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TDMS Study 05122-06 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                     NICKEL SULFATE HEXAHYDRATE


NTP Experiment-Test: 05122-06                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20           60           20           60           20           
  Scheduled Sacrifice                                              19                        20                        20           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19            1           11                        11                        
    Natural Death                                      7                        10                         4                        
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                         1                                                  
    Terminal Sacrifice                                33                        38                        45                        
  Animals Examined Microscopically                    60           11           60           10           60           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (59)         (6)          (55)         (5)          (57)         (5)          
      Wall, Cholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
   Intestine Large, Colon                             (60)         (6)          (57)         (5)          (58)         (5)          
   Intestine Large, Rectum                            (56)         (4)          (57)         (4)          (55)         (4)          
      Anus, Squamous Cell Papilloma                                              1 (2%)                                             
   Intestine Large, Cecum                             (60)         (6)          (57)         (5)          (60)         (5)          
      Lymphatic, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (2%)                                             
   Intestine Small, Duodenum                          (57)         (6)          (57)         (5)          (59)         (5)          
      Adenocarcinoma                                                                                       1 (2%)                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Serosa, Cholangiocarcinoma, Metastatic, Liver                              1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (6)          (58)         (5)          (59)         (5)          
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Small, Ileum                             (60)         (6)          (58)         (5)          (58)         (5)          
   Liver                                              (60)         (6)          (59)         (5)          (60)         (5)          
      Cholangiocarcinoma                                                         1 (2%)                                             
      Hepatocellular Carcinoma                         7 (12%)                   9 (15%)                   5 (8%)                   
      Hepatocellular Carcinoma, Multiple                                         5 (8%)                                             
      Hepatocellular Adenoma                          11 (18%)                  13 (22%)                  10 (17%)      2 (40%)     
      Hepatocellular Adenoma, Multiple                 2 (3%)                    1 (2%)                    1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                    2 (3%)                    2 (3%)                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
   Mesentery                                          (7)                       (4)                       (4)                       
      Carcinoma, Metastatic, Lung                                                                          1 (25%)                  
      Cholangiocarcinoma, Metastatic, Liver                                      1 (25%)                                            
      Fibrosarcoma, Metastatic, Skin                   1 (14%)                                                                      
      Histiocytic Sarcoma                              1 (14%)                                             1 (25%)                  
   Pancreas                                           (59)         (6)          (58)         (5)          (60)         (5)          
                                                             Page   2                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                              1 (2%)                   
   Salivary Glands                                    (60)         (6)          (59)         (5)          (60)         (5)          
   Stomach, Forestomach                               (60)         (6)          (58)         (5)          (60)         (5)          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Serosa, Cholangiocarcinoma, Metastatic, Liver                              1 (2%)                                             
   Stomach, Glandular                                 (59)         (6)          (58)         (5)          (59)         (5)          
      Carcinoma, Metastatic, Lung                                                                          1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (6)          (59)         (5)          (60)         (5)          
      Carcinoma, Metastatic, Lung                                                                          1 (2%)                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Epicardium, Cholangiocarcinoma, Metastatic,                                                                                   
           Liver                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (6)          (58)         (5)          (60)         (5)          
      Capsule, Adenoma                                 1 (2%)                                                                       
      Extra Adrenal Tissue, Carcinoma, Metastatic,                                                                                  
           Lung                                                                                            1 (2%)                   
      Extra Adrenal Tissue, Cholangiocarcinoma,                                                                                     
           Metastatic, Liver                                                     1 (2%)                                             
      Extra Adrenal Tissue, Histiocytic Sarcoma                                                            1 (2%)                   
   Adrenal Medulla                                    (59)         (6)          (57)         (5)          (60)         (5)          
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (59)         (6)          (56)         (5)          (59)         (5)          
      Adenoma                                          2 (3%)                    1 (2%)                    1 (2%)                   
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
   Parathyroid Gland                                  (40)         (4)          (44)         (3)          (50)         (5)          
   Pituitary Gland                                    (58)         (6)          (56)         (5)          (59)         (5)          
      Pars Distalis, Adenoma                           8 (14%)                   9 (16%)                   5 (8%)                   
      Pars Intermedia, Adenoma                                                                             1 (2%)                   
   Thyroid Gland                                      (59)         (6)          (59)         (5)          (60)         (5)          
      Follicular Cell, Adenoma                         1 (2%)                                              2 (3%)                   
      Follicular Cell, Adenoma, Multiple                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)                       (8)                       (4)                       
      Fibrosarcoma, Metastatic, Skin                                                                       1 (25%)                  
