National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3718

TDMS Study 05122-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                     NICKEL SULFATE HEXAHYDRATE


NTP Experiment-Test: 05122-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          58           12           58           12           59           11           
  Scheduled Sacrifice                                  5           12            5           12            5           11           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27                        32                        22                        
    Natural Death                                      4                         4                         3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                22                        17                        28                        
  Other                                                                                                    1                        
  Animals Examined Microscopically                    58            5           58            5           58            5           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)                      (55)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Intestine Large, Cecum                             (56)                      (58)                      (58)                      
      Lipoma                                                                     1 (2%)                                             
   Intestine Small, Duodenum                          (56)                      (58)                      (57)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Intestine Small, Jejunum                           (57)                      (58)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Intestine Small, Ileum                             (54)                      (56)                      (57)                      
      Fibrosarcoma                                                               1 (2%)                                             
   Liver                                              (57)                      (58)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Mesentery                                          (1)                       (2)                       (2)                       
      Lipoma                                                                                               1 (50%)                  
   Oral Mucosa                                        (3)                       (2)                       (2)                       
      Squamous Cell Carcinoma                          3 (100%)                  1 (50%)                   2 (100%)                 
      Squamous Cell Papilloma                                                    1 (50%)                                            
   Pancreas                                           (57)                      (58)                      (58)                      
      Carcinoma                                        1 (2%)                                                                       
   Salivary Glands                                    (57)                      (58)                      (58)                      
   Stomach, Forestomach                               (57)                      (58)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Stomach, Glandular                                 (57)                      (58)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)                      (58)                      (58)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (57)                      (58)                      (58)                      
   Adrenal Medulla                                    (56)                      (57)                      (58)                      
      Pheochromocytoma Complex                                                                             1 (2%)                   
      Pheochromocytoma Benign                          2 (4%)                    4 (7%)                    2 (3%)                   
   Islets, Pancreatic                                 (57)                      (58)                      (58)                      
   Pituitary Gland                                    (57)                      (58)                      (58)                      
      Pars Distalis, Adenoma                          22 (39%)                  24 (41%)                  24 (41%)                  
   Thyroid Gland                                      (57)                      (58)                      (58)                      
      C-Cell, Adenoma                                  1 (2%)                    2 (3%)                    4 (7%)                   
      C-Cell, Carcinoma                                1 (2%)                                              2 (3%)                   
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (6)                       (4)                       (2)                       
      Pericardial, Carcinoma, Metastatic, Pancreas     1 (17%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (56)                      (57)                      (57)                      
      Adenoma                                          4 (7%)                    4 (7%)                    3 (5%)                   
      Carcinoma                                                                  1 (2%)                                             
   Ovary                                              (57)                      (58)                      (58)                      
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
   Uterus                                             (57)                      (58)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Polyp Stromal                                    5 (9%)                    3 (5%)                    4 (7%)                   
      Schwannoma Malignant                                                       1 (2%)                                             
   Vagina                                             (1)                       (1)                       (1)                       
      Carcinoma, Metastatic, Pancreas                  1 (100%)                                                                     
      Fibroma                                                                                              1 (100%)                 
      Schwannoma Malignant                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (57)                      (58)                      (58)                      
   Lymph Node                                         (8)                       (7)                       (11)                      
      Iliac, Carcinoma, Metastatic, Pancreas           1 (13%)                                                                      
      Pancreatic, Carcinoma, Metastatic, Pancreas      1 (13%)                                                                      
   Lymph Node, Bronchial                              (54)         (5)          (57)         (5)          (54)         (4)          
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (57)                      (57)                      (56)                      
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (2%)                                                                       
   Lymph Node, Mesenteric                             (57)                      (58)                      (58)                      
   Lymph Node, Mediastinal                            (53)         (3)          (54)         (5)          (48)         (5)          
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Spleen                                             (57)                      (57)                      (58)                      
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Thymus                                             (53)                      (54)                      (56)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)                      (58)                      (58)                      
      Adenocarcinoma                                   4 (7%)                    4 (7%)                    1 (2%)                   
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    14 (25%)                  16 (28%)                   8 (14%)                  
      Fibroadenoma, Multiple                           3 (5%)                    2 (3%)                    2 (3%)                   
   Skin                                               (58)                      (58)                      (57)                      
      Fibroma                                                                                              1 (2%)                   
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (58)                      (58)                      
      Osteosarcoma                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)                      (58)                      (58)                      
      Astrocytoma NOS                                                                                      1 (2%)                   
      Cerebrum, Astrocytoma NOS                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (57)         (5)          (58)         (5)          (58)         (5)          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                                                           1 (2%)                   
   Nose                                               (56)         (5)          (57)         (5)          (58)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (5)                       (1)                       
      Retrobulbar, Carcinoma                                                     1 (20%)                                            
   Zymbal's Gland                                                                                         (1)                       
