TDMS Study 05122-05 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NICKEL SULFATE HEXAHYDRATE
NTP Experiment-Test: 05122-05 Report: PEIRPT03
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 010101970
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 12 58 12 59 11
Scheduled Sacrifice 5 12 5 12 5 11
Early Deaths
Moribund Sacrifice 27 32 22
Natural Death 4 4 3
Survivors
Terminal Sacrifice 22 17 28
Other 1
Animals Examined Microscopically 58 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (55) (58)
Hyperplasia, Lymphoid 1 (2%)
Intestine Large, Rectum (56) (56) (53)
Parasite Metazoan 2 (4%) 1 (2%) 1 (2%)
Intestine Large, Cecum (56) (58) (58)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Granulomatous 1 (2%)
Ulcer 1 (2%)
Intestine Small, Duodenum (56) (58) (57)
Ulcer 1 (2%)
Intestine Small, Jejunum (57) (58) (58)
Autolysis 1 (2%)
Peyer's Patch, Hyperplasia 2 (4%) 1 (2%) 3 (5%)
Intestine Small, Ileum (54) (56) (57)
Autolysis 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (57) (58) (58)
Angiectasis 3 (5%) 4 (7%) 2 (3%)
Basophilic Focus 49 (86%) 46 (79%) 45 (78%)
Clear Cell Focus 4 (7%) 1 (2%) 2 (3%)
Degeneration, Cystic 4 (7%) 5 (9%) 5 (9%)
Degeneration, Fatty 15 (26%) 13 (22%) 14 (24%)
Eosinophilic Focus 2 (4%) 4 (7%) 2 (3%)
Granuloma 2 (3%)
Hepatodiaphragmatic Nodule 5 (9%) 5 (9%) 6 (10%)
Inflammation 4 (7%)
Mixed Cell Focus 4 (7%) 1 (2%) 1 (2%)
Thrombosis, Multiple 1 (2%)
Bile Duct, Hyperplasia 10 (18%) 11 (19%) 16 (28%)
Centrilobular, Atrophy 2 (4%) 5 (9%) 7 (12%)
Hepatocyte, Necrosis 13 (23%) 11 (19%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (1) (2) (2)
Hemorrhage 1 (50%)
Pancreas (57) (58) (58)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Granulomatous 1 (2%)
Acinus, Atrophy 1 (2%) 4 (7%)
Salivary Glands (57) (58) (58)
Duct, Submandibular Gland, Hyperplasia 1 (2%)
Stomach, Forestomach (57) (58) (58)
Edema 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia 1 (2%)
Inflammation 1 (2%) 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (57) (58) (58)
Erosion 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation 1 (2%) 1 (2%)
Tongue (1)
Inflammation 1 (100%)
Tooth (3) (5)
Epithelium Alveolus, Hyperplasia, Squamous 1 (20%)
Peridontal Tissue, Inflammation 3 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (58) (58)
Cardiomyopathy 12 (21%) 9 (16%) 8 (14%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57) (58) (58)
Autolysis 1 (2%)
Congestion 2 (4%)
Cyst 2 (4%)
Degeneration 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 7 (12%) 6 (10%) 5 (9%)
Hypertrophy 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Vacuolization Cytoplasmic 8 (14%) 8 (14%) 7 (12%)
Adrenal Medulla (56) (57) (58)
Angiectasis 1 (2%)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 6 (11%) 4 (7%) 8 (14%)
Islets, Pancreatic (57) (58) (58)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (54) (55) (55)
Hyperplasia 2 (4%) 1 (2%)
Pituitary Gland (57) (58) (58)
Angiectasis 4 (7%) 5 (9%) 5 (9%)
Cyst 5 (9%) 4 (7%) 1 (2%)
Hemorrhage 2 (3%)
Pars Distalis, Hyperplasia, Diffuse 4 (7%) 1 (2%) 3 (5%)
Pars Distalis, Hyperplasia, Focal 13 (23%) 16 (28%) 12 (21%)
Thyroid Gland (57) (58) (58)
Autolysis 1 (2%)
Fibrosis 1 (2%)
