National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3710

TDMS Study 05122-06 Pathology Tables

NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|             
                                           | 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Intussusception                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         |                            1                                             |             
      Hemorrhage                           |                                  4                                       |             
      Infarct                              |                                  4                                       |             
      Inflammation                         |                                                                          |             
      Necrosis, Diffuse                    |                                     3                                    |             
      Necrosis                             |                   3                                         1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +        +        +              +      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Extra Adrenal Tissue, Inflammation   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  I  +  M  +  +  M  +  +  +  +  M  +  +  I  +  +  M  +  M  +  M|             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|             
                                           | 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           |                         1                                                |             
      Pars Distalis, Hyperplasia           |    1     1              1                                         2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |          2  1     1        1  1     2  1                 1           1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                          +            |             
      Thrombosis                           |                                                             X            |             
      Mediastinum, Inflammation            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       2                 1|             
      Inflammation                         |                                                                          |             
      Pigmentation                         |                                           1     1                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                X                          X                          1   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Hemorrhage                           | 4                                                                        |             
      Endometrium, Hyperplasia             | 2     1  3  3           2  2        2  3  3     2  2  3  3     1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                      2                                                   |             
      Hyperplasia, Megakaryocyte           |                                           2                              |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Myelofibrosis                        | 2     1  2  1     1     1     1     1  1  1     1     1        1     1   |             
      Erythroid Cell, Hyperplasia          |                   3                                                      |             
      Myeloid Cell, Hyperplasia            |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                             +                 +              +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Pancreatic, Inflammation             |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  I  +  I  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |       1     1        2     3        3           1                        |             
      Hyperplasia, Macrophage              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|             
                                           | 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                           1                              |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Hyperplasia, Lymphoid                | 3                    2  1  4  1     3                 2        3         |             
      Hyperplasia, Plasma Cell             |          1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       1                                                                  |             
      Edema                                |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  +  M  M  +  +  I  +  M  M  M  M  M  M  M  +  +  I  M  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2     2                                       |             
      Hematopoietic Cell Proliferation     | 2        1        4                       1  3                          2|             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1  3           1           2  2              2           2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Hindlimb, Hemorrhage                 |                                                                          |             
      Pinna, Inflammation                  |                                  4                                       |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Tail, Inflammation                   |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |             3                                                            |             
      Periosteum, Femur, Inflammation      |                      1                                                   |             
      Tibia, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                +      |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|             
                                           | 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Meninges, Inflammation               |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           1                              |             
      Hemorrhage                           |             2                                                     2      |             
      Hyperplasia, Macrophage              |                            1                                   1         |             
      Inflammation, Chronic Active         |       1                                                                  |             
      Pleura, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |       1                                         1                       1|             
      Respiratory Epithelium, Degeneration |       1                                         1                        |             
      Respiratory Epithelium, Inflammation |                                                    2              1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                          |             
      Medulla, Cyst                        |                                           X                              |             
      Perirenal Tissue, Inflammation       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|             
                                           | 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/M3                                  | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Intussusception                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       2                                                              2   |             
      Congestion                           |                                     4                                    |             
      Fatty Change                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                       1                  |             
      Necrosis, Diffuse                    |                                     3                    1               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                                                                  |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia, Focal           |          1                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Extra Adrenal Tissue, Inflammation   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  +  M  I  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Hyperplasia               |                                                          1               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|             
                                           | 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/M3                                  | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                             1            |             
      Pars Distalis, Hyperplasia           |    1        1                       3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |    2           1  1        2  1  1        1  1        2     3  1        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                 +                                                   |             
      Thrombosis                           |                                                                          |             
      Mediastinum, Inflammation            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  I  +  +  +|             
      Ectasia                              |                               1                 2                        |             
      Inflammation                         |                         3                                                |             
      Pigmentation                         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Cyst                                 |    X                                               X                     |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |    1           1                 3        1     2     2     2  3  3  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia, Plasma Cell             | 1                                                                        |             
      Myelofibrosis                        | 1              1  1     1     1  1  1  1  1  3  1  1  1     2     1  1   |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                      2                                   2     1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +                                                   |             
      Iliac, Hyperplasia, Lymphoid         |                   2                                                      |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |             2     3                                                      |             
      Pancreatic, Inflammation             |                      3                                                   |             
      Renal, Hyperplasia, Lymphoid         |                   2                                                      |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  I  +  +  +  +  +|             
      Congestion                           | 4                                                                        |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                   2     1  1              4     2  3                 1   |             
      Hyperplasia, Macrophage              |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|             
                                           | 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/M3                                  | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Congestion                           |                      3                                                   |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |    1              1                 2     4  3  3        3               |             
      Hyperplasia, Plasma Cell             |                                                                4        1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  M  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      4                    2                              |             
      Edema                                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  +  M  I  I  +|             
      Hyperplasia, Lymphoid                |                   2                       2        2                     |             
      Inflammation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                      2                                   3     1         |             
      Hyperplasia, Lymphoid                |             2                 1        1  2  1     3  1                 1|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Atrophy                              |          2              3                                3              2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                3         |             
      Hindlimb, Hemorrhage                 |                   2                                                      |             
      Pinna, Inflammation                  |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Tail, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
      Periosteum, Femur, Inflammation      |                                                                          |             
      Tibia, Fracture                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +  +                                                   |             
      Inflammation                         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|             
                                           | 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/M3                                  | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2                                                                       4|             
      Meninges, Inflammation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |    1                                                                     |             
      Hyperplasia, Macrophage              |       2                 1     2                    2        2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Pleura, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |    1     1                                                              2|             
      Olfactory Epithelium, Degeneration   | 1        1                                1                              |             
      Respiratory Epithelium, Degeneration |          1                    1                                          |             
      Respiratory Epithelium, Inflammation |                      2                                         3         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                          1               |             
      Nephropathy                          | 1                                                        2               |             
      Medulla, Cyst                        |                                                                          |             
      Perirenal Tissue, Inflammation       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 5| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3|                                            |            |
                                           | 1| 3| 6| 3| 5| 5| 3| 5| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0                                    | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/M3                                  | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  I  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +                                             |  57        |
      Intussusception                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      1  4.0|
      Fatty Change                         |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infarct                              |             4                                                            |      2  4.0|
      Inflammation                         |                                                                          |      1  1.0|
      Necrosis, Diffuse                    |             1                                                            |      4  2.0|
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   7        |
      Inflammation                         |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1     |
      Extra Adrenal Tissue, Inflammation   |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mineralization                       |                            1                                             |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 5| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3|                                            |            |
                                           | 1| 3| 6| 3| 5| 5| 3| 5| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0                                    | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/M3                                  | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  M  +  M  +  I                                             |  40        |
      Bilateral, Hyperplasia               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |          3                                                               |      3  1.7|
      Pars Distalis, Hyperplasia           |    2  2  4  1     1                                                      |     12  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicular Cell, Hyperplasia, Cystic |          3                                                               |     22  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   5        |
      Thrombosis                           |                                                                          |      1     |
      Mediastinum, Inflammation            |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Ectasia                              |                                                                          |      4  1.5|
      Inflammation                         |                      1                                                   |      2  2.0|
      Pigmentation                         |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                X                                                         |      6  1.0|
      Inflammation                         |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |    3  1  1  2     1        2                                             |     30  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Megakaryocyte           |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  1.0|
      Myelofibrosis                        | 1  1  1  1  1  1  1     1  2                                             |     39  1.2|
      Erythroid Cell, Hyperplasia          |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |    1                 3                                                   |      6  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |  11        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 5| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3|                                            |            |
                                           | 1| 3| 6| 3| 5| 5| 3| 5| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0                                    | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/M3                                  | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Hyperplasia, Plasma Cell      |                      4                                                   |      1  4.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.5|
      Pancreatic, Inflammation             |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  I  I  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  4.0|
      Edema                                |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |             1              1                                             |     15  1.8|
      Hyperplasia, Macrophage              |             1                                                            |      2  1.0|
      Hyperplasia, Plasma Cell             |                      2                                                   |      2  1.5|
      Inflammation                         |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |     15  2.4|
      Hyperplasia, Plasma Cell             |             2  3                                                         |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Congestion                           |    2                                                                     |      4  2.3|
      Edema                                |                3                                                         |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                      4                                                   |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  +  M  M  M  +  I                                             |  30        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                            2                                             |      3  2.0|
      Hematopoietic Cell Proliferation     |                2     3                                                   |     11  2.2|
      Hyperplasia, Lymphoid                |             2                                                            |     10  1.6|
      Necrosis                             |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |             1  2     4                                                   |     14  2.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 5| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3|                                            |            |
                                           | 1| 3| 6| 3| 5| 5| 3| 5| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0                                    | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/M3                                  | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
      Hindlimb, Hemorrhage                 |                                                                          |      1  2.0|
      Pinna, Inflammation                  |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                2                                                         |      1  2.0|
      Tail, Inflammation                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      1  3.0|
      Periosteum, Femur, Inflammation      |                                                                          |      1  1.0|
      Tibia, Fracture                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   4        |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      2  3.0|
      Meninges, Inflammation               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage                           |                1                                                         |      4  1.5|
      Hyperplasia, Macrophage              |                                                                          |      7  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Pleura, Inflammation                 |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Olfactory Epithelium, Atrophy        |                                                                          |      3  1.3|
      Olfactory Epithelium, Degeneration   | 1  1  1  1              1  1                                             |     12  1.0|
      Respiratory Epithelium, Degeneration | 1  1  1  1           1  1  1                                             |     11  1.0|
      Respiratory Epithelium, Inflammation |                         1                                                |      5  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 5| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3|                                            |            |
                                           | 1| 3| 6| 3| 5| 5| 3| 5| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0                                    | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/M3                                  | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |                2                                                         |      3  1.7|
      Medulla, Cyst                        |                                                                          |      1     |
      Perirenal Tissue, Inflammation       |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation                         |                      4                                                   |      1  4.0|
      Transitional Epithelium, Hyperplasia |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 2| 4| 2| 4| 2| 0| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 2|              |            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 0| 5| 0| 3| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 0|              |            |
                                           | 9| 9| 9| 7| 9| 7| 9| 7| 5| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0.0MG/M3                               | 8| 8| 9| 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5|              |      L     |
    LUNG TOX                               | 3| 4| 9| 6| 7| 9| 0| 4| 7| 9| 2| 5| 6| 4| 7| 8| 9| 5| 8| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    I  +                 +                 +  I     +                     |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +                 +                 +  +     +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +                 +                 +  +     +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M                 M                 +  +     +                     |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +                 +                 +  +     +                     |   6        |
      Cyst                                 |                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +                 +                 +  +     +                     |   6        |