      Carcinoma                                                                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (5)          (58)         (5)          (58)         (5)          
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Urinary Bladder                                    (58)                      (58)                      (58)                      
      Papilloma                                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(5)         *(58)        *(5)         *(58)        *(5)          
      Leukemia Mononuclear                            25 (43%)                  26 (45%)                  34 (59%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50                      53                      52                           
     Total Primary Neoplasms                           89                      99                      93                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36                      42                      36                           
     Total Benign Neoplasms                            53                      59                      50                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35                      34                      38                           
     Total Malignant Neoplasms                         36                      39                      42                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                               1                           
     Total Metastatic Neoplasm                         16                                               1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                               1                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                       1                           
     Total Uncertain Neoplasms                                                  1                       1                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10                                                               
  Scheduled Sacrifice                                  5           10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21                                                                            
    Accidently Killed                                  1                                                                            
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                29                                                                            
  Missing                                              1                                                                            
  Animals Examined Microscopically                    59            5                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)                                                                          
   Intestine Large, Cecum                             (58)                                                                          
   Intestine Small, Ileum                             (58)                                                                          
   Liver                                              (59)                                                                          
   Mesentery                                          (1)                                                                           
   Oral Mucosa                                        (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
   Pancreas                                           (59)                                                                          
   Salivary Glands                                    (59)                                                                          
   Stomach, Forestomach                               (58)                                                                          
   Stomach, Glandular                                 (59)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)                                                                          
   Adrenal Medulla                                    (59)                                                                          
      Pheochromocytoma Benign                          3 (5%)                                                                       
   Islets, Pancreatic                                 (59)                                                                          
   Parathyroid Gland                                  (52)                                                                          
   Pituitary Gland                                    (59)                                                                          
      Pars Distalis, Adenoma                          22 (37%)                                                                      
   Thyroid Gland                                      (57)                                                                          
      C-Cell, Adenoma                                  2 (4%)                                                                       
                                                             Page   7                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Carcinoma                                3 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)                                                                          
      Adenoma                                          2 (3%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (59)                                                                          
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
   Uterus                                             (59)                                                                          
      Polyp Stromal                                    7 (12%)                                                                      
      Sarcoma Stromal                                  1 (2%)                                                                       
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                                                                          
   Lymph Node                                         (3)                                                                           
   Lymph Node, Bronchial                              (54)         (5)                                                              
   Lymph Node, Mandibular                             (54)                                                                          
   Lymph Node, Mesenteric                             (59)                                                                          
   Lymph Node, Mediastinal                            (52)         (5)                                                              
   Spleen                                             (59)                                                                          
   Thymus                                             (57)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)                                                                          
      Adenocarcinoma                                   1 (2%)                                                                       
      Fibroadenoma                                     7 (12%)                                                                      
      Fibroadenoma, Multiple                           2 (3%)                                                                       
   Skin                                               (58)                                                                          
      Fibroma                                          1 (2%)                                                                       
      Pinna, Fibroma                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (5)                                                              
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
   Nose                                               (59)         (5)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (5)                                                              
   Urinary Bladder                                    (59)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(59)        *(5)                                                              
      Leukemia Mononuclear                            23 (39%)                                                                      
      Lymphoma Malignant                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48                                                                           
     Total Primary Neoplasms                           83                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36                                                                           
     Total Benign Neoplasms                            50                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29                                                                           
     Total Malignant Neoplasms                         33                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          3                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          59           11           58           12           58           12           
  Scheduled Sacrifice                                  5           11            5           12            5           12           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34                        30                        31                        
    Natural Death                                      4                         7                         3                        
    Accidently Killed                                                                                      1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                16                        16                        18                        
