Share This:
https://ntp.niehs.nih.gov/go/3722

TDMS Study 05122-05 Pathology Tables

NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|             
                                           | 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Inflammation, Granulomatous          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                        3                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Basophilic Focus                     | 3  2  1  1  1  2  2  3  1  1  3  1  2  1  1     1  2     3  1  3  1  4  2|             
      Clear Cell Focus                     |                      2                                               1   |             
      Degeneration, Cystic                 |                         2              1                                 |             
      Degeneration, Fatty                  |          2           2  1              2     2        4     2            |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X              X                  |             
      Inflammation                         |                         1           1                                    |             
      Mixed Cell Focus                     |                      3  2                                                |             
      Thrombosis, Multiple                 |                                                                          |             
      Bile Duct, Hyperplasia               |             3                    2                 1                     |             
      Centrilobular, Atrophy               |                                              3        2                  |             
      Hepatocyte, Necrosis                 |             3                    2           3              2           1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
      Peridontal Tissue, Inflammation      |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|             
                                           | 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 2  2                       2                                   4     2   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                     X                                    |             
      Degeneration                         |                      2                                                   |             
      Hyperplasia                          | 1                 1                                                      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |             3     1     4  1  1  1                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Hyperplasia                          |          2  1                    2  1                       1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                    X                     |             
      Pars Distalis, Hyperplasia, Diffuse  |                                  3           2                           |             
      Pars Distalis, Hyperplasia, Focal    |             2           1  2           2        1           2     1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      C-Cell, Hyperplasia                  |                                     1                                   2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                          +     +     +        +            |             
      Inflammation, Granulomatous          |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             1                       1              1                     |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X        X  X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Fibrosis                |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|             
                                           | 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            4                                             |             
      Myeloid Cell, Hyperplasia            |                                                    1  4                 3|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                    +           +              +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Inflammation, Granulomatous          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 4                        |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |                                        3                                 |             
      Pigmentation, Hemosiderin            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Granulomatous          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                                        2                                 |             
      Infarct                              |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Necrosis                             |                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3  2        1              3        3  3  2  2           2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation                         |                                                                          |             
      Dermis, Edema                        |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                             4           1|             
      Ligament, Intervertebral Disc,       |                                                                          |             
          Degeneration                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|             
                                           | 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          1        3  2              1                       3            |             
      Meninges, Inflammation               |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               1              1              1            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                1           1                                            4|             
      Hyperplasia, Macrophage              | 1                                   1     1                              |             
      Inflammation, Chronic Active         |    1  1        2     1     1                       1           1  1     2|             
      Inflammation, Granulomatous          |                                        2                                 |             
      Inflammation, Suppurative            |             2                                                            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 1                                         2                    2         |             
      Alveolus, Proteinosis                |                                                                          |             
      Interstitium, Infiltration Cellular  |                1                    1           1        1     1     1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                       1                  |             
      Thrombosis, Multiple                 |                                                             X            |             
      Nasolacrimal Duct, Ectasia           |                                                                          |             
      Nasolacrimal Duct, Inflammation      |             1                                                            |             
      Olfactory Epithelium, Degeneration   | 1  1     1     1  1  1     1  1  1  1  1  1  1  1  1     1  1  1  1     1|             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |          2                                                               |             
      Respiratory Epithelium, Degeneration |       1              1  1        1                                1      |             
      Respiratory Epithelium, Hyperplasia  |                      2           1                                       |             
      Respiratory Epithelium, Inflammation |                      2           1                       1     1         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                1         |             
      Vomeronasal Organ, Inflammation      |             1                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                          +      |             
      Anterior Chamber, Inflammation       |                                                                   1      |             
      Posterior Chamber, Inflammation      |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|             
                                           | 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Inflammation, Granulomatous          |                                        2                                 |             
      Nephropathy                          | 2  2  1  2  1  2  2  2  1  1  1     2        1  2     1  2  2     1  2  1|             
      Pelvis, Dilatation                   |             3                                                            |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|             
                             DAY ON TEST   | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|             
                                           | 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                   X                                                  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A|             
      Ulcer                                |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                                 3           1            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis                          |                                              1                           |             
      Basophilic Focus                     | 3  3  2  1     1  1     2        2  3  1  2  3  4  1  1  2  2  2  2  3   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                   1      |             
      Degeneration, Fatty                  |       1  1                    2           2     2     2  3               |             
      Eosinophilic Focus                   |                      2                                               3   |             
      Hepatodiaphragmatic Nodule           |                                     X        X           X               |             
      Inflammation                         |                                     1     3                              |             
      Mixed Cell Focus                     |                                                                   1      |             
      Thrombosis, Multiple                 |                               X                                          |             
      Bile Duct, Hyperplasia               |       3              2  3              3        2                    2   |             
      Centrilobular, Atrophy               |                                                                          |             
      Hepatocyte, Necrosis                 |       2              2  2  4  2                                1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                  +                       +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperkeratosis                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Erosion                              |                            3                                             |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Peridontal Tissue, Inflammation      |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|             
                             DAY ON TEST   | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|             
                                           | 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  2                 2           1                          4            |             
      Thrombosis                           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Autolysis                            |                            3                                             |             
      Congestion                           |                2                          3                              |             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Hyperplasia                          | 2                    1                          3                        |             
      Pigmentation, Hemosiderin            |                                        2                                 |             
      Vacuolization Cytoplasmic            |                                                             3            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis                          |                3                                                     3   |             
      Cyst                                 | X  X                                   X                                 |             
      Pars Distalis, Hyperplasia, Diffuse  |       2                    4                                             |             
      Pars Distalis, Hyperplasia, Focal    |                3        2     3        4        3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Fibrosis                             |                                                                          |             
      C-Cell, Hyperplasia                  | 2  1                    2  2  1                    3                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Ectasia                              | 2                                                                        |             
      Hyperplasia                          |                                           4                              |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Endometrium, Fibrosis                |    3                                            1                        |             
      Endometrium, Hyperplasia             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|             
                             DAY ON TEST   | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|             
                                           | 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                               3                                          |             
      Myeloid Cell, Hyperplasia            |    1                 2  3              1                             3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +     +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                  3              3                        |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Congestion                           |                                                                   4      |             
      Infarct                              |                               4                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A|             
      Autolysis                            |                                           3                              |             
      Congestion                           |                            1                             3               |             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |       3                 2              3                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Infarct                              |                                                       3                  |             
      Metaplasia, Osseous                  |                                        3                                 |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                         3  2           2        2                    3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Inflammation                         |                         2                                                |             
      Dermis, Edema                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                               4        2                                 |             
      Ligament, Intervertebral Disc,       |                                                                          |             
          Degeneration                     |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|             
                             DAY ON TEST   | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|             
                                           | 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Compression                          |          3           2                                         2         |             
      Meninges, Inflammation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation                         |                                              2  1           2        2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Congestion                           |                                           3                              |             
      Fibrosis                             |    1                             1        1                          1   |             
      Hyperplasia, Macrophage              |    3           1        4        1  1                                1   |             
      Inflammation, Chronic Active         |    1                             1        3  1                           |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    1           2                                                         |             
      Alveolus, Proteinosis                |                         1                                                |             
      Interstitium, Infiltration Cellular  |          1        1              1  1                             1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A|             
      Thrombosis                           |       1                    1                                             |             
      Thrombosis, Multiple                 |                                                                          |             
      Nasolacrimal Duct, Ectasia           |                                                                          |             
      Nasolacrimal Duct, Inflammation      | 1              3                                                     2   |             
      Olfactory Epithelium, Degeneration   |    1  1  1  1  1  1  1  1     1  1  1  1     1  1     1  1  1        1   |             
      Olfactory Epithelium, Inflammation   |                                        2                                 |             
      Olfactory Epithelium, Metaplasia     |                                                 1                        |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Degeneration |       1     1  1     1  1  1           1                          1      |             
      Respiratory Epithelium, Hyperplasia  |                            1        1  1        1                 3      |             
      Respiratory Epithelium, Inflammation |                                     1  1        1        1        2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Vomeronasal Organ, Inflammation      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Anterior Chamber, Inflammation       |                                                                          |             
      Posterior Chamber, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|             
                             DAY ON TEST   | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|             
                                           | 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                      3                    3                              |             
      Congestion                           |                                           3                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Nephropathy                          | 2  2  1  3  1  2     1  2  2     2  1  1     1  3  3        2  3  1      |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Necrosis               |                            3                                             |             
      Renal Tubule, Pigmentation           |                                        3              4                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 7| 7|                                                  |            |
                             DAY ON TEST   | 4| 1| 3| 2| 3| 6| 3| 2|                                                  |            |
                                           | 2| 3| 2| 9| 2| 6| 0| 9|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |      A     |
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +                                                   |  56        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  56        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  57        |
      Peyer's Patch, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +                                                   |  54        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Angiectasis                          |          1                                                               |      3  1.3|
      Basophilic Focus                     |    2  1  2  1  1  1                                                      |     49  1.9|
      Clear Cell Focus                     |          1           1                                                   |      4  1.3|
      Degeneration, Cystic                 | 2                                                                        |      4  1.5|
      Degeneration, Fatty                  | 2                                                                        |     15  2.0|
      Eosinophilic Focus                   |                                                                          |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Inflammation                         |                                                                          |      4  1.5|
      Mixed Cell Focus                     |       1                                                                  |      4  1.8|
      Thrombosis, Multiple                 |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 3                                                                        |     10  2.4|
      Centrilobular, Atrophy               |                                                                          |      2  2.5|
      Hepatocyte, Necrosis                 | 1                                                                        |     13  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  57        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  57        |
      Erosion                              |                                                                          |      1  3.0|
      Hyperplasia                          |       2                                                                  |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 7| 7|                                                  |            |
                             DAY ON TEST   | 4| 1| 3| 2| 3| 6| 3| 2|                                                  |            |
                                           | 2| 3| 2| 9| 2| 6| 0| 9|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |      A     |
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   3        |
      Peridontal Tissue, Inflammation      | 2                                                                        |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Cardiomyopathy                       |                1     2                                                   |     12  2.1|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  57        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      2  2.5|
      Cyst                                 |                X                                                         |      2     |
      Degeneration                         |                                                                          |      1  2.0|
      Hyperplasia                          |       1     1                                                            |      7  1.4|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                   2                                                      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  56        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  57        |
      Angiectasis                          |          1     1                                                         |      4  2.0|
      Cyst                                 |                X                                                         |      5     |
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      4  2.8|
      Pars Distalis, Hyperplasia, Focal    |                3                                                         |     14  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  57        |
      Fibrosis                             |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                      3                                                   |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   6        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +                                                   |  56        |
      Ectasia                              |                                                                          |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 7| 7|                                                  |            |
                             DAY ON TEST   | 4| 1| 3| 2| 3| 6| 3| 2|                                                  |            |
                                           | 2| 3| 2| 9| 2| 6| 0| 9|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |      A     |
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |          3                                                               |      2  3.5|
      Hyperplasia, Squamous                |                4                                                         |      1  4.0|
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Cyst                                 |    X           X                                                         |      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Endometrium, Fibrosis                |                                                                          |      2  2.0|
      Endometrium, Hyperplasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  57        |
      Atrophy                              |                                                                          |      2  3.5|
      Myeloid Cell, Hyperplasia            |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +                                                   |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia, Lymphoid                |          2        3                                                      |      5  2.6|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Congestion                           |                                                                          |      2  4.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +                                                   |  53        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |    2                                                                     |      3  2.0|
      Hyperplasia, Lymphoid                |                2                                                         |      2  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Atrophy                              |       1                                                                  |      1  1.0|
      Fibrosis                             |                                                                          |      3  2.7|
      Hematopoietic Cell Proliferation     |                3                                                         |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +                                                   |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 7| 7|                                                  |            |
                             DAY ON TEST   | 4| 1| 3| 2| 3| 6| 3| 2|                                                  |            |
                                           | 2| 3| 2| 9| 2| 6| 0| 9|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |      A     |
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |     14  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation                         |                                                                          |      1  2.0|