      Inflammation                         |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +                 +  +              +  +     +                     |   7        |
      Endometrium, Hyperplasia             |       2                    1              3  2     1                     |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M  +  +           +  M  +  +           +  M     I     +               |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 2| 4| 2| 4| 2| 0| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 2|              |            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 0| 5| 0| 3| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 0|              |            |
                                           | 9| 9| 9| 7| 9| 7| 9| 7| 5| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0.0MG/M3                               | 8| 8| 9| 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5|              |      L     |
    LUNG TOX                               | 3| 4| 9| 6| 7| 9| 0| 4| 7| 9| 2| 5| 6| 4| 7| 8| 9| 5| 8| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                               1                          1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +              +  +  +              +  +     +     +               |   9        |
      Hyperplasia, Lymphoid                |    2                 2     2              3  1           2               |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M  M           M  M  M  M           +  M     +     M               |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +                 +                 +  +     +                     |   6        |
      Atrophy                              |                         2                                                |      1  2.0|
      Cyst                                 |                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +                 +                 +  +     +                     |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +                 +                 +  +     +                     |   6        |
      Inflammation                         |                         3                                                |      1  3.0|
      Ulcer                                |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +                 +                 +  +     +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +                 +                 +  +     +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +                 M                 +  I     +                     |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +           +  +  +  +           +  +     +     +               |  11        |
      Interstitium, Infiltration Cellular  |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +           +  +  +  +           +  +     +     +               |  11        |
      Hemorrhage                           |                         3                                                |      1  3.0|
      Inflammation, Acute                  |                            1  1           1              1               |      4  1.0|
      Olfactory Epithelium, Degeneration   |                                           1                              |      1  1.0|
      Olfactory Epithelium, Respiratory    |                                                                          |            |
          Epithelium, Degeneration         |                                                          2               |      1  2.0|
      Respiratory Epithelium, Degeneration |       1                                                                  |      1  1.0|
      Vomeronasal Organ, Infiltration      |                                                                          |            |
          Cellular, Polymorphonuclear      |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +                 +                 +  +     +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 2| 4| 2| 4| 2| 0| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 2|              |            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 0| 5| 0| 3| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 0|              |            |
                                           | 9| 9| 9| 7| 9| 7| 9| 7| 5| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0.0MG/M3                               | 8| 8| 9| 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5|              |      L     |
    LUNG TOX                               | 3| 4| 9| 6| 7| 9| 0| 4| 7| 9| 2| 5| 6| 4| 7| 8| 9| 5| 8| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +           +  +  +  +           +  +     +     +               |  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +                                   +  +     +                     |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|             
                                           | 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/M3                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Autolysis                            |                   2                                                      |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis, Diffuse                    | 3                                            3                           |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +                                                      |             
      Inflammation                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Amyloid Deposition                   |                                                                         2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Squamous                |                   1                                                      |             
      Inflammation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                             +                                 |             
      Peridontal Tissue, Inflammation      |          2                             1                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  +|             
      Capsule, Hyperplasia                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|             
                                           | 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/M3                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Hyperplasia           |          1                                                           1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |       1     1  1                          3     1     2  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                     +|             
      Abdominal, Inflammation              |                                                                         2|             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Mediastinum, Inflammation            |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 1                    1   |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +|             
      Cyst                                 |             X                                                            |             
      Hemorrhage                           |                         4                                                |             
      Bilateral, Cyst                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia             | 1     3  3     3           3  3     2           2                 3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Myelofibrosis                        |    1  2  1  4  1     2  2  1  1     1  2  1  1  2     2           2  2  1|             
      Myeloid Cell, Hyperplasia            | 3  2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +                    +                       +               |             
      Iliac, Hyperplasia, Lymphoid         |                                  3                                       |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                          2               |             
      Renal, Hyperplasia, Lymphoid         |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +|             
      Amyloid Deposition                   |                                                                         2|             
      Congestion                           |                   3                                                      |             
      Hyperplasia, Lymphoid                |                         2        2                       2     2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                      1              1                                2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|             
                                           | 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/M3                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |       3                 2                 2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +  M|             
      Congestion                           |                                                          2               |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  +  +  +  I  +  M  M  M  +  M  +  M  M  +  M  M  M  M  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                       2                                            1   |             
      Hyperplasia, Lymphoid                |                                           2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  A  +  +  +  +|             
      Atrophy                              |                   3                          2     2           1         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  +|             
      Ectasia                              | 2                                                        1               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                                                                        |             
      Dermis, Fibrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Compression                          |    3                                                     1               |             
      Pons, Degeneration                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Emphysema                            |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              | 1  3                 1  1  1           1        2     1        4        1|             
      Inflammation, Chronic Active         | 1  2                          1        1        1              2        1|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|             
                                           | 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/M3                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                 2                        |             
      Alveolar Epithelium, Hyperplasia     | 1                       1              1                       1         |             
      Interstitium, Infiltration Cellular  |    3              2                             2              1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                            1                                             |             
      Olfactory Epithelium, Degeneration   |    1                       1                    1                 1      |             
      Olfactory Epithelium, Inflammation   |                                                 1                        |             
      Respiratory Epithelium, Degeneration | 1        1     1           1                    1        1        1      |             
      Respiratory Epithelium, Inflammation |                         2  3                    1        1              2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
      Hemorrhage                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                         1|             
      Nephropathy                          |                                                                          |             
      Glomerulus, Inflammation             | 3                                                                        |             
      Renal Tubule, Necrosis, Acute        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |                                                                         2|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|             
                                           | 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    0.25                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/M3                                  | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Concretion                           |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Autolysis                            |                                              4                           |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Autolysis                            |                                              3                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         |                                                                   3      |             
      Necrosis, Diffuse                    |          4                                                               |             
      Necrosis                             |                                                                      3   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                                                   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|             
                                           | 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    0.25                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/M3                                  | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            4                                             |             
      Pars Distalis, Hyperplasia           |    2                       1              1           3        1         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |    1  1     1        1     2        1     1                 2  2  4      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                    +                 +  +           +|             
      Abdominal, Inflammation              |                                                                          |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      |                                                          2               |             
      Mediastinum, Inflammation            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                1                                         3               |             
      Hyperplasia, Squamous                |                                                          3               |             
      Inflammation                         |             2                       2                    4               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                             X     X                 X      |             
      Hemorrhage                           |                                                                          |             
      Bilateral, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          3               |             
      Inflammation                         |                                                                          |             
      Thrombosis                           |                                                    X                     |             
      Endometrium, Hyperplasia             |    3  3     2  2        2  1     2  3  2  2        3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1  3  1     2  2     1  2  1     1  2  1  1     1  2  1  1     1  2      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +     +                             +              +  +   |             
      Iliac, Hyperplasia, Lymphoid         |                3                                                         |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                1        1                       2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                   2      |             
      Hyperplasia, Lymphoid                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|             
                                           | 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    0.25                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/M3                                  | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                  1                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +  A|             
      Congestion                           |       1                                                  3               |             
      Hyperplasia, Histiocytic             |                                                                   1      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  M  +  M  +  +  +  M  +  M  M  +  +  +  +  M  M  M  M  M  M  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                                 |             
      Hematopoietic Cell Proliferation     |          3           2                    3                       2      |             
      Hyperplasia, Lymphoid                |                1                                1                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                    3           1                    2     1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Dermis, Fibrosis                     |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                     +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               4                             3     1      |             
      Pons, Degeneration                   |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Emphysema                            |                                                                          |             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia, Macrophage              |    1                    1  1  1        1        1     1     1     1      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|             
                                           | 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    0.25                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/M3                                  | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                                            1     1                  |             
      Interstitium, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                               1                                          |             
      Olfactory Epithelium, Degeneration   |    1                       1                                1            |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Respiratory Epithelium, Degeneration |    1                       1  2        1              1                  |             
      Respiratory Epithelium, Inflammation |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                               3                                          |             
      Glomerulus, Inflammation             |                                                                          |             
      Renal Tubule, Necrosis, Acute        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         3|             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                          3               |             
      Transitional Epithelium, Hyperplasia |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7|                                            |            |
                                           | 3| 5| 3| 6| 0| 1| 6| 0| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25                                   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/M3                                  | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M                                             |  55        |
      Concretion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
      Inflammation                         |                                                                          |      1  3.0|
      Necrosis, Diffuse                    |                            3                                             |      4  3.3|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Inflammation                         |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Peridontal Tissue, Inflammation      |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | M  +  +  +  +  +  +  +  +  +                                             |  59        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7|                                            |            |
                                           | 3| 5| 3| 6| 0| 1| 6| 0| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25                                   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/M3                                  | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  M                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Pars Distalis, Angiectasis           |                                                                          |      2  3.0|
      Pars Distalis, Hyperplasia           |                      1                                                   |      8  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicular Cell, Hyperplasia, Cystic |       2           1     1                                                |     20  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   8        |
      Abdominal, Inflammation              |                                                                          |      1  2.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Mediastinum, Inflammation            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Ectasia                              |                                                                          |      4  1.5|
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation                         |             1                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |          X  X        X                                                   |      8     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Bilateral, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation                         |       3                                                                  |      1  3.0|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Hyperplasia             |       4  3        3                                                      |     25  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myelofibrosis                        |    1     3  1  1  2  1  1                                                |     43  1.5|
      Myeloid Cell, Hyperplasia            |       2        3                                                         |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +              +                                                   |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7|                                            |            |
                                           | 3| 5| 3| 6| 0| 1| 6| 0| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25                                   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/M3                                  | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Hyperplasia, Lymphoid         |       3                                                                  |      3  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +                                             |  54        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       3        1                                                         |      9  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Histiocytic             |    2                                                                     |      2  2.0|
      Hyperplasia, Lymphoid                |       2     1                                                            |      6  1.5|
      Hyperplasia, Plasma Cell             |                4                                                         |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  I                                             |  52        |
      Congestion                           |                                                                          |      3  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  +  M  +  M  +  +  M                                             |  28        |
      Hyperplasia, Plasma Cell             |                1                                                         |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       2     3                                                            |      9  2.2|
      Hyperplasia, Lymphoid                |          1                                                               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |  54        |
      Atrophy                              |                2           4                                             |     11  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                                                                          |      2  1.5|
      Hyperplasia                          |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  I  +  +  +  +  +  +                                             |  59        |
      Inflammation                         |                                                                          |      1  2.0|
      Dermis, Fibrosis                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   3        |
      Inflammation                         |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7|                                            |            |
                                           | 3| 5| 3| 6| 0| 1| 6| 0| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25                                   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/M3                                  | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Compression                          |                                                                          |      5  2.4|
