National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3286

TDMS Study 05120-04 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/16/94   
EXP: 05120                      BENZYL ACETATE                 TIME: 03:58:02   
TEST: 04              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 06508B   
CONT: N01-ES-55082                                             CAS: 140-11-4    
PATHOLOGIST: JAMES HEATH                     SCOT EUSTIS                        
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/16/94  
EXP: 05120                      BENZYL ACETATE                 TIME: 03:58:02  
TEST: 04              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 06508B  
CONT: N01-ES-55082                                             CAS: 140-11-4   
PATHOLOGIST: JAMES HEATH                     SCOT EUSTIS                       

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0%                                       |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      408   508   508   577   618   644   670   710   724   725                 |
 |      727                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .033%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 7      CENSORED DEATHS 10   TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      508   561   562   589   605   722   724                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .1%                                      |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 9      CENSORED DEATHS 10   TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      571   618   618   620   620   708   711   724   726                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   457   457   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = .3%                                      |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      477   524   552   584   600   647   651   683   701   724                 |
 |      725                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0%         |   100.0 100.0 100.0 100.0  98.3  98.3  94.3  92.3  88.3  78.3      |
 |           |                                                                    |
 |           |                                                                    |
 |.033%      |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  90.0  90.0  86.0      |
 |           |                                                                    |
 |           |                                                                    |
 |.1%        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  90.0  82.0      |
 |           |                                                                    |
 |           |                                                                    |
 |.3%        |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0  86.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0%           .033%        .1%          .3%      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.3%        86.0%        82.0%        78.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.718      P=0.444N     P=0.762N     P=1.000  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       619.9        610.1        657.3        624.4    |
 |NATURAL DEATHS (C)      |       (32.5)       (31.3)       (19.7)       (25.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       663.7        669.9        672.9        664.4    |
 |(STANDARD ERROR)        |       (14.4)       (13.7)       (13.3)       (13.9)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0%                                       |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      494   520   533   533   541   544   584   597   600   603                 |
 |      614   633   639   656   656   659   675   691   697   722                 |
 |      725                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .033%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      17    428   507   521   544   544   628   638   638   647                 |
 |      656   659   659   678   681   691   701   706   714   718                 |
 |      723   723                                                                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .1%                                      |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 10   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      114   568   649   683   702   708   712   716   720   722                 |
 |      722   723   723                                                           |
 |  CENSORED DEATHS                                                               |
 |      456   457   457   457   457   457   457   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = .3%                                      |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 6      CENSORED DEATHS 10   TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      302   544   552   574   590   594                                         |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0%         |   100.0 100.0 100.0 100.0 100.0 100.0  88.0  80.0  68.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |.033%      |    98.3  98.3  98.3  98.3  98.3  96.7  88.6  88.6  74.5  56.4      |
 |           |                                                                    |
 |           |                                                                    |
 |.1%        |   100.0  98.3  98.3  98.3  98.3  98.3  98.3  96.3  94.3  74.3      |
 |           |                                                                    |
 |           |                                                                    |
 |.3%        |   100.0 100.0 100.0  98.3  98.3  98.3  96.3  88.3  88.3  88.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0%           .033%        .1%          .3%      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       58.0%        56.4%        74.3%        88.3%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=1.000      P=0.068N     P=0.003N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       615.0        610.0        650.9        526.0    |
 |NATURAL DEATHS (C)      |       (15.1)       (33.0)       (46.4)       (45.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       643.8        640.1        666.8        663.3    |
 |(STANDARD ERROR)        |       (13.8)       (17.5)       (16.1)       (15.0)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           BENZYL ACETATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0%               = 1
                                                        .033%            = 2
                                                        .1%              = 3
                                                        .3%              = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

        |
        |
  100.0 +1                                                                1          4   2         3
        |
        |
        |                                                                 1          4   1  4     23       3
   97.5 +
        |
        |                                                                                   4   4
        |
   95.0 +
        |                                                                                1          1
P       |                                                                                       4 2  4 2
E       |
R  92.5 +                                                                                           1      1
C       |                                                                                            4 242
E       |
N       |
T  90.0 +                                                                                               42 1  14         3 2
        |
S       |
U       |                                                                                                     1    1
R  87.5 +
V       |
I       |                                                                                                      4   1 4   1 2 2
V       |
A  85.0 +
L       |                                                                                                                1 1
        |                                                                                                            4  4
        |
   82.5 +
        |                                                                                                               4  3 3
        |
        |
   80.0 +
        |
        |
        |                                                                                                                  1 1
   77.5 +
        |
        -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
         0         10         20         30         40         50         60         70         80         90         100        110

                                                                    WEEK

NOTE: 10 obs hidden.

                                                           BENZYL ACETATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0%               = 1
                                                        .033%            = 2
                                                        .1%              = 3
                                                        .3%              = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1  2               3                            4                             1
      |    2               3                            4                   2                 4   3
      |                                                                               1    1
      |                                                                     2           2  1 144  3           3
   95 +                                                                                 2  2
      |                                                                                        4  4           3     3
      |                                                                                    2 11   4   4             3  3
      |
   90 +                                                                                                                33
      |                                                                                       2       4    2                4
P     |                                                                                       1     1
E     |                                                                                             1  1   2 2          33
R  85 +
C     |
E     |                                                                                                11    22          33
N     |
T  80 +                                                                                                 11    22
      |                                                                                                        2 2
S     |                                                                                                  1  1
U     |                                                                                                     11
R  75 +                                                                                                          2 2
V     |                                                                                                      1 1          3 3
I     |                                                                                                            22
V     |
A  70 +                                                                                                        1 1  22
L     |                                                                                                              2 2
      |                                                                                                          1 1
      |                                                                                                            1 1
   65 +                                                                                                                22
      |                                                                                                              11
      |                                                                                                               1 221
      |
   60 +                                                                                                                  22
      |
      |                                                                                                                   1 1
      |                                                                                                                   2 2
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.