      Mediastinum, Carcinoma, Metastatic, Lung                                                             1 (25%)                  
      Mediastinum, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                                 1 (13%)                                            
      Mediastinum, Fibrosarcoma, Metastatic, Skin      1 (20%)                                                                      
      Thoracic, Carcinoma, Metastatic, Lung                                                                1 (25%)                  
      Thoracic, Neoplasm NOS, Metastatic,                                                                                           
          Uncertain Primary Site                                                 1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (58)         (6)          (58)         (5)          (60)         (5)          
      Cystadenoma                                      2 (3%)                    1 (2%)                                             
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                              1 (2%)                   
      Luteoma                                                                                 1 (20%)                               
      Bilateral, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (2%)                                             
   Uterus                                             (60)         (7)          (60)         (7)          (60)         (6)          
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibroma                                                                    1 (2%)                                             
      Hemangioma                                                                                           1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    1 (2%)                   
      Leiomyoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                                                                       1 (2%)                   
      Polyp Stromal                                    2 (3%)                    2 (3%)                                             
      Polyp Stromal, Multiple                                                    1 (2%)                                             
   Vagina                                                                                                 (1)                       
      Fibroma                                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (6)          (59)         (5)          (60)         (5)          
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (11)                      (11)                      (13)                      
      Axillary, Carcinoma, Metastatic, Lung                                                                1 (8%)                   
      Axillary, Fibrosarcoma, Metastatic, Skin         1 (9%)                                                                       
      Iliac, Fibrosarcoma, Metastatic, Skin            1 (9%)                                                                       
      Iliac, Histiocytic Sarcoma                       1 (9%)                    1 (9%)                    1 (8%)                   
      Inguinal, Carcinoma, Metastatic, Lung                                                                1 (8%)                   
      Inguinal, Histiocytic Sarcoma                    1 (9%)                    1 (9%)                                             
      Pancreatic, Carcinoma, Metastatic, Lung                                                              1 (8%)                   
                                                             Page   4                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Pancreatic, Histiocytic Sarcoma                  1 (9%)                                              1 (8%)                   
      Pancreatic, Neoplasm NOS                                                                             1 (8%)                   
      Renal, Histiocytic Sarcoma                       1 (9%)                    1 (9%)                    2 (15%)                  
   Lymph Node, Bronchial                              (50)         (7)          (54)         (9)          (58)         (9)          
      Carcinoma, Metastatic, Lung                                                                          1 (2%)                   
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    1 (2%)                   
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Lymph Node, Mandibular                             (55)         (9)          (56)         (7)          (60)         (6)          
      Histiocytic Sarcoma                                                        1 (2%)                    2 (3%)                   
   Lymph Node, Mesenteric                             (56)         (6)          (52)         (3)          (56)         (5)          
      Carcinoma, Metastatic, Lung                                                                          1 (2%)                   
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    2 (4%)                   
   Lymph Node, Mediastinal                            (30)         (2)          (28)         (5)          (33)         (1)          
      Carcinoma, Metastatic, Lung                                                                          1 (3%)                   
      Cholangiocarcinoma, Metastatic, Liver                                      1 (4%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (3%)                                                                       
      Histiocytic Sarcoma                                                        1 (4%)                    1 (3%)                   
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (4%)                                             
   Spleen                                             (60)         (6)          (58)         (5)          (60)         (5)          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                    2 (3%)                    1 (2%)                   
      Capsule, Cholangiocarcinoma, Metastatic,                                                                                      
           Liver                                                                 1 (2%)                                             
   Thymus                                             (57)         (6)          (54)         (3)          (54)         (5)          
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (6)          (58)         (5)          (60)         (5)          
      Carcinoma                                        2 (3%)                    1 (2%)                                             
      Fibroadenoma                                                               1 (2%)                                             
   Skin                                               (60)         (6)          (59)         (5)          (59)         (5)          
      Basosquamous Tumor Malignant                     1 (2%)                                                                       
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
      Subcutaneous Tissue, Fibrosarcoma                5 (8%)                                              1 (2%)                   
                                                             Page   5                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (6)          (60)         (5)          (60)         (5)          
      Maxilla, Fibrosarcoma, Metastatic, Skin          1 (2%)                                                                       
      Maxilla, Histiocytic Sarcoma                                                                         1 (2%)                   
   Skeletal Muscle                                    (4)                       (3)                       (3)                       
      Fibrosarcoma, Metastatic, Skin                   1 (25%)                                                                      
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (33%)                                            