      Pons, Degeneration                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | M  +  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation                         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Emphysema                            |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Macrophage              |    2     1  1     1  1                                                   |     24  1.3|
      Inflammation, Chronic Active         |                                                                          |      7  1.3|
      Inflammation                         |                            2                                             |      1  2.0|
      Mineralization                       |    3                                                                     |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       1           1                                                      |      9  1.0|
      Interstitium, Infiltration Cellular  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.0|
      Olfactory Epithelium, Degeneration   |          1                                                               |      8  1.0|
      Olfactory Epithelium, Inflammation   |                                                                          |      1  1.0|
      Respiratory Epithelium, Degeneration |          1              1                                                |     14  1.1|
      Respiratory Epithelium, Inflammation |                         4                                                |      7  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |    2                                                                     |      1  2.0|
      Mineralization                       |    2                                                                     |      2  1.5|
      Nephropathy                          |                                                                          |      1  3.0|
      Glomerulus, Inflammation             |                                                                          |      1  3.0|
      Renal Tubule, Necrosis, Acute        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7|                                            |            |
                                           | 3| 5| 3| 6| 0| 1| 6| 0| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25                                   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/M3                                  | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Calculus Micro Observation Only      |    X                                                                     |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 4| 4| 4| 2| 2| 2| 4| 2| 4| 2| 2| 2| 4| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 5| 5| 5| 5| 0| 0| 0| 5| 0| 5| 0| 0| 0| 5| 5| 0| 5|              |            |
                                           | 9| 7| 7| 9| 9| 9| 9| 7| 7| 7| 9| 7| 9| 7| 7| 7| 9| 9| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|              |      A     |
    .25MG/M3                               | 4| 5| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1| 1|              |      L     |
    LUNG TOX                               | 2| 1| 4| 5| 5| 9| 2| 4| 8| 3| 4| 6| 5| 6| 0| 3| 8| 0| 1| 3|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                 I     +              +     +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +                 +     +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                 +     +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +                 M     +              M     +               |   3        |
      Cyst                                 |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +                 +     +              +     +               |   5        |
      Follicular Cell, Hyperplasia, Focal  |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +        +                 +     +              +  +  +               |   7        |
      Endometrium, Hyperplasia             |    1        1                 2     1              2     3               |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M  +     +                 +     +     +  +     +  +  +               |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 4| 4| 4| 2| 2| 2| 4| 2| 4| 2| 2| 2| 4| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 5| 5| 5| 5| 0| 0| 0| 5| 0| 5| 0| 0| 0| 5| 5| 0| 5|              |            |
                                           | 9| 7| 7| 9| 9| 9| 9| 7| 7| 7| 9| 7| 9| 7| 7| 7| 9| 9| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|              |      A     |
    .25MG/M3                               | 4| 5| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1| 1|              |      L     |
    LUNG TOX                               | 2| 1| 4| 5| 5| 9| 2| 4| 8| 3| 4| 6| 5| 6| 0| 3| 8| 0| 1| 3|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |       1                                   1              1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +        +                 +     +        +     +     +               |   7        |
      Hyperplasia, Lymphoid                |    1                          1                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             M                 +     +              M     +               |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +     +                 I     M     +  M     I  +  M               |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M                 +     +              M     +               |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                 +     +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +                 +     +              +     +               |   5        |
      Subcutaneous Tissue, Inflammation    |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                 +     +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                 +     +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |             +                 +     I              +     +               |   4        |
      Inflammation                         |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +                 +     +     +  +     +  +  +               |  10        |
      Hyperplasia, Macrophage              |                                                    1                     |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +                 +     +     +  +     +  +  +               |  10        |
      Inflammation, Acute                  |    1                                      1  1        1                  |      4  1.0|
      Respiratory Epithelium, Degeneration |                                     1              1                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                 +     +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +                 +     +     +  +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +                 +     +              +     +               |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Infarct                              |                                                                          |             
      Necrosis, Diffuse                    |                   2                                                      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                2                                                         |             
      Duct, Cyst, Multiple                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                         1  1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Peridontal Tissue, Inflammation      |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |             1                                                            |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                      2        4  2                                       |             
      Pars Distalis, Hyperplasia           | 1  2  1              1                          1        3        2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic | 3  2        2        3  1  1  2  2              1     1        1     2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
      Abdominal, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  M  +  M  +  M  +  +  +|             
      Atrophy                              |                                                 1                        |             
      Ectasia                              |             1     1        1                          2              1   |             
      Inflammation                         |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X     X           X        X                     |             
      Bilateral, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                 2                        |             
      Endometrium, Hyperplasia             | 3  1  2                 2        3  3  2  3  1     2  1  1              1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Myelofibrosis                        | 2  1  3  1  1  2  2  3  2  2  2  2  1  1  2     1  1  1  1        2  1  1|             
      Myeloid Cell, Hyperplasia            |       1  1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                +                 +  +            |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                        2                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2           1                          2        2  1                     |             
      Hyperplasia, Macrophage              |             1           1     1  1                                1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          1                                                               |             
      Hyperplasia, Lymphoid                | 3                                      2                                 |             
      Hyperplasia, Mast Cell               |                                                                          |             
      Hyperplasia, Plasma Cell             |                      2        2           3           4                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Hyperplasia, Lymphoid                |                   2                    2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  I  +  +  +  +  M  M  M  M  +  +  M  +  M  M  +  +  +  +  +  M  +|             
      Hyperplasia, Histiocytic             |                   1  2                                                   |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                                                     |             
      Congestion                           |                                  1                                       |             
      Hematopoietic Cell Proliferation     |                   2  2                    2                 3            |             
      Hyperplasia, Lymphoid                |    2                    1           1  2  1     2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2              2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Inflammation                         |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             
      Dermis, Inflammation, Granulomatous  |                                                                          |             
      Neck, Inflammation                   |       4                                                                  |             
      Pinna, Inflammation                  |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibula, Fracture                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          3     1                                               3         |             
      Cerebrum, Degeneration               |                                     3                                   3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                     1           1                        |             
      Hyperplasia, Macrophage              | 1  1  1  2  2  1  1  1  3  1  1  1  2  2  1  2  1  1  2  1  1     1  1  1|             
      Inflammation, Chronic Active         |       1     1        1  1     1     1                                    |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1  1     2  1  1  1     1  1  1  1  1  1              1     1     1  1   |             
      Alveolus, Proteinosis                |             2  1        1              2                    1     1      |             
      Interstitium, Infiltration Cellular  | 1        1  1        1  2  1                          1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                1         |             
      Olfactory Epithelium, Degeneration   |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration |             1           1                                                |             
      Respiratory Epithelium, Inflammation |             1                 2  1     1                 2     3         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                        1                 1     3         |             
      Squamous Epithelium, Inflammation    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                               +                  |             
      External Ear, Inflammation           |       4                                               4                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                 +      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Extraorbital, Hyperplasia, Plasma    |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|             
                                           | 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
    MG/M3                                  | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation                         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |          4                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       3              2                                                   |             
      Infarct                              |                                                 3                        |             
      Necrosis, Diffuse                    |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                            +  +         |             
      Inflammation, Chronic                |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1                                                                        |             
      Inflammation                         |                                                                          |             
      Duct, Cyst, Multiple                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                     X                                    |             
      Pars Distalis, Angiectasis           | 3  3                 4                    3                    2         |             
      Pars Distalis, Hyperplasia           | 3  3              2  2                 1  3              1        1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|             
                                           | 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
    MG/M3                                  | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic | 1  1     2  1     1           4     1     3              1        2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +           +                                            +            |             
      Abdominal, Cyst                      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation                         |                            4                    4                        |             
      Pigmentation                         |       2                                                     1            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X           X           X                       X  X  X  X        X  X   |             
      Bilateral, Cyst                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia             | 2     2  1  3     2  1  1  1  1  4  1        3  2  3  3  1        1  2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                   2                                                      |             
      Myelofibrosis                        | 3        2  2  1  2     1  1  1  3  1  1  1  2  1  1  3  2        2  3  3|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +        +  +     +                       +  +         |             
      Iliac, Hyperplasia, Lymphoid         |                            2                                             |             
      Inguinal, Hyperplasia, Lymphoid      |                            3                                             |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1  1     1                 3  2  1        2              1              2|             
      Hyperplasia, Macrophage              | 1  1        1           2     1                       1  1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |          3                             1  2                              |             
      Hyperplasia, Mast Cell               |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |          3                                                              1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  M  +  +  M  +  +  +  M  +  +  +  I  M  M  M  M  +  +  M  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|             
                                           | 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
    MG/M3                                  | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    1  2                                                              1  2|             
      Hyperplasia, Lymphoid                |          3                 2           1                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Atrophy                              |       1        3  1                          1     3                    1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     4                                    |             
      Dermis, Fibrosis                     |                1                                                         |             
      Dermis, Inflammation, Granulomatous  |                                                             2            |             
      Neck, Inflammation                   |                                                                          |             
      Pinna, Inflammation                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibula, Fracture                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                            +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Cerebrum, Degeneration               |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              | 3  1  1  2  2  3  2  1  2  1  2  2     1     1  1  1  2  2  2     1  2  2|             
      Inflammation, Chronic Active         | 2  1     1           1           1                       1        1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2                                 |             
      Alveolar Epithelium, Hyperplasia     | 1  1        1  1  1  1  1     1     1  1           1     1        1      |             
      Alveolus, Proteinosis                |                   1     1        1                                       |             
      Interstitium, Infiltration Cellular  | 2                    1                                            1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|             
                                           | 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
    MG/M3                                  | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                    1        1            |             
      Respiratory Epithelium, Inflammation |                                                          1  1            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Squamous Epithelium, Inflammation    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      External Ear, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |       +                                                                  |             
      Extraorbital, Hyperplasia, Plasma    |                                                                          |             
          Cell                             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         2|             
      Metaplasia, Osseous                  |                      1                                                   |             
      Nephropathy                          |                                                                         3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3|                                            |            |
                                           | 1| 6| 2| 0| 1| 6| 3| 9| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.5                                    | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      2  2.5|
      Infarct                              |                                                                          |      1  3.0|
      Necrosis, Diffuse                    |                                                                          |      1  2.0|
      Necrosis                             | 3                    1                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Duct, Cyst, Multiple                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Squamous                |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3|                                            |            |
                                           | 1| 6| 2| 0| 1| 6| 3| 9| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.5                                    | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Angiectasis           |                                                                          |      8  2.9|
      Pars Distalis, Hyperplasia           |                                                                          |     15  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia, Cystic |    1  1              1                                                   |     27  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   4        |
      Abdominal, Cyst                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Atrophy                              |                                                                          |      1  1.0|
      Ectasia                              |                                                                          |      5  1.2|
      Inflammation                         |                   2                                                      |      3  3.3|
      Pigmentation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | X     X  X  X                                                            |     17     |
      Bilateral, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |    3     3  3  3  3  3  3  3                                             |     39  2.1|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Myelofibrosis                        | 1  2  1  2  2  2  2  3  1  1                                             |     52  1.7|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +  +                                             |  13        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                3  1                                                      |     16  1.6|
      Hyperplasia, Macrophage              |       1           1                                                      |     14  1.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3|                                            |            |
                                           | 1| 6| 2| 0| 1| 6| 3| 9| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.5                                    | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.2|
      Hyperplasia, Mast Cell               |    3                                                                     |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M                                             |  56        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  +  I  M  M  M  +  +                                             |  33        |
      Hyperplasia, Histiocytic             |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      8  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      9  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  I  +  +  +  +  +                                             |  54        |
      Atrophy                              |                                                                          |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation                         |                                                                          |      1  4.0|
      Dermis, Fibrosis                     |                                                                          |      1  1.0|
      Dermis, Inflammation, Granulomatous  |                                                                          |      1  2.0|
      Neck, Inflammation                   |                                                                          |      1  4.0|
      Pinna, Inflammation                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibula, Fracture                     | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Compression                          |                                                                          |      3  2.3|
      Cerebrum, Degeneration               |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3|                                            |            |