      Dermis, Edema                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperostosis                         |                                                                          |      4  2.8|
      Ligament, Intervertebral Disc,       |                                                                          |            |
          Degeneration                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Compression                          |    2                                                                     |      9  2.1|
      Meninges, Inflammation               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +                                                   |  56        |
      Inflammation                         |          1  1                                                            |      9  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |             1                                                            |      8  1.4|
      Hyperplasia, Macrophage              |       1                                                                  |     10  1.5|
      Inflammation, Chronic Active         |             2  1  1                                                      |     16  1.3|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    1                                                                     |      6  1.5|
      Alveolus, Proteinosis                |                                                                          |      1  1.0|
      Interstitium, Infiltration Cellular  |       1        1  1                                                      |     14  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  56        |
      Thrombosis                           | 1                                                                        |      4  1.0|
      Thrombosis, Multiple                 |                                                                          |      1     |
      Nasolacrimal Duct, Ectasia           |       2                                                                  |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                   1                                                      |      5  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 7| 7|                                                  |            |
                             DAY ON TEST   | 4| 1| 3| 2| 3| 6| 3| 2|                                                  |            |
                                           | 2| 3| 2| 9| 2| 6| 0| 9|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |      A     |
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Degeneration   |    1  1  1  1  1  1  1                                                   |     45  1.0|
      Olfactory Epithelium, Inflammation   |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Respiratory Epithelium, Degeneration |                1                                                         |     14  1.0|
      Respiratory Epithelium, Hyperplasia  |                   1  1                                                   |      9  1.3|
      Respiratory Epithelium, Inflammation |    1        1     1  1                                                   |     13  1.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
      Vomeronasal Organ, Inflammation      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Anterior Chamber, Inflammation       |                                                                          |      1  1.0|
      Posterior Chamber, Inflammation      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Autolysis                            |                                                                          |      2  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Nephropathy                          |       2  2  2     3  2                                                   |     43  1.7|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      A     |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 8| 8| 8| 9| 0| 1| 1|                                      |      L     |
    LUNG TOX                               | 1| 2| 3| 5| 8| 3| 5| 9| 1| 6| 7| 9|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +     +     +        +  +                                       |   5        |
      Hyperplasia, Lymphoid                |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |          +     +     M        +  I                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +     +        +  +                                       |   5        |
      Interstitium, Infiltration Cellular  |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +     +        +  +                                       |   5        |
      Olfactory Epithelium, Degeneration   |                1              1                                          |      2  1.0|
      Respiratory Epithelium, Degeneration |                               1                                          |      1  1.0|
      Respiratory Epithelium, Inflammation |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      A     |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 8| 8| 8| 9| 0| 1| 1|                                      |      L     |
    LUNG TOX                               | 1| 2| 3| 5| 8| 3| 5| 9| 1| 6| 7| 9|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +     +     +        +  +                                       |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|             
                                           | 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    MG/M3                                  | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  I  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                               2               |             
      Basophilic Focus                     | 2  2  3  1  1  4  1  1  2  3  1  2  4  4  1  3  1  1     3  2     2  2  2|             
      Clear Cell Focus                     |                                                             1            |             
      Degeneration, Cystic                 |                                              2  1                        |             
      Degeneration, Fatty                  |          4  2        4     2              3           2  1           3   |             
      Eosinophilic Focus                   |                      1  1        1                                       |             
      Hepatodiaphragmatic Nodule           |    X                                                                    X|             
      Mixed Cell Focus                     |                                              1                           |             
      Bile Duct, Hyperplasia               | 2        3                       2        2     2     4        4         |             
      Centrilobular, Atrophy               |                                                       2        3     2   |             
      Hepatocyte, Necrosis                 | 1        2           2                    2     1     2              2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                         +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      4                                                   |             
      Inflammation                         |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Epithelium Alveolus, Hyperplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|             
                                           | 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    MG/M3                                  | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    2              1     1                                            1   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2     1                       1  1|             
      Vacuolization Cytoplasmic            |          3                 2                 1     1     4               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Hyperplasia                          | 3           2                                            3               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                                                                     |             
      Cyst                                 |                                           X                              |             
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 3  4  1        4                          3                    3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                 1           2              1     1        3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Abdominal, Polyarteritis             |                                                                          |             
      Mediastinum, Inflammation            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       1              2                                   2           2   |             
      Hyperplasia                          |                                                                         4|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              4              1            |             
      Cyst                                 |          X                             X                       X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 4                        |             
      Endometrium, Hyperplasia             |                                              2                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                       4                  |             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|             
                                           | 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    MG/M3                                  | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                       3                  |             
      Myeloid Cell, Hyperplasia            | 3        2                 3              2                    2     3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +     +        +         |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   4      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                         3                                                |             
      Hyperplasia, Plasma Cell             |                                  3           2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                            3     1                                       |             
      Edema                                |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Inflammation                         |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      2                                                   |             
      Congestion                           |                                  2                                4      |             
      Hyperplasia, Histiocytic             |                                                       4                  |             
      Hyperplasia, Lymphoid                |    1                                                        2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Fibrosis                             |                                                                      2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |    1     2  1  4  2  3  2        3        2  4              2        3   |             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                      3                                                   |             
      Duct, Ectasia                        |          2  2                                                            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|             
                                           | 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    MG/M3                                  | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             4     2              2  2                    3  2        2  3|             
      Hemorrhage                           |                   2                                                      |             
      Ventricle, Hydrocephalus             |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1                                       |             
      Inflammation                         |    1        1                    2           1  1                       2|             
      Metaplasia, Squamous                 |                            1                                             |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Fibrosis                             | 1                                      1                       3         |             
      Hemorrhage                           |                         4                                                |             
      Hyperplasia, Macrophage              |                               1        1  1  1                 2         |             
      Inflammation, Chronic Active         | 1  1                             1     1                 1  2           1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                            2           1                                 |             
      Interstitium, Infiltration Cellular  |                               1        1                 1  1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Thrombosis                           |                                           1                          1   |             
      Nasolacrimal Duct, Inflammation      |                2                    2  2                                 |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                         2|             
      Nasopharyngeal Duct, Inflammation    |                                                                         3|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |    1  1                    1  1  1     1  1     1                       1|             
      Respiratory Epithelium, Degeneration | 1        1                    1           1     1     1                  |             
      Respiratory Epithelium, Hyperplasia  |                      1           1  1  1           1  1  3  1  1        1|             
      Respiratory Epithelium, Inflammation |                            1        1        1           3     2        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +     +  +                                          |             
      Inflammation                         |                            4                                             |             
      Phthisis Bulbi                       |                      X                                                   |             
      Synechia                             |                                                                          |             
      Anterior Chamber, Inflammation       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|             
                                           | 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    MG/M3                                  | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  1  1  1  3  1  2  2  1  3     3  3  4  1  4  2  2     4  3        2  2|             
      Pelvis, Dilatation                   |                                                                   3      |             
      Renal Tubule, Pigmentation           |          1                                3     4              1     3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|             
                             DAY ON TEST   | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|             
                                           | 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/M3                                  | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 3  1     3  1  2  2     1  2  1  1  1        3  2  1  4  4           1  1|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                 2                 1      |             
      Degeneration, Fatty                  |       3                                         3           3            |             
      Eosinophilic Focus                   |             1                                                            |             
      Hepatodiaphragmatic Nodule           |                   X                       X                              |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |       2                                                                  |             
      Centrilobular, Atrophy               |       3                                                        2         |             
      Hepatocyte, Necrosis                 |                                                             2  1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Hemorrhage                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                             +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                             4            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
      Inflammation                         |                                                             3            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                   +                  |             
      Epithelium Alveolus, Hyperplasia,    |                                                                          |             
           Squamous                        |                                                       3                  |             
      Peridontal Tissue, Inflammation      |                   1                                   2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|             
                             DAY ON TEST   | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|             
                                           | 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/M3                                  | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 2                 1     1                                2               |             
      Thrombosis                           |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
      Vacuolization Cytoplasmic            |                               3              3                 3         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                2                           |             
      Cyst                                 |    X        X                                                            |             
      Pars Distalis, Hyperplasia, Diffuse  |       2                                                                  |             
      Pars Distalis, Hyperplasia, Focal    | 4                 2        3  2        2     3     4     3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
      Abdominal, Polyarteritis             |                                                                          |             
      Mediastinum, Inflammation            |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           1        3                     |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 | X                                            X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|             
                             DAY ON TEST   | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|             
                                           | 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/M3                                  | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                           1                    2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +     +                  |             
      Iliac, Hyperplasia, Lymphoid         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                               2            |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                            1                                3            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Edema                                |                                                       3                  |             
      Hyperplasia, Histiocytic             |          1                                                               |             
      Inflammation                         |                                              2                           |             
      Pigmentation, Hemosiderin            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |             3                                               4  1         |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                            1                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                2         |             
      Hematopoietic Cell Proliferation     |                                           4                              |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2           3                                         3     2  2        1|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   1                                                      |             
      Hyperplasia                          |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
      Epithelium, Hyperplasia              |                2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|             
                             DAY ON TEST   | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|             
                                           | 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/M3                                  | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     3           2           1  2  3      |             
      Hemorrhage                           |       2                                                                  |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 1     1     1     1                 2  1                                1|             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                1  1                       1              1               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |       1           1              1              1     1        1         |             
      Inflammation, Chronic Active         |          1     1  1                       1        1                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       2                  |             
      Interstitium, Infiltration Cellular  | 1              1        1                          1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                1         |             
      Nasolacrimal Duct, Inflammation      |                                                 4                        |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |             
      Nasopharyngeal Duct, Inflammation    |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                     1                                    |             
      Olfactory Epithelium, Degeneration   |             1        1  1     1              1     1     1        1      |             
      Respiratory Epithelium, Degeneration |       1  1     1     1              1     1     1  1        1        1   |             
      Respiratory Epithelium, Hyperplasia  |                1                 1           1  2                        |             
      Respiratory Epithelium, Inflammation |                                                 4                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             
      Epithelium, Hyperplasia              |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                             +                  |             
      Inflammation                         |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Synechia                             |                                                       4                  |             
      Anterior Chamber, Inflammation       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|             
                             DAY ON TEST   | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|             
                                           | 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/M3                                  | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                          X               |             
      Nephropathy                          | 1  1           2  1     1  2  1  1  1           1  2  2  4  1  2  3  1   |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Pigmentation           |       4                       1                                3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 7| 5| 5| 6|                                                  |            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 5| 5|                                                  |            |
                                           | 4| 0| 0| 9| 0| 6| 0| 3|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +                                                   |  56        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  58        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Angiectasis                          |             2     1                                                      |      4  1.8|
      Basophilic Focus                     | 2     3     1  1     1                                                   |     46  2.0|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Degeneration, Cystic                 |                1                                                         |      5  1.4|
      Degeneration, Fatty                  |    3              3                                                      |     13  2.8|
      Eosinophilic Focus                   |                                                                          |      4  1.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      5     |
      Mixed Cell Focus                     |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    2              2  2                                                   |     11  2.5|
      Centrilobular, Atrophy               |                                                                          |      5  2.4|
      Hepatocyte, Necrosis                 |    2              2                                                      |     11  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  58        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Edema                                |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  58        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +     +                                                               |   5        |
      Epithelium Alveolus, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 7| 5| 5| 6|                                                  |            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 5| 5|                                                  |            |
                                           | 4| 0| 0| 9| 0| 6| 0| 3|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation      | 2  1     1                                                               |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Cardiomyopathy                       | 2                                                                        |      9  1.4|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperplasia                          |             1                                                            |      6  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  57        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperplasia                          |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +                                                   |  55        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Angiectasis                          |       3        2                                                         |      5  2.2|
      Cyst                                 |                   X                                                      |      4     |
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |    4  4                                                                  |     16  3.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  58        |
      C-Cell, Hyperplasia                  |                                                                          |      7  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +  +                                                                  |   4        |
      Abdominal, Polyarteritis             |       X                                                                  |      1     |
      Mediastinum, Inflammation            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +                                                   |  57        |
