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https://ntp.niehs.nih.gov/go/3288

TDMS Study 05120-03 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           BENZYL ACETATE


NTP Experiment-Test: 05120-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/15/94
Route: DOSED FEED                                                                                                 Time: 13:33:56




       Facility:  Southern Research Institute

       Chemical CAS #:  140-11-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           17           13           19                                     
    Natural Death                                      2            3                         3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           37           28                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Parasite Metazoan                                2 (3%)       1 (2%)       4 (7%)       4 (7%)                                
   Intestine Large, Rectum                            (59)         (59)         (60)         (59)                                   
      Parasite Metazoan                                5 (8%)       6 (10%)      1 (2%)       3 (5%)                                
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)                                   
      Dilatation                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       1 (2%)       2 (3%)                                             
      Congestion                                                    1 (2%)                                                          
      Cyst                                                                                    1 (2%)                                
      Degeneration, Cystic                                                       3 (5%)                                             
      Fatty Change                                    22 (37%)     17 (28%)     18 (30%)     22 (37%)                               
      Fibrosis, Focal                                  1 (2%)                                 1 (2%)                                
      Focal Cellular Change                           38 (63%)     44 (73%)     42 (70%)     45 (75%)                               
      Hematopoietic Cell Proliferation                 2 (3%)       2 (3%)       1 (2%)                                             
      Hepatodiaphragmatic Nodule                      12 (20%)     12 (20%)      5 (8%)       7 (12%)                               
      Hyperplasia, Multifocal                         21 (35%)     16 (27%)      9 (15%)     13 (22%)                               
      Infiltration Cellular, Mixed Cell                1 (2%)       5 (8%)       3 (5%)       2 (3%)                                
      Inflammation, Focal                             45 (75%)     53 (88%)     49 (82%)     44 (73%)                               
      Necrosis, Focal                                  3 (5%)       1 (2%)       2 (3%)       1 (2%)                                
      Pigmentation                                                                            1 (2%)                                
      Bile Duct, Hyperplasia                          43 (72%)     37 (62%)     38 (63%)     41 (68%)                               
      Biliary Tract, Fibrosis                         29 (48%)     23 (38%)     25 (42%)     19 (32%)                               
      Centrilobular, Atrophy                           6 (10%)      4 (7%)       9 (15%)      7 (12%)                               
   Mesentery                                          (11)         (5)          (7)          (12)                                   
      Inflammation, Chronic                                                      1 (14%)                                            
      Fat, Necrosis                                    7 (64%)      4 (80%)      2 (29%)      7 (58%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Atrophy, Focal                                  16 (27%)     20 (33%)     29 (48%)     19 (32%)                               
      Focal Cellular Change                            4 (7%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Lipocyte                  1 (2%)                                                                       
      Acinar Cell, Hyperplasia                         1 (2%)                    1 (2%)       1 (2%)                                
      Duct, Dilatation                                 1 (2%)                    1 (2%)       1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy, Focal                                                1 (2%)                    1 (2%)                                
      Focal Cellular Change                                         1 (2%)                                                          
      Infiltration Cellular, Lipocyte                  1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            1 (2%)                                 2 (3%)                                
      Erosion                                                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    3 (5%)       3 (5%)                                
      Ulcer                                                                      3 (5%)       1 (2%)                                
      Mucosa, Hyperplasia                                                        2 (3%)       2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Developmental Malformation                                                              1 (2%)                                
      Edema                                            1 (2%)                    1 (2%)                                             
      Erosion                                                                                 3 (5%)                                
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
      Mucosa, Cyst, Multiple                           1 (2%)                                                                       
   Tooth                                              (1)          (3)          (1)                                                 
      Incisor, Dysplasia                                            1 (33%)      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)          (1)                                                 
      Mesenteric Artery, Inflammation, Chronic                      1 (100%)     1 (100%)                                           
      Mesenteric Artery, Thrombosis                                 1 (100%)                                                        
      Thoracic, Artery, Aneurysm                                                 1 (100%)                                           