      Abdominal, Carcinoma, Metastatic, Lung                                                               1 (33%)                  
      Abdominal, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (33%)                                            
      Diaphragm, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (6)          (59)         (5)          (59)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (58)         (4)          (56)         (4)          (58)         (2)          
   Lung                                               (60)         (11)         (60)         (10)         (60)         (10)         
      Alveolar/Bronchiolar Adenoma                     3 (5%)                    3 (5%)                    2 (3%)                   
      Alveolar/Bronchiolar Carcinoma                   4 (7%)                    3 (5%)                    8 (13%)                  
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (2%)                   
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    2 (3%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Trachea                                            (60)         (6)          (60)         (5)          (60)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                              (2)                       (4)                       
      Adenoma                                                                    2 (100%)                  4 (100%)                 
   Zymbal's Gland                                                                                         (1)                       
      Carcinoma                                                                                            1 (100%)                 
                                                             Page   6                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (11)         (60)         (10)         (60)         (10)         
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                    2 (3%)                   
      Perirenal Tissue, Cholangiocarcinoma,                                                                                         
          Metastatic, Liver                                                      1 (2%)                                             
   Urinary Bladder                                    (59)         (5)          (60)         (5)          (58)         (5)          
      Serosa, Cholangiocarcinoma, Metastatic, Liver                              1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(11)        *(60)        *(10)        *(60)        *(10)         
      Histiocytic Sarcoma                              1 (2%)                    4 (7%)                    2 (3%)                   
      Lymphoma Malignant                               7 (12%)                  12 (20%)                   9 (15%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   7                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41                      45           1          40           2               
     Total Primary Neoplasms                           63                      78           1          58           2               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27                      34           1          22           2               
     Total Benign Neoplasms                            35                      41           1          28           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26                      27                      26                           
     Total Malignant Neoplasms                         28                      37                      29                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       5                       2                           
     Total Metastatic Neoplasm                         14                      33                      15                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                  1                           
     Total Uncertain Neoplasms                                                                          1                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   8                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20                                                               
  Scheduled Sacrifice                                              20                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17                                                                            
    Natural Death                                      6                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                37                                                                            
  Animals Examined Microscopically                    60           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (60)         (5)                                                              
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                        10 (17%)                                                                      
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           8 (13%)      1 (20%)                                                         
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Mesentery                                          (5)                                                                           
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (20%)                                                                      
      Histiocytic Sarcoma                              1 (20%)                                                                      
   Pancreas                                           (60)         (5)                                                              
   Stomach, Forestomach                               (60)         (6)                                                              
   Stomach, Glandular                                 (59)         (5)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (5)                                                              
   Islets, Pancreatic                                 (60)         (5)                                                              
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (57)         (4)                                                              
      Pars Distalis, Adenoma                           4 (7%)                                                                       
   Thyroid Gland                                      (60)         (5)                                                              
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (5)                                                              
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Tubulostromal Adenoma                            1 (2%)                                                                       
      Periovarian Tissue, Histiocytic Sarcoma          1 (2%)                                                                       
   Uterus                                             (60)         (6)                                                              
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Polyp Stromal                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (5)                                                              
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (13)                                                                          
      Axillary, Histiocytic Sarcoma                    1 (8%)                                                                       
      Iliac, Histiocytic Sarcoma                       1 (8%)                                                                       
      Pancreatic, Histiocytic Sarcoma                  3 (23%)                                                                      
      Renal, Histiocytic Sarcoma                       1 (8%)                                                                       
   Lymph Node, Bronchial                              (56)         (8)                                                              