  Animals Examined Microscopically                    59            5           58            5           58            5           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)                      (58)                      (58)                      
   Intestine Large, Cecum                             (59)                      (58)                      (58)                      
      Sarcoma                                                                    1 (2%)                                             
   Intestine Small, Duodenum                          (59)                      (58)                      (56)                      
   Intestine Small, Jejunum                           (59)                      (57)                      (55)                      
   Intestine Small, Ileum                             (59)                      (55)                      (53)                      
   Liver                                              (59)                      (58)                      (58)                      
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)                    1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)                                              2 (3%)                   
   Mesentery                                          (2)                       (4)                                                 
      Lipoma                                                                     2 (50%)                                            
      Schwannoma Benign                                1 (50%)                                                                      
   Oral Mucosa                                        (3)                       (2)                       (4)                       
      Squamous Cell Carcinoma                                                                              3 (75%)                  
      Squamous Cell Papilloma                          2 (67%)                   1 (50%)                   1 (25%)                  
   Pancreas                                           (58)                      (57)                      (58)                      
   Salivary Glands                                    (59)                      (58)                      (57)                      
   Stomach, Forestomach                               (59)                      (58)                      (57)                      
   Stomach, Glandular                                 (59)                      (58)                      (58)                      
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)                      (58)                      (58)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)                      (58)                      (58)                      
      Adenoma                                                                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Adrenal Medulla                                    (59)                      (58)                      (58)                      
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant                                                 3 (5%)                    2 (3%)                   
      Pheochromocytoma Benign                         11 (19%)                  10 (17%)                  12 (21%)                  
      Bilateral, Pheochromocytoma Benign               5 (8%)                    6 (10%)                                            
   Islets, Pancreatic                                 (57)                      (56)                      (57)                      
      Adenoma                                          2 (4%)                    2 (4%)                    1 (2%)                   
      Carcinoma                                                                                            1 (2%)                   
   Pituitary Gland                                    (59)                      (56)                      (58)                      
      Pars Distalis, Adenoma                          15 (25%)                  12 (21%)                  18 (31%)                  
   Thyroid Gland                                      (58)                      (58)                      (56)                      
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  7 (12%)                   1 (2%)                    2 (4%)                   
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                                                                             1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)                       (1)                       (5)                       
      Cholangiocarcinoma, Metastatic, Liver            1 (25%)                                                                      
      Fibroma                                                                                              1 (20%)                  
      Paraganglioma                                    1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)                      (58)                      (58)                      
   Preputial Gland                                    (59)                      (58)                      (57)                      
      Adenoma                                          2 (3%)                                              3 (5%)                   
      Carcinoma                                        1 (2%)                    3 (5%)                    1 (2%)                   
   Prostate                                           (59)                      (57)                      (58)                      
   Seminal Vesicle                                    (59)                      (58)                      (58)                      
   Testes                                             (59)                      (58)                      (58)                      
      Bilateral, Interstitial Cell, Adenoma           37 (63%)                  43 (74%)                  43 (74%)                  
      Interstitial Cell, Adenoma                      13 (22%)                   8 (14%)                   7 (12%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                      (57)                      (57)                      
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Lymph Node                                         (11)                      (14)                      (11)                      
   Lymph Node, Bronchial                              (56)         (5)          (54)         (5)          (52)         (5)          
      Carcinoma, Metastatic, Preputial Gland                                     1 (2%)                                             
   Lymph Node, Mandibular                             (55)                      (57)                      (56)                      
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                                           2 (4%)                   
   Lymph Node, Mesenteric                             (59)                      (58)                      (58)                      
      Hemangioma                                                                                           1 (2%)                   
   Lymph Node, Mediastinal                            (56)         (3)          (52)         (5)          (51)         (4)          
   Spleen                                             (59)                      (58)                      (56)                      
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (54)                      (53)                      (53)         (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)                      (53)                      (53)                      
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
      Fibroadenoma                                                                                         1 (2%)                   
      Fibroadenoma, Multiple                                                     1 (2%)                                             
   Skin                                               (58)                      (58)                      (58)                      
      Fibroma                                                                    1 (2%)                                             
      Keratoacanthoma                                  5 (9%)                    1 (2%)                    1 (2%)                   
      Lipoma                                                                     1 (2%)                    1 (2%)                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                                              2 (3%)                   
      Lip, Trichoepithelioma                                                     1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)                      (58)                      (58)                      
      Humerus, Osteosarcoma                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)                      (58)                      (58)         (1)          
      Glioma NOS                                       1 (2%)                                                                       
      Oligodendroglioma NOS                                                                                             1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  13                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (59)                      (57)                      (58)                      
   Lung                                               (59)         (5)          (58)         (5)          (58)         (5)          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                              1 (2%)                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                                  1 (2%)                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Nose                                               (59)         (5)          (57)         (5)          (58)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                 (2)                       
