National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3312

TDMS Study 05121-05 Pathology Tables

NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96
Route: GAVAGE                                                                                                     Time: 21:10:36




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  6533-68-2

       Lock Date:  05/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10                        10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           10            6            7                                     
    Natural Death                                      3           15           16           16                                     
    Dosing Accident                                                 2            2            5                                     
    Accidently Killed                                              16                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           17           26           22                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (57)         (57)                                   
      Parasite Metazoan                                2 (3%)       4 (7%)       2 (4%)       5 (9%)                                
   Intestine Large, Rectum                            (60)         (59)         (57)         (57)                                   
      Parasite Metazoan                                7 (12%)      2 (3%)       4 (7%)                                             
   Intestine Small, Duodenum                          (60)         (60)         (60)         (59)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (56)         (57)         (56)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                22 (37%)     11 (18%)     21 (35%)     23 (38%)                               
      Clear Cell Focus                                 1 (2%)       1 (2%)                                                          
      Eosinophilic Focus                               3 (5%)       4 (7%)       4 (7%)       5 (8%)                                
      Fatty Change                                     2 (3%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                      14 (23%)      9 (15%)      6 (10%)     11 (18%)                               
      Hyperplasia, Adenomatous                         1 (2%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Bile Duct, Inflammation, Chronic                              1 (2%)                                                          
      Serosa, Fibrosis                                                                        1 (2%)                                
   Mesentery                                          (1)          (3)          (3)          (2)                                    
      Fat, Necrosis                                    1 (100%)     3 (100%)     2 (67%)      2 (100%)                              
      Lymphatic, Cyst                                                            1 (33%)                                            
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Acinus, Atrophy                                 16 (27%)      7 (12%)      8 (13%)      6 (10%)                               
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Duct, Concretion                                                                        1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (58)                                   
      Hyperkeratosis                                   1 (2%)                                                                       
      Ulcer                                            2 (3%)       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (60)         (59)                                   
      Ulcer                                            3 (5%)                    1 (2%)       1 (2%)                                
      Artery, Mineralization                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (59)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
   Heart                                              (60)         (60)         (60)         (60)                                   
      Atrium, Thrombosis                                            1 (2%)       1 (2%)       1 (2%)                                
      Myocardium, Degeneration                        30 (50%)     17 (28%)     31 (52%)     24 (40%)                               
      Myocardium, Mineralization                       1 (2%)                                                                       
      Valve, Thrombosis                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Degeneration                                     1 (2%)                                                                       
      Hyperplasia                                     11 (18%)      5 (8%)       6 (10%)      4 (7%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       1 (2%)       1 (2%)                                             
      Bilateral, Hyperplasia                                                                  1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Cyst                                            39 (65%)     28 (47%)     37 (62%)     31 (52%)                               
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Pars Distalis, Angiectasis                       1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                      16 (27%)     11 (18%)     16 (27%)     17 (28%)                               
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Hyperplasia                              5 (8%)       1 (2%)       2 (3%)       2 (3%)                                
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (60)         (58)         (60)                                   
      Ectasia                                          5 (8%)       1 (2%)                                                          
      Hyperplasia                                                   2 (3%)                    1 (2%)                                
      Inflammation, Suppurative                        2 (3%)       2 (3%)       1 (2%)                                             
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)       2 (3%)       1 (2%)       3 (5%)                                
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Decidual Reaction                                                          1 (2%)                                             
      Dilatation                                                    1 (2%)                                                          
      Hyperplasia, Cystic                                                                     1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
   Vagina                                             (2)                       (1)                                                 
      Infiltration Cellular, Polymorphonuclear         1 (50%)                                                                      
      Epithelium, Vacuolization Cytoplasmic                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Inflammation, Granulomatous                                                             1 (2%)                                
      Myelofibrosis                                                                           1 (2%)                                
      Myelostromal Proliferation                                    1 (2%)                                                          
   Lymph Node                                         (2)          (2)          (2)                                                 
      Renal, Pigmentation, Hemosiderin                              1 (50%)                                                         
   Lymph Node, Mandibular                             (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
      Inflammation, Subacute                           1 (2%)                                                                       
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibrosis                                         2 (3%)       2 (3%)       2 (3%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       4 (7%)       1 (2%)       2 (3%)                                