      Thoracic, Artery, Inflammation, Chronic                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                                          1 (2%)       2 (3%)                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Congestion                                                                 3 (5%)       1 (2%)                                
      Focal Cellular Change                           10 (17%)      6 (10%)      7 (12%)      5 (8%)                                
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
      Inflammation, Focal                                           1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)                    1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      3 (5%)       4 (7%)       1 (2%)       5 (8%)                                
   Parathyroid Gland                                  (58)         (60)         (59)         (57)                                   
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       6 (10%)      5 (8%)       4 (7%)                                
      Cyst                                             5 (8%)       3 (5%)       9 (15%)     10 (17%)                               
      Hemorrhage                                                    1 (2%)                                                          
      Pars Distalis, Focal Cellular Change             1 (2%)       3 (5%)       8 (13%)      3 (5%)                                
      Pars Distalis, Hyperplasia, Focal                             2 (3%)                    3 (5%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (59)                                   
      Ultimobranchial Cyst                             1 (2%)                    2 (3%)       1 (2%)                                
      C-Cell, Hyperplasia                             17 (28%)     10 (17%)     14 (23%)     10 (17%)                               
      Follicle, Cyst                                   1 (2%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (60)         (59)                                   
      Degeneration, Cystic                            51 (85%)     54 (90%)     48 (80%)     47 (80%)                               
      Hyperplasia                                      2 (3%)       1 (2%)       1 (2%)       4 (7%)                                
      Inflammation, Chronic                                         2 (3%)       1 (2%)       1 (2%)                                
   Ovary                                              (60)         (60)         (60)         (59)                                   
      Angiectasis                                      2 (3%)                                                                       
      Hyperplasia, Histiocytic                                      1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
      Follicle, Cyst                                   6 (10%)      1 (2%)       2 (3%)       4 (7%)                                
      Periovarian Tissue, Cyst                         1 (2%)       1 (2%)       1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Adenomyosis                                                                             1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Decidual Reaction                                1 (2%)                                 1 (2%)                                
      Dilatation                                                                 1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Hydrometra                                       4 (7%)       5 (8%)       3 (5%)       4 (7%)                                
      Inflammation, Suppurative                        4 (7%)       3 (5%)       4 (7%)       2 (3%)                                
      Prolapse                                                                                1 (2%)                                
      Cervix, Hyperplasia                              1 (2%)                                                                       
      Endometrium, Angiectasis                                      1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                34 (57%)     38 (63%)     40 (67%)     43 (72%)                               
      Endometrium, Infarct                                          1 (2%)                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Epithelium, Hyperplasia, Papillary               3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Lumen, Exudate                                                             1 (2%)                                             
   Vagina                                             (2)          (1)          (2)          (2)                                    
      Angiectasis                                      1 (50%)                                                                      
      Cyst                                             1 (50%)      1 (100%)     1 (50%)      1 (50%)                               
      Mucosa, Hyperplasia                              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hypercellularity                                 1 (2%)                                 1 (2%)                                
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
      Axillary, Angiectasis                            1 (2%)                                                                       
      Axillary, Hyperplasia                            1 (2%)                                                                       
      Deep Cervical, Hyperplasia                       1 (2%)                                                                       
      Mediastinal, Angiectasis                         1 (2%)       4 (7%)       1 (2%)       2 (3%)                                
      Mediastinal, Pigmentation                        1 (2%)                                                                       
      Pancreatic, Angiectasis                                                                 1 (2%)                                
      Pancreatic, Hyperplasia, Lymphoid                             1 (2%)                                                          
   Lymph Node, Mandibular                             (60)         (60)         (60)         (59)                                   
      Angiectasis                                      1 (2%)       2 (3%)                    3 (5%)                                
      Hyperplasia                                      1 (2%)       3 (5%)                                                          
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (59)                                   
      Angiectasis                                      1 (2%)       1 (2%)                    1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Depletion Lymphoid                                                         1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Developmental Malformation                       1 (2%)                                                                       