      Ectasia                              |             2                                                            |      7  1.9|
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      5     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 7| 5| 5| 6|                                                  |            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 5| 5|                                                  |            |
                                           | 4| 0| 0| 9| 0| 6| 0| 3|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Autolysis                            |                      2                                                   |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |    2  2                                                                  |     10  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                 +                                                   |   7        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Congestion                           |          3                                                               |      4  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Autolysis                            |                      2                                                   |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                      2                                                   |      1  2.0|
      Congestion                           |                                                                          |      2  2.0|
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +                                                   |  54        |
      Autolysis                            |                      2                                                   |      2  2.0|
      Congestion                           |             2                                                            |      6  2.7|
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hemorrhage                           |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +                                                   |  54        |
      Atrophy                              |       2                                                                  |     19  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 7| 5| 5| 6|                                                  |            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 5| 5|                                                  |            |
                                           | 4| 0| 0| 9| 0| 6| 0| 3|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Autolysis                            |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperostosis                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Compression                          | 1                                                                        |     14  2.3|
      Hemorrhage                           |                                                                          |      2  2.0|
      Ventricle, Hydrocephalus             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |     13  1.2|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      7  1.3|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Macrophage              |                                                                          |     11  1.1|
      Inflammation, Chronic Active         |                2                                                         |     13  1.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      3  1.7|
      Interstitium, Infiltration Cellular  | 1              1                                                         |     10  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Thrombosis                           |                   1                                                      |      4  1.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      4  2.5|
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 7| 5| 5| 6|                                                  |            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 5| 5|                                                  |            |
                                           | 4| 0| 0| 9| 0| 6| 0| 3|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasopharyngeal Duct, Inflammation    |                                                                          |      1  3.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   | 1     1  1                                                               |     20  1.0|
      Respiratory Epithelium, Degeneration |    1                                                                     |     17  1.0|
      Respiratory Epithelium, Hyperplasia  | 1              1  1                                                      |     17  1.2|
      Respiratory Epithelium, Inflammation |    1                                                                     |      8  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  58        |
      Inflammation                         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Inflammation                         |                                                                          |      1  4.0|
      Phthisis Bulbi                       |                                                                          |      1     |
      Synechia                             |                                                                          |      1  4.0|
      Anterior Chamber, Inflammation       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 2     1     3                                                            |     41  2.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Inflammation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |      A     |
    0.12MGM3                               | 1| 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| 6|                                      |      L     |
    LUNG TOX                               | 2| 4| 9| 4| 2| 4| 7| 4| 6| 5| 8| 6|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +     +  +     +                                                      |   5        |
      Hyperplasia, Lymphoid                | 2  2     1        1                                                      |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +     +  +     +                                                      |   5        |
      Hyperplasia, Lymphoid                | 2                 1                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +     +                                                      |   5        |
      Hyperplasia, Macrophage              |             1     1                                                      |      2  1.0|
      Inflammation, Chronic Active         | 1        1                                                               |      2  1.0|
      Interstitium, Infiltration Cellular  | 1  1        1     1                                                      |      4  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +     +                                                      |   5        |
      Olfactory Epithelium, Degeneration   |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |      A     |
    0.12MGM3                               | 1| 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| 6|                                      |      L     |
    LUNG TOX                               | 2| 4| 9| 4| 2| 4| 7| 4| 6| 5| 8| 6|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|             
                                           | 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                 4                        |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    1           2  3  2  1  3        1  1  4  1     2  2  4     3  1  1   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                1                                                         |             
      Degeneration, Fatty                  | 1  3  3           3     2     4     2        2                           |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X        X                                                         |             
      Mixed Cell Focus                     |                                                    1                     |             
      Bile Duct, Hyperplasia               |    2  3                 3     3     2     1  3              2        2  2|             
      Centrilobular, Atrophy               | 1                       2           2                       2            |             
      Hepatocyte, Necrosis                 |       2                                                     1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
      Acinus, Atrophy                      | 2        3                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                               3                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Thrombosis                           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|             
                                           | 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |          4                                                               |             
      Hyperplasia                          |                         2                 3  1     1                     |             
      Hypertrophy                          |                            3                                             |             
      Vacuolization Cytoplasmic            |                1              4                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                       2  1                 4  2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                       4  2                  |             
      Cyst                                 |       X                                                                  |             
      Hemorrhage                           |                                                 1                        |             
      Pars Distalis, Hyperplasia, Diffuse  |    3                                         4        3                  |             
      Pars Distalis, Hyperplasia, Focal    |       2           2  3     2                       4     3     3  3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      C-Cell, Hyperplasia                  | 1              2                                   3  2                 3|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       4                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |    4                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                4         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                         2|             
      Hyperplasia                          |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2        2                    1           4  2              3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +                 +  +              +        +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|             
                                           | 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                 2                        |             
      Congestion                           |                            4                                             |             
      Pigmentation, Hemosiderin            |                         1     2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M     M  +  +  +  +  +  +  +  M  +  +  +  I  M  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Fibrosis                             |       3                       2  1           3                           |             
      Hyperplasia, Re Cell                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  4              1        2              2           2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
      Hyperostosis                         |                               1                             2            |             
      Tibia, Fracture                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      2                                                   |             
      Compression                          |                2                                                         |             
      Degeneration                         |                               2                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
      Inflammation                         |       1        1     3     1        1                 1        1     1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 3                        |             
      Fibrosis                             | 2  1  1        1        2  2  1  1  1     2  2  2  1  1  2  2  1     2  3|             
      Hyperplasia, Macrophage              |    1  2        3  1  2     2  1  2              1  1     3     1  1      |             
      Inflammation, Chronic Active         | 2  2  2        2  2     3  3  1  2  2  1  2  2  3  1  3  2  2  2  1  2  3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|             
                                           | 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |       4        1                                                         |             
      Alveolus, Proteinosis                |                1        1  1     1              1        2     1  1  2   |             
      Interstitium, Infiltration Cellular  |                                  2                       1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |       1  1                          1                                    |             
      Nasolacrimal Duct, Inflammation      |                                                    1                     |             
      Nasopharyngeal Duct, Hyperplasia     |                                           2                              |             
      Nasopharyngeal Duct, Inflammation    |                               1                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   | 1  1           1                                               1     1   |             
      Olfactory Epithelium, Erosion        |                                                                          |             
      Olfactory Epithelium, Inflammation   |                                        1                          1      |             
      Olfactory Epithelium, Metaplasia     |                                                             2            |             
      Respiratory Epithelium, Degeneration | 1  1                                               1                 1   |             
      Respiratory Epithelium, Erosion      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |       3        1                          3        1           1         |             
      Respiratory Epithelium, Inflammation |       3                                2  1                    1  1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Infarct                              |                                              2                           |             
      Nephropathy                          |    1  2        3  3     1  2  2  1  2  1  1     1  2  1  2     1        1|             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Degeneration           |                                                             3            |             
      Renal Tubule, Necrosis               |       2                                                                  |             
      Renal Tubule, Pigmentation           | 3  3                          4     4        2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|             
                                           | 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25                                   | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          1              2|             
      Basophilic Focus                     | 1  2  1  1  1  2        1  1  2  4  1  3  3     2     4  1  2  2  4  3  1|             
      Clear Cell Focus                     |                                     1                                    |             
      Degeneration, Cystic                 |                1                    1     1           1                  |             
      Degeneration, Fatty                  |                   3        3                          1           1      |             
      Eosinophilic Focus                   |                                        2                                 |             
      Granuloma                            |                                     2                                    |             
      Hepatodiaphragmatic Nodule           |             X     X              X     X                                 |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |                3  2  2                 1                                 |             
      Centrilobular, Atrophy               |                      2                                                   |             
      Hepatocyte, Necrosis                 |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             | +                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4                                                                        |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                            4                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2           2                                   2        2      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|             
                                           | 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25                                   | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                        1                                 |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                1                       1  1                    1     1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1  1                    1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                      4     3  4                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      C-Cell, Hyperplasia                  |                      3                                               2   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    2                     |             
      Hyperplasia                          |             4                                                            |             
      Inflammation                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             3                                                            |             
      Endometrium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Hyperplasia                          |                                                                         2|             
      Myeloid Cell, Hyperplasia            |                2     3                 3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +     +                    +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|             
                                           | 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25                                   | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                                1                    2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Pigmentation, Hemosiderin            |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  I  M  I  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 3                                2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                        2                                 |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2              2              2                    3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                      X   |             
      Hyperostosis                         |                                                                          |             
      Tibia, Fracture                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Compression                          |    4        2                                            1        2      |             
      Degeneration                         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |       1  2  1  1        1              1  1     3              1     1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             | 1  2  3  2  2  2     1  1  3  2  2  2  2  2     1     2  2  1     1  2   |             
      Hyperplasia, Macrophage              |       2  2              1        1  2  1  2     1  2  1  1  1  1  2  2  2|             
      Inflammation, Chronic Active         | 3  2  3  3  3  1  1  2     3  2  3  2  2  3     1     2  2  1  1  2  3  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|             
                                           | 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25                                   | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |       3                                   2                       2      |             
      Alveolus, Proteinosis                |       2                          2  1     2     2  1        1  1     2  2|             
      Interstitium, Infiltration Cellular  |                                           1                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                1  1                                                      |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |             
      Nasopharyngeal Duct, Inflammation    |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |             1        1     1                          1                  |             
      Olfactory Epithelium, Erosion        |          2                                                               |             
      Olfactory Epithelium, Inflammation   |                                              1                           |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                   1      |             
      Respiratory Epithelium, Erosion      |          2                                                               |             
      Respiratory Epithelium, Hyperplasia  | 1        1        2                    1        1     1        2  1  1   |             
      Respiratory Epithelium, Inflammation | 1        1                                            1        2  1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
      Inflammation                         |                                                                1         |             
      Metaplasia, Squamous                 |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Cornea, Fibrosis                     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 2  2  3  2     1  2           1  1  1  1  2  1  3     3  3        4  2   |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                2           1                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7|                                               |            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 9| 3| 3| 3|                                               |            |
                                           | 1| 1| 2| 0| 9| 7| 0| 2| 2|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |      A     |
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 1| 2|                                               |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  I  +  I  +  +  +  +  +                                                |  53        |
      Parasite Metazoan                    |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia           |    3                    3                                                |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +                                                |  57        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  58        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | 1  4  2  3  1  1     2  3                                                |     45  2.0|
      Clear Cell Focus                     |       3                                                                  |      2  2.0|
      Degeneration, Cystic                 |                                                                          |      5  1.0|
      Degeneration, Fatty                  |    1           4                                                         |     14  2.4|
      Eosinophilic Focus                   |          1                                                               |      2  1.5|
      Granuloma                            |       3                                                                  |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Mixed Cell Focus                     |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 3              2                                                         |     16  2.3|
      Centrilobular, Atrophy               | 2                 2                                                      |      7  1.9|
      Hepatocyte, Necrosis                 |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  58        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Acinus, Atrophy                      |             2                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  58        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  58        |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7|                                               |            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 9| 3| 3| 3|                                               |            |
                                           | 1| 1| 2| 0| 9| 7| 0| 2| 2|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |      A     |
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 1| 2|                                               |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |       2              2  2                                                |      8  2.0|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +                                                |  58        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      5  1.6|
      Hypertrophy                          |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      7  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +                                                |  58        |
      Hyperplasia                          |                                                                          |      8  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +                                                |  55        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |  58        |
      Angiectasis                          |       4                                                                  |      5  3.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                3                                                         |      2  2.0|
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      3  3.3|
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |     12  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |                                                                          |      7  2.3|
      Follicular Cell, Hyperplasia         |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +                                                |  57        |
      Ectasia                              |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +                                                |  58        |
      Cyst                                 |                   X                                                      |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +                                                |  58        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia             |                      3                                                   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7|                                               |            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 9| 3| 3| 3|                                               |            |
                                           | 1| 1| 2| 0| 9| 7| 0| 2| 2|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |      A     |
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 1| 2|                                               |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  58        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                3                                                         |     10  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +                                                |  54        |