                                           | 1| 6| 2| 0| 1| 6| 3| 9| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.5                                    | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          | 4                                                                        |      2  2.5|
      Inflammation                         | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           | 1                                                                        |      3  1.0|
      Hyperplasia, Macrophage              |    1  1  3  2  2  2        2                                             |     53  1.5|
      Inflammation, Chronic Active         |             1                                                            |     14  1.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    1  1  1                                                               |     32  1.0|
      Alveolus, Proteinosis                |       3                    1                                             |     11  1.4|
      Interstitium, Infiltration Cellular  |          1  1  1  1                                                      |     16  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  1.0|
      Respiratory Epithelium, Degeneration |                                                                          |      4  1.0|
      Respiratory Epithelium, Inflammation |             1     1        1                                             |     11  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      3  1.7|
      Squamous Epithelium, Inflammation    |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      External Ear, Inflammation           |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Extraorbital, Hyperplasia, Plasma    |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +                                             |  58        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 4| 2| 4| 4| 2| 2| 4| 2| 4| 2| 4| 4| 2| 4| 2| 4| 2| 4|              |            |
                             DAY ON TEST   | 0| 0| 5| 0| 5| 5| 0| 0| 5| 0| 5| 0| 5| 5| 0| 5| 0| 5| 0| 5|              |            |
                                           | 7| 7| 9| 7| 9| 9| 7| 7| 9| 7| 9| 7| 9| 9| 7| 9| 7| 9| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5MG/M3                               | 0| 1| 2| 3| 3| 3| 3| 3| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7|              |      L     |
    LUNG TOX                               | 9| 6| 0| 3| 4| 6| 7| 8| 4| 6| 1| 9| 1| 2| 3| 4| 5| 6| 0| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +                       M              +     +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +                       +              +     +               |   5        |
      Pars Distalis, Hyperplasia, Focal    |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +     +                       +              +     +               |   5        |
      Cyst                                 |       X                                                                  |      1     |
      Periovarian Tissue, Cyst             |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +     +     +                 +              +     +               |   6        |
      Endometrium, Hyperplasia             |             1     1                 3              2     3               |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +                       +              +     +               |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 4| 2| 4| 4| 2| 2| 4| 2| 4| 2| 4| 4| 2| 4| 2| 4| 2| 4|              |            |
                             DAY ON TEST   | 0| 0| 5| 0| 5| 5| 0| 0| 5| 0| 5| 0| 5| 5| 0| 5| 0| 5| 0| 5|              |            |
                                           | 7| 7| 9| 7| 9| 9| 7| 7| 9| 7| 9| 7| 9| 9| 7| 9| 7| 9| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5MG/M3                               | 0| 1| 2| 3| 3| 3| 3| 3| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7|              |      L     |
    LUNG TOX                               | 9| 6| 0| 3| 4| 6| 7| 8| 4| 6| 1| 9| 1| 2| 3| 4| 5| 6| 0| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +  +  +     +                 +     +        +  I  +               |   9        |
      Hyperplasia, Lymphoid                |          1  1                                            1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +     +                 +              +     +               |   6        |
      Hyperplasia, Lymphoid                |       2           2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     M  M  M     +                 M     M        M  M  M               |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +                       +              +     +               |   5        |
      Hyperplasia, Lymphoid                |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +                       +              +     +               |   5        |
      Cyst                                 |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +                       +              +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +     I                       +              I     I               |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +     +                 +     +        +  +  +               |  10        |
      Hyperplasia, Macrophage              |                                     1     1        1                     |      3  1.0|
      Alveolar Epithelium, Hyperplasia     |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +     +                 +     +        +  +  +               |  10        |
      Inflammation, Acute                  |                                           1                              |      1  1.0|
      Olfactory Epithelium, Degeneration   |       1                                                                  |      1  1.0|
      Olfactory Epithelium, Respiratory    |                                                                          |            |
          Epithelium, Degeneration         |                   1                                                      |      1  1.0|
      Respiratory Epithelium, Degeneration |       1                             1                                    |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +                       +              +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +     +                 +     +        +  +  +               |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 4| 2| 4| 4| 2| 2| 4| 2| 4| 2| 4| 4| 2| 4| 2| 4| 2| 4|              |            |
                             DAY ON TEST   | 0| 0| 5| 0| 5| 5| 0| 0| 5| 0| 5| 0| 5| 5| 0| 5| 0| 5| 0| 5|              |            |
                                           | 7| 7| 9| 7| 9| 9| 7| 7| 9| 7| 9| 7| 9| 9| 7| 9| 7| 9| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5MG/M3                               | 0| 1| 2| 3| 3| 3| 3| 3| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7|              |      L     |
    LUNG TOX                               | 9| 6| 0| 3| 4| 6| 7| 8| 4| 6| 1| 9| 1| 2| 3| 4| 5| 6| 0| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +                       +              +     +               |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|             
                                           | 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0                                    | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  M  +  M  +  I  I  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Necrosis, Diffuse                    |                1                                                         |             
      Necrosis                             |                                              2     2                     |             
      Bile Duct, Degeneration              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                                                     +      |             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Inflammation                         | 2                                                                        |             
      Necrosis                             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   1      |             
      Duct, Ectasia                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Peridontal Tissue, Inflammation      |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Extra Adrenal Tissue, Inflammation   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  I  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|             
                                           | 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0                                    | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                    3                     |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       2        1  1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic | 1  1  2     2  1  2     3     2     1  1                 1  1  1  1     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Abdominal, Inflammation              | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    1                     |             
      Inflammation                         |                            3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                      2                                                   |             
      Cyst                                 |                X                                                  X      |             
      Hemorrhage                           |       4                                      2                           |             
      Inflammation                         | 4                                                                        |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              4                           |             
      Inflammation                         | 3                                                                        |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia             | 3  1        2  2  1  3  1  2     1  2     3  2  3     2  1  3  3        3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Myelofibrosis                        |    1  2     1     2     1  1  1     1  1  1           2  1  2  3  1  2  2|             
      Myeloid Cell, Hyperplasia            |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +              +                                   +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      | 3                                                                        |             
      Inguinal, Hyperplasia, Histiocytic   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                1                                                         |             
      Inguinal, Pigmentation               |                               2                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Pancreatic, Inflammation             |                                                                   1      |             
      Renal, Fibrosis                      |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|             
                                           | 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0                                    | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |    2  1  4        2     3  1  2     3                 1  3  2  2        2|             
      Hyperplasia, Macrophage              |       1  1        1     1  1  1  1  1     2     2     2  2  3  1  1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Cyst                                 |                                                 X                        |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1                     |             
      Hyperplasia, Plasma Cell             |                3                                                         |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  I  I  M  +  I  +  +  +  M  M  +  I  I  M  M  M  M  +  +  I  +  M  M|             
      Hyperplasia, Lymphoid                | 1                       1                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                1     1  1                                                |             
      Hyperplasia, Lymphoid                | 2                 3     1                    1  1        1  1            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2  3           3     3                 1   |             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                4                 4                                       |             
      Pinna, Inflammation                  |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|             
                                           | 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0                                    | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Macrophage              | 3  1  2  3  2  2  2  2  2  2  4  2  2  2  3  2  2  2  3  3  3  3  3  3  3|             
      Inflammation, Chronic Active         | 1     2     2     2     1  1     1  3  2     1  1     1  1  2  2     1  3|             
      Alveolar Epithelium, Hyperplasia     | 2  1  1  1  1     1  1  1  1  1  1  2  1              1  1  1  1  1  1  1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                                          |             
      Alveolus, Proteinosis                | 3        2  3  2  2  1     1  3  2  3  1     1  2  1  1     1  2  4     3|             
      Bronchiole, Degeneration             |                                                                          |             
      Interstitium, Infiltration Cellular  | 2     1           1  1  2  2  2     2  1  2  1           1  1  1     1  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |       1        1     1        1        1              1           1      |             
      Olfactory Epithelium, Degeneration   |                   1           1        1              1  1              1|             
      Olfactory Epithelium, Inflammation   |                   1                                   1                  |             
      Respiratory Epithelium, Degeneration |                   1           1                       1  1               |             
      Respiratory Epithelium, Inflammation |    1              1                                                      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
      Squamous Epithelium, Inflammation    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      1                                                   |             
      Nephropathy                          |                               1                                          |             
      Pelvis, Dilatation                   |                                  1                                       |             
      Perirenal Tissue, Inflammation       | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|             
                                           | 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/M3                                  | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  A  A  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                   3                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                   4      |             
      Necrosis, Diffuse                    |                                  4           1     2  3                  |             
      Necrosis                             |                                                                          |             
      Bile Duct, Degeneration              |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |             2                                                            |             
      Extra Adrenal Tissue, Inflammation   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  +  +  +  M  +  +  +  I  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|             
                                           | 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/M3                                  | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                4         |             
      Pars Distalis, Hyperplasia           |    3  1  3     3                                               3  1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                                         1               |             
      Follicular Cell, Hyperplasia, Cystic |    1     1  1     1                                   1  1     1  1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                 +                        |             
      Abdominal, Inflammation              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               3                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               3                                          |             
      Atrophy                              |                                                                          |             
      Cyst                                 |    X              X                                X                    X|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Pigmentation, Hemosiderin            |             1                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia             | 2     3  3  3  3     3        3  2        1     4  3  2  3           1  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Myelofibrosis                        |    1  1     1  1  2  3        1  2     1     1  3     1  3     1  1  1  2|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                      +     +  +     +        +   |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                      4   |             
      Inguinal, Hyperplasia, Histiocytic   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                       2                  |             
      Pancreatic, Inflammation             |                                                                          |             
      Renal, Fibrosis                      |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|             
                                           | 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/M3                                  | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |    1     1     2  2  1  2                                2        1     2|             
      Hyperplasia, Macrophage              |          1  2  3  1  1     1           1        1  1     2        1  2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                | 1        3              2                                3               |             
      Hyperplasia, Plasma Cell             |                                                                   4      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +     +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Inflammation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  I  M  +  M  M  M  +  M  I  M  M  M  +  +  M  M  +  +  M  M  M|             
      Hyperplasia, Lymphoid                |          1                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3                                2                 3  4           2      |             
      Hyperplasia, Lymphoid                |                   1                                      3               |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                2  3  2  2                              |             
      Autolysis                            |                                  3                                       |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              1                           |             
      Pinna, Inflammation                  |                                                                   4      |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|             
                                           | 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/M3                                  | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                              1                           |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     1                                    |             
      Hyperplasia, Macrophage              | 2  2  2  2  2  3  2  3  2  3  3  2     2  1  2  2  3  2  3  2  2  2  2  2|             
      Inflammation, Chronic Active         | 2  1     1  1  3  2  3  1  1                 2  2  2  1  3     2  1      |             
      Alveolar Epithelium, Hyperplasia     |    1  1  1  1  1  1  1     1     2     1     1  1        1     1     1  1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                          2               |             
      Alveolus, Proteinosis                |          2  1  1  3  2     2     2     2     2  1  3  1  3  2  2  2  1   |             
      Bronchiole, Degeneration             |                                              1           1               |             
      Interstitium, Infiltration Cellular  |    1     2  1  1  1  2     2     1           2  1        2     1  2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |             1           1  1     1     1     1                       1   |             
      Olfactory Epithelium, Degeneration   |          1                                   2                           |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Respiratory Epithelium, Degeneration |                         1                                      1         |             
      Respiratory Epithelium, Inflammation |                            3                       2        2     1  1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            3                                2            |             
      Squamous Epithelium, Hyperplasia     |                                                    2                     |             
      Squamous Epithelium, Inflammation    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Nephropathy                          |                            2                 1                           |             
      Pelvis, Dilatation                   |       2                                                                  |             
      Perirenal Tissue, Inflammation       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3|                                            |            |
                                           | 0| 5| 6| 2| 9| 3| 1| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    1.0                                    | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | I  M  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Necrosis, Diffuse                    |             3                                                            |      6  2.3|
      Necrosis                             |                                                                          |      2  2.0|
      Bile Duct, Degeneration              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +                                                      |   5        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      1  1.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |       2                                                                  |      1  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Extra Adrenal Tissue, Inflammation   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3|                                            |            |
                                           | 0| 5| 6| 2| 9| 3| 1| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    1.0                                    | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Congestion                           |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |       2  4                                                               |     11  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      2  1.0|
      Follicular Cell, Hyperplasia, Cystic | 1                       2  3                                             |     27  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Abdominal, Inflammation              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  I  +  +  +  M  +                                             |  58        |
      Ectasia                              |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 | X                    X                                                   |      8     |
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation                         |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  3.0|
      Prolapse                             |    X                                                                     |      1     |
      Endometrium, Hyperplasia             | 3  3     3     2  1  3  2  2                                             |     41  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Histiocytic             |             2                                                            |      1  2.0|
      Myelofibrosis                        | 2     1  2        3  2  1  3                                             |     41  1.6|
      Myeloid Cell, Hyperplasia            |    1           1                                                         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +                                                            |  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3|                                            |            |
                                           | 0| 5| 6| 2| 9| 3| 1| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    1.0                                    | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Hyperplasia, Lymphoid         |    2                                                                     |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      2  3.5|
      Inguinal, Hyperplasia, Histiocytic   |             3                                                            |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  1.0|
      Inguinal, Pigmentation               |                                                                          |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Pancreatic, Inflammation             |                                                                          |      1  1.0|
