 1 2 3 1 2 3 1 3 1 |
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mucosa, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 1 |
Cyst | X X X X X X X |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 1 1 3 2 1|
Inflammation, Suppurative | 3 1|
Mineralization | 1 1 1 1 2 2 1 1 1 1 |
Renal Tubule, Atrophy | 1 3 1 |
Renal Tubule, Dilatation | 2|
Renal Tubule, Hyperplasia | |
Renal Tubule, Regeneration | 2 1 1 2 2 2 1 2 2 1 1 1 2 2 1 1 1 2 1 1 1 1 1 3|
Transitional Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 3|
Inflammation, Suppurative | 3 3|
Mucosa, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5|
| 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X|
Clear Cell Focus | X X X |
Hyperplasia, Focal | 3 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | |
Mixed Cell Focus | |
Nuclear Alteration | |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 2 3 |
Lobules, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Focal Cellular Change | X X |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Pharynx | |
Ulcer | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Erosion | 3 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5|
| 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X|
Angiectasis | |
Cyst | |
Hyperplasia, Focal | 2 1 |
Hypertrophy, Focal | 1 2 2 2 1 1 1 1 2 2 1 2 1 |
Vacuolization Cytoplasmic, Focal | 2 |
Capsule, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + I M + + + M + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
Ectasia | 4 3 3 3 4 4 3 4 4 4 3 4 |
Inflammation, Chronic | 2 2 3 2 2 3 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5|
| 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 |
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 3 1 2 2 1 1 1 3 2|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 2 |
Hyperplasia, Reticulum Cell | |
Necrosis | 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + M + + I + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Depletion Cellular | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5|
| 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcolemmal Nuclei, Hyperplasia | |
Sarcoplasm, Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 3 2 2 2 3 2 1 2 3 3 2 2 3 2 1 2 1 3 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 1 2 |
Infiltration Cellular, Histiocyte | 4 2 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Exudate | X X X X |
Glands, Hyperplasia, Cystic | 2 2 1 2 1 1 1 |
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 |
Mucosa, Degeneration | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Mucosa, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 3 1 1 1 1 |
Cyst | X X X X X X X X X X |
Glomerulosclerosis | 2 |
Hyperplasia, Lymphoid | 1 1 2 1 2 1 1 1 2 3 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | 3 1 2 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Hyperplasia | 1 2 |
Renal Tubule, Regeneration | 1 1 1 3 1 1 1 2 2 2 1 1 2 3 2 2 2 2 1 2 2 1 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | |
| 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X | 7 |
Hyperplasia, Focal | | 2 2.5|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Subacute | | 1 1.0|
Mixed Cell Focus | X | 3 |
Nuclear Alteration | | 1 2.0|
Centrilobular, Necrosis | | 1 4.0|
Hepatocyte, Cytomegaly | | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 4 2.3|
Kupffer Cell, Hyperplasia | 2 | 3 2.3|
Lobules, Necrosis | 2 | 4 3.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 2 1.0|
Focal Cellular Change | | 3 |
Acinar Cell, Cytoplasmic Alteration | | 3 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Subacute | 3 | 3 2.7|
Mucosa, Hyperplasia | 3 | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | |
| 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 3 1.7|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Dysplasia | 2 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 9 |
Angiectasis | 3 | 1 3.0|
Cyst | | 1 |
Hyperplasia, Focal | 1 | 7 1.6|
Hypertrophy, Focal | 3 1 2 2 2 | 29 1.7|
Vacuolization Cytoplasmic, Focal | 2 | 5 1.6|
Capsule, Hyperplasia | 3 2 2 | 11 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Hyperplasia | 3 1 2 3 | 11 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 52 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 5 1.0|
Follicle, Cyst | X X | 6 |
Follicular Cell, Hyperplasia | 1 1 | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | |
| 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 38 |
Atrophy | | 1 3.0|
Ectasia | 4 2 4 4 3 | 33 3.4|
Inflammation, Chronic | 2 4 2 3 | 18 2.3|
Inflammation, Suppurative | 3 | 3 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Seminiferous Tubule, Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 2 2 | 8 2.3|
Necrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Depletion Cellular | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Depletion Cellular | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 3 2.0|
Hemorrhage | 2 2 | 18 1.9|
Hyperplasia, Lymphoid | 2 | 4 2.5|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 2 2 3 | 13 2.5|
Hyperplasia, Reticulum Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | |
| 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | | 1 2.0|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | 4 | 1 4.0|
Red Pulp, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + + | 52 |
Cyst | X | 12 |
Depletion Cellular | | 4 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 2 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Sarcolemmal Nuclei, Hyperplasia | | 1 2.0|
Sarcoplasm, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization | 3 2 2 1 3 1 3 1 | 46 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 | 5 1.8|
Infiltration Cellular, Histiocyte | 3 | 7 3.1|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Cyst | | 1 |
Exudate | | 8 |
Glands, Hyperplasia, Cystic | 1 1 3 1 | 24 1.6|
Mucosa, Atrophy | 1 1 1 1 1 1 1 | 30 1.0|
Mucosa, Degeneration | 1 1 1 1 1 1 | 36 1.0|
Mucosa, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | |
| 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 2 | 10 1.4|
Cyst | X X X X | 21 |
Glomerulosclerosis | | 1 2.0|
Hyperplasia, Lymphoid | 1 1 1 | 18 1.4|
Inflammation, Suppurative | | 2 2.0|
Mineralization | 1 1 1 1 1 1 1 | 29 1.1|
Renal Tubule, Atrophy | | 6 1.8|
Renal Tubule, Dilatation | | 2 1.5|
Renal Tubule, Hyperplasia | | 2 1.5|
Renal Tubule, Regeneration | 2 2 1 1 1 3 2 1 1 2 | 57 1.6|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 | 2 1.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X |
Nuclear Alteration | |
Thrombosis | X |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 3 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | |
Fat, Hemorrhage | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cyst | |
Focal Cellular Change | X |
Acinar Cell, Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 1 |
Inflammation, Subacute | 3|
Mucosa, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 2 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X|
Angiectasis | 2 |
Hyperplasia, Focal | 1 1 3 1 2 |
Hypertrophy, Focal | 1 2 2 2 2 2 1 1|
Vacuolization Cytoplasmic, Focal | 1 2 |
Capsule, Hyperplasia | 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 4 4 3 3 3 3 2 3 4 3 4|
Inflammation, Chronic | 2 3 2 2 2 4 2 3 2 3 4 2 3 2|
Inflammation, Suppurative | 3 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + I + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 2 |
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | 2 3 2 2 2 1 2 1 2 |
Hyperplasia, Lymphoid | 4 3 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 2 |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + + + + + + + +|
Cyst | X X X |
Depletion Cellular | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Granuloma | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hemorrhage | 3 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Sarcolemmal Nuclei, Hyperplasia | |
Sarcoplasm, Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Thalamus, Mineralization | 2 2 2 2 1 3 2 2 2 2 3 3 3 3 1 1 3 3 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 3 2 2|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X|
Glands, Hyperplasia, Cystic | 1 2 1 1 2 2 2 1 1 1 1 1 1 2 1 2 1 2|
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Degeneration | 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 2 1 |
Cyst | X X X X X X X X X X X|
Glomerulosclerosis | 1 1 |
Hyperplasia, Lymphoid | 1 1 1 1 1 2 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1 1 2 1 1 1 1 1|
Renal Tubule, Atrophy | 2 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
.033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 2 2 1 1 1 1 2 1 1 1 2 1 2 2 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3|
| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 3 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 |
Mixed Cell Focus | |
Nuclear Alteration | |
Thrombosis | |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 3 |
Fat, Hemorrhage | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X |
Focal Cellular Change | X |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Inflammation, Subacute | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3|
| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 2 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X|
Angiectasis | |
Hyperplasia, Focal | 1 1 1 1 2 1 1 |
Hypertrophy, Focal | 2 1 1 1 1 2 1 1 2 |
Vacuolization Cytoplasmic, Focal | 1 1|
Capsule, Hyperplasia | 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3|
| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Ectasia | 2 4 3 4 3 3 3 4 3 3 3 3 2 3 3 4 |
Inflammation, Chronic | 2 2 2 2 3 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | 2 2 1 1 1 2 2 1 1 1 1 1 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + I + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | X X X X X X |
Depletion Cellular | 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Granuloma | 3 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3|
| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hemorrhage | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Sarcolemmal Nuclei, Hyperplasia | 2 |
Sarcoplasm, Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Thalamus, Mineralization | 1 2 3 3 2 2 1 1 2 1 2 1 2 2 2 2 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 4 4 |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X|