      Congestion                           |    3                 2                                                   |      2  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +                                                |  56        |
      Hyperplasia, Lymphoid                |                3                                                         |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +                                                |  58        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |    3                                                                     |      2  3.5|
      Pigmentation, Hemosiderin            |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +                                                |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  58        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fibrosis                             | 2                                                                        |      6  2.2|
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +                                                |  56        |
      Atrophy                              |             4  2  4                                                      |     13  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +                                                |  58        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  57        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  58        |
      Fracture                             |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      2  1.5|
      Tibia, Fracture                      |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7|                                               |            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 9| 3| 3| 3|                                               |            |
                                           | 1| 1| 2| 0| 9| 7| 0| 2| 2|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |      A     |
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 1| 2|                                               |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Autolysis                            |                                                                          |      1  2.0|
      Compression                          |                                                                          |      5  2.2|
      Degeneration                         |                                                                          |      1  2.0|
      Necrosis                             |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +                                                |  57        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |    1  1                 1                                                |     21  1.2|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  58        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             | 1        2  2  1  1  3  1                                                |     46  1.7|
      Hyperplasia, Macrophage              | 1  1        1     2  2  1                                                |     35  1.5|
      Inflammation, Chronic Active         | 2  1  2  2  2  2  2  3  2                                                |     53  2.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                    4                                                |      7  2.6|
      Alveolus, Proteinosis                | 1  2        2     2  1  1                                                |     25  1.4|
      Interstitium, Infiltration Cellular  |       2                                                                  |      4  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  58        |
      Thrombosis                           |                                                                          |      5  1.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  1.0|
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |      1  2.0|
      Nasopharyngeal Duct, Inflammation    |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        | 1                                                                        |      1  1.0|
      Olfactory Epithelium, Degeneration   |    1                    1                                                |     11  1.0|
      Olfactory Epithelium, Erosion        |                                                                          |      1  2.0|
      Olfactory Epithelium, Inflammation   |                                                                          |      3  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Degeneration |                                                                          |      5  1.0|
      Respiratory Epithelium, Erosion      |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  | 2     1           1                                                      |     17  1.4|
      Respiratory Epithelium, Inflammation |    1                    1                                                |     12  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  58        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7|                                               |            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 9| 3| 3| 3|                                               |            |
                                           | 1| 1| 2| 0| 9| 7| 0| 2| 2|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |      A     |
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 1| 2|                                               |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cornea, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  58        |
      Degeneration, Fatty                  |          2                                                               |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          |    1  1  1  3     1  2  2                                                |     41  1.8|
      Pelvis, Dilatation                   |          2        1                                                      |      2  1.5|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                4                                                         |      8  2.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +                                                |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                         |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|                                         |      A     |
    0.25MGM3                               | 5| 5| 6| 8| 8| 9| 9| 0| 0| 0| 1|                                         |      L     |
    LUNG TOX                               | 3| 5| 3| 0| 9| 1| 2| 3| 4| 9| 9|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     M     +  +           +                                          |   4        |
      Hyperplasia, Lymphoid                |    1           1  1           1                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +     +     +  +           +                                          |   5        |
      Hyperplasia, Lymphoid                |                   1           1                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +     +  +           +                                          |   5        |
      Hyperplasia, Macrophage              |    1           1  1           1                                          |      4  1.0|
      Inflammation, Chronic Active         |    2     1     1              1                                          |      4  1.3|
      Interstitium, Infiltration Cellular  |    2     1     1  1           1                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +     +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                         |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|                                         |      A     |
    0.25MGM3                               | 5| 5| 6| 8| 8| 9| 9| 0| 0| 0| 1|                                         |      L     |
    LUNG TOX                               | 3| 5| 3| 0| 9| 1| 2| 3| 4| 9| 9|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +     +  +           +                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|             
                                           | 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2  1  3  1        1           2  3  2  2  3  1  1  1  4  1  3  1  1  4  2|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                      2                                                   |             
      Degeneration, Cystic                 |                   1                                                  1   |             
      Degeneration, Fatty                  | 1        1                 4                                1            |             
      Eosinophilic Focus                   |          1                                                           1   |             
      Hepatodiaphragmatic Nodule           |       X                    X                                            X|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               | 2        1                    3                       2     3        2   |             
      Centrilobular, Atrophy               |          2                                                               |             
      Hepatocyte, Necrosis                 | 1        2                                                  1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             | 3                                                                        |             
      Acinus, Atrophy                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1                    1  2  2  1           2        2           2  2|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|             
                                           | 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                  3                       2  4        3   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 3                 4     2  3     3  1           1                       1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                          1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          4                                                               |             
      Autolysis                            |                                                 3                        |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |          3                    2     3     2        2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                 4                        |             
      C-Cell, Hyperplasia                  |                         1                                                |             
      Follicular Cell, Hyperplasia         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +     +        +                                      +                  |             
      Hemorrhage                           |                4                                                         |             
      Oral, Inflammation, Granulomatous    |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       2                  |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                   2                                                      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Bilateral, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2                                                         |             
      Inflammation                         |                            3                                             |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|             
                                           | 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |       3  1                    2                       2     3        2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                           1                       2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +|             
      Hyperplasia, Lymphoid                |          2                                                        2      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                      3   |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   3      |             
      Hemorrhage                           |                                                 4                        |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                  2     2                                 |             
      Pigmentation                         |                   3     1           1  2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |                                                 3                        |             
      Fibrosis                             | 2                                                           3            |             
      Hematopoietic Cell Proliferation     |                         3                                                |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1  3        2     2     1        2  3                              |             
      Autolysis                            |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                        2                                 |             
      Duct, Hyperplasia                    |                               4                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         | 4  X                                                                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Hemorrhage                           |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        4                    4     3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|             
                                           | 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                        3                                 |             
      Hemorrhage                           |                3                                                         |             
      Hydrocephalus                        |                                                             1            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
      Meninges, Hemorrhage                 |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |          1                 2     2  1     1           1                 1|             
      Metaplasia, Squamous                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                             X            |             
      Fibrosis                             | 1  1  1  1  1  1  1     1  1  2  3  1  1  2     1  2  2  3  3  2  3  2  2|             
      Hyperplasia, Macrophage              | 2  2  3     1  2     1     1  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2|             
      Inflammation, Chronic Active         | 2  1  2  3  1  1  2     1  1  2  3  2  1  3  2  1  1  2  3  3  2  3  2  3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  1           2                           |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                             3     2      |             
      Alveolus, Proteinosis                | 2  2  3  4  2  2  4     2  1  2  4  2  1  4  1  2  1  3  2  2  2  4  2  4|             
      Interstitium, Infiltration Cellular  |                1                    1        1                          1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Hemorrhage                           |                2                                                         |             
      Thrombosis                           |                            1                                             |             
      Thrombosis, Multiple                 |                                                                          |             
      Nasolacrimal Duct, Hyperplasia       |                                     3                                    |             
      Nasolacrimal Duct, Inflammation      |                         3        1  3     1           2  2  1            |             
      Nasopharyngeal Duct, Hyperplasia     |       1                                                                  |             
      Nasopharyngeal Duct, Inflammation    |       2                                                                  |             
      Olfactory Epithelium, Atrophy        |    2        1                 1                             1            |             
      Olfactory Epithelium, Degeneration   |       1                                   1                 1        1  1|             
      Respiratory Epithelium, Degeneration |                                                    1                     |             
      Respiratory Epithelium, Hyperplasia  |                               2     2           2     3  1  1        2   |             
      Respiratory Epithelium, Inflammation |                                                 2     4     2     1  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                       +                    +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|             
                                           | 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                                 4                        |             
      Phthisis Bulbi                       |                         X                                            X   |             
      Synechia                             |                                                                          |             
      Anterior Chamber, Inflammation       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                 3                        |             
      Nephropathy                          |    1  1  2  1     3           2  2  1  2  1  1  2  1  1  2  3     1  2  2|             
      Pigmentation                         |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Necrosis, Acute        |                            2                                             |             
      Renal Tubule, Pigmentation           |          4                 4                                2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|             
                                           | 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  I  +  I  +  +  +  +  +  I  +  +  +  I  I  +  +     +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Peyer's Patch, Hyperplasia           |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Basophilic Focus                     | 3  2  2  4  2  1  3     1  1  3  1  2  1     2  2  2  3        1  2      |             
      Clear Cell Focus                     |                            1  1                 2                        |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                 1              2         |             
      Degeneration, Fatty                  |                                           4                             2|             
      Eosinophilic Focus                   |                                                       1                  |             
      Hepatodiaphragmatic Nodule           |                         X  X                    X     X                  |             
      Mixed Cell Focus                     |                               2                                          |             
      Bile Duct, Hyperplasia               |                         2                                3        2     4|             
      Centrilobular, Atrophy               |                                                          2               |             
      Hepatocyte, Necrosis                 |                         2                 1              3        2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
      Peridontal Tissue, Inflammation      |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy                       |             2                       2                          2         |             
      Thrombosis                           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|             
                                           | 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 1                       2                             1                  |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 4           1     3                       3           3                 2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                1              1                 2        3              1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +     +  +  M  +|             
      Hyperplasia, Focal                   |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                               X        X              X                  |             
      Hemorrhage                           |                                           2                              |             
      Pars Distalis, Hyperplasia, Diffuse  |    1                                                                     |             
      Pars Distalis, Hyperplasia, Focal    | 4                             4     1     1                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +|             
      Autolysis                            |                                                                          |             
      C-Cell, Hyperplasia                  |    1     4                                         2              1      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Hemorrhage                           |                                                                          |             
      Oral, Inflammation, Granulomatous    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Ectasia                              | 4                       3                                                |             
      Hyperplasia                          | 4           3                                                            |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         | 4                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |                                                 4                        |             
      Congestion                           |                                                                      1   |             
      Cyst                                 |          X                                   X  X  X     X               |             
      Bilateral, Cyst                      | X                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation                         |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|             
                                           | 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Lymphoid                | 2     1  2                 2  2              2  1     2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Pigmentation, Hemosiderin            |                                        2                          3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                           2                              |             
      Hyperplasia, Lymphoid                |    1     2           2                          2     1                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Focal                  |                                           2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |          2                    3        2  3        4                     |             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation                         |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperostosis                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Compression                          |                4                                                  3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|             
                                           | 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Meninges, Hemorrhage                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 1           2           1                             1        2        2|             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Fibrosis                             | 2        1  2  1  2     2  2  2  1  3  3  2  2  1  1  3  2     1  2     3|             
      Hyperplasia, Macrophage              | 1  2  2  1  1  2  2  2  2  2  2  2  2  2  1  1  2  1  2        2         |             
      Inflammation, Chronic Active         | 3  2  1  2  3  2  2  2  2  3  3  1  3  3  2  2  2  2  3  2     2  2     3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          1  2              2  2                    1  2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                                          |             
      Alveolus, Proteinosis                | 3  1  2  3  4  3  4     3  4  2  1  3  4  1  3  3  2  3  2     3  2     1|             
      Interstitium, Infiltration Cellular  | 1           1        1                          1     1        1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                         1                                                |             
      Thrombosis, Multiple                 |                                           X                              |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
      Nasolacrimal Duct, Inflammation      |             1                                                            |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |             
      Nasopharyngeal Duct, Inflammation    |                                                                          |             
      Olfactory Epithelium, Atrophy        |                         1                    2                 2         |             
      Olfactory Epithelium, Degeneration   |             1     1        1        1                                    |             
      Respiratory Epithelium, Degeneration |       1                             1                                    |             
      Respiratory Epithelium, Hyperplasia  |             1           2                             2  3        2      |             
      Respiratory Epithelium, Inflammation |             1           2     1                    1     3        2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +                                                  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|             
                                           | 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5MG/M3                               | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |    3                                                                     |             
      Hemorrhage                           |                                                                          |             
      Phthisis Bulbi                       | X                                                                        |             
      Synechia                             |    4                                                     2               |             
      Anterior Chamber, Inflammation       |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Autolysis                            |                                           3                              |             
      Nephropathy                          |       1  1  2  2  3     3  2  1  1  3  2     2  4  2  1        3  2      |             
      Pigmentation                         |                         3                                                |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Necrosis, Acute        |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                   3     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 3| 5| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3|                                            |            |
                                           | 1| 7| 9| 9| 2| 0| 8| 9| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  I  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia           |                            3                                             |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Basophilic Focus                     | 3     4     3     1     1  1                                             |     45  2.0|
      Clear Cell Focus                     |          2                                                               |      4  1.5|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      4  1.3|