      Fibrosis                                         4 (7%)       3 (5%)       3 (5%)       6 (10%)                               
      Hematopoietic Cell Proliferation                 4 (7%)       6 (10%)      3 (5%)       5 (8%)                                
      Hyperplasia, Histiocytic                                      2 (3%)                                                          
      Hyperplasia, Lymphoid                                         2 (3%)                                                          
      Necrosis, Focal                                                                         1 (2%)                                
   Thymus                                             (59)         (54)         (59)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Dilatation                                      41 (68%)     36 (60%)     34 (57%)     35 (58%)                               
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Hyperplasia                                     10 (17%)      8 (13%)      7 (12%)      6 (10%)                               
   Skin                                               (60)         (60)         (60)         (60)                                   
      Hyperkeratosis, Focal                                                      1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                    12 (20%)     21 (35%)     12 (20%)     22 (37%)                               
      Adventitia, Mandible, Inflammation, Chronic                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     16 (27%)     13 (22%)      8 (13%)     12 (20%)                               
      Hemorrhage                                                                              2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Bronchiectasis                                                1 (2%)                                                          
      Congestion                                       1 (2%)       2 (3%)                    1 (2%)                                
      Fibrosis, Focal                                               1 (2%)                    1 (2%)                                
      Granuloma                                                                               1 (2%)                                
      Hemorrhage                                                    1 (2%)       2 (3%)       2 (3%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Macrophage                          1 (2%)       6 (10%)      1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         2 (3%)       1 (2%)                                             
      Pigmentation                                                  2 (3%)                                                          
      Alveolar Epithelium, Hyperplasia                 3 (5%)       3 (5%)       4 (7%)       2 (3%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Fungus                                           8 (13%)      3 (5%)       3 (5%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Suppurative                       14 (23%)      9 (15%)     16 (27%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (4)          (2)                                                 
      Atrophy                                          1 (50%)                                                                      
      Cataract                                                      4 (100%)     2 (100%)                                           
      Hemorrhage                                                                 1 (50%)                                            
      Inflammation, Chronic                            1 (50%)                                                                      
      Cornea, Necrosis                                 1 (50%)                                                                      
      Retina, Degeneration                             1 (50%)      3 (75%)      2 (100%)                                           
   Harderian Gland                                    (1)                       (1)          (1)                                    
      Dilatation, Focal                                                          1 (100%)                                           
      Inflammation, Focal                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Mineralization                                   9 (15%)     11 (18%)      9 (15%)     10 (17%)                               
      Necrosis, Focal                                                                         1 (2%)                                
      Nephropathy                                     48 (80%)     55 (92%)     47 (78%)     44 (73%)                               
      Pigmentation                                     1 (2%)                                 1 (2%)                                
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Dilatation                               1 (2%)                    1 (2%)                                             
      Renal Tubule, Dilatation                                                   1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           12           16           14                                     
    Natural Death                                      3            4            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           34           30           33                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (60)         (60)         (60)         (59)                                   
      Parasite Metazoan                                             1 (2%)                    1 (2%)                                
   Intestine Large, Colon                             (60)         (60)         (59)         (59)                                   
      Cyst                                                                                    1 (2%)                                
      Parasite Metazoan                                4 (7%)       8 (13%)      2 (3%)       3 (5%)                                
   Intestine Large, Rectum                            (59)         (60)         (59)         (58)                                   
      Parasite Metazoan                                5 (8%)       2 (3%)       3 (5%)       7 (12%)                               
   Intestine Small, Ileum                             (59)         (60)         (60)         (59)                                   
      Congestion                                                    1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (60)         (60)         (58)                                   
      Diverticulum                                                                            1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Mucosa, Dysplasia                                                                       1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      4 (7%)       2 (3%)                                                          
