National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3716

TDMS Study 05122-05 Pathology Tables

NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50

                                                     29 Week SSAC Lung Tox




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     01/04/89 - 01/05/89

       Treatment Groups:       Include All


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |     A      |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 8| 8| 8| 9| 0| 1| 1|                                      |     L      |
    LUNG TOX                               | 1| 2| 3| 5| 8| 3| 5| 9| 1| 6| 7| 9|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +     +     +        +  +                                       |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |          +     +     M        +  I                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +     +        +  +                                       |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +     +        +  +                                       |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +     +     +        +  +                                       |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |          +     +     +        +  +                                       |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |     A      |
    0.12MGM3                               | 1| 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| 6|                                      |     L      |
    LUNG TOX                               | 2| 4| 9| 4| 2| 4| 7| 4| 6| 5| 8| 6|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +     +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +     +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                         |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|                                         |     A      |
    0.25MGM3                               | 5| 5| 6| 8| 8| 9| 9| 0| 0| 0| 1|                                         |     L      |
    LUNG TOX                               | 3| 5| 3| 0| 9| 1| 2| 3| 4| 9| 9|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     M     +  +           +                                          |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +     +     +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +     +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +     +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +     +  +           +                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +     +     +  +           +                                          |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    0.5MG/M3                               | 9| 0| 1| 2| 3| 4| 4| 5| 5| 6|                                            |     L      |
    LUNG TOX                               | 3| 1| 3| 1| 7| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +     +  +        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +  +     +  +        +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +     +  +        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +     +  +        +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +  +        +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +  +     +  +        +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                         |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                         |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                         |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     A      |
    0.0MG/M3                               | 0| 2| 2| 2| 3| 3| 3| 4| 6| 6| 7|                                         |     L      |
    LUNG TOX                               | 5| 2| 6| 9| 1| 4| 8| 8| 2| 4| 0|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +        +  +        +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M        +  M        +  +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +        +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +        +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +        +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +        +  +        +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|                                      |     A      |
    0.12MGM3                               | 4| 6| 6| 6| 7| 7| 7| 8| 9| 9| 0| 0|                                      |     L      |
    LUNG TOX                               | 3| 2| 3| 8| 0| 8| 9| 0| 2| 9| 0| 7|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +           +        +  +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +           +        +  +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +           +        +  +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +           +        +  +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +           +        +  +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                    +                                             |   3        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +           +        +  +                                          |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                      |     A      |
    0.25MGM3                               | 8| 8| 9| 9| 9| 9| 1| 2| 3| 3| 3| 4|                                      |     L      |
    LUNG TOX                               | 5| 8| 2| 3| 6| 9| 1| 7| 0| 5| 8| 0|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                       +  +                                       |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                       M  +                                       |   4        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |   1        |
      Oligodendroglioma NOS                | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                       +  +                                       |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                       +  +                                       |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                       +  +                                       |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                  +                                       |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                       +  +                                       |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05122-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:16:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |     A      |
    0.5MG/M3                               | 3| 3| 3| 3| 5| 5| 6| 6| 7| 8| 8| 8|                                      |     L      |
    LUNG TOX                               | 0| 3| 6| 9| 2| 8| 4| 5| 6| 6| 7| 9|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +     +  +              +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +     +  +              M                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +  +              +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +  +              +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +              +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                                                                  |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +     +  +              +                                          |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------                                      
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.