      Renal, Fibrosis                      |          4                                                               |      1  4.0|
      Renal, Hyperplasia, Histiocytic      |             4                                                            |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |    3                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Hyperplasia, Histiocytic             |             4                                                            |      1  4.0|
      Hyperplasia, Lymphoid                | 3                 2     2  2                                             |     26  2.0|
      Hyperplasia, Macrophage              | 1  1        3  2     2  2  2                                             |     37  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |  55        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Histiocytic             |             4                                                            |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.0|
      Hyperplasia, Plasma Cell             |    3                    2                                                |      4  3.0|
      Inflammation                         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +                                             |  51        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                         3                                                |      2  2.5|
      Inflammation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  +  M  +  M  M  +  M  +  M                                             |  22        |
      Hyperplasia, Lymphoid                |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |             2                                                            |      9  2.1|
      Hyperplasia, Lymphoid                |                      1                                                   |     10  1.5|
      Hyperplasia, Plasma Cell             |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +                                             |  56        |
      Atrophy                              |             3  2                                                         |     12  2.4|
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3|                                            |            |
                                           | 0| 5| 6| 2| 9| 3| 1| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    1.0                                    | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      3  3.0|
      Pinna, Inflammation                  |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | I  +  +  +  +  +  +  +  +  +                                             |  56        |
      Degeneration                         |                                                                          |      1  1.0|
      Hyperplasia                          |                         4                                                |      1  4.0|
      Inflammation                         |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  1.0|
      Hyperplasia, Macrophage              | 3  2  2  3  2  3  2  2  3  3                                             |     59  2.4|
      Inflammation, Chronic Active         | 1     1  1  1     1     2  3                                             |     40  1.6|
      Alveolar Epithelium, Hyperplasia     | 1  1  1  1  1     1  1  1  1                                             |     45  1.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Alveolus, Proteinosis                | 2  1     1  3  3  2  2  1  2                                             |     45  1.9|
      Bronchiole, Degeneration             |                                                                          |      2  1.0|
      Interstitium, Infiltration Cellular  | 2  1  1  1        1  1  2  2                                             |     39  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Olfactory Epithelium, Atrophy        | 1                 1     1                                                |     17  1.0|
      Olfactory Epithelium, Degeneration   |                                                                          |      8  1.1|
      Olfactory Epithelium, Inflammation   |                                                                          |      2  1.0|
      Respiratory Epithelium, Degeneration |             1                                                            |      7  1.0|
      Respiratory Epithelium, Inflammation | 1           1        1  1                                                |     11  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.5|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Squamous Epithelium, Inflammation    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3|                                            |            |
                                           | 0| 5| 6| 2| 9| 3| 1| 3| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    1.0                                    | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Degeneration                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |      3  1.3|
      Pelvis, Dilatation                   |                                                                          |      2  1.5|
      Perirenal Tissue, Inflammation       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 2| 4| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 2| 4| 4| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 5| 5| 5| 0| 5| 0| 5| 5| 5|              |            |
                                           | 9| 7| 7| 7| 9| 7| 7| 7| 7| 7| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    1.0MG/M3                               | 6| 6| 6| 7| 7| 8| 8| 9| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4|              |      L     |
    LUNG TOX                               | 1| 2| 9| 6| 9| 2| 5| 7| 2| 3| 0| 1| 9| 4| 5| 8| 2| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                  +  I        +     +     +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +              +  +        +     +     +               |   6        |
      Diverticulum                         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                  +  +              +     I               |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                  +  +        +     I     +               |   4        |
      Pars Distalis, Hyperplasia, Focal    |                                  1  1                                    |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                  +  +        +     +     +               |   5        |
      Ectasia                              |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                  +  +        +     +     +               |   5        |
      Cyst                                 |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +                             +  +        +     +     +               |   6        |
      Endometrium, Hyperplasia             |    2                             2  2        2     2                     |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 2| 4| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 2| 4| 4| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 5| 5| 5| 0| 5| 0| 5| 5| 5|              |            |
                                           | 9| 7| 7| 7| 9| 7| 7| 7| 7| 7| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    1.0MG/M3                               | 6| 6| 6| 7| 7| 8| 8| 9| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4|              |      L     |
    LUNG TOX                               | 1| 2| 9| 6| 9| 2| 5| 7| 2| 3| 0| 1| 9| 4| 5| 8| 2| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     +        M              +  +     +  +  +  +     I               |   8        |
      Hyperplasia, Lymphoid                |    2                             2  1     1  2  2  1                     |      7  1.6|
      Hyperplasia, Macrophage              |                                  1  1        1     1                     |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +                       +  +        +     +     +               |   6        |
      Hyperplasia, Lymphoid                |                                              2                           |      1  2.0|
      Hyperplasia, Plasma Cell             |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                  +  +        +     +     M               |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M     M        M              M  M     M  +  M  +     M               |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                  +  +        +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                  +  +        +     +     I               |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +        +              +  +     +  +  +  +     +               |  10        |
      Hyperplasia, Macrophage              |    1     1        1              1  1     1  1  1  2     1               |     10  1.1|
      Inflammation, Chronic Active         |          1                       1  2        1  1  1     1               |      7  1.1|
      Alveolar Epithelium, Hyperplasia     |                                  1  1        1     1     1               |      5  1.0|
      Alveolus, Proteinosis                |                                  1  1        1     1     2               |      5  1.2|
      Interstitium, Infiltration Cellular  |                                  2  1        1  2  1     1               |      6  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +        +              +  +     +  +  +  +     +               |  10        |
      Inflammation, Acute                  |    1              1                 1     1     1                        |      5  1.0|
      Olfactory Epithelium, Atrophy        |                                              1                           |      1  1.0|
      Respiratory Epithelium, Degeneration |                                  1                       1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                  +  +        +     +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 2| 4| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 2| 4| 4| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 5| 5| 5| 0| 5| 0| 5| 5| 5|              |            |
                                           | 9| 7| 7| 7| 9| 7| 7| 7| 7| 7| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    1.0MG/M3                               | 6| 6| 6| 7| 7| 8| 8| 9| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4|              |      L     |
    LUNG TOX                               | 1| 2| 9| 6| 9| 2| 5| 7| 2| 3| 0| 1| 9| 4| 5| 8| 2| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +        +              +  +     +  +  +  +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                  +  +        +     +     +               |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|             
                                           | 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   1                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2                                                                        |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |       3                                                                  |             
      Infarct                              |                               4                    4        4            |             
      Necrosis, Diffuse                    |                                        4                             3   |             
      Centrilobular, Degeneration          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       3              2                             3                 2   |             
      Inflammation                         |    3                                                                     |             
      Atrium, Thrombosis                   |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |             3                          1        1     2     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|             
                                           | 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                            +                                             |             
      Hyperplasia, Squamous                |                            3                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                                                      |             
      Ectasia                              | 2  3  3  2  1     2     1  2  3     3  3        2  2     4  2        2   |             
      Inflammation                         |    3           2  2              2  2  2           2  3  3  3  3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation                         |                                     2                    2              3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                         1|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |    1           3           2  1     3              2     3              1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +              +     +           +  +  +  +              +|             
      Iliac, Hyperplasia, Histiocytic      |                                     2                                    |             
      Iliac, Hyperplasia, Lymphoid         |                4                                3                        |             
      Iliac, Hyperplasia, Plasma Cell      |                               2     3              3  3  3              3|             
      Iliac, Pigmentation                  |                                                          1               |             
      Inguinal, Hyperplasia, Lymphoid      |                                                 3  2                    3|             
      Inguinal, Hyperplasia, Plasma Cell   |                                     2              2                     |             
      Inguinal, Inflammation               |                                     1                                    |             
      Inguinal, Pigmentation               |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                         3|             
      Popliteal, Hyperplasia, Plasma Cell  |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                3                                                         |             
      Renal, Hyperplasia, Plasma Cell      |                                     3                                   3|             
      Renal, Inflammation                  |                                                                         1|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  I  I  +  +  I  M  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         1                       3                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|             
                                           | 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                    3                     |             
      Inflammation                         |    3                                   3                 1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  I  +  M  M  +  M  M  +  M  M  M  M  +  M  M  +  I  M  M  M  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                2                    3  2  3              3              3|             
      Hyperplasia, Histiocytic             |                                  2                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              | 1     3        1  3  1     1  1     4  4                 3           2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              2                           |             
      Foot, Inflammation                   |                                                                          |             
      Foot, Necrosis                       |                                                                          |             
      Prepuce, Hyperplasia, Squamous       |                                                                          |             
      Prepuce, Inflammation                |                            3                             3           4   |             
      Subcutaneous Tissue, Inflammation    |                                                                         4|             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation                   |                                                 3                       3|             
      Tail, Necrosis                       |    4           4           4  4        4                             4  4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                       2                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Macrophage              | 4                                                                        |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Inflammation                         |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
      Bronchiole, Hyperplasia              |                                                                          |             
      Interstitium, Infiltration Cellular  | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|             
                                           | 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Inflammation |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                    +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                3              2     3                    3              3|             
      Nephropathy                          |    2                    1                                                |             
      Pelvis, Dilatation                   |    2              1           3                       3  3           4   |             
      Renal Tubule, Pigmentation           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                         +           +   |             
      Calculus Micro Observation Only      |                X                                         X           X   |             
      Inflammation                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation                         |                4              4     4                    4              4|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|             
                                           | 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    MG/M3                                  | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                      2   |             
      Clear Cell Focus                     |                               2                                          |             
      Congestion                           |                                                                          |             
      Infarct                              |                                                 4           4            |             
      Necrosis, Diffuse                    |                                     1     2                    4         |             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +  I|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Hyperplasia           |       1                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic | 1           1                 1  2     1     1  3  1  1           2     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|             
                                           | 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    MG/M3                                  | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                       +  +               |             
      Hyperplasia, Squamous                |                                                       3  4               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              | 1  2  3  2     3  2  2  2  3  1  3  3  3  3  3  2  1  3  3  3  2  2  2   |             
      Inflammation                         |                3                 4  4  3  4              3  4     3  2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                            2        1  3  3           1     2  3     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +        +     +        +  +              +     +  +  +      |             
      Iliac, Hyperplasia, Histiocytic      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                            3        3  3                    4  2         |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |             2              3                                             |             
      Inguinal, Hyperplasia, Plasma Cell   |                                        2              1     1            |             
      Inguinal, Inflammation               |                                                                          |             
      Inguinal, Pigmentation               |                                                                1  1      |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Popliteal, Hyperplasia, Plasma Cell  |                                                                3         |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                3         |             
      Renal, Inflammation                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  I  +  +  +  +  +  +  M  M  I  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |             1                                                            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|             
                                           | 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    MG/M3                                  | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                         1|             
      Inflammation                         |                                        2                       3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  +  +  M  +  M  M  M  +  M  M  M  M  +  M  M  M  I  M  +  M  +  M  M  I|             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Hyperplasia, Plasma Cell             |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3     3           2     1  3     2  1              1  3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    2           2                                                     3   |             
      Foot, Inflammation                   |                                           4                              |             
      Foot, Necrosis                       |                            1                                             |             
      Prepuce, Hyperplasia, Squamous       |                                              3                           |             
      Prepuce, Inflammation                |                            2                 4        4  3  4            |             
      Subcutaneous Tissue, Inflammation    |                                                                          |             
      Tail, Hyperkeratosis                 |                                     1                                    |             
      Tail, Inflammation                   |                                  2  1                                    |             
      Tail, Necrosis                       |                            4              4                    4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Macrophage              |             2        2  4                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |                                                 1                        |             
      Interstitium, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|             
                                           | 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    MG/M3                                  | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Inflammation   |                2                                                         |             
      Respiratory Epithelium, Degeneration | 1                                                                        |             
      Respiratory Epithelium, Inflammation |             2                                2                           |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                        1                       4         |             
      Nephropathy                          |                            1        1              1     1        1     1|             
      Pelvis, Dilatation                   |                            2           1                 1           1   |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                        +                                 |             
      Dilatation                           |                                                                          |             
      Inflammation                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                     +     +     +                    +  +|             
      Calculus Micro Observation Only      |                                     X     X     X                    X  X|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Calculus Micro Observation Only      |                                                    X                     |             
      Dilatation                           |                                                       1                  |             
      Inflammation                         |                                        3                                 |             
      Transitional Epithelium, Hyperplasia |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 2| 7| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1|                                            |            |
