National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3298

TDMS Study 05120-03 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/15/94   
EXP: 05120                      BENZYL ACETATE                 TIME: 14:10:36   
TEST: 03              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 06508B   
CONT: N01-ES-55082                                             CAS: 140-11-4    
PATHOLOGIST: DR FARNELL                      SCOT EUSTIS                        
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/15/94  
EXP: 05120                      BENZYL ACETATE                 TIME: 14:10:36  
TEST: 03              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 06508B  
CONT: N01-ES-55082                                             CAS: 140-11-4   
PATHOLOGIST: DR FARNELL                      SCOT EUSTIS                       

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0%                                       |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 23     CENSORED DEATHS 10   TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      467   487   495   525   542   560   574   600   600   631                 |
 |      633   643   654   668   682   705   705   710   714   724                 |
 |      725   725   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.3%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      396   488   504   528   553   570   581   600   618   630                 |
 |      633   655   693   704   705   710                                         |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.6%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      457   491   589   622   633   634   641   644   658   668                 |
 |      674   683   693   696   697   699   701   710   710   724                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   457   457   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1.2%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      431   501   539   546   573   584   613   630   631   638                 |
 |      643   644   668   686   715   724   724                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0%         |   100.0 100.0 100.0 100.0 100.0  98.0  90.0  82.0  74.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.3%       |   100.0 100.0 100.0 100.0  98.3  98.3  92.3  84.3  76.3  68.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.6%       |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  94.3  82.2  60.2      |
 |           |                                                                    |
 |           |                                                                    |
 |1.2%       |   100.0 100.0 100.0 100.0 100.0  98.3  94.3  88.3  76.3  66.2      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0%           0.3%         0.6%         1.2%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.0%        68.2%        60.2%        66.2%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.455N     P=0.291N     P=0.632N     P=0.346N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       630.2        598.0        651.2        617.1    |
 |NATURAL DEATHS (C)      |       (17.7)       (22.4)       (15.7)       (19.6)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       645.8        648.8        657.8        651.8    |
 |(STANDARD ERROR)        |       (14.1)       (14.5)       (13.5)       (14.1)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0%                                       |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      420   508   525   560   584   603   606   627   631   634                 |
 |      658   693   693   696   704   708   710   721   724   727                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.3%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      430   487   520   584   584   621   633   654   654   655                 |
 |      693   696   701   704   707   710   710   710   710   726                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   457   457   457   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.6%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 10   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      367   521   592   696   700   707   710   711   711   715                 |
 |      725   725   727                                                           |
 |  CENSORED DEATHS                                                               |
 |      456   457   457   457   457   457   457   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1.2%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      553   582   593   631   641   658   667   668   668   668                 |
 |      669   672   693   700   704   707   707   707   707   708                 |
 |      715   726                                                                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                  BENZYL ACETATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0%         |   100.0 100.0 100.0 100.0  98.3  98.3  94.3  88.3  78.3  60.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.3%       |   100.0 100.0 100.0 100.0 100.0  98.3  94.3  90.3  80.3  60.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.6%       |   100.0 100.0 100.0 100.0  98.3  98.3  96.3  94.3  94.3  74.3      |
 |           |                                                                    |
 |           |                                                                    |
 |1.2%       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  94.0  88.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0%           0.3%         0.6%         1.2%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       60.2%        60.2%        74.3%        56.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.946      P=1.000N     P=0.134N     P=0.924  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.6        644.5        662.1        670.2    |
 |NATURAL DEATHS (C)      |       (18.9)       (18.8)       (29.8)       ( 9.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       653.9        656.5        670.4        662.9    |
 |(STANDARD ERROR)        |       (14.1)       (14.1)       (14.4)       (13.0)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           BENZYL ACETATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0%               = 1
                                                        0.3%             = 2
                                                        0.6%             = 3
                                                        1.2%             = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                                              2    4    31
      |                                                                2    4    3   234
      |                                                                           1  1
      |                                                                              112     4        3
   95 +
      |                                                                               12   1244       3   3
      |                                                                                    12 12  4       3 3
      |
   90 +                                                                                       121 2 4
      |                                                                                           224    4  33
      |                                                                                         1 1
      |                                                                                           12   1 4 4
P  85 +
E     |                                                                                                2  2443 3
R     |                                                                                                1  2214 3  3
C     |
E  80 +                                                                                                    22     33
N     |                                                                                                     2  2   33
T     |                                                                                                     11
      |                                                                                                      1 1  4 32
S  75 +
U     |                                                                                                        1  1 4232
R     |                                                                                                           1 1    4
V     |
I  70 +                                                                                                             1  1244
V     |                                                                                                               332   2
A     |
L     |                                                                                                                11 4 4
   65 +
      |
      |                                                                                                                 1 1
      |
   60 +                                                                                                                   3 3
      |
      |
      |
   55 +
      |                                                                                                                   1 1
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 21 obs hidden.

                                                           BENZYL ACETATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0%               = 1
                                                        0.3%             = 2
                                                        0.6%             = 3
                                                        1.2%             = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                         3       1 2                  4
      |                                                           3       1 2        2  1  3
      |                                                                                        4    4
      |                                                                              2  1  1        4 3
   95 +
      |                                                                                    1    1   2 3     4         3
      |                                                                                         1   1       44
      |
   90 +                                                                                             1   1 2  4 4      33
      |                                                                                                   2 2          33
P     |                                                                                                        4  4
E     |                                                                                                 1  12  2
R  85 +
C     |                                                                                                    11
E     |                                                                                                                 33
N     |
T  80 +                                                                                                     1  1     2   33
      |                                                                                                        1     12
S     |
U     |                                                                                                           4  422
R  75 +
V     |                                                                                                              11   3 3
I     |                                                                                                               11
V     |
A  70 +                                                                                                                11
L     |
      |
      |                                                                                                                 11
   65 +
      |                                                                                                                  11
      |                                                                                                                42 2
      |
   60 +                                                                                                                 441 1
      |
      |                                                                                                                  44
      |                                                                                                                   4 4
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 20 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.