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TDMS Study 05122-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: LITRI                                             NICKEL SULFATE HEXAHYDRATE                              DATE: 05/20/95       
EXPERIMENT: 05122 TEST: 06                                                                                     TIME: 04:07:32       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: Y01ES30108                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C60344       
PATHOLOGIST: F. HAHN                                                                                           CAS: 010101970       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: LITRI                                             NICKEL SULFATE HEXAHYDRATE                              DATE: 05/20/95      
EXPERIMENT: 05122 TEST: 06                                                                                     TIME: 04:07:32      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: Y01ES30108                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C60344      
PATHOLOGIST: F. HAHN                                                                                           CAS: 010101970      

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      230   287   452   514   516   516   552   553   555   568                 |
 |      570   570   573   580   585   597   597   598   601   607                 |
 |      608   609   614   614   616   627   640   642   642   665                 |
 |      676   687   688   734                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 1      CENSORED DEATHS 19   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      395                                                                       |
 |  CENSORED DEATHS                                                               |
 |      206   206   206   206   206   206   206   206   206   206                 |
 |      458   458   458   458   458   458   458   458   458                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.25    MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      118   286   325   400   438   510   516   516   517   549                 |
 |      552   552   559   562   564   567   567   569   581   584                 |
 |      594   594   614   621   640   641   644   649   663   663                 |
 |      671   687   694   699   714   720   721                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = .25MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 1      CENSORED DEATHS 19   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      122                                                                       |
 |  CENSORED DEATHS                                                               |
 |      206   206   206   206   206   206   206   206   206   458                 |
 |      458   458   458   458   458   458   458   458   458                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.5     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      245   284   310   337   419   482   485   511   513   538                 |
 |      552   553   564   564   578   581   591   594   613   613                 |
 |      614   621   627   629   639   640   642   642   648   672                 |
 |      696   699   702   705   717   728                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.5MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      384   455                                                                 |
 |  CENSORED DEATHS                                                               |
 |      206   206   206   206   206   206   206   206   206   206                 |
 |      458   458   458   458   458   458   458   458                             |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 35     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      169   328   394   404   503   529   533   533   561   568                 |
 |      570   572   594   597   597   601   603   604   610   621                 |
 |      630   638   640   641   641   657   675   675   676   676                 |
 |      679   699   699   709   720                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      447   458                                                                 |
 |  CENSORED DEATHS                                                               |
 |      206   206   206   206   206   206   206   206   206   206                 |
 |      458   458   458   458   458   458   458   458                             |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0        |   100.0 100.0  98.3  96.7  96.7  95.0  90.0  68.3  50.0  43.3      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.0MG/M3LUN|   100.0 100.0 100.0 100.0  90.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.25       |   100.0  98.3  98.3  95.0  93.3  91.7  85.0  63.3  50.0  38.3      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |.25MG/M3LUN|   100.0  95.0  95.0  95.0  95.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.5        |   100.0 100.0  98.3  93.3  91.7  88.3  83.3  70.0  51.7  40.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.5MG/M3LUN|   100.0 100.0 100.0 100.0  90.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |1.0        |   100.0  98.3  98.3  96.7  93.3  93.3  86.7  70.0  56.7  41.7      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |1.0MG/M3LUN|   100.0 100.0 100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0.0         0.0MG/M3LUNG0.25        .25MG/M3LUNG0.5         0.5MG/M3LUNG1.0         1.0MG/M3L|NG
 |                                MG/M3       TOX         MG/M3       TOX         MG/M3       TOX         MG/M3       TOX      |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       43.3%        0.0%       38.3%        0.0%       40.0%        0.0%       41.7%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=1.000N     -----      P=0.657     P=1.000     P=0.877     P=0.307     P=1.000N    P=0.307  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       578.9       395.0       569.2       122.0       570.8       419.5       587.0       452.5    |
 |NATURAL DEATHS (C)      |       (17.0)      (  . )      (20.7)      (  . )      (20.4)      (35.5)      (19.4)      ( 5.5)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       647.4       328.9       633.5       327.8       637.3       328.2       649.5       331.5    |
 |(STANDARD ERROR)        |       (14.0)      (28.4)      (16.6)      (30.1)      (16.1)      (28.3)      (14.8)      (28.8)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      258   335   384   398   440   530   547   585   595   598                 |
 |      626   627   627   629   654   655   670   696   700   705                 |
 |      707   714   714   723   725   728                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 1      CENSORED DEATHS 19   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      35                                                                        |
 |  CENSORED DEATHS                                                               |
 |      207   207   207   207   207   207   207   207   207   459                 |
 |      459   459   459   459   459   459   459   459   459                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.25    MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      14    361   375   398   483   511   559   578   588   614                 |
 |      624   635   649   666   672   679   687   703   711   725                 |
 |      728                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = .25MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      207   207   207   207   207   207   207   207   207   207                 |
 |      459   459   459   459   459   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.5     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      334   454   510   539   567   577   614   629   649   656                 |
 |      672   672   681   681   714                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.5MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      207   207   207   207   207   207   207   207   207   207                 |
 |      459   459   459   459   459   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      281   310   361   370   393   457   463   516   521   562                 |
 |      562   571   596   601   604   659   669   675   679   698                 |
 |      713   714   728                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      207   207   207   207   207   207   207   207   207   207                 |
 |      459   459   459   459   459   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0        |   100.0 100.0  98.3  96.7  93.3  91.7  90.0  83.3  73.3  56.7      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.0MG/M3LUN|    95.0  95.0  95.0  95.0  95.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.25       |    98.3  98.3  98.3  96.7  93.3  91.7  90.0  85.0  78.3  65.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |.25MG/M3LUN|   100.0 100.0 100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.5        |   100.0 100.0 100.0  98.3  98.3  96.7  93.3  90.0  83.3  75.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.5MG/M3LUN|   100.0 100.0 100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |1.0        |   100.0 100.0 100.0  95.0  91.7  88.3  85.0  75.0  73.3  61.7      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |1.0MG/M3LUN|   100.0 100.0 100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0.0         0.0MG/M3LUNG0.25        .25MG/M3LUNG0.5         0.5MG/M3LUNG1.0         1.0MG/M3L|NG
 |                                MG/M3       TOX         MG/M3       TOX         MG/M3       TOX         MG/M3       TOX      |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.7%        0.0%       65.0%        0.0%       75.0%        0.0%       61.7%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.693N     -----      P=0.494N    P=0.766N    P=0.062N    P=0.766N    P=0.843N    P=0.766N |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       598.8        35.0       569.5          .        596.6          .        552.3          .     |
 |NATURAL DEATHS (C)      |       (25.9)      (  . )      (37.1)      (  . )      (26.6)      (  . )      (28.6)      (  . )   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       673.2       324.4       673.8       333.0       696.7       333.0       661.9       333.0    |
 |(STANDARD ERROR)        |       (14.0)      (32.0)      (16.2)      (28.9)      ( 9.9)      (28.9)      (15.6)      (28.9)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                     NICKEL SULFATE HEXAHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0     MG/M3    = 1
                                                        0.0MG/M3LUNG TOX = 2
                                                        0.25    MG/M3    = 3
                                                        .25MG/M3LUNG TOX = 4
                                                        0.5     MG/M3    = 5
                                                        0.5MG/M3LUNG TOX = 6
                                                        1.0     MG/M3    = 7
                                                        1.0MG/M3LUNG TOX = 8