                                           | 7| 7| 7| 5| 9| 0| 9| 2| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  M  +  +  I                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      2  2.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      5  4.0|
      Necrosis, Diffuse                    |             2           3                                                |      7  2.7|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      4  2.5|
      Inflammation                         |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                X                                                         |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  M  M                                             |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +                                             |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 2| 7| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1|                                            |            |
                                           | 7| 7| 7| 5| 9| 0| 9| 2| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia, Cystic | 1  2  1  1  2        1     1                                             |     26  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Penis                                   |          +                                                               |   4        |
      Hyperplasia, Squamous                |          2                                                               |      4  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              |       2     3     2     2  3                                             |     44  2.3|
      Inflammation                         | 2  1                 4                                                   |     23  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation                         |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      1  1.0|
      Hemorrhage                           |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Granuloma Sperm                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erythroid Cell, Hyperplasia          |                2                                                         |      1  2.0|
      Myeloid Cell, Hyperplasia            |                         2                                                |     17  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +           +  +  +                                             |  23        |
      Iliac, Hyperplasia, Histiocytic      |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |          2           2                                                   |      4  2.8|
      Iliac, Hyperplasia, Plasma Cell      |                            3                                             |     12  2.9|
      Iliac, Pigmentation                  |                                                                          |      1  1.0|
      Inguinal, Hyperplasia, Lymphoid      |          1           1  2                                                |      8  2.1|
      Inguinal, Hyperplasia, Plasma Cell   |                            3                                             |      6  1.8|
      Inguinal, Inflammation               |                                                                          |      1  1.0|
      Inguinal, Pigmentation               |                                                                          |      2  1.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Popliteal, Hyperplasia, Plasma Cell  |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 2| 7| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1|                                            |            |
                                           | 7| 7| 7| 5| 9| 0| 9| 2| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hyperplasia, Plasma Cell      |                            4                                             |      4  3.3|
      Renal, Inflammation                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  M  +  +  I  +  +                                             |  46        |
      Edema                                |                3                                                         |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Hyperplasia, Plasma Cell             |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +                                             |  55        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Congestion                           |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  I  M  M  +  +  +                                             |  18        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |             2           2  2                                             |      9  2.4|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  I  +  +  +  +  +  +  +  +                                             |  54        |
      Atrophy                              |       1  2  3  3     2  3  3                                             |     27  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      4  2.3|
      Foot, Inflammation                   |                                                                          |      1  4.0|
      Foot, Necrosis                       |                                                                          |      1  1.0|
      Prepuce, Hyperplasia, Squamous       |                                                                          |      1  3.0|
      Prepuce, Inflammation                |                                                                          |      8  3.4|
      Subcutaneous Tissue, Inflammation    |                                                                          |      1  4.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  1.0|
      Tail, Inflammation                   |       1                                                                  |      5  2.0|
      Tail, Necrosis                       |                         4                                                |     11  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |       3                                                                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 2| 7| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1|                                            |            |
                                           | 7| 7| 7| 5| 9| 0| 9| 2| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  I  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  2.5|
      Fibrosis                             |                3                                                         |      1  3.0|
      Hyperplasia, Macrophage              |                3        2                                                |      6  2.8|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|
      Interstitium, Infiltration Cellular  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Olfactory Epithelium, Inflammation   |                                                                          |      1  2.0|
      Respiratory Epithelium, Degeneration |                            1                                             |      2  1.0|
      Respiratory Epithelium, Inflammation |                                                                          |      2  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                            4                                             |      8  2.9|
      Nephropathy                          |                      1                                                   |      9  1.1|
      Pelvis, Dilatation                   |    3     3  2        1  3  2                                             |     16  2.2|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                            +                                             |   2        |
      Dilatation                           |                            2                                             |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |          +        +                                                      |  10        |
      Calculus Micro Observation Only      |          X        X                                                      |     10     |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 2| 7| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1|                                            |            |
                                           | 7| 7| 7| 5| 9| 0| 9| 2| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                                                          |      1  1.0|
      Inflammation                         |                            4                                             |      7  3.9|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 2| 3| 2| 4| 2| 2| 4| 4| 4| 2| 4| 2| 2| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 5| 0| 9| 0| 5| 0| 0| 5| 5| 5| 0| 5| 0| 0| 5| 0| 5|              |            |
                                           | 8| 6| 6| 8| 6| 5| 6| 8| 6| 6| 8| 8| 8| 6| 8| 6| 6| 8| 6| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0MG/M3                               | 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8|              |      L     |
    LUNG TOX                               | 6| 3| 9| 3| 5| 7| 1| 3| 7| 3| 0| 2| 3| 2| 4| 5| 4| 7| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +     +        +  +  +              M                     |   5        |
      Hyperkeratosis                       |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +        +  +  I              +                     |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +     +        +  +  +              +                     |   6        |
      Hepatocyte, Hyperplasia              |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                +                                                         |   1        |
      Hyperkeratosis                       |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +     +        +  +  +              +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +     +        +  +  +              +                     |   6        |
      Cardiomyopathy                       |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +     +        +  +  I              M                     |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +     +        +  +  +              +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +  +        +  +  +              +  +                  |   8        |
      Ectasia                              |                2  2  3        4  3  3              2  2                  |      8  2.6|
      Inflammation                         |                               4                    3                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +     +        +  I  +              +                     |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 2| 3| 2| 4| 2| 2| 4| 4| 4| 2| 4| 2| 2| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 5| 0| 9| 0| 5| 0| 0| 5| 5| 5| 0| 5| 0| 0| 5| 0| 5|              |            |
                                           | 8| 6| 6| 8| 6| 5| 6| 8| 6| 6| 8| 8| 8| 6| 8| 6| 6| 8| 6| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0MG/M3                               | 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8|              |      L     |
    LUNG TOX                               | 6| 3| 9| 3| 5| 7| 1| 3| 7| 3| 0| 2| 3| 2| 4| 5| 4| 7| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +     +        +  +  +              +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +     +        +  +  +              +                     |   6        |
      Myeloid Cell, Hyperplasia            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   1        |
      Renal, Hyperplasia, Plasma Cell      |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +        +  M  +  +        +  +  M  +           +  +                  |   9        |
      Hyperplasia, Lymphoid                |                      1                 1                                 |      2  1.0|
      Hyperplasia, Macrophage              |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +     +        +  M  +              +                     |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +     +        M  +  +              +                     |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M        M  M  M  M        M  M  I  M           M  M                  |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +     +        +  +  +              +                     |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +     +        +  +  +              I                     |   5        |
      Atrophy                              |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     M        +  M  M              M                     |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +     +        +  +  +              +                     |   6        |
      Hyperkeratosis                       |                3                                                         |      1  3.0|
      Inflammation                         |                2                                                         |      1  2.0|
      Subcutaneous Tissue, Inflammation    |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +     +        +  +  +              +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +     +        +  +  +              +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                M     +        +  +  +              +                     |   5        |
      Inflammation                         |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +        +  +  +  +           +  +                  |  11        |
      Inflammation, Acute                  |                                        1                                 |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                               1                                          |      1  1.0|
      Interstitium, Inflammation, Focal    |                                                    1                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 2| 2| 4| 2| 3| 2| 4| 2| 2| 4| 4| 4| 2| 4| 2| 2| 4| 2| 4|              |            |
                             DAY ON TEST   | 5| 0| 0| 5| 0| 9| 0| 5| 0| 0| 5| 5| 5| 0| 5| 0| 0| 5| 0| 5|              |            |
                                           | 8| 6| 6| 8| 6| 5| 6| 8| 6| 6| 8| 8| 8| 6| 8| 6| 6| 8| 6| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0MG/M3                               | 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8|              |      L     |
    LUNG TOX                               | 6| 3| 9| 3| 5| 7| 1| 3| 7| 3| 0| 2| 3| 2| 4| 5| 4| 7| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +        +  +  +  +           +  +                  |  11        |
      Inflammation, Acute                  |                                     1                 1                  |      2  1.0|
      Glands, Inflammation                 |                                  1                                       |      1  1.0|
      Olfactory Epithelium, Degeneration   |                                  1  1                                    |      2  1.0|
      Respiratory Epithelium, Degeneration |                                  1  1                                    |      2  1.0|
      Vomeronasal Organ, Infiltration      |                                                                          |            |
          Cellular, Polymorphonuclear      |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +     +        +  +  +              +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +        +  +  +  +           +  +                  |  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +     +        +  +  +              +                     |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|             
                             DAY ON TEST   | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|             
                                           | 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Autolysis                            |                                  2                                      4|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Anus, Inflammation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Peyer's Patch, Inflammation          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                     3                                2   |             
      Cyst                                 |                                                                          |             
      Fatty Change                         |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                  2                                       |             
      Necrosis, Diffuse                    |                                                                          |             
      Necrosis                             |                2                                                         |             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +  +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2                                    |             
      Autolysis                            |                                              3                           |             
      Inflammation                         |                                     3                                    |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                  4                                       |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|             
                             DAY ON TEST   | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|             
                                           | 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst Multilocular                    |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Capsule, Hyperplasia                 |          3                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  M  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Pars Distalis, Hyperplasia           |                                     1  2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |       1                 2           1     1     1     2  1     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                       +            |             
      Abdominal, Abscess                   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   | +                       +                                                |             
      Hyperplasia, Squamous                | 1                                                                        |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectasia                              |    2  2  3     3        3              3  2  2     3     3     2  3      |             
      Inflammation                         |                4  2  3     2  3  3  3              3  3  3  3  2     4  4|             
      Duct, Hyperplasia                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Congestion                           |                                                                          |             
      Inflammation                         |                                                          1               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              1                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |    1        3        1           1           4                       2  4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +  +  +                    +           +  +  +  +  +   |             
      Iliac, Hyperplasia, Lymphoid         |                                                                   3      |             
      Iliac, Hyperplasia, Plasma Cell      |                   3                          3                       2   |             
      Iliac, Inflammation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      | 1                 2  1  2                                      1     2   |             
      Inguinal, Hyperplasia, Plasma Cell   |                                              2                    3      |             
      Inguinal, Inflammation               |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|             
                             DAY ON TEST   | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|             
                                           | 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  M  +  +  +  +  I  +  +  +  +  +  +  +  +  M  M  +|             
      Congestion                           |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hyperplasia, Histiocytic             |                                              3                           |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Hyperplasia, Plasma Cell             |                                  2                       3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                   1                                                      |             
      Hyperplasia, Plasma Cell             |             2                                                            |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Congestion                           |                      2           2  3                                    |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hyperplasia, Histiocytic             |                                              2                          2|             
      Hyperplasia, Lymphoid                |          1           1                                                   |             
      Inflammation                         |    1                       1                             3              2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  +  +  M  M  M  I  +  +  +  +  M  +  +  M  +  M  +  +  M  M  M  M|             
      Hyperplasia, Histiocytic             |                                              3           1               |             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              4     3     4  2           4|             
      Hyperplasia, Lymphoid                |                                  1                                       |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  M  M  +  I  +  A  M  +  +  +  +  +  M  +  +|             
      Atrophy                              |             1                                            3     2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Necrosis                             |                2                                                         |             
      Foot, Inflammation                   |                                                                          |             
      Pinna, Inflammation                  |             4                                                            |             
      Prepuce, Edema                       |                                                                          |             
      Prepuce, Inflammation                |                   3     4     4                                4  4  4   |             
      Tail, Inflammation                   |                                                                         4|             
      Tail, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|             
                             DAY ON TEST   | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|             
                                           | 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Osteoporosis                  |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation               |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Macrophage              |                            2        3     1                 1            |             
      Infarct                              |                1                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                                                          1               |             
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |                            1                                             |             
      Respiratory Epithelium, Degeneration |                            1                                             |             
      Respiratory Epithelium, Inflammation |                1                                            3            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Dilatation                           |                                                                          |             
      Fibrosis                             |                                                                         1|             
      Inflammation                         |                                              3           3              1|             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                                     2                                2   |             
      Cortex, Cyst                         |                               1                                          |             
      Pelvis, Dilatation                   | 2  3              3     2                          3  3  3           3  3|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +              +  +         |             
      Calculus Micro Observation Only      |                                                             X            |             
      Inflammation                         |                                              2                 1         |             
      Transitional Epithelium, Hyperplasia |                                                                2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Calculus Micro Observation Only      |                                           X                              |             
      Inflammation                         |                                                                         4|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|             
