Share This:
https://ntp.niehs.nih.gov/go/3733

TDMS Study 05123-06 Pathology Tables

NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21

                                                     LUNG TOX CORE ANIMALS




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  1313-99-1

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25026 Other
                               25006 Terminal Sacrifice                25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Exclude 001    0 MG/M3
                               Exclude 002    0 MG/M3
                               Exclude 005    1.25MGM3
                               Exclude 006    1.25MGM3
                               Exclude 010    2.5MG/M3
                               Exclude 013    5.0MG/M3
                               Exclude 014    5.0MG/M3
                               Exclude 009    2.5MG/M3

























Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 0| 0| 0| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 2| 2|                                            |            |
                                           | 6| 9| 0| 0| 3| 2| 2| 1| 4| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |     A      |
    0 MG/M3                                | 8| 8| 8| 9| 9| 0| 0| 2| 3| 5|                                            |     L      |
      LUNGTX                               | 4| 7| 8| 2| 8| 4| 8| 0| 2| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +              I  +  M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M              +  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +              +  +  M                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    M              +  +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +              +  +  +                                                |   4        |
      Teratoma Benign                      |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +              M  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                 +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +              M  M  M                                                |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 0| 0| 0| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 2| 2|                                            |            |
                                           | 6| 9| 0| 0| 3| 2| 2| 1| 4| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |     A      |
    0 MG/M3                                | 8| 8| 8| 9| 9| 0| 0| 2| 3| 5|                                            |     L      |
      LUNGTX                               | 4| 7| 8| 2| 8| 4| 8| 0| 2| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M              M  M  M                                                |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +              M  +  +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +              A  +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +              +  +  I                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +              +  +  A                                                |   3        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +              +  +  +                                                |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 7| 7| 6| 0| 7| 7| 1|                                            |            |
                             DAY ON TEST   | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6|                                            |            |
                                           | 7| 7| 3| 3| 3| 6| 6| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    1.25MGM3                               | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2|                                            |     L      |
      LUNGTX                               | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  M  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +        +  A        +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +  +        +  A        +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +        +  A        +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  M        M                                             |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +        +                                             |   6        |
      Pars Distalis, Adenoma               | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +        +                                             |   6        |
      Teratoma Benign                      |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +        +                                             |   6        |
      Hemangiosarcoma                      |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 7| 7| 6| 0| 7| 7| 1|                                            |            |
                             DAY ON TEST   | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6|                                            |            |
                                           | 7| 7| 3| 3| 3| 6| 6| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    1.25MGM3                               | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2|                                            |     L      |
      LUNGTX                               | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Lymphoma Malignant            | X                                                                        |          1 |
      Renal, Lymphoma Malignant            | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +        +  +        M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +  +        M                                             |   5        |
      Sarcoma, Metastatic, Skin            |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  M        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M        I  M        M                                             |   1        |
      Lymphoma Malignant                   | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +        +                                             |   6        |
      Lymphoma Malignant                   | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +                                                         |   2        |
      Sarcoma                              |       X                                                                  |          1 |
      Pinna, Sarcoma                       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +        +                                             |   6        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | A  +  +        +  +        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +        +  A        +                                             |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +        +                                             |   6        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 7| 7| 6| 0| 7| 7| 1|                                            |            |
                             DAY ON TEST   | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6|                                            |            |
                                           | 7| 7| 3| 3| 3| 6| 6| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    1.25MGM3                               | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2|                                            |     L      |
      LUNGTX                               | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 6| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 3| 7| 3| 3| 3| 3|                                            |            |
                                           | 6| 2| 6| 0| 1| 6| 0| 1| 2| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    2.5MG/M3                               | 1| 1| 1| 3| 4| 4| 5| 5| 6| 7|                                            |     L      |
      LUNGTX                               | 0| 1| 4| 3| 5| 9| 1| 4| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +     +                                                         |   4        |
      Hepatocellular Carcinoma             |       X  X                                                               |          2 |
      Hepatocellular Adenoma               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  M     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M     +  +     +                                                         |   3        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 6| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 3| 7| 3| 3| 3| 3|                                            |            |
                                           | 6| 2| 6| 0| 1| 6| 0| 1| 2| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    2.5MG/M3                               | 1| 1| 1| 3| 4| 4| 5| 5| 6| 7|                                            |     L      |
      LUNGTX                               | 0| 1| 4| 3| 5| 9| 1| 4| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     +  M     +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  M     +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +     +                                                         |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +     +                                                         |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 4| 6| 3| 3| 3| 9| 9| 5| 3|                                            |            |