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Lymphoid Follicle, Atrophy                       1 (2%)                                 2 (3%)                                
      Red Pulp, Atrophy                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (58)                                   
      Edema                                                         1 (2%)                                                          
      Hyperplasia, Cystic                              2 (3%)       1 (2%)       1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                                                 1 (2%)                                             
      Hyperkeratosis                                                                          1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Ulcer                                                         2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteopetrosis                                                 2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Erythrophagocytosis                              1 (2%)                                                                       
      Foreign Body                                                  1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)                    2 (3%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Subacute                           1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (3%)       2 (3%)       4 (7%)       1 (2%)                                
      Alveolus, Edema                                               1 (2%)                                                          
      Bronchus, Inflammation, Acute                                              1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                                       1 (2%)                                                          
      Inflammation, Suppurative                                                  2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (1)                                                              
      External Ear, Ulcer                                           1 (100%)                                                        
   Eye                                                (2)          (3)          (2)                                                 
      Inflammation, Chronic                                         1 (33%)                                                         
      Anterior Chamber, Inflammation                                             1 (50%)                                            
      Cornea, Necrosis                                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hydronephrosis                                                                          1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Nephropathy                                     35 (58%)     22 (37%)     29 (48%)     14 (23%)                               
      Pelvis, Inflammation, Chronic                                              1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (59)         (60)                                   
      Calculus Gross Observation                       1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                 1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           30           20           17                                     
    Natural Death                                      5            4            7            4                                     
    Dosing Accident                                    2            2            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           14           22           28                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
      Periesophageal Tissue, Inflammation, Chronic     1 (2%)                                                                       
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Parasite Metazoan                                4 (7%)                    2 (3%)       2 (3%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Rectum                            (59)         (60)         (60)         (60)                                   
      Parasite Metazoan                                9 (15%)      1 (2%)       4 (7%)       3 (5%)                                
   Intestine Large, Cecum                             (60)         (60)         (59)         (60)                                   
      Parasite Metazoan                                                                       1 (2%)                                
      Ulcer                                                         1 (2%)                    1 (2%)                                
   Intestine Small, Jejunum                           (60)         (60)         (59)         (59)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (60)         (60)         (60)         (59)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                 4 (7%)       5 (8%)       6 (10%)      5 (8%)                                
      Clear Cell Focus                                 1 (2%)       1 (2%)                    2 (3%)                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                             9 (15%)      3 (5%)       4 (7%)                                             
      Eosinophilic Focus                               2 (3%)       3 (5%)       2 (3%)       4 (7%)                                
      Fatty Change                                                  2 (3%)       5 (8%)       5 (8%)                                
      Hepatodiaphragmatic Nodule                       4 (7%)       5 (8%)       7 (12%)      4 (7%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Mixed Cell Focus                                 2 (3%)       2 (3%)                                                          
      Necrosis                                         1 (2%)                    1 (2%)       1 (2%)                                
      Centrilobular, Degeneration                      1 (2%)       1 (2%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Portal, Degeneration                                                                    1 (2%)                                
      Sinusoid, Congestion, Focal                      1 (2%)                                                                       
   Mesentery                                          (7)          (15)         (24)         (15)                                   
      Inflammation, Suppurative                                     1 (7%)                                                          
      Artery, Thrombosis                               1 (14%)                                                                      
      Fat, Inflammation                                                                       1 (7%)                                
      Fat, Necrosis                                    6 (86%)     14 (93%)     19 (79%)     13 (87%)                               
      Lymphatic, Cyst                                  1 (14%)                                                                      
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Acinus, Atrophy                                 20 (33%)     17 (28%)     10 (17%)     14 (23%)                               
      Arteriole, Inflammation, Chronic                              1 (2%)                                                          
      Artery, Inflammation, Chronic                    1 (2%)                    1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Hyperkeratosis                                                                          1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Ulcer                                            3 (5%)       6 (10%)      4 (7%)       7 (12%)                               
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Erosion                                          1 (2%)                                                                       
      Mineralization                                                1 (2%)       1 (2%)                                             
      Ulcer                                            8 (13%)      6 (10%)      2 (3%)                                             
   Tongue                                                          (1)                                                              