Glands, Hyperplasia, Cystic | 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1|
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Degeneration | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 3 1 1 3 1 1 |
Cyst | X X X |
Glomerulosclerosis | 1 1 |
Hyperplasia, Lymphoid | 2 1 2 1 1 1 1 1|
Mineralization | 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3|
| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 1 1 2 3 1 1 1 1 3 1 1 2 1 1 1 2 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | |
DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | |
| 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 1.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 59 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Clear Cell Focus | X | 4 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Hyperplasia, Focal | 3 | 3 2.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Subacute | 3 | 3 1.7|
Mixed Cell Focus | | 2 |
Nuclear Alteration | 3 | 1 3.0|
Thrombosis | | 1 |
Centrilobular, Necrosis | 4 | 2 3.5|
Hepatocyte, Vacuolization Cytoplasmic| | 1 1.0|
Kupffer Cell, Hyperplasia | 2 | 2 2.5|
Lobules, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Suppurative | | 1 3.0|
Fat, Hemorrhage | | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 2 2.5|
Cyst | | 1 |
Focal Cellular Change | | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | |
DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | |
| 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | 2 | 3 1.7|
Inflammation, Subacute | 2 2 | 3 2.3|
Mucosa, Hyperplasia | 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | X | 6 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Dysplasia | | 3 2.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 10 |
Angiectasis | | 1 2.0|
Hyperplasia, Focal | 1 | 13 1.3|
Hypertrophy, Focal | 2 1 1 1 1 | 22 1.4|
Vacuolization Cytoplasmic, Focal | | 4 1.3|
Capsule, Hyperplasia | 2 | 8 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 2 | 13 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 58 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 4 1.5|
Follicle, Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | |
DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | |
| 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 1 | 8 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | X | 1 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 42 |
Ectasia | 3 3 4 2 3 3 4 3 | 40 3.2|
Inflammation, Chronic | 2 2 2 2 | 25 2.4|
Inflammation, Suppurative | | 4 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 2 | 4 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Depletion Cellular | 3 | 1 3.0|
Dilatation | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 2 | 6 2.3|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | 2 | 3 2.7|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Ectasia | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 5 1.2|
Hemorrhage | 1 2 1 | 24 1.5|
Hyperplasia, Lymphoid | 3 | 5 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | |
DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | |
| 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 2 3 | 14 2.4|
Lymphoid Follicle, Atrophy | | 1 2.0|
Lymphoid Follicle, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 55 |
Cyst | X X X | 12 |
Depletion Cellular | | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 1.0|
Granuloma | | 1 3.0|
Hemorrhage | | 1 3.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 1 1.0|
Sarcolemmal Nuclei, Hyperplasia | 2 | 2 2.0|
Sarcoplasm, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Ectopic Tissue | | 1 |
Thalamus, Mineralization | 2 2 3 2 2 2 2 2 2 2 | 48 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Hemorrhage | 1 | 2 1.0|
Hyperplasia, Lymphoid | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 1 | 8 2.4|
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | |
DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | |
| 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Exudate | X | 18 |
Glands, Hyperplasia, Cystic | 2 1 1 1 1 1 1 1 1 | 46 1.2|
Mucosa, Atrophy | 1 1 1 1 1 1 1 1 1 1 | 57 1.0|
Mucosa, Degeneration | 1 1 1 1 1 1 1 1 1 1 | 55 1.1|
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 52 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 1 1 | 16 1.3|
Cyst | X X | 16 |
Glomerulosclerosis | | 4 1.0|
Hyperplasia, Lymphoid | | 17 1.2|
Mineralization | 2 2 1 1 1 1 1 | 48 1.2|
Renal Tubule, Atrophy | 1 1 | 3 1.3|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Regeneration | 2 1 1 1 2 1 1 1 2 1 | 51 1.3|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3|
| 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X |
Centrilobular, Necrosis | 1 |
Hepatocyte, Cytomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 2 2 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mucosa, Hyperplasia | 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3|
| 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 1 2 1 |
Hypertrophy, Focal | 1 1 2 1 1 2 1 2 1 2 1|
Vacuolization Cytoplasmic, Focal | 2 1 |
Capsule, Hyperplasia | 2 2 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M + + + + +|
Cyst | |
Ectopic Thymus | X |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Hypospermia | |