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Neoplasm NOS, Metastatic, Lung                   1 (2%)                                                                       
   Lymph Node, Mandibular                             (55)         (6)                                                              
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Mast Cell Tumor Benign                           1 (2%)                                                                       
   Lymph Node, Mesenteric                             (51)         (4)                                                              
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Lymph Node, Mediastinal                            (22)         (2)                                                              
      Carcinoma, Metastatic, Lung                      1 (5%)                                                                       
      Histiocytic Sarcoma                              1 (5%)                                                                       
   Spleen                                             (60)         (5)                                                              
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (56)         (5)                                                              
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (5)                                                              
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (60)         (5)                                                              
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)                                                                       
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (5)                                                              
      Vertebra, Osteosarcoma                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (56)         (4)                                                              
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
   Lung                                               (60)         (10)                                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Neoplasm NOS                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                                              
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                                                             
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
                                                             Page  11                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)                                                             
      Histiocytic Sarcoma                              4 (7%)                                                                       
      Lymphoma Malignant                               6 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36           2                                                               
     Total Primary Neoplasms                           49           2                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16           2                                                               
     Total Benign Neoplasms                            20           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25                                                                           
     Total Malignant Neoplasms                         28                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6                                                                           
     Total Metastatic Neoplasm                         13                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20           60           20           60           20           
  Scheduled Sacrifice                                              19                        19                        18           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                29            1           29                        28            1           
    Natural Death                                      5                         8            1            8            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                        23                        24                        
  Animals Examined Microscopically                    60           11           60           11           60           12           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (6)          (58)         (6)          (54)         (7)          
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
   Intestine Large, Colon                             (59)         (6)          (60)         (6)          (58)         (7)          
   Liver                                              (60)         (6)          (60)         (7)          (60)         (8)          
      Carcinoma                                        1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                              2 (3%)                   
      Hepatocellular Carcinoma                        10 (17%)                   8 (13%)                  12 (20%)                  
      Hepatocellular Carcinoma, Multiple                                         3 (5%)                    3 (5%)                   
      Hepatocellular Adenoma                          16 (27%)      3 (50%)      6 (10%)      1 (14%)     17 (28%)      2 (25%)     
      Hepatocellular Adenoma, Multiple                 1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                    1 (2%)                   
   Mesentery                                          (1)                       (2)                       (1)                       
      Carcinoma, Metastatic, Liver                     1 (100%)                                                                     
      Histiocytic Sarcoma                                                        1 (50%)                                            
   Pancreas                                           (60)         (6)          (59)         (6)          (58)         (7)          
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (60)         (6)          (60)         (6)          (60)         (7)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (6)          (59)         (6)          (59)         (7)          
      Capsule, Adenoma                                 1 (2%)                    1 (2%)       1 (17%)      3 (5%)                   
      Extra Adrenal Tissue, Histiocytic Sarcoma                                  1 (2%)                                             
   Islets, Pancreatic                                 (60)         (6)          (59)         (6)          (55)         (7)          
                                                             Page  14                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                                                                              1 (2%)                   
   Thyroid Gland                                      (60)         (6)          (60)         (6)          (59)         (7)          
      Follicular Cell, Adenoma                                                   2 (3%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (2)                       (1)                       
      Hemangiosarcoma, Metastatic, Bone                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (6)          (60)         (6)          (60)         (7)          
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                              2 (3%)                   
   Testes                                             (60)         (6)          (60)         (6)          (60)         (7)          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (6)          (60)         (6)          (59)         (7)          
      Hemangiosarcoma, Metastatic, Bone                1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (23)         (1)          (21)         (1)          (20)         (2)          
      Iliac, Histiocytic Sarcoma                                                 1 (5%)                                             
