TDMS Study 05120-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/16/94
EXP: 05120 BENZYL ACETATE TIME: 03:58:02
TEST: 04 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 06508B
CONT: N01-ES-55082 CAS: 140-11-4
PATHOLOGIST: JAMES HEATH SCOT EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/16/94
EXP: 05120 BENZYL ACETATE TIME: 03:58:02
TEST: 04 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 06508B
CONT: N01-ES-55082 CAS: 140-11-4
PATHOLOGIST: JAMES HEATH SCOT EUSTIS
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 408 508 508 577 618 644 670 710 724 725 |
| 727 |
| CENSORED DEATHS |
| 456 456 456 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .033% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 508 561 562 589 605 722 724 |
| CENSORED DEATHS |
| 456 456 457 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 571 618 618 620 620 708 711 724 726 |
| CENSORED DEATHS |
| 456 456 457 457 457 457 457 458 458 458 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = .3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 477 524 552 584 600 647 651 683 701 724 |
| 725 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 457 457 457 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0% | 100.0 100.0 100.0 100.0 98.3 98.3 94.3 92.3 88.3 78.3 |
| | |
| | |
|.033% | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 90.0 86.0 |
| | |
| | |
|.1% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 82.0 |
| | |
| | |
|.3% | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 86.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0% .033% .1% .3% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 86.0% 82.0% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.718 P=0.444N P=0.762N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 619.9 610.1 657.3 624.4 |
|NATURAL DEATHS (C) | (32.5) (31.3) (19.7) (25.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 663.7 669.9 672.9 664.4 |
|(STANDARD ERROR) | (14.4) (13.7) (13.3) (13.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 494 520 533 533 541 544 584 597 600 603 |
| 614 633 639 656 656 659 675 691 697 722 |
| 725 |
| CENSORED DEATHS |
| 456 456 456 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .033% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 17 428 507 521 544 544 628 638 638 647 |
| 656 659 659 678 681 691 701 706 714 718 |
| 723 723 |
| CENSORED DEATHS |
| 456 456 457 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 10 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 114 568 649 683 702 708 712 716 720 722 |
| 722 723 723 |
| CENSORED DEATHS |
| 456 457 457 457 457 457 457 458 458 458 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = .3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 6 CENSORED DEATHS 10 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 302 544 552 574 590 594 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 457 457 457 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0% | 100.0 100.0 100.0 100.0 100.0 100.0 88.0 80.0 68.0 58.0 |
| | |
| | |
|.033% | 98.3 98.3 98.3 98.3 98.3 96.7 88.6 88.6 74.5 56.4 |
| | |
| | |
|.1% | 100.0 98.3 98.3 98.3 98.3 98.3 98.3 96.3 94.3 74.3 |
| | |
| | |
|.3% | 100.0 100.0 100.0 98.3 98.3 98.3 96.3 88.3 88.3 88.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0% .033% .1% .3% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 56.4% 74.3% 88.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=1.000 P=0.068N P=0.003N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 615.0 610.0 650.9 526.0 |
|NATURAL DEATHS (C) | (15.1) (33.0) (46.4) (45.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 643.8 640.1 666.8 663.3 |
|(STANDARD ERROR) | (13.8) (17.5) (16.1) (15.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZYL ACETATE
KAPLAN-MEIER SURVIVAL CURVES
0% = 1
.033% = 2
.1% = 3
.3% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 1 4 2 3
|
|
| 1 4 1 4 23 3
97.5 +
|
| 4 4
|
95.0 +
| 1 1
P | 4 2 4 2
E |
R 92.5 + 1 1
C | 4 242
E |
N |
T 90.0 + 42 1 14 3 2
|
S |
U | 1 1
R 87.5 +
V |
I | 4 1 4 1 2 2
V |
A 85.0 +
L | 1 1
| 4 4
|
82.5 +
| 4 3 3
|
|
80.0 +
|
|
| 1 1
77.5 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
BENZYL ACETATE
KAPLAN-MEIER SURVIVAL CURVES
0% = 1
.033% = 2
.1% = 3
.3% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 4 1
| 2 3 4 2 4 3
| 1 1
| 2 2 1 144 3 3
95 + 2 2
| 4 4 3 3
| 2 11 4 4 3 3
|
90 + 33
| 2 4 2 4
P | 1 1
E | 1 1 2 2 33
R 85 +
C |
E | 11 22 33
N |
T 80 + 11 22
| 2 2
S | 1 1
U | 11
R 75 + 2 2
V | 1 1 3 3
I | 22
V |
A 70 + 1 1 22
L | 2 2
| 1 1
| 1 1
65 + 22
| 11
| 1 221
|
60 + 22
|
| 1 1
| 2 2
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.