Inflammation, Chronic | 2 |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + |
Ectasia | 4 2 4 4 3 4 4 4 2 3 3 3 |
Inflammation, Chronic | 2 1 2 2 2 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3|
| 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 1 2 3 2 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Atrophy | 2 |
Red Pulp, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + M + + + + + + + +|
Cyst | X X X X X X X|
Depletion Cellular | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Sarcolemmal Nuclei, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3|
| 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | X |
Hydrocephalus | 3 |
Vacuolization Cytoplasmic | 3 |
Glial Cell, Proliferation | 3 |
Thalamus, Mineralization | 2 3 1 2 2 3 2 3 2 1 3 2 2 3 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Infiltration Cellular, Histiocyte | 1 2 |
Alveolar Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X X X|
Glands, Hyperplasia, Cystic | 1 1 1 2 1 1 1 1 2 1 2 1 2 1 2 2 1 2 2 1|
Mucosa, Atrophy | 2 2 1 1 2 2 2 3 1 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2|
Mucosa, Degeneration | 2 2 2 1 2 2 2 3 1 2 3 2 2 2 2 1 3 2 2 2 1 2 2 2 2|
Mucosa, Pigmentation | 2 1 2 1 1 1 1 1 1 1 2 2 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | 3 |
Cornea, Hyperplasia | 3 |
__________________________________________________________________________|
Harderian Gland | + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 |
Cyst | X X X X X|
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 1 3 1 1 1|
Mineralization | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 2 1 1|
Renal Tubule, Atrophy | 1 1 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 1 1 1 2 2 2 1 1 2 1 2 1 2 2 1 2 2 1 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X X |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Focal | |
Inflammation, Subacute | 1 |
Mixed Cell Focus | |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Focal Cellular Change | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 1 1 |
Hypertrophy, Focal | 2 1 1 1 1 1 2|
Vacuolization Cytoplasmic, Focal | |
Capsule, Hyperplasia | 2 2 3 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + M + + +|
Cyst | X |
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X |
Hypospermia | |
Inflammation, Chronic | |
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 4 3 4 3 3 3 4 3 3 4 3 3 3|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 3 2|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Seminiferous Tubule, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hematopoietic Cell Proliferation | 2 1 2 1 2|
Hemorrhage | 1 2 2 3 2 2 3 2 1|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 1|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Atrophy | |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Depletion Cellular | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Sarcolemmal Nuclei, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | |
Hydrocephalus | |
Vacuolization Cytoplasmic | |
Glial Cell, Proliferation | |
Thalamus, Mineralization | 3 2 3 2 2 2 2 1 2 2 3 2 2 3 2 2 2 2 2 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 4|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X X|
Glands, Hyperplasia, Cystic | 1 1 1 2 1 3 1 1 1 2 1 1 1 1 2 1 1 1 1|
Mucosa, Atrophy | 2 2 2 3 2 2 3 2 2 2 3 3 3 2 2 2 2 2 2 1 1 2 2 2 2|
Mucosa, Degeneration | 2 2 2 3 2 2 3 2 2 2 3 3 3 2 2 2 2 2 2 1 1 2 2 2 2|
Mucosa, Pigmentation | 1 1 1 1 2 1 2 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | 3 |
Cornea, Hyperplasia | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 2 1 1 1|
Cyst | X X X X X X |
Glomerulosclerosis | 1 |
Hyperplasia, Lymphoid | 1 1 2 1 1 1 1 1 |
Mineralization | 1 1 1 1 1 2 1 1 2 1 1 1 2 2 1 1 1 |
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | 1|
Renal Tubule, Regeneration | 2 1 2 1 1 2 1 1 3 1 1 1 2 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 5 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Focal | | 1 1.0|
Inflammation, Subacute | | 2 1.0|
Mixed Cell Focus | X | 2 |
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Cytomegaly | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.0|
Kupffer Cell, Hyperplasia | | 2 2.0|
Kupffer Cell, Pigmentation | | 1 2.0|
Lobules, Necrosis | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 2 1.5|
Focal Cellular Change | X | 1 |
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Subacute | 2 2 | 3 2.0|
Mucosa, Hyperplasia | 2 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 8 |
Hyperplasia, Diffuse | 2 | 1 2.0|
Hyperplasia, Focal | 1 | 8 1.1|
Hypertrophy, Focal | 1 1 1 1 1 | 23 1.3|
Vacuolization Cytoplasmic, Focal | | 2 1.5|
Capsule, Hyperplasia | | 9 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 11 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 55 |
Cyst | X | 2 |
Ectopic Thymus | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 58 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 8 1.3|
Follicle, Cyst | | 3 |
Follicular Cell, Hyperplasia | | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | | 2 |
Hypospermia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 35 |