      Congestion                                                    1 (2%)       1 (2%)                                             
      Degeneration, Cystic                            17 (28%)     20 (33%)     14 (23%)     14 (23%)                               
      Fatty Change                                    36 (60%)     37 (62%)     33 (55%)     35 (58%)                               
      Fibrosis, Focal                                               1 (2%)       1 (2%)                                             
      Focal Cellular Change                           27 (45%)     29 (48%)     28 (47%)     29 (48%)                               
      Hematopoietic Cell Proliferation                              3 (5%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       9 (15%)      6 (10%)      4 (7%)       4 (7%)                                
      Hyperplasia, Multifocal                         16 (27%)     17 (28%)     11 (18%)     18 (30%)                               
      Infiltration Cellular, Mixed Cell                7 (12%)      5 (8%)       5 (8%)       7 (12%)                               
      Inflammation, Focal                             44 (73%)     36 (60%)     37 (62%)     38 (63%)                               
      Necrosis, Focal                                  1 (2%)       1 (2%)       3 (5%)       2 (3%)                                
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Dilatation                                                                   1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          56 (93%)     60 (100%)    59 (98%)     60 (100%)                              
      Biliary Tract, Fibrosis                         54 (90%)     55 (92%)     57 (95%)     58 (97%)                               
      Centrilobular, Atrophy                          13 (22%)     14 (23%)     15 (25%)     10 (17%)                               
      Centrilobular, Necrosis                          1 (2%)       3 (5%)                    1 (2%)                                
   Mesentery                                          (17)         (16)         (13)         (11)                                   
      Inflammation, Chronic                            1 (6%)       2 (13%)                   1 (9%)                                
      Fat, Necrosis                                   12 (71%)      9 (56%)     10 (77%)      9 (82%)                               
   Pancreas                                           (60)         (60)         (60)         (59)                                   
      Atrophy, Focal                                  32 (53%)     32 (53%)     30 (50%)     30 (51%)                               
      Focal Cellular Change                            6 (10%)                                4 (7%)                                
      Acinar Cell, Hyperplasia                         3 (5%)       1 (2%)       7 (12%)      3 (5%)                                
   Salivary Glands                                    (60)         (60)         (60)         (59)                                   
      Atrophy, Focal                                                             1 (2%)                                             
      Dilatation                                                                              1 (2%)                                
      Focal Cellular Change                                         1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                                         1 (2%)       1 (2%)       1 (2%)                                
      Erosion                                                       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       5 (8%)       2 (3%)       1 (2%)                                
      Ulcer                                            1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Mucosa, Hyperplasia                              3 (5%)       5 (8%)       3 (5%)       3 (5%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Edema                                            2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Erosion                                          3 (5%)       1 (2%)       3 (5%)       3 (5%)                                
      Hyperplasia, Lymphoid                            3 (5%)                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Pigmentation                                     1 (2%)                                 2 (3%)                                
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Pigmentation                                                       1 (2%)                                             
   Tongue                                             (60)         (60)         (59)         (60)                                   
      Ectopic Tissue                                                1 (2%)                                                          
      Mucosa, Hyperplasia                                                        1 (2%)                                             
   Tooth                                              (2)                                    (1)                                    
      Incisor, Dysplasia                               1 (50%)                                1 (100%)                              
      Incisor, Inflammation, Suppurative               2 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)          (3)          (1)          (6)                                    
      Mesenteric Artery, Inflammation, Chronic         3 (100%)     3 (100%)     1 (100%)     5 (83%)                               
      Thoracic, Artery, Inflammation, Chronic                                                 1 (17%)                               
   Heart                                              (60)         (60)         (60)         (60)                                   
      Dilatation                                                                              1 (2%)                                
      Thrombosis                                                    2 (3%)       2 (3%)       2 (3%)                                
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Epicardium, Inflammation, Chronic                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                             2 (3%)                    1 (2%)                                
      Angiectasis                                                                1 (2%)                                             
      Congestion                                       1 (2%)                    1 (2%)                                             
      Focal Cellular Change                            9 (15%)      6 (10%)      7 (12%)      6 (10%)                               