      Foreign Body                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Atrium, Thrombosis                               3 (5%)       2 (3%)       5 (8%)       3 (5%)                                
      Myocardium, Degeneration                        48 (80%)     51 (85%)     48 (80%)     43 (72%)                               
      Valve, Inflammation, Chronic                     1 (2%)                                                                       
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      8 (13%)     10 (17%)     12 (20%)      7 (12%)                               
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       5 (8%)       4 (7%)       2 (3%)                                
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)                                                                       
   Parathyroid Gland                                  (55)         (55)         (55)         (59)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (59)         (58)         (60)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Cyst                                             5 (8%)       8 (14%)      5 (8%)       7 (12%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                      19 (32%)     19 (33%)     12 (20%)     21 (35%)                               
      Pars Intermedia, Hyperplasia, Tubular                                                   1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Hyperplasia                              3 (5%)       3 (5%)       6 (10%)      4 (7%)                                
      C-Cell, Infiltration Cellular                                 1 (2%)                                                          
      Follicle, Dilatation                             2 (3%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (60)         (60)         (58)         (60)                                   
      Ectasia                                                       1 (2%)                    2 (3%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      1 (2%)       2 (3%)                                                          
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Suppurative                        6 (10%)      2 (3%)       4 (7%)       3 (5%)                                
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Fibrosis                                                                   1 (2%)                                             
   Testes                                             (60)         (60)         (60)         (60)                                   
      Atrophy                                          1 (2%)                                                                       
      Germinal Epithelium, Atrophy                     2 (3%)       4 (7%)       6 (10%)      3 (5%)                                
      Interstitial Cell, Hyperplasia                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
   Lymph Node                                         (5)          (8)          (5)          (9)                                    
      Lumbar, Angiectasis                                                                     1 (11%)                               
      Mediastinal, Angiectasis                                      1 (13%)                                                         
      Mediastinal, Pigmentation, Hemosiderin                                     1 (20%)                                            
      Renal, Pigmentation, Hemosiderin                                                        1 (11%)                               
   Lymph Node, Mandibular                             (60)         (59)         (60)         (58)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                              1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibrosis                                        11 (18%)     11 (18%)      6 (10%)      8 (13%)                               
      Hematopoietic Cell Proliferation                 3 (5%)       3 (5%)       4 (7%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Thymus                                             (55)         (55)         (58)         (57)                                   
      Atrophy                                          2 (4%)                                 1 (2%)                                
      Congestion                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (57)         (57)         (56)                                   
      Hyperplasia, Cystic                              2 (4%)       1 (2%)       1 (2%)                                             
      Lymphatic, Ectasia                               1 (2%)                                                                       
   Skin                                               (60)         (60)         (60)         (59)                                   
      Hyperkeratosis                                   2 (3%)                                                                       
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
      Dermis, Fibrosis, Focal                                       1 (2%)                                                          
      Hair Follicle, Atrophy, Focal                                 1 (2%)                                                          
      Subcutaneous Tissue, Edema                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrous Osteodystrophy                                        1 (2%)                                                          
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Hypothalamus, Hemorrhage                         1 (2%)                                                                       
      Medulla, Gliosis                                                                        1 (2%)                                
      Ventricle, Hydrocephalus                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05121-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:10:36  
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         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Ectopic Tissue                                                1 (2%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                      3 (5%)                                 1 (2%)                                
      Inflammation, Subacute                           1 (2%)                    1 (2%)       3 (5%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Alveolus, Edema                                                                         1 (2%)                                
      Interstitium, Inflammation                                                 1 (2%)                                             
      Pleura, Inflammation, Chronic                    1 (2%)                                                                       
   Nose                                               (60)         (60)         (60)         (60)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Suppurative                        2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (6)                       (1)          (2)                                    
      Inflammation, Chronic                            3 (50%)                                                                      
      External Ear, Hyperkeratosis                     2 (33%)                                                                      
      External Ear, Inflammation, Chronic                                                     1 (50%)                               
   Eye                                                (1)          (1)          (1)          (1)                                    
      Degeneration                                     1 (100%)                                                                     
      Lens, Cataract                                                             1 (100%)     1 (100%)                              
   Harderian Gland                                    (1)                       (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Nephropathy                                     57 (95%)     54 (90%)     57 (95%)     50 (83%)                               
      Renal Tubule, Pigmentation, Hemosiderin                                    1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.