Ectasia | 4 4 3 4 4 | 32 3.4|
Inflammation, Chronic | 2 | 18 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Seminiferous Tubule, Atrophy | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 3 2.0|
Pigmentation, Hemosiderin | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 4 2.5|
Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 | 8 1.5|
Hemorrhage | 3 3 1 2 3 | 19 2.1|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 9 2.4|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia | 2 | 1 2.0|
Red Pulp, Atrophy | | 1 2.0|
Red Pulp, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Cyst | X X X | 15 |
Depletion Cellular | 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 2 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 1 | 3 1.3|
Sarcolemmal Nuclei, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Hydrocephalus | | 1 3.0|
Vacuolization Cytoplasmic | | 1 3.0|
Glial Cell, Proliferation | | 1 3.0|
Thalamus, Mineralization | 2 2 2 3 2 2 1 2 1 | 54 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 2 1.5|
Infiltration Cellular, Histiocyte | | 8 1.6|
Alveolar Epithelium, Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X X X X X | 39 |
Glands, Hyperplasia, Cystic | 2 1 1 1 1 1 1 1 1 | 48 1.3|
Mucosa, Atrophy | 3 2 2 1 2 2 1 1 2 2 | 60 2.0|
Mucosa, Degeneration | 3 2 2 1 2 2 1 1 2 2 | 60 2.0|
Mucosa, Pigmentation | 1 1 2 1 1 1 1 1 1 1 | 60 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Inflammation, Chronic | 2 | 3 2.7|
Cornea, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
.1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 1 1 | 13 1.1|
Cyst | X X X X X | 16 |
Glomerulosclerosis | | 1 1.0|
Hyperplasia, Lymphoid | 1 1 | 15 1.2|
Mineralization | 1 1 1 1 1 1 | 42 1.2|
Renal Tubule, Atrophy | 1 2 | 5 1.2|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Regeneration | 1 1 2 2 1 1 1 | 47 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Subacute | 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Hyperplasia | 3 2 |
Kupffer Cell, Pigmentation | 4 |
Lobules, Necrosis | 4 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | 4 |
Acinar Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Erosion | |
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Degeneration, Ballooning | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Myocardium, Hemorrhage | |
Myocardium, Inflammation, Chronic | 1 |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Hyperplasia, Focal | 2 1 1 2 |
Hypertrophy, Focal | 1 3 3 1 2 2 1 1 1 |
Vacuolization Cytoplasmic, Focal | 1 1 1 |
Capsule, Hyperplasia | 3 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 3 |
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Ectasia | 4 3 2 4 4 3 2 3 3 3 3 |
Inflammation, Chronic | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Mineralization | 3 |
Seminiferous Tubule, Atrophy | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 1 2 1 2 3 1 2 1 2|
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 |
Lymphoid Follicle, Atrophy | 3 3 |
Lymphoid Follicle, Hyperplasia | 2|
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + M + I + + + + + + + + + + + +|
Cyst | X X X X X|
Depletion Cellular | 3 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Inflammation, Chronic | 1 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Sarcolemmal Nuclei, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
Thalamus, Mineralization | 1 1 2 1 2 2 2 3 2 2 2 2 3 2 2 3 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 4 2|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Exudate | X X X X X X X X X X X X X X|
Glands, Hyperplasia, Cystic | 3 2 2 3 3 1 1 2 2 2 2 2 1 2 1 1 2 2 1 3 1 2 2 1 2|
Mucosa, Atrophy | 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Mucosa, Degeneration | 3 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Mucosa, Pigmentation | 2 2 2 2 2 2 1 2 2 2 2 1 2 1 1 3 2 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic | |
Cornea, Hyperplasia | |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 2 1|
Cyst | X X X X X |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 1 1 1 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 2 1 1 1 1 1 1 1 1 2 1 2 2 2 1 3 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7|
| 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Subacute | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Subacute | |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia, Lymphoid | 1|
Acinar Cell, Cytoplasmic Alteration | 3 2 3|
Acinar Cell, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Erosion | 2 |
Inflammation, Subacute | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7|
| 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Degeneration, Ballooning | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Myocardium, Hemorrhage | 1 |
Myocardium, Inflammation, Chronic | 1 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X|
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 2 1 2 1 1 1 2 1 1 1 1|
Vacuolization Cytoplasmic, Focal | 1 |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Ectasia | 4 3 3 2 3 3 3 3 4 3 |
Inflammation, Chronic | 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7|
| 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Mineralization | |