      Degeneration, Fatty                  |                   4                                                      |      7  2.4|
      Eosinophilic Focus                   |                                                                          |      3  1.0|
      Hepatodiaphragmatic Nodule           |                         X                                                |      8     |
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    2              2                                                      |     12  2.3|
      Centrilobular, Atrophy               |                                                                          |      2  2.0|
      Hepatocyte, Necrosis                 |    1                                                                     |      8  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Necrosis                             |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                   4                                                      |      1  4.0|
      Ulcer                                |                   4                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       |    2                                                                     |     13  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 3| 5| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3|                                            |            |
                                           | 1| 7| 9| 9| 2| 0| 8| 9| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Hyperplasia                          |             1                                                            |      8  2.1|
      Necrosis                             |                   2                                                      |      1  2.0|
      Vacuolization Cytoplasmic            |                   3     2                                                |     16  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                      4                                                   |      8  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                         1                                                |      2  2.5|
      Autolysis                            |                                                                          |      1  3.0|
      Cyst                                 |             X                                                            |      4     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |       3  2              2  4                                             |     13  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
      C-Cell, Hyperplasia                  |    1              2     3                                                |      8  1.9|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   5        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Oral, Inflammation, Granulomatous    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      3  3.0|
      Hyperplasia                          |                            2                                             |      3  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 3| 5| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3|                                            |            |
                                           | 1| 7| 9| 9| 2| 0| 8| 9| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      5     |
      Bilateral, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia             |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Necrosis                             |                   3                                                      |      1  3.0|
      Myeloid Cell, Hyperplasia            |    2  2                                                                  |      9  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +                                             |  54        |
      Hyperplasia, Lymphoid                | 2           2                                                            |     12  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Hyperplasia, Plasma Cell             |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Lymphoid                |                            1                                             |      1  1.0|
      Hyperplasia, Macrophage              |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  M                                             |  52        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      7  1.7|
      Pigmentation                         |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  2.0|
      Autolysis                            |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      3  2.7|
      Hematopoietic Cell Proliferation     |       3     1                                                            |      3  2.3|
      Inflammation, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  I  +  +  +  +                                             |  57        |
      Atrophy                              |                   3                                                      |     13  2.4|
      Autolysis                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 3| 5| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3|                                            |            |
                                           | 1| 7| 9| 9| 2| 0| 8| 9| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Duct, Ectasia                        |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperostosis                         |                                                                          |      3  3.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Compression                          |                                                                          |      5  3.6|
      Degeneration                         |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  1.0|
      Necrosis                             |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Meninges, Hemorrhage                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |          2  1                                                            |      2  1.5|
      Inflammation                         |       2  1                                                               |     15  1.4|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst, Squamous                       |       X                                                                  |      2     |
      Fibrosis                             | 2  3  3  3  2     1  1  2  2                                             |     52  1.8|
      Hyperplasia, Macrophage              |    2  2  2  3  2  2  2  2                                                |     50  1.8|
      Inflammation, Chronic Active         | 3  3  3  3  3  2  1  2  3  2                                             |     57  2.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             2              2                                             |     10  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Squamous                        |    1  1                                                                  |      4  1.8|
      Alveolus, Proteinosis                | 3     1  2  3  1     2  2  3                                             |     54  2.4|
      Interstitium, Infiltration Cellular  |       1                                                                  |     11  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 3| 5| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3|                                            |            |
                                           | 1| 7| 9| 9| 2| 0| 8| 9| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Thrombosis                           |                   1                                                      |      3  1.0|
      Thrombosis, Multiple                 |                                                                          |      1     |
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      8  1.8|
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |      1  1.0|
      Nasopharyngeal Duct, Inflammation    |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy        | 2                                                                        |      8  1.5|
      Olfactory Epithelium, Degeneration   |                   1  1     1                                             |     12  1.0|
      Respiratory Epithelium, Degeneration |          1                                                               |      4  1.0|
      Respiratory Epithelium, Hyperplasia  | 1     1  1  1           2                                                |     17  1.7|
      Respiratory Epithelium, Inflammation |       1                 2                                                |     13  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
      Cataract                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Phthisis Bulbi                       |                                                                          |      3     |
      Synechia                             |                                                                          |      2  3.0|
      Anterior Chamber, Inflammation       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.0|
      Nephropathy                          | 2     1  3  1     2  1  1  2                                             |     44  1.8|
      Pigmentation                         |                                                                          |      1  3.0|
      Renal Tubule, Degeneration           |    2                                                                     |      1  2.0|
      Renal Tubule, Necrosis, Acute        |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |    3                                                                     |      6  2.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 9| 0| 1| 2| 3| 4| 4| 5| 5| 6|                                            |      L     |
    LUNG TOX                               | 3| 1| 3| 1| 7| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +     +  +        +                                             |   5        |
      Hyperplasia, Lymphoid                |          1     1  1        2                                             |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +  +     +  +        +                                             |   5        |
      Hyperplasia, Lymphoid                |       1  1                                                               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +     +  +        +                                             |   5        |
      Hyperplasia, Macrophage              |       2  2     2  2        2                                             |      5  2.0|
      Inflammation, Chronic Active         |       2  2     2  2        2                                             |      5  2.0|
      Alveolus, Proteinosis                |                1           1                                             |      2  1.0|
      Interstitium, Infiltration Cellular  |          1        1        1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +     +  +        +                                             |   5        |
      Olfactory Epithelium, Atrophy        |                            1                                             |      1  1.0|
      Respiratory Epithelium, Inflammation |       1           1        1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    0.5MG/M3                               | 9| 0| 1| 2| 3| 4| 4| 5| 5| 6|                                            |      L     |
    LUNG TOX                               | 3| 1| 3| 1| 7| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
      Cataract                             |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +  +        +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|             
                                           | 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1        3                                2                    2      |             
      Basophilic Focus                     | 2  1     1        1  1           1  2     1  3        1  1     3  2     2|             
      Clear Cell Focus                     |          1                                                               |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 | 1                             1        2                       2  1  2  2|             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                                                             1  2         |             
      Hepatodiaphragmatic Nodule           |                            X                       X                     |             
      Infarct                              |                                                                          |             
      Mixed Cell Focus                     |                                                          1               |             
      Thrombosis                           |       X                                                              X   |             
      Bile Duct, Hyperplasia               |    3  1     4     1  1     1  2  1  2  4     2     4     1  4  3  3  2   |             
      Centrilobular, Atrophy               |       3                                            2        1            |             
      Hepatocyte, Hyperplasia              |                                                                1         |             
      Hepatocyte, Necrosis                 |    1        1              1        2  3           1        2        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                  +           +        +                  |             
      Hyperplasia, Squamous                |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Infarct                              |                                                                          |             
      Acinus, Atrophy                      |       2  4                                2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |          4     2                                      3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|             
                                           | 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +     +                 +     +                                 |             
      Peridontal Tissue, Inflammation      |          2     2                 1     2                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  1     2     2        3  2  4  3  1        2     2     2        2|             
      Thrombosis                           |                                        X                             X   |             
      Epicardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                       1                  |             
      Hypertrophy                          |                                                             3            |             
      Vacuolization Cytoplasmic            |    2           3              2                       2           1  2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 4           4        2           3  4              1  4     4        2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                       2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Hemorrhage                           |       4                                                                  |             
      Pars Distalis, Hyperplasia, Focal    |    2                                4  2        1              4     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  2  2                 3                  |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Polyarteritis           |                                                                          |             
      Oral, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                   +                                                      |             
      Inflammation                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                             +            |             
      Inflammation                         |                                                             1            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|             
                                           | 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |             4                                                  2         |             
      Infiltration Cellular                |                                                                          |             
      Inflammation                         |                                                          3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              4                          3|             
      Cyst                                 |                                  X                                       |             
      Interstitial Cell, Hyperplasia, Focal|                   1  1        1  1     1  2           1  1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Atrophy                              |                                        2                                 |             
      Erythroid Cell, Hyperplasia          |                                           2                              |             
      Myeloid Cell, Hyperplasia            | 3  2                       3  2  2  4     2  2     2           2  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +  +           +  +                    +        +     +      |             
      Renal, Inflammation                  |                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Autolysis                            |       2                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Autolysis                            |       2                                                                  |             
      Congestion                           |                                                                          |             
      Fibrosis                             | 2                    2           2                 3        2           3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  I  +|             
      Atrophy                              |       3  2     3  2              2     4                                2|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|             
                                           | 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation                         |                                                    4     2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          X                                                               |             
      Hyperostosis                         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   3                                                      |             
      Hemorrhage                           |       2        2                                      4                  |             
      Ventricle, Hydrocephalus             | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2        1                             1                           |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                1                                                         |             
      Hyperplasia, Macrophage              |                                                    1     1     1         |             
      Inflammation, Chronic Active         |                   1        1           1  1              1              1|             
      Metaplasia, Osseous                  |    1                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 3                                                                        |             
      Interstitium, Infiltration Cellular  | 1        1                                1              1              1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multiple                 |                                        X           X                 X   |             
      Nasolacrimal Duct, Inflammation      |                               1     1                                    |             
      Nasopharyngeal Duct, Inflammation    |                                                       1                  |             
      Olfactory Epithelium, Degeneration   | 1  1     1  1  1  1  1     1  1     1     1     1     1  1  1  1        1|             
      Respiratory Epithelium, Degeneration |                1                                                         |             
      Respiratory Epithelium, Hyperplasia  |                2     1        1           1           3  1     1  1      |             
      Respiratory Epithelium, Inflammation |                1           2  1  1                 1  2                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            1                       1                     |             
      Vomeronasal Organ, Inflammation      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|             
                                           | 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retinal Detachment                   |                                                                          |             
      Synechia                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                          X            |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 4  2  1  4  3  2  1  3  1  1  3  4  4  3     4  2  3  1  1  2  4  4  2  4|             
      Renal Tubule, Pigmentation           |                   1        2        3  2                                 |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                 X                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|             
                                           | 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |       3                                      3                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                           3      |             
      Basophilic Focus                     | 1     1        1        1  2     3        1  1  1  1  1  1  2  1     2  1|             
      Clear Cell Focus                     |                1                                                         |             
      Congestion                           |                1  2                                                      |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |             1                             1  1                           |             
      Degeneration, Fatty                  |          1                          2  1     1                    1      |             
      Eosinophilic Focus                   |                1                                         1               |             
      Hepatodiaphragmatic Nodule           |       X                                               X                  |             
      Infarct                              |                                                                   3      |             
      Mixed Cell Focus                     |                                                                      1   |             
      Thrombosis                           |                                                                   X      |             
      Bile Duct, Hyperplasia               |    1     3  3        3  3        2  2  2  2  1     2           1  3      |             
      Centrilobular, Atrophy               |                            2                                             |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |          1  1        1              3  1     1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                       +      |             
      Fat, Necrosis                        |                                                                   4      |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Infarct                              |                                     2                                    |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|             
                                           | 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                     1                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +     +                    +     +|             
      Peridontal Tissue, Inflammation      |                                        3     2                    3     2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2  2  1  2           2     2        3        2        3     2     3|             
      Thrombosis                           |          X  X                       X  X                          X      |             
      Epicardium, Inflammation             |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                            2     1                                       |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |    3                                   2                          4  1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    2     1     4        4  2     1  2  4  1     1  2     1  2     2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                    2                           |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    3     1  2           3  4           3     2     3  2           1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                    2     4               |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                       +                        |             
      Mediastinum, Polyarteritis           |                         X                                                |             
      Oral, Inflammation                   |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|             
                                           | 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                         1                          4                     |             
      Hyperplasia                          |                                                    3                     |             
      Infiltration Cellular                |                                     2                                    |             
      Inflammation                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2        2               |             
      Ectasia                              |                                                                         3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                       2  2                          4            |             
      Cyst                                 |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|             1        2                       1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |             1                                                            |             
      Atrophy                              |                                                                          |             
      Erythroid Cell, Hyperplasia          |                                     3                                    |             
      Myeloid Cell, Hyperplasia            |          4  1  2                             2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +  +                                 |             
      Renal, Inflammation                  |                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                                3           4            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                               1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |       2        2                                                         |             
      Hyperplasia, Macrophage              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |                                                                          |             
      Congestion                           |       2        2  3                       2              2               |             
      Fibrosis                             |          3  3  2        2                                2  3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |          1                    2     4           3  3              3  2   |             
      Congestion                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|             
                                           | 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  M  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       2                                                                 4|             