      Carcinoma                                        1 (100%)                                            2 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (5)          (57)         (5)          (57)         (5)          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (59)                      (58)         (3)          (58)         (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(59)        *(5)         *(58)        *(5)         *(58)        *(5)          
      Leukemia Mononuclear                            31 (53%)                  36 (62%)                  39 (67%)                  
      Lymphoma Malignant                                                                                   1 (2%)                   
      Mesothelioma Malignant                                                     1 (2%)                                             
      Mesothelioma NOS                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58                      57                      56           1               
     Total Primary Neoplasms                          144                     142                     148           1               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 54                      55                      55                           
     Total Benign Neoplasms                           104                      91                      97                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37                      43                      42                           
     Total Malignant Neoplasms                         39                      50                      51                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       3                       3                           
     Total Metastatic Neoplasm                          6                       3                       3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1                                   1               
     Total Uncertain Neoplasms                          1                       1                                   1               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          58           12                                                               
  Scheduled Sacrifice                                  5           12                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28                                                                            
    Natural Death                                      4                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                20                                                                            
    Moribund Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    58            5                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)                                                                          
   Intestine Large, Cecum                             (57)                                                                          
   Intestine Small, Duodenum                          (58)                                                                          
   Intestine Small, Jejunum                           (58)                                                                          
   Intestine Small, Ileum                             (58)                                                                          
   Liver                                              (58)                                                                          
      Hepatocellular Adenoma                           2 (3%)                                                                       
   Mesentery                                          (1)                                                                           
   Pancreas                                           (58)                                                                          
   Salivary Glands                                    (58)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)                                                                          
   Adrenal Medulla                                    (58)                                                                          
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          9 (16%)                                                                      
      Bilateral, Pheochromocytoma Benign               2 (3%)                                                                       
   Islets, Pancreatic                                 (58)                                                                          
      Adenoma                                          4 (7%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (53)                                                                          
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (58)                                                                          
                                                             Page  16                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          14 (24%)                                                                      
   Thyroid Gland                                      (57)                                                                          
      C-Cell, Adenoma                                  1 (2%)                                                                       
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)                                                                           
      Paraganglioma                                    1 (25%)                                                                      
      Abdominal, Chondrosarcoma                        1 (25%)                                                                      
      Thoracic, Chordoma                               1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (58)                                                                          
      Adenoma                                          3 (5%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Prostate                                           (58)                                                                          
   Testes                                             (58)                                                                          
      Bilateral, Interstitial Cell, Adenoma           43 (74%)                                                                      
      Interstitial Cell, Adenoma                      11 (19%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)                                                                          
   Lymph Node                                         (12)                                                                          
   Lymph Node, Bronchial                              (56)         (5)                                                              
   Lymph Node, Mandibular                             (57)                                                                          
   Lymph Node, Mesenteric                             (58)                                                                          
   Lymph Node, Mediastinal                            (54)         (4)                                                              
   Spleen                                             (58)                                                                          
   Thymus                                             (50)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)                                                                          
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (58)                                                                          
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Fibroma                                          3 (5%)                                                                       
      Squamous Cell Papilloma                          2 (3%)                                                                       
                                                             Page  17                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Osteosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (5)                                                              
      Alveolar/Bronchiolar Adenoma                     2 (3%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Chordoma, Metastatic, Tissue NOS                 1 (2%)                                                                       
   Nose                                               (58)         (5)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (5)                                                              
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (58)         (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(5)                                                              
      Leukemia Mononuclear                            38 (66%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  18                                                               
NTP Experiment-Test: 05122-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            55                                                                           
     Total Primary Neoplasms                          150                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 55                                                                           
     Total Benign Neoplasms                           101                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41                                                                           
     Total Malignant Neoplasms                         49                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  19                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.