Seminiferous Tubule, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 2 1 1 1 1 3 3 2 1 3 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Depletion Cellular | 2 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7|
| 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 |
Sarcolemmal Nuclei, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
Thalamus, Mineralization | 1 1 2 3 2 2 2 2 2 2 3 1 1 2 3 1 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 1 |
Infiltration Cellular, Histiocyte | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Exudate | X X X X X X X X X X X X X X |
Glands, Hyperplasia, Cystic | 3 1 2 1 2 1 2 3 2 2 2 2 2 3 1 1 2 1 2 2 1 1 1 1 2|
Mucosa, Atrophy | 2 3 3 3 3 2 3 3 3 3 2 3 3 3 3 2 2 3 3 3 3 3 2 3 3|
Mucosa, Degeneration | 2 3 3 3 3 3 3 3 3 3 2 3 3 3 3 2 2 3 3 3 3 3 2 3 3|
Mucosa, Pigmentation | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | 3 |
Cornea, Hyperplasia | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 |
Cyst | X X X X X X X X X |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 1 2 1 2 2 |
Mineralization | 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 2 2 1 2 1 1 2 1 1 3 1 1 2 1 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | |
| 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
Cyst | | 1 |
Inflammation, Subacute | | 1 1.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Clear Cell Focus | | 2 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Inflammation, Subacute | 1 1 | 3 1.0|
Mixed Cell Focus | | 2 |
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Necrosis | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.5|
Kupffer Cell, Hyperplasia | 2 | 4 2.3|
Kupffer Cell, Pigmentation | 2 | 2 3.0|
Lobules, Necrosis | 4 | 4 2.8|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | | 1 1.0|
Acinar Cell, Cytoplasmic Alteration | 3 | 5 3.0|
Acinar Cell, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 7 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | 3 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | |
| 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Mucosa, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | X X X | 6 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Epithelium, Degeneration, Ballooning | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 2 1.5|
Myocardium, Hemorrhage | | 1 1.0|
Myocardium, Inflammation, Chronic | | 2 1.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X X | 8 |
Hyperplasia, Focal | 3 1 | 7 1.6|
Hypertrophy, Focal | 1 2 1 1 2 | 26 1.4|
Vacuolization Cytoplasmic, Focal | 1 | 5 1.0|
Capsule, Hyperplasia | 2 | 7 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + | 57 |
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 2 | 8 1.6|
Follicle, Cyst | | 5 |
Follicular Cell, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | |
| 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 25 |
Ectasia | 4 X 3 | 24 3.1|
Inflammation, Chronic | 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Granuloma Sperm | | 2 3.0|
Mineralization | | 1 3.0|
Seminiferous Tubule, Atrophy | 3 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M | 59 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 2 | 23 1.9|
Hyperplasia, Lymphoid | | 4 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 3 3 | 8 2.5|
Lymphoid Follicle, Atrophy | 3 | 3 3.0|
Lymphoid Follicle, Hyperplasia | | 3 2.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + | 54 |
Cyst | X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | |
| 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Cellular | 3 3 | 5 2.8|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 2 1.0|
Inflammation, Chronic | | 1 1.0|
Subcutaneous Tissue, Edema | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Dysplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 1.0|
Sarcolemmal Nuclei, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Vacuolization Cytoplasmic | | 1 2.0|
Thalamus, Mineralization | 3 2 1 2 2 2 3 2 3 | 47 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | 1 2 3 | 5 1.6|
Hyperplasia, Lymphoid | | 2 1.0|
Infiltration Cellular, Histiocyte | | 4 2.8|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Exudate | X X X | 31 |
Glands, Hyperplasia, Cystic | 1 2 2 1 2 2 2 1 2 2 | 60 1.8|
Mucosa, Atrophy | 3 3 3 3 3 3 3 3 3 3 | 60 2.9|
Mucosa, Degeneration | 3 3 3 3 3 3 3 3 3 3 | 60 2.9|
Mucosa, Pigmentation | 2 2 2 2 3 3 2 2 1 2 | 60 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05120-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 12:17:52
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | |
| 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Inflammation, Chronic | | 1 3.0|
Cornea, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 | 7 1.3|
Cyst | X X X | 17 |
Glomerulosclerosis | 2 1 | 2 1.5|
Hyperplasia, Lymphoid | 1 1 | 12 1.3|
Mineralization | 1 2 1 1 1 | 38 1.1|
Renal Tubule, Atrophy | 1 | 2 1.0|
Renal Tubule, Dilatation | 1 | 2 1.5|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 1 1 1 | 51 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
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---------- END OF REPORT ----------
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