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                  34       7       1  5     1      7        6 2      8
      |                     4                        1    5 3 5        73 5  3  1   4  7 1
P     |                                                              6 2  5  38 68  25 731  77 1
E     |                                                                                 53   5 1171
R  80 +                                                                         68  6          33311  77
C     |                                                                                          5 11 517
E     |                                                                                          3333 51157
N     |                                                                                             3 3 1155 7
T  60 +                                                                                                  131 3 7
      |                                                                                                    1 137 3 7
S     |                                                                                                      15  131 15
U     |                                                                                                              13535  11
R  40 +                                                                                                                 335  3
V     |
I     |
V     |
A  20 +
L     |
      |
      |
    0 +                                                                             2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 98 obs hidden.

                                                     NICKEL SULFATE HEXAHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0     MG/M3    = 1
                                                        0.0MG/M3LUNG TOX = 2
                                                        0.25    MG/M3    = 3
                                                        .25MG/M3LUNG TOX = 4
                                                        0.5     MG/M3    = 5
                                                        0.5MG/M3LUNG TOX = 6
                                                        1.0     MG/M3    = 7
                                                        1.0MG/M3LUNG TOX = 8

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 3   2                                  1   7    7  1   3              5 4
      |       2                                           7  1   373 1 1     1  5 2 3   5    5   5
P     |                                                                7     1   77 3   37  1  135 31    5 5
E     |                                                                                  7 7     7 31 11 3 1  55  5
R  80 +                                                                                          77    7   33 3   3 5
C     |                                                                                                77  1   1 71353  5   5
E     |                                                                                                           17 3113 3
N     |                                                                                                               711 3 3
T  60 +                                                                                                                 1 1 7
      |                                                                                                                   1 1
S     |
U     |
R  40 +
V     |
I     |
V     |
A  20 +
L     |
      |
      |
    0 +                                                                           2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 69 obs hidden.