      Pancreatic, Carcinoma, Metastatic, Liver         1 (4%)                                                                       
      Renal, Carcinoma, Metastatic, Liver              1 (4%)                                                                       
      Renal, Histiocytic Sarcoma                                                 1 (5%)                                             
   Lymph Node, Bronchial                              (46)         (9)          (48)         (9)          (44)         (8)          
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Lymph Node, Mandibular                             (55)         (5)          (49)         (6)          (55)         (8)          
   Lymph Node, Mesenteric                             (55)         (5)          (53)         (5)          (55)         (5)          
   Lymph Node, Mediastinal                            (18)                      (24)         (7)          (20)                      
   Spleen                                             (60)         (6)          (60)         (6)          (59)         (7)          
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (54)         (5)          (48)         (6)          (51)         (7)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  15                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (6)          (60)         (7)          (60)         (7)          
      Subcutaneous Tissue, Mast Cell Tumor NOS                                                1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (6)          (60)         (6)          (60)         (7)          
      Hemangiosarcoma                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (59)         (5)          (58)         (6)          (56)         (6)          
   Lung                                               (60)         (11)         (60)         (11)         (60)         (12)         
      Alveolar/Bronchiolar Adenoma                     3 (5%)                    4 (7%)                    3 (5%)                   
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   9 (15%)                  10 (17%)                   3 (5%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                   3 (5%)                    1 (2%)                   
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    2 (3%)                    3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                                                           
      Fibrosarcoma                                     1 (50%)                                                                      
   Harderian Gland                                                              (2)                       (2)                       
      Adenoma                                                                    2 (100%)                  2 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (11)         (60)         (11)         (59)         (12)         
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Urinary Bladder                                    (59)         (6)          (59)         (6)          (58)         (7)          
      Histiocytic Sarcoma                                                        1 (2%)                                             
                                                                                                                                    
                                                             Page  16                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(11)        *(60)        *(11)        *(60)        *(12)         
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    2 (3%)                   
      Lymphoma Malignant                               2 (3%)                    1 (2%)                    3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  17                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0          0.0MG/M3     0.25         .25MG/M3     0.5          0.5MG/M3        
                                                   MG/M3        LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37           3          35           3          40           2               
     Total Primary Neoplasms                           49           3          44           3          53           2               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21           3          16           2          23           2               
     Total Benign Neoplasms                            23           3          17           2          27           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20                      22                      25                           
     Total Malignant Neoplasms                         26                      27                      26                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       2                       3                           
     Total Metastatic Neoplasm                         11                       2                       3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  18                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20                                                               
  Scheduled Sacrifice                                              18                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27                                                                            
    Natural Death                                      8            2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                                                                            
  Animals Examined Microscopically                    60           12                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (59)         (6)                                                              
      Hepatocellular Carcinoma                         8 (14%)                                                                      
      Hepatocellular Carcinoma, Multiple               2 (3%)                                                                       
      Hepatocellular Adenoma                          10 (17%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (6)                                                              
      Capsule, Adenoma                                 1 (2%)                                                                       
   Thyroid Gland                                      (60)         (7)                                                              
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page  19                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (11)                                                             
      Alveolar/Bronchiolar Adenoma                     4 (7%)                                                                       
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   3 (5%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                             Page  20                                                               
NTP Experiment-Test: 05122-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:47:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1.0          1.0MG/M3                                                            
                                                   MG/M3        LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            27                                                                           
     Total Primary Neoplasms                           31                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16                                                                           
     Total Benign Neoplasms                            18                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13                                                                           
     Total Malignant Neoplasms                         13                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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