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Vacuolization Cytoplasmic                                                  2 (3%)                                             
   Adrenal Gland, Medulla                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                     12 (20%)     12 (20%)     16 (27%)     13 (22%)                               
      Mineralization                                                             1 (2%)                                             
   Parathyroid Gland                                  (60)         (55)         (58)         (58)                                   
      Hyperplasia                                                                2 (3%)       1 (2%)                                
   Pituitary Gland                                    (59)         (60)         (59)         (58)                                   
      Angiectasis                                      2 (3%)       1 (2%)                    1 (2%)                                
      Cyst                                             3 (5%)       3 (5%)       4 (7%)       1 (2%)                                
      Hemorrhage                                                    2 (3%)                                                          
      Pars Distalis, Focal Cellular Change             5 (8%)       4 (7%)       7 (12%)      6 (10%)                               
      Pars Distalis, Hyperplasia, Focal                1 (2%)       2 (3%)       2 (3%)       3 (5%)                                
      Pars Distalis, Vacuolization Cytoplasmic                                   1 (2%)                                             
      Pars Nervosa, Focal Cellular Change                                                     1 (2%)                                
      Rathke's Cleft, Hyperplasia, Cystic                                        1 (2%)                                             
   Thyroid Gland                                      (60)         (59)         (60)         (58)                                   
      Degeneration, Cystic                             1 (2%)                                                                       
      Fibrosis, Focal                                                            1 (2%)                                             
      Pigmentation                                     1 (2%)                                 1 (2%)                                
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                              4 (7%)       5 (8%)       6 (10%)      7 (12%)                               
      Follicle, Cyst                                   3 (5%)       2 (3%)                    2 (3%)                                
      Follicular Cell, Hyperplasia                     2 (3%)                    2 (3%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (2)          (1)                                    
      Thoracic, Metaplasia, Osseous                                              1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Atrophy                                                       1 (2%)                                                          
   Preputial Gland                                    (60)         (60)         (60)         (60)                                   
      Degeneration, Cystic                            54 (90%)     60 (100%)    59 (98%)     60 (100%)                              
      Hyperplasia                                      1 (2%)       3 (5%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)       4 (7%)       3 (5%)                                
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Dilatation                                       2 (3%)       1 (2%)                    1 (2%)                                
      Hyperplasia                                      1 (2%)       6 (10%)      2 (3%)       1 (2%)                                
      Inflammation, Suppurative                       37 (62%)     27 (45%)     26 (43%)     28 (47%)                               
      Vacuolization Cytoplasmic                                                               1 (2%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Dilatation                                       3 (5%)                                 1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
      Germinal Epithelium, Degeneration               10 (17%)      7 (12%)      8 (13%)     11 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (59)                                   
      Hypercellularity                                              3 (5%)                                                          
      Hypocellularity                                  1 (2%)                                 1 (2%)                                
      Myelofibrosis                                                 1 (2%)                    1 (2%)                                
   Lymph Node                                         (60)         (60)         (60)         (59)                                   
      Cyst                                             1 (2%)                                                                       
      Mediastinal, Angiectasis                         4 (7%)       2 (3%)       5 (8%)       1 (2%)                                
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Mediastinal, Hyperplasia                                                                1 (2%)                                
      Mediastinal, Pigmentation                                     1 (2%)                                                          
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Pancreatic, Cyst                                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (60)         (59)         (60)         (58)                                   
      Angiectasis                                      2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Cyst                                             1 (2%)       3 (5%)       2 (3%)                                             
      Edema                                            1 (2%)                                                                       
      Hyperplasia                                      3 (5%)       2 (3%)                                                          
   Lymph Node, Mesenteric                             (60)         (60)         (58)         (59)                                   
      Angiectasis                                                                1 (2%)       2 (3%)                                
      Cyst                                             1 (2%)       2 (3%)                    3 (5%)                                
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                        10 (17%)     12 (20%)     10 (17%)      8 (13%)                               