      Hemorrhage                           |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  1  1                                2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Fibrosis                             |                1                 1                                1      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                         1                          3                     |             
      Inflammation, Chronic Active         |       1  2     1           1     1                          1            |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             1            |             
      Interstitium, Infiltration Cellular  |       1        1                                      1     1  2  1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multiple                 |                      X              X  X                          X      |             
      Nasolacrimal Duct, Inflammation      |       2                                      1                           |             
      Nasopharyngeal Duct, Inflammation    |                                                          3               |             
      Olfactory Epithelium, Degeneration   | 1  1  1     1        1           1        1  1  1  1  1  1     1     1  1|             
      Respiratory Epithelium, Degeneration |                                           1                              |             
      Respiratory Epithelium, Hyperplasia  |    1  2        1                          1     1  1     2  1            |             
      Respiratory Epithelium, Inflammation |    1  2                                         1  1     2  1            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Vomeronasal Organ, Inflammation      |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|             
                                           | 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                      3   |             
      Retinal Detachment                   |                                                                      4   |             
      Synechia                             |                                                                      4   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                   2      |             
      Nephropathy                          | 1  1  4  4  1  3     1  4  3     4  1  1  4  2  3  2  1  4  3  3  3  2  4|             
      Renal Tubule, Pigmentation           |             2        1                       2                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                   +                                                      |             
      Calculus Micro Observation Only      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 4| 7| 6| 5|                                               |            |
                             DAY ON TEST   | 2| 9| 0| 0| 7| 5| 3| 1| 3|                                               |            |
                                           | 2| 3| 3| 5| 9| 8| 6| 0| 9|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      A     |
    0.0MG/M3                               | 5| 6| 6| 6| 6| 6| 6| 6| 6|                                               |      L     |
                                           | 9| 0| 1| 3| 5| 6| 7| 8| 9|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  59        |
      Parasite Metazoan                    |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  59        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  59        |
      Peyer's Patch, Hyperplasia           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
      Angiectasis                          |                                                                          |      6  2.0|
      Basophilic Focus                     |    1        3     3  3                                                   |     34  1.6|
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Congestion                           |                                                                          |      2  1.5|
      Cyst                                 |    X                                                                     |      1     |
      Degeneration, Cystic                 |          1                                                               |     11  1.4|
      Degeneration, Fatty                  |                      2                                                   |      6  1.3|
      Eosinophilic Focus                   |       X                                                                  |      5  1.3|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      5     |
      Infarct                              |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      2  1.0|
      Thrombosis                           |    X                                                                     |      4     |
      Bile Duct, Hyperplasia               |    4  4  1  2     1     3                                                |     36  2.3|
      Centrilobular, Atrophy               |       2                 2                                                |      6  2.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  1.0|
      Hepatocyte, Necrosis                 |    1  2                                                                  |     16  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   3        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  58        |
      Cytoplasmic Alteration               |             2                                                            |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Acinus, Atrophy                      |          2     3  3                                                      |      6  2.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Hyperplasia, Squamous                |                      4                                                   |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 4| 7| 6| 5|                                               |            |
                             DAY ON TEST   | 2| 9| 0| 0| 7| 5| 3| 1| 3|                                               |            |
                                           | 2| 3| 3| 5| 9| 8| 6| 0| 9|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      A     |
    0.0MG/M3                               | 5| 6| 6| 6| 6| 6| 6| 6| 6|                                               |      L     |
                                           | 9| 0| 1| 3| 5| 6| 7| 8| 9|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                      4                                                   |      1  4.0|
      Perforation                          |                      X                                                   |      1     |
      Ulcer                                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  59        |
      Erosion                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   9        |
      Peridontal Tissue, Inflammation      | 1                                                                        |      9  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
      Cardiomyopathy                       | 3     3  2  3        3                                                   |     31  2.2|
      Thrombosis                           |       X                                                                  |      8     |
      Epicardium, Inflammation             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |                      3                                                   |      1  3.0|
      Hyperplasia                          |                                                                          |      3  1.3|
      Hypertrophy                          |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |       2                                                                  |     11  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Cyst                                 |                      X                                                   |      1     |
      Hyperplasia                          |    2  1     2     2                                                      |     28  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  57        |
      Hyperplasia                          |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +                                                |  54        |
      Hyperplasia                          |    2                                                                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Angiectasis                          |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     16  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  58        |
      C-Cell, Hyperplasia                  |                                                                          |      5  2.6|
      Follicular Cell, Hyperplasia, Cystic |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +        +                                                            |   4        |
      Mediastinum, Polyarteritis           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 4| 7| 6| 5|                                               |            |
                             DAY ON TEST   | 2| 9| 0| 0| 7| 5| 3| 1| 3|                                               |            |
                                           | 2| 3| 3| 5| 9| 8| 6| 0| 9|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      A     |
    0.0MG/M3                               | 5| 6| 6| 6| 6| 6| 6| 6| 6|                                               |      L     |
                                           | 9| 0| 1| 3| 5| 6| 7| 8| 9|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
      Oral, Inflammation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      3  3.0|
      Infiltration Cellular                |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  59        |
      Inflammation                         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |                                                                          |      2  2.0|
      Ectasia                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |                   4                                                      |      7  3.1|
      Cyst                                 |                                                                          |      1     |
      Interstitial Cell, Hyperplasia, Focal|                                                                          |     11  1.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
      Atrophy                              |                                                                          |      1  2.0|
      Erythroid Cell, Hyperplasia          |                                                                          |      2  2.5|
      Myeloid Cell, Hyperplasia            |    3  2                                                                  |     17  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |  11        |
      Renal, Inflammation                  |                      2                                                   |      1  2.0|
      Renal, Pigmentation, Hemosiderin     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +                                                |  56        |
      Inflammation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +                                                |  55        |
      Hyperplasia, Lymphoid                | 2           4                                                            |      5  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +                                                |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 4| 7| 6| 5|                                               |            |
                             DAY ON TEST   | 2| 9| 0| 0| 7| 5| 3| 1| 3|                                               |            |
                                           | 2| 3| 3| 5| 9| 8| 6| 0| 9|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      A     |
    0.0MG/M3                               | 5| 6| 6| 6| 6| 6| 6| 6| 6|                                               |      L     |
                                           | 9| 0| 1| 3| 5| 6| 7| 8| 9|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |          3                                                               |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +                                                |  56        |
      Autolysis                            |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |          2                                                               |      3  2.0|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |                                                                          |      1  3.0|
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      5  2.2|
      Fibrosis                             |    3                                                                     |     13  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +                                                |  54        |
      Atrophy                              |       3           4                                                      |     16  2.7|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  I  +  +  +  +  +                                                |  58        |
      Angiectasis                          |       3                                                                  |      1  3.0|
      Inflammation                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
      Hyperostosis                         |                         4                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
      Compression                          |          3  2                                                            |      5  2.8|
      Hemorrhage                           |                                                                          |      3  2.7|
      Ventricle, Hydrocephalus             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Inflammation                         |          2              1                                                |      8  1.4|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Congestion                           |                      1                                                   |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 4| 7| 6| 5|                                               |            |
                             DAY ON TEST   | 2| 9| 0| 0| 7| 5| 3| 1| 3|                                               |            |
                                           | 2| 3| 3| 5| 9| 8| 6| 0| 9|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      A     |
    0.0MG/M3                               | 5| 6| 6| 6| 6| 6| 6| 6| 6|                                               |      L     |
                                           | 9| 0| 1| 3| 5| 6| 7| 8| 9|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      3  1.0|
      Hemorrhage                           |          2                                                               |      2  1.5|
      Hyperplasia, Macrophage              |          1        1                                                      |      7  1.3|
      Inflammation, Chronic Active         |    2              1                                                      |     14  1.1|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   2                                                      |      3  2.0|
      Interstitium, Infiltration Cellular  |                   1                                                      |     12  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Thrombosis, Multiple                 |                         X                                                |      8     |
      Nasolacrimal Duct, Inflammation      |                                                                          |      4  1.3|
      Nasopharyngeal Duct, Inflammation    |                                                                          |      2  2.0|
      Olfactory Epithelium, Degeneration   | 1  1  1     1  1     1  1                                                |     39  1.0|
      Respiratory Epithelium, Degeneration |                                                                          |      2  1.0|
      Respiratory Epithelium, Hyperplasia  |       1                 1                                                |     18  1.3|
      Respiratory Epithelium, Inflammation |       1                 1                                                |     14  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
      Vomeronasal Organ, Inflammation      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retinal Detachment                   |                                                                          |      1  4.0|
      Synechia                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Cyst                                 |                                                                          |      2     |
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          | 3  4  3  1  3  2  1  4                                                   |     55  2.6|
      Renal Tubule, Pigmentation           |                                                                          |      7  1.9|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Calculus Micro Observation Only      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Calculus Micro Observation Only      |                                                                          |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                         |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                         |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                         |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |      A     |
    0.0MG/M3                               | 0| 2| 2| 2| 3| 3| 3| 4| 6| 6| 7|                                         |      L     |
    LUNG TOX                               | 5| 2| 6| 9| 1| 4| 8| 8| 2| 4| 0|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +        +  +        +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M        +  M        +  +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +        +  +                                                |   5        |
      Interstitium, Infiltration Cellular  | 1           1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +        +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +        +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|             
                                           | 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.12                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
      Peyer's Patch, Hyperplasia           | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2           3                 4                 2  3         |             
      Autolysis                            |                                                    4                     |             
      Basophilic Focus                     | 3              2  1  1     2  1  1  2     3  2           1  3  1  2  2  1|             
      Clear Cell Focus                     | 1                 1        1                 1                           |             
      Degeneration, Cystic                 | 2                 1     1  1                    1     1        2         |             
      Degeneration, Fatty                  |    2     2                                                               |             
      Eosinophilic Focus                   |                   1  1        2                                3         |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Mixed Cell Focus                     |                         1  1                                             |             
      Thrombosis                           |                                                                      X   |             
      Bile Duct, Hyperplasia               |    4     4  2  1        2     3  4        2  2              2  4         |             
      Centrilobular, Atrophy               |                               2  3                                       |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |    2     2                                         2  1     1        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|             
                                           | 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.12                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                    3                     |             
      Inflammation                         |          1                                                               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Peridontal Tissue, Inflammation      |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3           2  1     2  1  3  1  1        3  3  2  2  1     3        2  3|             
      Inflammation                         |                                                                          |             
      Thrombosis                           |    X     X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                      2                                                   |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |    2     2           2                    2  2     3                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2                 2     4        1  2     3                             2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             4        3   |             
      Pars Distalis, Hyperplasia, Diffuse  |                               1                                          |             
      Pars Distalis, Hyperplasia, Focal    | 1        2        2  2           2  3     2           4        1         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      C-Cell, Hyperplasia                  |             1        2                                2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                        +                                 |             
      Inflammation                         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                              2                 1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|             
                                           | 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.12                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                            3     3        4                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2        3                                                   |             
      Hyperplasia, Cystic                  |                            2                                             |             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  4           2                           |             
      Cyst                                 |                                                                         X|             
      Interstitial Cell, Hyperplasia, Focal|          3           1                 2     2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |             3           2        4  3     3           2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
      Inguinal, Inflammation, Granulomatous|                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Autolysis                            |                                                    2                     |             
      Congestion                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2                                      4            |             
      Hyperplasia, Plasma Cell             |                4                                   3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                 2                    4   |             
      Hyperplasia, Lymphoid                | 1                 1                                         2            |             
      Hyperplasia, Plasma Cell             |                2                                                         |             
      Pigmentation, Hemosiderin            |                               4                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                3                                                         |             
      Autolysis                            |                                                    4                     |             
      Congestion                           |       2                    2                                             |             
      Fibrosis                             |          2  3  3           2  1                             2  3        3|             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|             
                                           | 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.12                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    3           3     3  3     3           3  4  2                        |             
      Autolysis                            |                                                                      4   |             
      Congestion                           |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                      X     X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                3     1                 4                    4            |             
      Degeneration                         |                                                 1                        |             
      Hemorrhage                           |    2                                                                     |             
      Hydrocephalus                        |                                        1                                 |             
      Infarct                              |    4                                                                     |             
      Infiltration Cellular, Histiocyte    |       3                                                                  |             
      Necrosis                             |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1     1                       2     2                       1         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Congestion                           |       3                                                                  |             
      Emphysema                            | 1                                                                        |             
      Fibrosis                             |                                           1                              |             
      Hemorrhage                           |    1  2  2                             1  2                              |             
      Hyperplasia, Macrophage              |                            1              1                 1            |             
      Inflammation, Chronic Active         |    1        1     1                       1                          1   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       3                  |             
      Interstitium, Infiltration Cellular  |                            1                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |    1     1                                                     1         |             
      Thrombosis, Multiple                 |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                      1                                      2           3|             
      Nasopharyngeal Duct, Hyperplasia,    |                                                                          |             
           Lymphoid                        | 3                                                                        |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|             
                                           | 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.12                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasopharyngeal Duct, Inflammation    | 2           1                                               1            |             
      Olfactory Epithelium, Degeneration   |                   1        1     1           1  1                        |             
      Olfactory Epithelium, Necrosis       |          1                                                               |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             1  1           2              1  1                          2|             
      Respiratory Epithelium, Inflammation |                            2                                1           1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            1                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
      Infarct                              |          2                                                               |             
      Inflammation                         |                                                                          |             
      Nephropathy                          | 4  1     1  4  2  3  2  2  3  2  3  1  2  4  4  4     2  1  3  4  1  4  3|             
      Renal Tubule, Pigmentation           |    2     4              3     2                                      3   |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                                                                  |             
      Calculus Micro Observation Only      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
      Calculus Micro Observation Only      |                                                          X        X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|             
                             DAY ON TEST   | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|             
                                           | 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |    X                                   X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2  2                                                            |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     |       1        1  2     2              2  4  1  2  1  3  3        1      |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |       2                                         1     1     2        2   |             
      Degeneration, Fatty                  |          2  2  4                                                         |             
      Eosinophilic Focus                   |                   1                                         2            |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  2  3  3     1     4  4  2  3  2  2              2     4        3  1|             
      Centrilobular, Atrophy               |       2                                                                  |             
      Hepatocyte, Hyperplasia              |                                  3                                       |             
      Hepatocyte, Necrosis                 | 2           2           2     2  2  1  1                    3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                                    |             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                  +                                       |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Acinus, Atrophy                      |                                  2        4                          3   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Ulcer                                |                4                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|             
                             DAY ON TEST   | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|             
                                           | 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Inflammation                         |             3                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                             +                  |             
      Peridontal Tissue, Inflammation      |                         2                             1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2           2     3  2  1     2  2     2     3  2  3     2  2   |             
      Inflammation                         |                                                                          |             
      Thrombosis                           |    X                                                        X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                              X                           |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia                          |                   3        1     4  2        2                    1      |             
      Vacuolization Cytoplasmic            |       2                                               3              2  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        4                                 |             
      Hyperplasia                          |    2     1                 3  3  3  1     2           2  2  3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1           2                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                   4        3  3   |             
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    4  2                                                           4  1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      C-Cell, Hyperplasia                  |                            1           1  1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +        +                                                         |             
      Inflammation                         |       3        2                                                         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1     2                                                |             
      Ectasia                              |                            2                                         2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|             
                             DAY ON TEST   | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|             
                                           | 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                            2           2                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       4        4                    4              1                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|          1                                               1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            | 3     3           1                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +           +  +  +                                      +   |             
      Inguinal, Inflammation, Granulomatous|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  M  I  +  +  +  M  +  +|             
      Autolysis                            |                      2                                                   |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4                                                   |             
      Atrophy                              |                                                             3            |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             | 2                                2  2     3     1     1     3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                         2                                                |             
      Pigmentation, Hemosiderin            |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|             
                             DAY ON TEST   | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|             
                                           | 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                         2                       2           2  2         |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                2                                                         |             
      Degeneration                         |          1                                                               |             
      Hemorrhage                           |                                  4                                       |             
      Hydrocephalus                        |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation                         | 1                       1  2                          1                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                      3                                         2         |             
      Emphysema                            |                                                                          |             
      Fibrosis                             |                1           2     1                                      1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                   1                                      1  2           1|             
      Inflammation, Chronic Active         |          1  2  1           2                 1              1            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    3                                                                     |             
      Interstitium, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Thrombosis                           |                                     1                       1            |             
      Thrombosis, Multiple                 |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                           2                              |             
      Nasopharyngeal Duct, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                                          |             
      Nasopharyngeal Duct, Hyperplasia     |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|             
                             DAY ON TEST   | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|             
                                           | 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.12                                   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasopharyngeal Duct, Inflammation    |                            3                                             |             
      Olfactory Epithelium, Degeneration   |    1        1     1                       1  1     1  1  1        1  1   |             
      Olfactory Epithelium, Necrosis       |                                                                          |             
      Respiratory Epithelium, Degeneration |                                              1                           |             
      Respiratory Epithelium, Hyperplasia  |          2  3     2                       1           1  1        3      |             
      Respiratory Epithelium, Inflammation |          1  2     2              1                 1     2        3      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                          3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Nephropathy                          | 3  2     3  2  4  2  4  3  3  1  2  1  2  2  2  1  2  4     4     2     3|             
      Renal Tubule, Pigmentation           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                +     +   |             
      Calculus Micro Observation Only      |                                                                X     X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Calculus Micro Observation Only      |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 5| 6| 5|                                                  |            |
                             DAY ON TEST   | 8| 5| 3| 3| 3| 6| 8| 6|                                                  |            |
                                           | 2| 8| 3| 6| 6| 6| 3| 6|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 0| 0| 0| 0| 0| 0| 0| 1|                                                  |      L     |
    MG/M3                                  | 2| 3| 4| 5| 6| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  57        |
      Autolysis                            |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  I                                                   |  55        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Angiectasis                          | 2     2  3           2                                                   |     11  2.5|
      Autolysis                            |                                                                          |      1  4.0|
      Basophilic Focus                     |       3  3  3     1                                                      |     32  1.9|
      Clear Cell Focus                     |             2                                                            |      5  1.2|
      Degeneration, Cystic                 |    1                                                                     |     13  1.4|
      Degeneration, Fatty                  |                                                                          |      5  2.4|
      Eosinophilic Focus                   |          4                                                               |      7  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Mixed Cell Focus                     |             1                                                            |      3  1.0|
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2     3  3     3  4  3                                                   |     33  2.7|
      Centrilobular, Atrophy               |                2                                                         |      4  2.3|
      Hepatocyte, Hyperplasia              |          4                                                               |      2  3.5|
      Hepatocyte, Necrosis                 | 2        1        3  1                                                   |     18  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   4        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +                                                                        |   2        |
      Hyperplasia, Squamous                | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  57        |
      Acinus, Atrophy                      |       2  2           2                                                   |      6  2.5|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 5| 6| 5|                                                  |            |
                             DAY ON TEST   | 8| 5| 3| 3| 3| 6| 8| 6|                                                  |            |
                                           | 2| 8| 3| 6| 6| 6| 3| 6|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 0| 0| 0| 0| 0| 0| 0| 1|                                                  |      L     |
    MG/M3                                  | 2| 3| 4| 5| 6| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Diverticulum                         |             3                                                            |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Peridontal Tissue, Inflammation      |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Cardiomyopathy                       |       3  2                                                               |     31  2.1|
      Inflammation                         | 2                                                                        |      1  2.0|
      Thrombosis                           | X                                                                        |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |          1  3                                                            |      3  2.0|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hyperplasia                          |       1                                                                  |      7  2.0|
      Vacuolization Cytoplasmic            |                                                                          |     10  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |       1           4  3                                                   |     20  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  56        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +                                                   |  54        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  56        |
      Angiectasis                          |       3                                                                  |      7  3.3|
      Pars Distalis, Hyperplasia, Diffuse  |          2                                                               |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    | 2  1  2                                                                  |     16  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |             1                                                            |      7  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 5| 6| 5|                                                  |            |
                             DAY ON TEST   | 8| 5| 3| 3| 3| 6| 8| 6|                                                  |            |
                                           | 2| 8| 3| 6| 6| 6| 3| 6|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 0| 0| 0| 0| 0| 0| 0| 1|                                                  |      L     |
    MG/M3                                  | 2| 3| 4| 5| 6| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   3        |
      Inflammation                         |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |                                                                          |      2  1.5|
      Ectasia                              | 4                                                                        |      5  2.2|
      Inflammation                         |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +                                                   |  57        |
      Inflammation                         |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |                                                                          |      3  2.3|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |          4                                                               |      3  3.3|
      Cyst                                 |                                                                          |      1     |
      Interstitial Cell, Hyperplasia, Focal|                1                                                         |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  57        |
      Atrophy                              |                                                                          |      1  3.0|
      Erythroid Cell, Hyperplasia          | 2                                                                        |      1  2.0|
      Myeloid Cell, Hyperplasia            |       3  4                                                               |     11  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +  +                                                   |  14        |
      Inguinal, Inflammation, Granulomatous|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  I  +  +  +                                                   |  54        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia, Lymphoid                | 2                                                                        |      3  2.7|
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            | 3                                                                        |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +                                                   |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 5| 6| 5|                                                  |            |
                             DAY ON TEST   | 8| 5| 3| 3| 3| 6| 8| 6|                                                  |            |
                                           | 2| 8| 3| 6| 6| 6| 3| 6|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 0| 0| 0| 0| 0| 0| 0| 1|                                                  |      L     |
    MG/M3                                  | 2| 3| 4| 5| 6| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Autolysis                            | 3                                                                        |      2  2.5|
      Congestion                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.3|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Angiectasis                          |          4                                                               |      2  4.0|
      Atrophy                              |                                                                          |      2  3.0|
      Autolysis                            |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      2  2.0|
      Fibrosis                             |          2                                                               |     16  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +                                                   |  53        |
      Atrophy                              | 2                                                                        |     13  2.6|
      Autolysis                            |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  M                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperostosis                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Compression                          |                                                                          |      5  2.8|
      Degeneration                         |                                                                          |      2  1.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 5| 6| 5|                                                  |            |
                             DAY ON TEST   | 8| 5| 3| 3| 3| 6| 8| 6|                                                  |            |
                                           | 2| 8| 3| 6| 6| 6| 3| 6|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 0| 0| 0| 0| 0| 0| 0| 1|                                                  |      L     |
    MG/M3                                  | 2| 3| 4| 5| 6| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Inflammation                         |                                                                          |      9  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      3  2.7|
      Emphysema                            |                                                                          |      1  1.0|
      Fibrosis                             |       1                                                                  |      6  1.2|
      Hemorrhage                           |                                                                          |      5  1.6|
      Hyperplasia, Macrophage              |       2     1                                                            |      9  1.2|
      Inflammation, Chronic Active         |       1                                                                  |     12  1.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
      Interstitium, Infiltration Cellular  |             1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Thrombosis                           |                1                                                         |      6  1.0|
      Thrombosis, Multiple                 | X                                                                        |      1     |
      Nasolacrimal Duct, Inflammation      |                                                                          |      4  2.0|
      Nasopharyngeal Duct, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  3.0|
      Nasopharyngeal Duct, Hyperplasia     |          1                                                               |      2  1.5|
      Nasopharyngeal Duct, Inflammation    |                                                                          |      4  1.8|
      Olfactory Epithelium, Degeneration   |    1  1  1        1                                                      |     19  1.0|
      Olfactory Epithelium, Necrosis       |                                                                          |      1  1.0|
      Respiratory Epithelium, Degeneration |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |       1  2  2                                                            |     16  1.6|
      Respiratory Epithelium, Inflammation |       2     1        2                                                   |     13  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Cyst                                 |                                                                          |      1     |
      Infarct                              |                   2                                                      |      2  2.0|
      Inflammation                         | 2                                                                        |      1  2.0|
      Nephropathy                          |    1  3  2  4     4  4                                                   |     50  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 5| 6| 5|                                                  |            |
                             DAY ON TEST   | 8| 5| 3| 3| 3| 6| 8| 6|                                                  |            |
                                           | 2| 8| 3| 6| 6| 6| 3| 6|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |      A     |
    0.12                                   | 0| 0| 0| 0| 0| 0| 0| 1|                                                  |      L     |
    MG/M3                                  | 2| 3| 4| 5| 6| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Pigmentation           |                4                                                         |      7  3.1|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
      Calculus Micro Observation Only      |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Calculus Micro Observation Only      |    X                                                                     |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|                                      |      A     |
    0.12MGM3                               | 4| 6| 6| 6| 7| 7| 7| 8| 9| 9| 0| 0|                                      |      L     |
    LUNG TOX                               | 3| 2| 3| 8| 0| 8| 9| 0| 2| 9| 0| 7|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +           +        +  +                                          |   5        |
      Hyperplasia, Lymphoid                | 2     2           2        1  1                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +           +        +  +                                          |   5        |
      Hyperplasia, Lymphoid                | 1     1           2        2                                             |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +           +        +  +                                          |   5        |
      Hyperplasia, Macrophage              |                               1                                          |      1  1.0|
      Inflammation, Chronic Active         |       1           1        1  1                                          |      4  1.0|
      Interstitium, Infiltration Cellular  | 1     1           2        2  2                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +           +        +  +                                          |   5        |
      Respiratory Epithelium, Hyperplasia  | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|                                      |      A     |
    0.12MGM3                               | 4| 6| 6| 6| 7| 7| 7| 8| 9| 9| 0| 0|                                      |      L     |
    LUNG TOX                               | 3| 2| 3| 8| 0| 8| 9| 0| 2| 9| 0| 7|                                      |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +           +        +  +                                          |   5        |
      Nephropathy                          |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                    +                                             |   3        |
      Calculus Micro Observation Only      | X     X                    X                                             |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|             
                                           | 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1           2                                 |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     | 2  3  1     2  2  1     1  1  1     1  2  1  1     3  2     1     1  2  1|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |             2                          2                                 |             
      Degeneration, Fatty                  |                3        2           2                             1      |             
      Eosinophilic Focus                   |                                                 3                 3     1|             
      Fatty Change                         |                      4                                                   |             
      Hepatodiaphragmatic Nodule           |                X                 X        X                       X      |             
      Bile Duct, Hyperplasia               | 3     2  2  3  3        2  3  3     3  2  3        2  1     3  4  4  2  3|             
      Centrilobular, Atrophy               |       1                 2     2                             2            |             
      Hepatocyte, Hyperplasia              |                                                 3                        |             
      Hepatocyte, Necrosis                 |       2  3     3        2  2  2     2                       1  2        2|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Acinus, Atrophy                      |             2           2                             3              3   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Ulcer                                |                2                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                       +               |             
      Developmental Malformation           |                                  X                       X               |             
      Peridontal Tissue, Hyperplasia       |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|             
                                           | 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cardiomyopathy                       | 2  2  1        2  3           2     2     2     2  2        3  3  3  2   |             
      Proliferation Connective Tissue      |                                                                      1   |             
      Thrombosis                           |                                     X                          X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                        2                          1      |             
      Vacuolization Cytoplasmic            |          1     2  2     1              1           2  4                 1|             
      Capsule, Fibrosis                    |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          | 2  2  1     4     2                    4                          4  3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                4         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           3                              |             
      Pars Distalis, Hyperplasia, Focal    |                   4     3  2        2     4                 2     4     4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      C-Cell, Hyperplasia                  |    2  1                                2        2              2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +  +  +  +                                                      |             
      Pelvic, Ectopic Tissue               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           1                              |             
      Autolysis                            |                                                                          |             
      Ectasia                              |                                                    2              2      |             
      Hyperplasia                          |                                                                         2|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       3                          2                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                                                                     |             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|             
                                           | 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3        1                                                  4         |             
      Germinal Epithelium, Degeneration    |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|       2     1                    2                       2     1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Atrophy                              |                                                 4                        |             
      Hyperplasia                          |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2     4     4  3        3  3  3                       3     2           3|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                       +  +  +      |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Pancreatic, Inflammation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Hyperplasia, Plasma Cell             |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  4                    2  4           3   |             
      Hyperplasia, Plasma Cell             |                                                    3                     |             
      Inflammation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             |                               3                 4              2  3  2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2              2     2  3                             2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Prepuce, Fibrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|             
                                           | 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Inflammation        |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                2     3                                               2   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             
      Inflammation                         |    2        1           1                 1              2     1         |             
      Metaplasia, Squamous                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |    2  1        2        1  2           1  1     2  1     1  1  2  2  2  1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              | 2  2  1              2     2     1  1     1     1  1  2                  |             
      Inflammation, Chronic Active         |    3  2  2  3  2  3     1  1  2  1     2  2  1     2  2  2  2  2  2  3  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2                          3  1                                          |             
      Alveolus, Proteinosis                | 1  1                                      1           2              2   |             
      Interstitium, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                         1     1     1                                    |             
      Thrombosis, Multiple                 |          X                 X                                             |             
      Glands, Inflammation                 |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                      2                                                   |             
      Nasopharyngeal Duct, Inflammation    |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                       1                  |             
      Olfactory Epithelium, Degeneration   |    1        1        1        1     1           1  1                 1   |             
      Olfactory Epithelium, Inflammation   |                                                                      1   |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                      1   |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2     1  1     2  1                    2  3        2  2           3  1  1|             
      Respiratory Epithelium, Inflammation | 1        1     3                       2  3                       4      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                1                                                         |             
      Vomeronasal Organ, Inflammation      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|             
                                           | 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/M3                                  | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                      3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Infarct                              |                                                                4         |             
      Inflammation                         | 2                                                                        |             
      Nephropathy                          | 3  4  3     1  3  1  3  3  1  3  1  1  2  3        4  3     2  3  4  4  4|             
      Renal Tubule, Pigmentation           |                2           4  2                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                              X        X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|             
                                           | 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Autolysis                            | 3                                                                       3|             
      Basophilic Focus                     | 1  1     3  1  1  2  1     1  2     4     2  1     1  3  2  1  1  2  1   |             
      Clear Cell Focus                     |          1                                               1               |             
      Congestion                           | 3                       3                                                |             
      Degeneration, Cystic                 |                1                    2     2           1              1   |             
      Degeneration, Fatty                  |                                        4        2              1  1      |             
      Eosinophilic Focus                   |                                  2                                       |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Bile Duct, Hyperplasia               | 2     2              1     4     3  1  2  2     4     2  2  3     1      |             
      Centrilobular, Atrophy               |                                  2                                       |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                                 3                    3   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                   +                                                  +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                               4|             
      Acinus, Atrophy                      | 2                    2           2                                       |             
      Acinus, Hyperplasia                  |          1                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                 2                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Developmental Malformation           |                                                                          |             
      Peridontal Tissue, Hyperplasia       |                                                                         2|             
      Peridontal Tissue, Inflammation      |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|             
                                           | 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Cardiomyopathy                       | 1     3  3           3           2        2     3        3        3      |             
      Proliferation Connective Tissue      |                                                                          |             
      Thrombosis                           |                                  X     X        X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Hyperplasia                          |                                     1                                    |             
      Vacuolization Cytoplasmic            |                   2                    2        2     1        2         |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Hyperplasia                          |          3                 2     2        2     1     2     2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                       1                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                      4               |             
      Pars Distalis, Hyperplasia, Focal    |                   2        2        2           3  1     4  1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Autolysis                            |                         4                                                |             
      C-Cell, Hyperplasia                  |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Pelvic, Ectopic Tissue               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
      Autolysis                            |                                                                         3|             
      Ectasia                              |                                                 1                        |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                          1                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                    2                 2                                 |             
      Autolysis                            |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|             
                                           | 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      4              4           1                 4      |             
      Germinal Epithelium, Degeneration    |                               2                                          |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                           2                 2            |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |             4                                                            |             
      Myeloid Cell, Hyperplasia            |       3  1                          3     3                       2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +        +     +                             +         |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                4                                                         |             
      Pancreatic, Inflammation             |                   1                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |    1              3                                                      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2        4  1                                1                  |             
      Hyperplasia, Plasma Cell             |                                     4     3                       1      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  A  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Congestion                           |          3                                                           3  4|             
      Hyperplasia, Lymphoid                |                2                                      2                  |             
      Hyperplasia, Macrophage              |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                                                 2                        |             
      Congestion                           |                                                 2                        |             
      Fibrosis                             |          1                 3              1     2     4  2               |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A|             
      Atrophy                              |                                        3        3                    3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                      X   |             
      Prepuce, Fibrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|             
                                           | 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Inflammation        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                          1                                    |             
      Inflammation                         |          2        2                 1  1              1                  |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 4                                                                       3|             
      Fibrosis                             |          3     1  1  1           2  2  1  3     2     3  2  1     1      |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Macrophage              | 1     2  3     2  2  1  3  4  1  1  2     1     2  1  2     1  2  1  1  1|             
      Inflammation, Chronic Active         | 2        2     1  1  2        1  2  3  1  1     2     2  2        2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    1                                                                     |             
      Alveolus, Proteinosis                |                2     1  1           2              1  1              1   |             
      Interstitium, Infiltration Cellular  |                                     1           2     2                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                        1                                 |             
      Thrombosis, Multiple                 |                                                 X                        |             
      Glands, Inflammation                 |                                                          1               |             
      Nasolacrimal Duct, Inflammation      |                                  2                                       |             
      Nasopharyngeal Duct, Inflammation    |                                  2     1                                 |             
      Olfactory Epithelium, Atrophy        | 1                                                                        |             
      Olfactory Epithelium, Degeneration   |    1           1  1                                               1      |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                   1      |             
      Respiratory Epithelium, Hyperplasia  | 2        1     1  2  1     3     3  2     1                 3     2  1   |             
      Respiratory Epithelium, Inflammation | 4           1     3  1     3     4  1     1           1     2        1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            2                                             |             
      Vomeronasal Organ, Inflammation      |                                                          1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|             
                                           | 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25                                   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Autolysis                            | 4                       3                                                |             
      Infarct                              |                                                 4                        |             
      Inflammation                         |                                                                          |             
      Nephropathy                          |    1  2  4     2  3  4     3  1  2  4  3  4  2  4  2  4  2  1     2  1   |             
      Renal Tubule, Pigmentation           |                                  1     3                 4     1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                               X              X        X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6|                                                  |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 8| 2| 8|                                                  |            |
                                           | 7| 1| 6| 3| 7| 4| 6| 5|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |      A     |
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 5|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +                                                   |  57        |
      Autolysis                            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  55        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Angiectasis                          |    1                                                                     |      4  1.5|
      Autolysis                            |                                                                          |      2  3.0|
      Basophilic Focus                     | 2  2  1  2  1  1  2  2                                                   |     46  1.6|
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Congestion                           |                                                                          |      2  3.0|
      Degeneration, Cystic                 |                                                                          |      7  1.6|
      Degeneration, Fatty                  |    2           3  1  1                                                   |     12  1.9|
      Eosinophilic Focus                   |             1                                                            |      5  2.0|
      Fatty Change                         |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      6     |
      Bile Duct, Hyperplasia               | 2     2  2  3  2  1                                                      |     37  2.4|
      Centrilobular, Atrophy               |                                                                          |      5  1.8|
      Hepatocyte, Hyperplasia              |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                                                                          |     12  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                   +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      2  3.5|
      Acinus, Atrophy                      |    3        4                                                            |      9  2.6|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Ulcer                                |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  58        |
      Necrosis                             |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 112                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6|                                                  |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 8| 2| 8|                                                  |            |
                                           | 7| 1| 6| 3| 7| 4| 6| 5|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |      A     |
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 5|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Developmental Malformation           |                                                                          |      2     |
      Peridontal Tissue, Hyperplasia       |                                                                          |      1  2.0|
      Peridontal Tissue, Inflammation      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Cardiomyopathy                       | 2  2  2  2        1  2                                                   |     29  2.2|
      Proliferation Connective Tissue      |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          |                   1                                                      |      4  1.3|
      Vacuolization Cytoplasmic            |    2  1        3  1                                                      |     17  1.8|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          | 2     2     1                                                            |     18  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +                                                   |  56        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Angiectasis                          |                                                                          |      3  3.0|
      Pars Distalis, Hyperplasia, Focal    |          2                                                               |     16  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  56        |
      Autolysis                            |                                                                          |      1  4.0|
      C-Cell, Hyperplasia                  |       2     3                                                            |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   5        |
      Pelvic, Ectopic Tissue               |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +                                                   |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 113                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6|                                                  |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 8| 2| 8|                                                  |            |
                                           | 7| 1| 6| 3| 7| 4| 6| 5|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |      A     |
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 5|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      2  1.5|
      Autolysis                            |                                                                          |      1  3.0|
      Ectasia                              |          2  4                                                            |      5  2.2|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +                                                   |  58        |
      Inflammation                         |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |    2     1           2                                                   |      7  1.7|
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Atrophy                              |       4           3  2                                                   |     10  3.0|
      Germinal Epithelium, Degeneration    |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia, Focal|    1                                                                     |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  57        |
      Atrophy, Focal                       |                                                                          |      2  2.0|
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  4.0|
      Myeloid Cell, Hyperplasia            | 3        1  3                                                            |     18  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        +                                                         |  11        |
      Iliac, Pigmentation                  |       2                                                                  |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  4.0|
      Pancreatic, Inflammation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  I                                                   |  52        |
      Hyperplasia, Lymphoid                |          2                                                               |      4  2.0|
      Hyperplasia, Plasma Cell             |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  +                                                   |  56        |
      Hyperplasia, Lymphoid                |                      2                                                   |      9  2.6|
      Hyperplasia, Plasma Cell             |    2              3                                                      |      6  2.7|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +                                                   |  51        |
      Congestion                           |                                                                          |      3  3.3|
      Hyperplasia, Lymphoid                |          2        2                                                      |      5  2.0|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 114                                                               
NTP Experiment-Test: 05122-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:40:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6|                                                  |            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 8| 2| 8|                                                  |            |
                                           | 7| 1| 6| 3| 7| 4| 6| 5|                                                  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |      A     |
    0.25                                   | 4| 4| 4| 4| 4| 4| 4| 5|                                                  |      L     |
    MG/M3                                  | 3| 4| 5| 6| 7| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  56        |
      Atrophy                              |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             | 2        2     4                                                         |     14  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Th