                             DAY ON TEST   | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|             
                                           | 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|             
                                           | 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|             
    MG/M3                                  | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Autolysis                            |                                                                          |             
      Anus, Inflammation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Inflammation          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                         2|             
      Cyst                                 |                                                                          |             
      Fatty Change                         |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis, Diffuse                    |                      3                 2                    1            |             
      Necrosis                             |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |                                                                          |             
      Inflammation                         |                                                                          |             
      Acinus, Hyperplasia                  |                                     1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation                         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|             
                                           | 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|             
    MG/M3                                  | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst Multilocular                    |                                                                          |             
      Hypertrophy                          | 2                                                                        |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  M  +  +  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Cystic |                   1     2     1  2     1  2        2     1  2  1  1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Abscess                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                   +           +                    +     +               |             
      Hyperplasia, Squamous                |                                                    3                     |             
      Inflammation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Ectasia                              | 1  1  2  3           3     1     3        2        3     3  2  2         |             
      Inflammation                         |       3     2     3  3  2     3        3     3     2  2  3     2  4  3  4|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Inflammation                         |                3                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                3                             2     2        3     2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +              +     +     +              +     +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                  2           3              3     3      |             
      Iliac, Inflammation                  |                                              1                           |             
      Inguinal, Hyperplasia, Lymphoid      |                   2                          2                           |             
      Inguinal, Hyperplasia, Plasma Cell   |                                        2     2                    3      |             
      Inguinal, Inflammation               |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|             
                                           | 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|             
    MG/M3                                  | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  M  +  +  I  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                            1                                             |             
      Hyperplasia, Lymphoid                |          1                                                        2      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                1                             2                           |             
      Inflammation                         |                                              1                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |             2                    2                                       |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  I  +  M  M  +  +  M  I  +  +  M  +  M  M  I  +  M  M  M  I  +  +  M|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Hematopoietic Cell Proliferation     |                      3        2        2     3           2  1            |             
      Hyperplasia, Lymphoid                |             2                                   2                        |             
      Inflammation                         |                2                                                        2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |    2           2  2  2              2                 1                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              4                           |             
      Necrosis                             |                                                                          |             
      Foot, Inflammation                   |                                                                          |             
      Pinna, Inflammation                  |                                                                          |             
      Prepuce, Edema                       |                                  2                                       |             
      Prepuce, Inflammation                |                               4        4  4        3  4              4   |             
      Tail, Inflammation                   |                                                       4                  |             
      Tail, Necrosis                       |                                  4                          4            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|             
                                           | 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|             
    MG/M3                                  | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Osteoporosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Macrophage              |          1                 2                                            1|             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                         1  1                                             |             
      Inflammation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                       3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Inflammation |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Dilatation                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation                         |                4  2                                   2     2            |             
      Mineralization                       |                   1                                                      |             
      Nephropathy                          |                                                 1        1     2         |             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Dilatation                   |                   2           2           2  3        3     3        2   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                   +                                +  +  +  +        +   |             
      Calculus Micro Observation Only      |                   X                                X     X           X   |             
      Inflammation                         |                                                       2     3            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Calculus Micro Observation Only      |                                                                X         |             
      Inflammation                         |                   2                          2        4     4            |             
      Transitional Epithelium, Hyperplasia |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|             
                                           | 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|             
    MG/M3                                  | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 5| 6| 5| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3|                                            |            |
                                           | 9| 4| 8| 4| 9| 3| 2| 9| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.25                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +                                             |  56        |
      Autolysis                            |                                                                          |      1  4.0|
      Anus, Inflammation                   |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  4.0|
      Peyer's Patch, Inflammation          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                3                                                         |      4  2.5|
      Cyst                                 |                      X                                                   |      1     |
      Fatty Change                         |          2                                                               |      1  2.0|
      Infarct                              |             4                                                            |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
      Necrosis, Diffuse                    |             3  1                                                         |      5  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Centrilobular, Degeneration          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  2.0|
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  I  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |          2                                                               |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 5| 6| 5| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3|                                            |            |
                                           | 9| 4| 8| 4| 9| 3| 2| 9| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.25                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  M                                             |  59        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cyst Multilocular                    |                         X                                                |      1     |
      Hypertrophy                          |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M                                             |  57        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  M  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +                                             |  53        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia, Cystic |    2  1        1  2  2     1                                             |     26  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Abdominal, Abscess                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                                  |   7        |
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Inflammation                         |       3                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Ectasia                              | 2  2  2  2  3  4     2                                                   |     31  2.4|
      Inflammation                         |    3     4     3  3  2     1                                             |     35  2.9|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |             4                                                            |      1  4.0|
      Inflammation                         |             2                                                            |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 5| 6| 5| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3|                                            |            |
                                           | 9| 4| 8| 4| 9| 3| 2| 9| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.25                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myeloid Cell, Hyperplasia            |                2  2                                                      |     15  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +     +  +     +                                                |  21        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Plasma Cell      | 3              3  2                                                      |     10  2.7|
      Iliac, Inflammation                  |                                                                          |      1  1.0|
      Inguinal, Hyperplasia, Lymphoid      |                2  2     3                                                |     11  1.8|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      5  2.4|
      Inguinal, Inflammation               |                                                                          |      2  1.0|
      Inguinal, Pigmentation               |          2                                                               |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  I  +  I  +  +  +  +                                             |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                            1                                             |      4  1.5|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |    1                                                                     |      2  1.0|
      Hyperplasia, Plasma Cell             |                                                                          |      3  1.7|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  I  +  +  +  +                                             |  53        |
      Congestion                           |                            1                                             |      4  2.0|
      Hematopoietic Cell Proliferation     | 2                                                                        |      2  1.5|
      Hyperplasia, Histiocytic             |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  1.5|
      Inflammation                         |          1                                                               |      5  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  I  M  M  M  I  M  M  +                                             |  24        |
      Hyperplasia, Histiocytic             |                                                                          |      2  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 1                                                                        |     12  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Inflammation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  +                                             |  48        |
      Atrophy                              | 1        2  2     2     1                                                |     14  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 5| 6| 5| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3|                                            |            |
                                           | 9| 4| 8| 4| 9| 3| 2| 9| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.25                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation                         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  2.0|
      Foot, Inflammation                   | 4                                                                        |      1  4.0|
      Pinna, Inflammation                  |                                                                          |      1  4.0|
      Prepuce, Edema                       |                                                                          |      1  2.0|
      Prepuce, Inflammation                |       3  3              2                                                |     15  3.6|
      Tail, Inflammation                   |                                                                          |      2  4.0|
      Tail, Necrosis                       | 4                       4                                                |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      1  1.0|
      Femur, Osteoporosis                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Meninges, Inflammation               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  I  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Macrophage              |    1                       1                                             |      9  1.4|
      Infarct                              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Inflammation                         |          1                                                               |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |      4  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Olfactory Epithelium, Degeneration   |                                                                          |      1  1.0|
      Respiratory Epithelium, Degeneration |             1                                                            |      2  1.0|
      Respiratory Epithelium, Inflammation |                                                                          |      2  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 5| 6| 5| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3|                                            |            |
                                           | 9| 4| 8| 4| 9| 3| 2| 9| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.25                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    MG/M3                                  | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Dilatation                           |             4                                                            |      1  4.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      7  2.4|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          |    1                 1  1                                                |      8  1.4|
      Cortex, Cyst                         | X                                                                        |      2  1.0|
      Pelvis, Dilatation                   | 2              1  3                                                      |     19  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +  +  +                                                      |  12        |
      Calculus Micro Observation Only      |             X     X                                                      |      7     |
      Inflammation                         |                                                                          |      4  2.0|
      Transitional Epithelium, Hyperplasia |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Calculus Micro Observation Only      |                                                                          |      2     |
      Inflammation                         |       4                                                                  |      6  3.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 4| 2| 4| 2| 4| 4| 2| 1| 2| 2| 2| 4| 4| 4| 2| 4| 4| 4|              |            |
                             DAY ON TEST   | 0| 0| 5| 0| 5| 0| 5| 5| 0| 2| 0| 0| 0| 5| 5| 5| 0| 5| 5| 5|              |            |
                                           | 6| 6| 8| 6| 8| 6| 8| 8| 6| 2| 6| 6| 6| 8| 8| 8| 6| 8| 8| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    .25MG/M3                               | 7| 7| 8| 8| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4|              |      L     |
    LUNG TOX                               | 0| 1| 7| 9| 3| 4| 6| 0| 1| 3| 5| 1| 7| 9| 1| 3| 5| 7| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +        I     +           +  +           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +        +     +           +  M           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +        +     +           +  M           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +        +     +           +  M           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |             +  +     +     +           +  +           +                  |   7        |
      Infarct, Focal                       |                      2                                                   |      1  2.0|
      Hepatocyte, Hyperplasia              |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +        +     +           +  +           I                  |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +        +     +           +  +           +                  |   6        |
      Autolysis                            |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +        +     +           +  +           +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |             +        +     I           +  +           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +        +     M           +  +           I                  |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             I        +     +           +  I           +                  |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +        +     +           +  +           +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +        +     +           +  +           +                  |   6        |
      Ectasia                              |             3        2                 1  2           4                  |      5  2.4|
      Inflammation                         |             3                                         4                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +        +     +           +  +           +                  |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 4| 2| 4| 2| 4| 4| 2| 1| 2| 2| 2| 4| 4| 4| 2| 4| 4| 4|              |            |
                             DAY ON TEST   | 0| 0| 5| 0| 5| 0| 5| 5| 0| 2| 0| 0| 0| 5| 5| 5| 0| 5| 5| 5|              |            |
                                           | 6| 6| 8| 6| 8| 6| 8| 8| 6| 2| 6| 6| 6| 8| 8| 8| 6| 8| 8| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    .25MG/M3                               | 7| 7| 8| 8| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4|              |      L     |
    LUNG TOX                               | 0| 1| 7| 9| 3| 4| 6| 0| 1| 3| 5| 1| 7| 9| 1| 3| 5| 7| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   1        |
      Iliac, Hyperplasia, Lymphoid         |             3                                                            |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M        +  +  +     +  I  +  +        +  +           +                  |   9        |
      Hyperplasia, Lymphoid                |                      2        1           1           1                  |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +        +     +           +  +           +                  |   6        |
      Inflammation                         |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +        +     M           +  +           +                  |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +        M  +  +     +  +  M  M        +  M           +                  |   7        |
      Hyperplasia, Lymphoid                |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +        +     +           +  +           +                  |   6        |
      Atrophy                              |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +        M     +           +  M           M                  |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +  +     +     +           +  +           +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +        +     +           +  +           +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +        +     +           +  +           +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |             +        +     +           +  +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +  +     +  +  +  +        +  +           +                  |  11        |
      Hyperplasia, Macrophage              |                      1                                                   |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +  +     +  +  +  +        +  +           +                  |  11        |
      Developmental Malformation           |                                        X                                 |      1     |
      Inflammation, Acute                  |                1        1                                                |      2  1.0|
      Vomeronasal Organ, Infiltration      |                                                                          |            |
          Cellular, Polymorphonuclear      |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +        +     +           +  +           +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 4| 2| 4| 2| 4| 4| 2| 1| 2| 2| 2| 4| 4| 4| 2| 4| 4| 4|              |            |
                             DAY ON TEST   | 0| 0| 5| 0| 5| 0| 5| 5| 0| 2| 0| 0| 0| 5| 5| 5| 0| 5| 5| 5|              |            |
                                           | 6| 6| 8| 6| 8| 6| 8| 8| 6| 2| 6| 6| 6| 8| 8| 8| 6| 8| 8| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    .25MG/M3                               | 7| 7| 8| 8| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4|              |      L     |
    LUNG TOX                               | 0| 1| 7| 9| 3| 4| 6| 0| 1| 3| 5| 1| 7| 9| 1| 3| 5| 7| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +  +     +  +  +  +        +  +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                            +                                             |   1        |