      Hematopoietic Cell Proliferation                 3 (5%)       6 (10%)      2 (3%)       3 (5%)                                
      Hemorrhage                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Histiocytic                         1 (2%)                                 2 (3%)                                
      Necrosis, Focal                                  2 (3%)       1 (2%)       2 (3%)                                             
   Thymus                                             (58)         (58)         (58)         (55)                                   
      Cyst                                             3 (5%)       1 (2%)       1 (2%)                                             
      Depletion Cellular                                                         1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (58)         (58)         (60)                                   
      Dilatation                                       7 (12%)      8 (14%)      8 (14%)      8 (13%)                               
      Fibrosis                                                                   1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Exudate                                                       1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)       1 (2%)                                                          
      Ulcer                                            2 (3%)                                                                       
      Epidermis, Hyperplasia                           1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fat, Necrosis               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                                  1 (2%)       1 (2%)                                             
      Trabecula, Proliferation                                                                1 (2%)                                
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      3 (5%)       2 (3%)       1 (2%)       2 (3%)                                
      Hemorrhage                                       2 (3%)       2 (3%)       1 (2%)       1 (2%)                                
      Hydrocephalus                                    2 (3%)                                                                       
      Meninges, Angiectasis                                         1 (2%)                                                          
      Meninges, Hemorrhage                                          1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Exudate                                                       1 (2%)                                                          
      Fibrosis, Focal                                               1 (2%)                                                          
      Fungus                                                        1 (2%)                                                          
      Granuloma                                                                  1 (2%)                                             
      Hemorrhage                                       6 (10%)      4 (7%)       3 (5%)       4 (7%)                                
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Macrophage                                       2 (3%)       2 (3%)       3 (5%)                                
      Infiltration Cellular, Mixed Cell                2 (3%)       3 (5%)                                                          
      Inflammation, Chronic                                         4 (7%)                    2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 8 (13%)     10 (17%)      3 (5%)       3 (5%)                                
      Mediastinum, Cyst                                                                       1 (2%)                                
      Mediastinum, Ectopic Tissue                                   1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Foreign Body                                                                            1 (2%)                                
      Fungus                                          11 (18%)     16 (27%)     15 (25%)     14 (23%)                               
      Inflammation, Suppurative                       16 (27%)     18 (30%)     23 (38%)     18 (30%)                               
      Mucosa, Hyperkeratosis                           1 (2%)                                                                       
      Mucosa, Metaplasia, Squamous                     2 (3%)                                 1 (2%)                                
      Nasolacrimal Duct, Cyst                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (1)          (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
   Eye                                                (3)          (2)          (1)          (2)                                    
      Atrophy                                                       1 (50%)                                                         
      Cataract                                         1 (33%)      2 (100%)     1 (100%)                                           
      Inflammation, Chronic                            1 (33%)                                1 (50%)                               
      Cornea, Necrosis                                 1 (33%)                                1 (50%)                               
      Retina, Degeneration                             1 (33%)      2 (100%)     1 (100%)                                           
      Retrobulbar, Inflammation, Suppurative                                                  1 (50%)                               
   Zymbal's Gland                                     (1)                       (1)          (2)                                    
      Dilatation                                                                              1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                          2 (3%)                    2 (3%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Nephropathy                                     59 (98%)     59 (98%)     59 (98%)     60 (100%)                              
      Pigmentation                                     1 (2%)       2 (3%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:33:56  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Pelvis, Dilatation                                            1 (2%)                                                          
   Urethra                                            (1)                       (1)                                                 
      Bulbourethral Gland, Dilatation                  1 (100%)                  1 (100%)                                           
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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