C-Cell, Hyperplasia 9 (16%) 7 (12%) 7 (12%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (6) (4) (2)
Inflammation, Granulomatous 1 (17%)
Abdominal, Polyarteritis 1 (25%)
Mediastinum, Inflammation 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (56) (57) (57)
Ectasia 4 (7%) 7 (12%) 2 (4%)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation 1 (2%) 2 (4%)
Ovary (57) (58) (58)
Atrophy 2 (3%)
Cyst 7 (12%) 5 (9%) 4 (7%)
Uterus (57) (58) (58)
Hemorrhage 1 (2%) 1 (2%)
Endometrium, Fibrosis 2 (4%)
Endometrium, Hyperplasia 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (57) (58) (58)
Atrophy 2 (4%)
Atrophy, Diffuse 1 (2%)
Atrophy, Focal 1 (2%)
Autolysis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Myeloid Cell, Hyperplasia 8 (14%) 10 (17%) 10 (17%)
Lymph Node (8) (7) (11)
Iliac, Hyperplasia, Lymphoid 1 (14%)
Lymph Node, Bronchial (54) (5) (57) (5) (54) (4)
Congestion 4 (7%) 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 1 (20%) 1 (2%) 4 (80%) 4 (100%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (57) (57) (56)
Autolysis 1 (2%)
Hyperplasia, Lymphoid 5 (9%) 3 (5%) 5 (9%)
Hyperplasia, Plasma Cell 2 (4%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mesenteric (57) (58) (58)
Autolysis 1 (2%) 1 (2%)
Congestion 2 (4%) 2 (3%) 2 (3%)
Edema 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Infarct 1 (2%)
Inflammation 1 (2%)
Inflammation, Granulomatous 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%) 3 (5%)
Lymph Node, Mediastinal (53) (3) (54) (5) (48) (5)
Autolysis 1 (2%) 2 (4%)
Congestion 3 (6%) 6 (11%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 4 (7%) 2 (40%) 2 (4%) 2 (40%)
Inflammation, Granulomatous 1 (2%)
Spleen (57) (57) (58)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Fibrosis 3 (5%) 2 (4%) 6 (10%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Infarct 1 (2%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
Thymus (53) (54) (56)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 14 (26%) 19 (35%) 13 (23%)
Autolysis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (58) (58)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Duct, Ectasia 2 (3%)
Epithelium, Hyperplasia 1 (2%)
Skin (58) (58) (57)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Inflammation 1 (2%)
Dermis, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58)
Fracture 1 (2%)
Hyperostosis 4 (7%) 1 (2%) 2 (3%)
Ligament, Intervertebral Disc, Degeneration 1 (2%)
Tibia, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (58) (58)
Autolysis 1 (2%)
Compression 9 (16%) 14 (24%) 5 (9%)
Degeneration 1 (2%)
Hemorrhage 2 (3%)
Necrosis 1 (2%)
Meninges, Inflammation 1 (2%)
Ventricle, Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (56) (57) (57)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 9 (16%) 13 (23%) 21 (37%)
Metaplasia, Squamous 1 (2%)
Lung (57) (5) (58) (5) (58) (5)
Congestion 1 (2%) 1 (2%) 1 (2%)
Fibrosis 8 (14%) 7 (12%) 46 (79%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Hemorrhage 1 (2%)
Hyperplasia, Macrophage 10 (18%) 11 (19%) 2 (40%) 35 (60%) 4 (80%)
Inflammation, Chronic Active 16 (28%) 13 (22%) 2 (40%) 53 (91%) 4 (80%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 6 (11%) 3 (5%) 7 (12%)