      Calculus Micro Observation Only      |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +        +     +           +  +           +                  |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|             
                                           | 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Autolysis                            |                      4  1                                                |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                     4                                    |             
      Eosinophilic Focus                   |                                        3                                 |             
      Infarct                              |                                                                      4   |             
      Inflammation                         |       1                                                                  |             
      Necrosis, Diffuse                    |                                     3                                3   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      Inflammation                         |                               3                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +     +                                               +|             
      Peridontal Tissue, Inflammation      |                   2     2                                               2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|             
                                           | 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |    1                                                                     |             
      Infarct                              | 4                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 4                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Autolysis                            |                      2                                                   |             
      Cyst                                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      Follicular Cell, Hyperplasia, Cystic | 2  2        1  2        1        2     1     2  1     1  1     2  2     2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Penis                                   |                   +     +     +                                          |             
      Hyperplasia, Squamous                |                   1           3                                          |             
      Inflammation                         |                         2     3                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              | 3                 2        2     3  2           2     2     2  2  3  1   |             
      Inflammation                         |    4  3  4  4  4        2  3  2     2  3     2  3  4  3  3        3     3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    3                     |             
      Inflammation                         |                               2                    3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2                                                                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   1      |             
      Autolysis                            |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |             2  1  2                                2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +              +              +     +        +           +|             
      Iliac, Hyperplasia, Lymphoid         |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|             
                                           | 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                               1                    3        3            |             
      Inguinal, Hyperplasia, Histiocytic   |                               1                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                2                                   3                    2|             
      Inguinal, Hyperplasia, Plasma Cell   |                                                    2        1            |             
      Inguinal, Inflammation               |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Pancreatic, Thrombosis               |                                              1                           |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                               2                                          |             
      Renal, Hyperplasia, Plasma Cell      |                               2                                          |             
      Renal, Inflammation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  I  M  M  +  A  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Macrophage              | 1  1                             1     1     1           1        1     2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |             1                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3           1         |             
      Congestion                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  M  +  I  A  M  M  M  M  I  +  M  M  I  M  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3                                                                  |             
      Hematopoietic Cell Proliferation     |       3     1              2        1                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Atrophy                              |       2                 3     4     4                 2     1        2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                   3                                                      |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation                         |                      3                          2                        |             
      Foot, Inflammation                   |                                                                          |             
      Prepuce, Inflammation                | 4     2  3  3     4     2     3           4        4        4            |             
      Tail, Hyperkeratosis                 |                                     2                                    |             
      Tail, Inflammation                   |                                     2                                    |             
      Tail, Necrosis                       |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|             
                                           | 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                         2        1                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Degeneration               |                                                          2               |             
      Hippocampus, Degeneration            |                            1                                             |             
      Thalamus, Degeneration               |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +|             
      Autolysis                            |       3                                                                  |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      Fibrosis                             |                                                       2                  |             
      Hemorrhage                           |                            1                                             |             
      Hyperplasia, Macrophage              | 1  1     1  1  1        1  2  2  1     2  1     1     4  2  1  2  2     2|             
      Inflammation, Chronic Active         | 2                             1                       2        1  1     2|             
      Alveolar Epithelium, Hyperplasia     | 2  1                                                  1  1  1  1  1     1|             
      Interstitium, Infiltration Cellular  |                                                       2        1        1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                            1                                      1     1|             
      Respiratory Epithelium, Inflammation |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3                                                                  |             
      Epithelium, Hyperplasia              |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Phthisis Bulbi                       |                            X                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation                         |       4  1                    3                    1                     |             
      Nephropathy                          | 1  1                             1        1  1                           |             
      Cortex, Cyst                         |                         X                                                |             
      Pelvis, Dilatation                   |          1              2                                                |             
                                            __________________________________________________________________________|             
   Ureter                                  |       +                                                                  |             
      Inflammation                         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +        +        +     +  +     +  +                 +            |             
      Calculus Micro Observation Only      |       X        X        X     X  X     X  X                 X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|             
                                           | 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |       2                       3                             2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                   X      |             
      Inflammation                         |       4                       4                    4        4            |             
      Transitional Epithelium, Hyperplasia |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|             
                             DAY ON TEST   | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|             
                                           | 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MG/M3                                  | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        1                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                    2                     |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     |                      2                                                   |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis, Diffuse                    |          1           2                                   2               |             
      Necrosis                             |                                                    2                     |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    1                     |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Peridontal Tissue, Inflammation      |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                              3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|             
                             DAY ON TEST   | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|             
                                           | 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MG/M3                                  | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                  3                       2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  I  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |    2  2                 1     2     2     1  2              1            |             
      Follicular Cell, Hyperplasia         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                         +     +  +         |             
      Hyperplasia, Squamous                |             3                                                  3         |             
      Inflammation                         |                                                             4            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Ectasia                              | 1           3  2  2  3  2     4  2  3     3     4           4  3     3   |             
      Inflammation                         |    2  4  2              4  4  3     3        4  3  4  3           3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |             2           2                       2                 3     4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                    +  +        +           +           +     +     +|             
      Iliac, Hyperplasia, Lymphoid         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|             
                             DAY ON TEST   | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|             
                                           | 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MG/M3                                  | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      | 2                       2                                   3     3      |             
      Inguinal, Hyperplasia, Histiocytic   |                                                                         1|             
      Inguinal, Hyperplasia, Lymphoid      |                            2                                             |             
      Inguinal, Hyperplasia, Plasma Cell   | 1                                               3                        |             
      Inguinal, Inflammation               |                                                                   1      |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                             3            |             
      Pancreatic, Thrombosis               |                                                                          |             
      Renal, Congestion                    | 2                                                                        |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Inflammation                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  M|             
      Congestion                           |          2                                                               |             
      Hyperplasia, Lymphoid                |                                                 1                        |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      2   |             
      Hyperplasia, Lymphoid                |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           | 2                                                                        |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  I  M  M  M  M  M  +  I  M  M  M  M  +  M  +  M  M  M  M  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                2        2                                1        2     3|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |    3     1     3  1                    2           1     1  3     2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation                         |                                        2                          2      |             
      Foot, Inflammation                   | 4                                                                        |             
      Prepuce, Inflammation                | 3           3           3                       4              3         |             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation                   |                                                                          |             
      Tail, Necrosis                       |             4                                   4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|             
                             DAY ON TEST   | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|             
                                           | 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MG/M3                                  | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Degeneration               |                                                                          |             
      Hippocampus, Degeneration            |                                                                          |             
      Thalamus, Degeneration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Squamous                |                                                          1               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              | 2     1        1  2  2        1  1  2     3  2        1  1  1     1      |             
      Inflammation, Chronic Active         |                                           2  1                           |             
      Alveolar Epithelium, Hyperplasia     | 1     1           1  1        1  1        1  1  1                    1   |             
      Interstitium, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        | 1  1        1                                   1           1  1         |             
      Respiratory Epithelium, Inflammation |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                4        4|             
      Inflammation                         |                         3                                         2     4|             
      Nephropathy                          |                   1                       1              1               |             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Dilatation                   | 3  2        1                          4                          2      |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                                  +        +         |             
      Calculus Micro Observation Only      |    X                                                  X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|             
                             DAY ON TEST   | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|             
                                           | 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MG/M3                                  | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation                         |                         2                                         3     3|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 5| 6| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1|                                            |            |
                                           | 9| 8| 2| 2| 8| 9| 7| 2| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                                            |      L     |
    MG/M3                                  | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  I  M  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Autolysis                            |                                                                          |      2  2.5|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  4.0|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  1.0|
      Necrosis, Diffuse                    |       2              1                                                   |      7  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Inflammation                         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Squamous                |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Peridontal Tissue, Inflammation      |                                                                          |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 108                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 5| 6| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1|                                            |            |
                                           | 9| 8| 2| 2| 8| 9| 7| 2| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                                            |      L     |
    MG/M3                                  | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |                   1                                                      |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      3  2.0|
      Hypertrophy                          |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +                                             |  49        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +                                             |  56        |
      Autolysis                            |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia, Cystic |    1        1        3                                                   |     25  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                +  I        +                                             |   9        |
      Hyperplasia, Squamous                |                4           2                                             |      6  2.7|
      Inflammation                         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |       1                                                                  |      2  1.5|
      Ectasia                              |       3  2  2  2     2  2                                                |     31  2.5|
      Inflammation                         |    3           3     3     3                                             |     33  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 5| 6| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1|                                            |            |
                                           | 9| 8| 2| 2| 8| 9| 7| 2| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                                            |      L     |
    MG/M3                                  | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  1.0|
      Autolysis                            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myeloid Cell, Hyperplasia            |    2           2                                                         |     11  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +     +     +                                             |  20        |
      Iliac, Hyperplasia, Lymphoid         |    2                       3                                             |      4  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      7  2.4|
      Inguinal, Hyperplasia, Histiocytic   |                                                                          |      2  1.0|
      Inguinal, Hyperplasia, Lymphoid      |                3     2     2                                             |      7  2.3|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      4  1.8|
      Inguinal, Inflammation               |                                                                          |      1  1.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Pancreatic, Thrombosis               |                                                                          |      1  1.0|
      Renal, Congestion                    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
      Renal, Inflammation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  +  +  +  M  +  M                                             |  44        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Macrophage              |                                                                          |      8  1.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |             2           1                                                |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +                                             |  55        |
      Angiectasis                          |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                   1        1                                             |      2  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  M  M  M                                             |  20        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    1     1                                                               |     11  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  +  +  +  +  +                                             |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 110                                                               
NTP Experiment-Test: 05122-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 5| 6| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1|                                            |            |
                                           | 9| 8| 2| 2| 8| 9| 7| 2| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                                            |      L     |
    MG/M3                                  | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |       2                                                                  |     17  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      4  2.3|
      Foot, Inflammation                   |          4                                                               |      2  4.0|
      Prepuce, Inflammation                |                4  3        4                                             |     18  3.3|
      Tail, Hyperkeratosis                 |                                                                          |      1  2.0|
      Tail, Inflammation                   |                                                                          |      1  2.0|
      Tail, Necrosis                       |       4  4                                                               |      5  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cerebrum, Degeneration               |                                                                          |      1  2.0|
      Hippocampus, Degeneration            |                                                                          |      1  1.0|
      Thalamus, Degeneration               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  I  +  +  +  +  +  +                                             |  56        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |