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TDMS Study 05122-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: LITRI                                             NICKEL SULFATE HEXAHYDRATE                              DATE: 05/20/95       
EXPERIMENT: 05122 TEST: 05                                                                                     TIME: 03:19:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: Y01-ES-30108                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C60344       
PATHOLOGIST: K. NIKULA                                                                                         CAS: 010101970       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: LITRI                                             NICKEL SULFATE HEXAHYDRATE                              DATE: 05/20/95      
EXPERIMENT: 05122 TEST: 05                                                                                     TIME: 03:19:35      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: Y01-ES-30108                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C60344      
PATHOLOGIST: K. NIKULA                                                                                         CAS: 010101970      

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 38     CENSORED DEATHS 5    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      117   262   482   496   505   518   536   539   539   550                 |
 |      565   569   577   597   610   614   618   622   622   626                 |
 |      634   637   655   657   657   658   662   679   679   686                 |
 |      693   703   703   708   720   721   726   731                             |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 11     UNCENSORED DEATHS 0      CENSORED DEATHS 11   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199   199   199   199                 |
 |      199                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.12    MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 37     CENSORED DEATHS 5    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      352   363   539   547   551   566   566   570   580   598                 |
 |      600   607   615   632   640   640   643   644   646   650                 |
 |      658   675   679   682   683   683   685   692   702   703                 |
 |      704   708   720   720   726   726   732                                   |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458                                               |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.12MGM3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 12     UNCENSORED DEATHS 0      CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199   199   199   199                 |
 |      199   199                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.25    MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 34     CENSORED DEATHS 6    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      279   432   471   492   535   535   538   550   551   551                 |
 |      576   597   597   601   606   607   614   617   621   628                 |
 |      643   651   679   683   684   685   697   706   711   713                 |
 |      725   726   727   732                                                     |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   717                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.25MGM3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 12     UNCENSORED DEATHS 0      CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199   199   199   199                 |
 |      199   199                                                                 |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 32     CENSORED DEATHS 5    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      320   419   420   433   460   539   552   563   576   583                 |
 |      584   584   602   628   628   628   629   630   634   638                 |
 |      640   651   654   671   676   688   688   697   697   699                 |
 |      713   726                                                                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.5MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 12     UNCENSORED DEATHS 0      CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199   199   199   199                 |
 |      199   199                                                                 |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0MG/M3   |   100.0  98.3  96.6  96.6  96.6  94.8  83.6  74.3  50.2  29.7      |
 |           |                                                                    |
 |           |                                                                    |
 |0.0MG/M3LUN|   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.12       |   100.0 100.0 100.0  96.6  96.6  96.6  94.7  79.5  60.6  30.3      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.12MGM3LUN|   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.25       |   100.0 100.0 100.0  98.3  98.3  94.7  87.1  73.8  58.7  35.6      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.25MGM3LUN|   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.5MG/M3   |   100.0 100.0 100.0  98.3  94.8  91.2  89.3  76.0  57.0  39.9      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5MG/M3LUN|   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0.0MG/M3    0.0MG/M3LUNG0.12        0.12MGM3LUNG0.25        0.25MGM3LUNG0.5MG/M3    0.5MG/M3L|NG
 |                                            TOX         MG/M3       TOX         MG/M3       TOX                     TOX      |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       29.7%        0.0%       30.3%        0.0%       35.6%        0.0%       39.9%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.373N     -----      P=0.730N    P=1.000N    P=0.597N    P=1.000N    P=0.417N    P=1.000N |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       601.9          .        633.2          .        610.6          .        601.6          .     |
 |NATURAL DEATHS (C)      |       (19.8)      (  . )      (14.4)      (  . )      (16.9)      (  . )      (17.3)      (  . )   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       625.3       199.0       645.6       199.0       637.3       199.0       636.8       199.0    |
 |(STANDARD ERROR)        |       (16.2)      ( 0.0)      (13.2)      ( 0.0)      (14.3)      ( 0.0)      (14.5)      ( 0.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 31     CENSORED DEATHS 5    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      446   503   536   538   542   566   584   589   621   622                 |
 |      640   643   643   643   643   658   663   666   669   677                 |
 |      683   686   688   690   691   692   696   713   714   721                 |
 |      727                                                                       |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 12     UNCENSORED DEATHS 0      CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200   200   200   200                 |
 |      200   200                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.12    MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 36     CENSORED DEATHS 5    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      392   489   537   537   539   550   559   559   573   580                 |
 |      592   596   596   600   605   607   619   620   627   636                 |
 |      643   644   644   644   653   656   657   658   664   664                 |
 |      676   678   682   691   706   725                                         |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.12MGM3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 12     UNCENSORED DEATHS 0      CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200   200   200   200                 |
 |      200   200                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.25    MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 25     CENSORED DEATHS 5    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      403   510   605   608   617   629   629   642   647   648                 |
 |      648   655   661   662   662   662   675   675   683   697                 |
 |      700   706   710   711   715                                               |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.25MGM3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 11     UNCENSORED DEATHS 0      CENSORED DEATHS 11   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200   200   200   200                 |
 |      200                                                                       |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 24     CENSORED DEATHS 7    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      28    119   272   370   432   475   480   497   527   538                 |
 |      538   538   541   568   637   648   654   661   662   681                 |
 |      685   688   697   702                                                     |
 |  CENSORED DEATHS                                                               |
 |      190   323   459   459   459   459   459                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.5MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 10   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200   200   200   200                 |
 |                                                                                |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0MG/M3   |   100.0 100.0 100.0 100.0 100.0  98.3  90.7  85.0  68.0  41.6      |
 |           |                                                                    |
 |           |                                                                    |
 |0.0MG/M3LUN|   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.12       |   100.0 100.0 100.0 100.0  98.3  98.3  90.7  71.8  43.5  32.1      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.12MGM3LUN|   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.25       |   100.0 100.0 100.0 100.0  98.3  98.3  96.4  94.5  69.9  52.9      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |0.25MGM3LUN|   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.5MG/M3   |    98.3  96.7  96.7  95.0  93.2  87.7  76.3  74.4  64.8  55.3      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5MG/M3LUN|   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 ==================================================================================

                            NICKEL SULFATE HEXAHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0.0MG/M3    0.0MG/M3LUNG0.12        0.12MGM3LUNG0.25        0.25MGM3LUNG0.5MG/M3    0.5MG/M3L|NG
 |                                            TOX         MG/M3       TOX         MG/M3       TOX                     TOX      |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       41.6%        0.0%       32.1%        0.0%       52.9%        0.0%       55.3%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.157N     -----      P=0.160      -----      P=0.299N     -----      P=0.509N     -----   |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       638.5          .        613.8          .        646.4          .        526.6          .     |
 |NATURAL DEATHS (C)      |       (12.5)      (  . )      (11.0)      (  . )      (13.4)      (  . )      (36.5)      (  . )   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       657.3       200.0       634.2       200.0       670.1       200.0       609.8       200.0    |
 |(STANDARD ERROR)        |       (11.9)      ( 0.0)      (12.0)      ( 0.0)      (11.6)      ( 0.0)      (21.8)      ( 0.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                     NICKEL SULFATE HEXAHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0MG/M3         = 1
                                                        0.0MG/M3LUNG TOX = 2
                                                        0.12    MG/M3    = 3
                                                        0.12MGM3LUNG TOX = 4
                                                        0.25    MG/M3    = 5
                                                        0.25MGM3LUNG TOX = 6
                                                        0.5MG/M3         = 7
                                                        0.5MG/M3LUNG TOX = 8

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                  1                      1 5      7    33        7 5
      |                                           1              3        7 5    7 51 1 1    3 3
P     |                                                                          7      11   1 3 3
E     |                                                                                      1 1 3337  3
R  80 +                                                                                        1 1117  333
C     |                                                                                            1   151 733
E     |                                                                                                 511
N     |                                                                                                   11133
T  60 +                                                                                                    51531   3
      |                                                                                                        7  7337
S     |                                                                                                        1 1 13355
U     |                                                                                                            111715 5
R  40 +                                                                                                                1135 5
V     |                                                                                                                 111 5
I     |                                                                                                                   1 1
V     |
A  20 +
L     |
      |
      |
    0 +                                           2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 104 obs hidden.

                                                     NICKEL SULFATE HEXAHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0MG/M3         = 1
                                                        0.0MG/M3LUNG TOX = 2
                                                        0.12    MG/M3    = 3
                                                        0.12MGM3LUNG TOX = 4
                                                        0.25    MG/M3    = 5
                                                        0.25MGM3LUNG TOX = 6
                                                        0.5MG/M3         = 7
                                                        0.5MG/M3LUNG TOX = 8

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1   7              7                       2                  3 5     1      3 15
      |                    7                       7              7         7        3 15    11         5 5
P     |                                                                     7      77 7      31331  1     55
E     |                                                                               7     77  3 331 1   15 55
R  80 +                                                                                      77    3  33  1  155
C     |                                                                                       7   7    33   7  5 5
E     |                                                                                                 3 3 7171 115
N     |                                                                                                   333    7115 5
T  60 +                                                                                                     33     111555
      |                                                                                                      3 3      7755  5
S     |                                                                                                              11 1
U     |                                                                                                        3 3 3    111
R  40 +                                                                                                            333    1 1
V     |                                                                                                              3 3  3
I     |                                                                                                                   3 3
V     |
A  20 +
L     |
      |
      |
    0 +                                            2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 57 obs hidden.