Alveolus, Proteinosis 1 (2%) 25 (43%)
Interstitium, Infiltration Cellular 14 (25%) 1 (20%) 10 (17%) 4 (80%) 4 (7%) 5 (100%)
Nose (56) (5) (57) (5) (58) (5)
Thrombosis 4 (7%) 4 (7%) 5 (9%)
Thrombosis, Multiple 1 (2%)
Nasolacrimal Duct, Ectasia 1 (2%)
Nasolacrimal Duct, Inflammation 5 (9%) 4 (7%) 1 (2%)
Nasopharyngeal Duct, Hyperplasia 1 (2%) 1 (2%)
Nasopharyngeal Duct, Inflammation 1 (2%) 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%) 1 (2%)
Olfactory Epithelium, Degeneration 45 (80%) 2 (40%) 20 (35%) 1 (20%) 11 (19%)
Olfactory Epithelium, Erosion 1 (2%)
Olfactory Epithelium, Inflammation 1 (2%) 3 (5%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Degeneration 14 (25%) 1 (20%) 17 (30%) 5 (9%)
Respiratory Epithelium, Erosion 1 (2%)
Respiratory Epithelium, Hyperplasia 9 (16%) 17 (30%) 17 (29%)
Respiratory Epithelium, Inflammation 13 (23%) 1 (20%) 8 (14%) 12 (21%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Vomeronasal Organ, Inflammation 1 (2%)
Trachea (57) (58) (58)
Hyperplasia 1 (2%)
Inflammation 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (5) (1)
Inflammation 1 (20%)
Phthisis Bulbi 1 (20%)
Synechia 1 (20%)
Anterior Chamber, Inflammation 1 (50%) 1 (20%)
Cornea, Fibrosis 1 (100%)
Posterior Chamber, Inflammation 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (5) (58) (5) (58) (5)
Autolysis 2 (4%) 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%)
Infarct 1 (2%)
Inflammation, Granulomatous 1 (2%)
Nephropathy 43 (75%) 41 (71%) 41 (71%)
Pelvis, Dilatation 1 (2%) 1 (2%) 2 (3%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 3 (5%) 8 (14%) 8 (14%)
Urinary Bladder (58) (58) (58)
Inflammation 1 (2%)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10
Scheduled Sacrifice 5 10
Early Deaths
Moribund Sacrifice 21
Accidently Killed 1
Natural Death 3
Survivors
Terminal Sacrifice 29
Missing 1
Animals Examined Microscopically 59 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (50)
Parasite Metazoan 1 (2%)
Intestine Large, Cecum (58)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (59)
Peyer's Patch, Hyperplasia 3 (5%)
Liver (59)
Basophilic Focus 45 (76%)
Clear Cell Focus 4 (7%)
Congestion 1 (2%)
Degeneration, Cystic 4 (7%)
Degeneration, Fatty 7 (12%)
Eosinophilic Focus 3 (5%)
Hepatodiaphragmatic Nodule 8 (14%)
Mixed Cell Focus 1 (2%)
Bile Duct, Hyperplasia 12 (20%)
Centrilobular, Atrophy 2 (3%)
Hepatocyte, Necrosis 8 (14%)
Pancreas (59)
Necrosis 1 (2%)
Acinus, Atrophy 1 (2%)
Stomach, Forestomach (58)
Inflammation 1 (2%)
Ulcer 2 (3%)
Tooth (1)
Peridontal Tissue, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59)
Cardiomyopathy 13 (22%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59)
Cytoplasmic Alteration 1 (2%)
Hyperplasia 8 (14%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 16 (27%)
Adrenal Medulla (59)
Hyperplasia 8 (14%)
Islets, Pancreatic (59)
Hyperplasia 1 (2%)
Parathyroid Gland (52)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (59)
Angiectasis 2 (3%)
Autolysis 1 (2%)
Cyst 4 (7%)
Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Diffuse 1 (2%)
Pars Distalis, Hyperplasia, Focal 13 (22%)
Thyroid Gland (57)
Autolysis 1 (2%)
C-Cell, Hyperplasia 8 (14%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (5)
Hemorrhage 1 (20%)
Oral, Inflammation, Granulomatous 1 (20%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59)
Ectasia 3 (5%)
Hyperplasia 3 (5%)
Hyperplasia, Squamous 1 (2%)
Inflammation 1 (2%)
Ovary (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 1 (2%)
Congestion 1 (2%)
Cyst 5 (8%)
Bilateral, Cyst 1 (2%)
Uterus (59)
Fibrosis 1 (2%)
Inflammation 1 (2%)
Endometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59)
Necrosis 1 (2%)
Myeloid Cell, Hyperplasia 9 (15%)
Lymph Node, Bronchial (54) (5)
Hyperplasia, Lymphoid 12 (22%) 4 (80%)
Lymph Node, Mandibular (54)
Hyperplasia, Lymphoid 3 (6%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (59)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Macrophage 1 (2%)
Pigmentation, Hemosiderin 2 (3%)
Lymph Node, Mediastinal (52) (5)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 7 (13%) 2 (40%)
Pigmentation 4 (8%)
Spleen (59)
Atrophy 1 (2%)
Autolysis 1 (2%)
Fibrosis 3 (5%)
Hematopoietic Cell Proliferation 3 (5%)
Inflammation, Focal 1 (2%)
Thymus (57)
Atrophy 13 (23%)
Autolysis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59)
Duct, Ectasia 1 (2%)
Duct, Hyperplasia 1 (2%)
Skin (58)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59)
Hyperostosis 3 (5%)
Skeletal Muscle (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59)
Compression 5 (8%)
Degeneration 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Necrosis 1 (2%)
Spinal Cord (1)
Meninges, Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58)
Hyperplasia 2 (3%)
Inflammation 15 (26%)
Metaplasia, Squamous 1 (2%)
Lung (59) (5)
Cyst, Squamous 2 (3%)
Fibrosis 52 (88%)
Hyperplasia, Macrophage 50 (85%) 5 (100%)
Inflammation, Chronic Active 57 (97%) 5 (100%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 10 (17%)
Alveolar Epithelium, Metaplasia, Squamous 4 (7%)
Alveolus, Proteinosis 54 (92%) 2 (40%)
Interstitium, Infiltration Cellular 11 (19%) 3 (60%)
Nose (59) (5)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Thrombosis 3 (5%)
Thrombosis, Multiple 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation 8 (14%)
Nasopharyngeal Duct, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasopharyngeal Duct, Inflammation 1 (2%)
Olfactory Epithelium, Atrophy 8 (14%) 1 (20%)
Olfactory Epithelium, Degeneration 12 (20%)
Respiratory Epithelium, Degeneration 4 (7%)
Respiratory Epithelium, Hyperplasia 17 (29%)
Respiratory Epithelium, Inflammation 13 (22%) 3 (60%)
Trachea (59)
Autolysis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (7) (1)
Cataract 1 (14%) 1 (100%)
Hemorrhage 1 (14%)
Phthisis Bulbi 3 (43%)
Synechia 2 (29%)
Anterior Chamber, Inflammation 1 (14%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (5)
Autolysis 2 (3%)
Nephropathy 44 (75%)
Pigmentation 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Necrosis, Acute 1 (2%)
Renal Tubule, Pigmentation 6 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 59 11 58 12 58 12
Scheduled Sacrifice 5 11 5 12 5 12
Early Deaths
Moribund Sacrifice 34 30 31
Natural Death 4 7 3
Accidently Killed 1
Survivors
Terminal Sacrifice 16 16 18
Animals Examined Microscopically 59 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (58) (58)
Autolysis 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%) 2 (3%)
Intestine Large, Rectum (59) (58) (57)
Autolysis 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Cecum (59) (58) (58)
Autolysis 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Small, Duodenum (59) (58) (56)
Autolysis 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (59) (57) (55)
Autolysis 1 (2%)
Peyer's Patch, Hyperplasia 2 (3%) 1 (2%) 1 (2%)
Intestine Small, Ileum (59) (55) (53)
Autolysis 1 (2%)
Liver (59) (58) (58)
Angiectasis 6 (10%) 11 (19%) 4 (7%)
Autolysis 1 (2%) 2 (3%)
Basophilic Focus 34 (58%) 32 (55%) 46 (79%)
Clear Cell Focus 2 (3%) 5 (9%) 2 (3%)
Congestion 2 (3%) 2 (3%)
Cyst 1 (2%)
Degeneration, Cystic 11 (19%) 13 (22%) 7 (12%)
Degeneration, Fatty 6 (10%) 5 (9%) 12 (21%)
Eosinophilic Focus 5 (8%) 7 (12%) 5 (9%)
Fatty Change 1 (2%)
Hepatodiaphragmatic Nodule 5 (8%) 2 (3%) 6 (10%)
Infarct 1 (2%)
Mixed Cell Focus 2 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 4 (7%) 1 (2%)
Bile Duct, Hyperplasia 36 (61%) 33 (57%) 37 (64%)
Centrilobular, Atrophy 6 (10%) 4 (7%) 5 (9%)
Hepatocyte, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Hepatocyte, Necrosis 16 (27%) 18 (31%) 12 (21%)
Mesentery (2) (4)
Cyst 1 (25%)
Fat, Necrosis 1 (50%)
Oral Mucosa (3) (2) (4)
Hyperplasia, Squamous 1 (33%) 1 (50%)
Pancreas (58) (57) (58)
Autolysis 2 (3%)
Cytoplasmic Alteration 1 (2%)
Infarct 1 (2%)
Acinus, Atrophy 6 (10%) 6 (11%) 9 (16%)
Acinus, Hyperplasia 1 (2%) 1 (2%)
Stomach, Forestomach (59) (58) (57)
Diverticulum 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation 1 (2%)
Perforation 1 (2%)
Ulcer 4 (7%) 1 (2%) 2 (4%)
Stomach, Glandular (59) (58) (58)
Autolysis 1 (2%)
Erosion 1 (2%)
Inflammation 2 (3%)
Necrosis 1 (2%) 1 (2%)
Ulcer 1 (2%)
Tooth (9) (3) (3)
Developmental Malformation 2 (67%)
Peridontal Tissue, Hyperplasia 1 (33%)
Peridontal Tissue, Inflammation 9 (100%) 3 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (58) (58)
Autolysis 1 (2%)
Cardiomyopathy 31 (53%) 31 (53%) 29 (50%)
Inflammation 1 (2%)
Proliferation Connective Tissue 1 (2%)
Thrombosis 8 (14%) 5 (9%) 5 (9%)
Epicardium, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (58)
Atrophy 1 (2%) 3 (5%)
Autolysis 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration 1 (2%)
Hyperplasia 3 (5%) 7 (12%) 4 (7%)
Hypertrophy 1 (2%)
Vacuolization Cytoplasmic 11 (19%) 10 (17%) 17 (29%)
Capsule, Fibrosis 1 (2%)
Adrenal Medulla (59) (58) (58)
Autolysis 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 28 (47%) 20 (34%) 18 (31%)
Islets, Pancreatic (57) (56) (57)
Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Parathyroid Gland (54) (54) (56)
Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Pituitary Gland (59) (56) (58)
Angiectasis 3 (5%) 7 (13%) 3 (5%)
Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Diffuse 2 (4%)
Pars Distalis, Hyperplasia, Focal 16 (27%) 16 (29%) 16 (28%)
Thyroid Gland (58) (58) (56)
Autolysis 1 (2%) 1 (2%)
C-Cell, Hyperplasia 5 (9%) 7 (12%) 8 (14%)
Follicular Cell, Hyperplasia, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (1) (5)
Mediastinum, Polyarteritis 1 (25%)
Oral, Inflammation 1 (25%)
Pelvic, Ectopic Tissue 1 (20%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (3)
Inflammation 1 (100%) 3 (100%)
Penis (1)
Inflammation 1 (100%)
Preputial Gland (59) (58) (57)
Atrophy 1 (2%) 2 (3%) 2 (4%)
Autolysis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ectasia 2 (3%) 5 (9%) 5 (9%)
Hyperplasia 3 (5%) 1 (2%)
Infiltration Cellular 1 (2%)
Inflammation 2 (3%) 5 (9%) 1 (2%)
Prostate (59) (57) (58)
Inflammation 1 (2%) 4 (7%) 4 (7%)
Seminal Vesicle (59) (58) (58)
Atrophy 2 (3%) 3 (5%) 7 (12%)
Autolysis 1 (2%)
Ectasia 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Cystic 1 (2%)
Inflammation 1 (2%)
Testes (59) (58) (58)
Atrophy 7 (12%) 3 (5%) 10 (17%)
Cyst 1 (2%) 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
Interstitial Cell, Hyperplasia, Focal 11 (19%) 7 (12%) 6 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (57) (57)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Atrophy, Focal 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Erythroid Cell, Hyperplasia 2 (3%) 1 (2%)
Myeloid Cell, Hyperplasia 17 (29%) 11 (19%) 18 (32%)
Lymph Node (11) (14) (11)
Iliac, Pigmentation 1 (9%)
Inguinal, Hyperplasia, Lymphoid 1 (9%)
Inguinal, Inflammation, Granulomatous 1 (7%)
Pancreatic, Inflammation 1 (9%)
Renal, Inflammation 1 (9%)
Renal, Pigmentation, Hemosiderin 1 (9%)
Lymph Node, Bronchial (56) (5) (54) (5) (52) (5)
Autolysis 1 (2%)
Congestion 1 (2%)
Hyperplasia, Lymphoid 5 (100%) 4 (8%) 2 (40%)
Hyperplasia, Plasma Cell 2 (4%)
Inflammation 2 (4%)
Lymph Node, Mandibular (55) (57) (56)
Hyperplasia, Lymphoid 5 (9%) 3 (5%) 9 (16%)
Hyperplasia, Plasma Cell 1 (2%) 2 (4%) 6 (11%)
Inflammation 1 (2%)
Lymph Node, Mesenteric (59) (58) (58)
Autolysis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (3%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mediastinal (56) (3) (52) (5) (51) (4)
Autolysis 1 (2%) 2 (4%)
Congestion 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 3 (5%) 3 (6%) 4 (80%) 5 (10%) 2 (50%)
Hyperplasia, Macrophage 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (59) (58) (56)
Angiectasis 2 (3%)
Atrophy 1 (2%) 2 (3%) 1 (2%)
Autolysis 1 (2%) 1 (2%)
Congestion 5 (8%) 2 (3%) 1 (2%)
Fibrosis 13 (22%) 16 (28%) 14 (25%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Infarct 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 2 (3%)
Thymus (54) (53) (53) (1)
Atrophy 16 (30%) 13 (25%) 10 (19%)
Autolysis 1 (2%)
Congestion 1 (2%) 1 (2%) 1 (100%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (53) (53)
Hemorrhage 1 (2%)
Skin (58) (58) (58)
Angiectasis 1 (2%)
Cyst Epithelial Inclusion 3 (5%) 1 (2%)
Inflammation 2 (3%)
Prepuce, Fibrosis 1 (2%)
Sebaceous Gland, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (58) (58)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (58) (58) (1)
Compression 5 (8%) 5 (9%) 5 (9%)
Degeneration 2 (3%)
Hemorrhage 3 (5%) 2 (3%) 1 (2%)
Hydrocephalus 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%)
Ventricle, Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (59) (57) (58)
Hyperplasia 3 (5%)
Inflammation 8 (14%) 9 (16%) 13 (22%)
Metaplasia, Squamous 1 (2%)
Lung (59) (5) (58) (5) (58) (5)
Autolysis 1 (2%)
Congestion 2 (3%) 3 (5%) 2 (3%)
Emphysema 1 (2%)
Fibrosis 3 (5%) 6 (10%) 35 (60%)
Hemorrhage 2 (3%) 5 (9%) 1 (2%)
Hyperplasia, Macrophage 7 (12%) 9 (16%) 1 (20%) 37 (64%) 5 (100%)
Inflammation, Chronic Active 14 (24%) 12 (21%) 4 (80%) 43 (74%) 4 (80%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (5%) 2 (3%) 4 (7%)
Alveolus, Proteinosis 13 (22%)
Interstitium, Infiltration Cellular 12 (20%) 2 (40%) 2 (3%) 5 (100%) 3 (5%) 5 (100%)
Nose (59) (5) (57) (5) (58) (5)
Thrombosis 6 (11%) 4 (7%)
Thrombosis, Multiple 8 (14%) 1 (2%) 4 (7%)
Glands, Inflammation 1 (2%)
Nasolacrimal Duct, Inflammation 4 (7%) 4 (7%) 4 (7%)
Nasopharyngeal Duct, Hyperplasia 2 (4%)
Nasopharyngeal Duct, Hyperplasia, Lymphoid 1 (2%)
Nasopharyngeal Duct, Inflammation 2 (3%) 4 (7%) 2 (3%)
Olfactory Epithelium, Atrophy 3 (5%) 1 (20%)
Olfactory Epithelium, Degeneration 39 (66%) 19 (33%) 14 (24%)
Olfactory Epithelium, Inflammation 1 (2%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Olfactory Epithelium, Necrosis 1 (2%)
Respiratory Epithelium, Degeneration 2 (3%) 1 (2%) 1 (2%) 1 (20%)
Respiratory Epithelium, Hyperplasia 18 (31%) 16 (28%) 1 (20%) 27 (47%)
Respiratory Epithelium, Inflammation 14 (24%) 13 (23%) 18 (31%)
Respiratory Epithelium, Metaplasia, Squamous 2 (3%) 2 (4%) 2 (3%) 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Vomeronasal Organ, Inflammation 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cataract 1 (100%) 1 (100%)
Retinal Detachment 1 (100%)
Synechia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (5) (57) (5) (57) (5)
Autolysis 2 (4%)
Cyst 2 (3%) 1 (2%)
Infarct 1 (2%) 2 (4%) 2 (4%)
Inflammation 1 (2%) 1 (2%)
Nephropathy 55 (93%) 50 (88%) 1 (20%) 49 (86%)
Renal Tubule, Pigmentation 7 (12%) 7 (12%) 8 (14%)
Urethra (1) (3)
Calculus Micro Observation Only 1 (100%) 3 (100%)
Urinary Bladder (59) (58) (3) (58) (1)
Autolysis 1 (2%)
Calculus Micro Observation Only 3 (5%) 4 (7%) 3 (100%) 6 (10%) 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 12
Scheduled Sacrifice 5 12
Early Deaths
Moribund Sacrifice 28
Natural Death 4
Survivors
Terminal Sacrifice 20
Moribund Sacrifice 1
Animals Examined Microscopically 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57)
Parasite Metazoan 2 (4%)
Intestine Large, Cecum (57)
Parasite Metazoan 2 (4%)
Intestine Small, Jejunum (58)
Peyer's Patch, Hyperplasia 4 (7%)
Liver (58)
Angiectasis 10 (17%)
Basophilic Focus 40 (69%)
Clear Cell Focus 4 (7%)
Degeneration, Cystic 8 (14%)
Degeneration, Fatty 8 (14%)
Eosinophilic Focus 5 (9%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 8 (14%)
Mixed Cell Focus 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 35 (60%)
Centrilobular, Atrophy 7 (12%)
Hepatocyte, Necrosis 16 (28%)
Pancreas (58)
Atrophy, Focal 1 (2%)
Inflammation, Focal 1 (2%)
Polyarteritis 1 (2%)
Thrombosis 1 (2%)
Acinus, Atrophy 6 (10%)
Stomach, Forestomach (57)
Edema 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (58)
Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (3)
Peridontal Tissue, Inflammation 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58)
Cardiomyopathy 32 (55%)
Fibrosis 1 (2%)
Infarct 1 (2%)
Thrombosis 2 (3%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia 4 (7%)
Vacuolization Cytoplasmic 16 (28%)
Adrenal Medulla (58)
Hyperplasia 26 (45%)
Islets, Pancreatic (58)
Hyperplasia 4 (7%)
Parathyroid Gland (53)
Hyperplasia 2 (4%)
Bilateral, Hyperplasia 1 (2%)
Pituitary Gland (58)
Angiectasis 2 (3%)
Cyst 1 (2%)
Pigmentation, Ceroid 1 (2%)
Pars Distalis, Hyperplasia, Focal 19 (33%)
Thyroid Gland (57)
Autolysis 1 (2%)
C-Cell, Hyperplasia 6 (11%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4)
Hemorrhage 1 (25%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (58)
Granuloma Sperm 1 (2%)
Spermatocele 1 (2%)
Preputial Gland (58)
Ectasia 5 (9%)
Inflammation 2 (3%)
Prostate (58)
Inflammation 3 (5%)
Seminal Vesicle (58)
Atrophy 2 (3%)
Hyperplasia 1 (2%)
Testes (58)
Atrophy 4 (7%)
Infarct 1 (2%)
Interstitial Cell, Hyperplasia, Focal 5 (9%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58)
Atrophy, Focal 1 (2%)
Myeloid Cell, Hyperplasia 18 (31%)
Lymph Node (12)
Iliac, Hyperplasia, Plasma Cell 1 (8%)
Inguinal, Hyperplasia, Histiocytic 1 (8%)
Pancreatic, Pigmentation, Hemosiderin 1 (8%)
Renal, Pigmentation, Hemosiderin 1 (8%)
Lymph Node, Bronchial (56) (5)
Congestion 1 (2%)
Edema 2 (4%)
Hyperplasia, Lymphoid 11 (20%) 5 (100%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (57)
Hyperplasia, Lymphoid 6 (11%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation 1 (2%)
Lymph Node, Mediastinal (54) (4)
Congestion 1 (2%)
Edema 2 (4%)
Hyperplasia, Lymphoid 7 (13%) 2 (50%)
Hyperplasia, Macrophage 1 (2%)
Hyperplasia, Plasma Cell 2 (4%)
Pigmentation 4 (7%)
Spleen (58)
Atrophy 1 (2%)
Congestion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 14 (24%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 2 (3%)
Thymus (50)
Atrophy 17 (34%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (58)
Cyst Epithelial Inclusion 2 (3%)
Edema 1 (2%)
Hyperkeratosis 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58)
Compression 5 (9%)
Degeneration 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58)
Inflammation 8 (14%)
Necrosis 1 (2%)
Lung (58) (5)
Congestion 1 (2%)
Fibrosis 45 (78%)
Hemorrhage 1 (2%)
Hyperplasia, Macrophage 53 (91%) 5 (100%)
Inflammation, Chronic Active 51 (88%) 5 (100%)
Inflammation, Suppurative 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (3%) 1 (20%)
Alveolus, Proteinosis 45 (78%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 24
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Bronchus, Hyperplasia, Lymphoid 2 (40%)
Interstitium, Infiltration Cellular 11 (19%) 5 (100%)
Nose (58) (5)
Thrombosis 1 (2%)
Thrombosis, Multiple 8 (14%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation 3 (5%)
Nasopharyngeal Duct, Hyperplasia, Lymphoid 1 (2%)
Nasopharyngeal Duct, Inflammation 1 (2%)
Olfactory Epithelium, Atrophy 7 (12%) 1 (20%)
Olfactory Epithelium, Degeneration 14 (24%) 1 (20%)
Olfactory Epithelium, Inflammation 1 (2%)
Respiratory Epithelium, Hyperplasia 34 (59%) 1 (20%)
Respiratory Epithelium, Inflammation 25 (43%)
Respiratory Epithelium, Metaplasia, Squamous 6 (10%) 1 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Synechia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (5)
Cyst 1 (2%)
Nephropathy 44 (76%)
Renal Tubule, Pigmentation 8 (14%)
Urethra (1)
Calculus Micro Observation Only 1 (100%)
Urinary Bladder (58) (2)
Calculus Micro Observation Only 3 (5%) 2 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 25
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------