                                           | 0| 4| 9| 3| 0| 1| 6| 8| 8| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                            |     A      |
    5.0MG/M3                               | 8| 9| 9| 9| 0| 0| 1| 2| 2| 2|                                            |     L      |
      LUNGTX                               | 0| 1| 5| 8| 1| 7| 7| 0| 1| 3|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    M  +           +  A  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +           +  +  +                                                |   5        |
      Hepatocellular Carcinoma             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +           +  +  +                                                |   5        |
      Squamous Cell Papilloma              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +           +  +  M                                                |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +  +  +                                                |   5        |
      Follicular Cell, Adenoma             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
      Hemangiosarcoma, Metastatic          |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 4| 6| 3| 3| 3| 9| 9| 5| 3|                                            |            |
                                           | 0| 4| 9| 3| 0| 1| 6| 8| 8| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                            |     A      |
    5.0MG/M3                               | 8| 9| 9| 9| 0| 0| 1| 2| 2| 2|                                            |     L      |
      LUNGTX                               | 0| 1| 5| 8| 1| 7| 7| 0| 1| 3|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +  +  +                                                |   5        |
      Hemangiosarcoma, Metastatic          |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M  +           +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           M  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +           +  +  +                                                |   5        |
      Hemangiosarcoma                      |                   X     X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +           +  +  +                                                |   5        |
      Alveolar/Bronchiolar Carcinoma       |       X           X                                                      |          2 |
      Hepatocellular Carcinoma, Metastatic |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +  +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +           +  +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 7| 9| 3| 7| 7| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    O MG/M3                                | 0| 2| 3| 5| 7| 7| 7| 7| 7| 8|                                            |     L      |
      LUNGTX                               | 2| 7| 9| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
      Hemangiosarcoma                      | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +                                                                  |   2        |
      Hemangiosarcoma, Metastatic          | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 7| 9| 3| 7| 7| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    O MG/M3                                | 0| 2| 3| 5| 7| 7| 7| 7| 7| 8|                                            |     L      |
      LUNGTX                               | 2| 7| 9| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +                                                                  |   2        |
      Hemangiosarcoma, Metastatic          | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                                                                  |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +                                                                  |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 7| 7| 7| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2|                                            |            |
                                           | 7| 6| 7| 1| 7| 7| 7| 7| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    1.25MGM3                               | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3|                                            |     L      |
      LUNGTX                               | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    M  +  +  +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    M  +  M  +        M  +  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A  +  +  +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +        +  +  +                                             |   7        |
      Hepatocellular Carcinoma             |    X                       X                                             |          2 |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +        +  +  +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |       +     +        +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  +        M  +  +                                             |   6        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +        +  +  +                                             |   7        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 7| 7| 7| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2|                                            |            |
                                           | 7| 6| 7| 1| 7| 7| 7| 7| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    1.25MGM3                               | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3|                                            |     L      |
      LUNGTX                               | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +        +  +  +                                             |   5        |
      Iliac, Lymphoma Malignant            |          X                                                               |          1 |
      Inguinal, Lymphoma Malignant         |          X                                                               |          1 |
      Renal, Lymphoma Malignant            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  M  +  +        +  +  +                                             |   6        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +        +  M  +                                             |   6        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M  M  M        M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  I        +  +  I                                             |   4        |
      Lymphoma Malignant                   |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +        +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  +  I        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +        +  +  +                                             |   7        |
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |          1 |
      Hepatocellular Carcinoma, Metastatic |                            X                                             |          1 |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 7| 7| 7| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2|                                            |            |
                                           | 7| 6| 7| 1| 7| 7| 7| 7| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    1.25MGM3                               | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3|                                            |     L      |
      LUNGTX                               | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +        +  +  +                                             |   7        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 4| 2| 3| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 4| 6| 3| 7| 3|                                            |            |
                                           | 9| 4| 8| 9| 2| 5| 8| 7| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5MG/M3                               | 2| 3| 4| 6| 6| 7| 7| 7| 8| 9|                                            |     L      |
      LUNGTX                               | 3| 9| 1| 4| 9| 2| 3| 6| 1| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A        +  +  M     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +        +  A  A     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +        +  A  A     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +        +  A  A     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A        +  A  A     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A        +  A  A     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A        +  A  A     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +  +  +     +                                                |   6        |
      Hepatocellular Carcinoma, Multiple   |                         X                                                |          1 |
      Hepatocellular Adenoma, Multiple     |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +        +  A  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +        +  A  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +        +  M  M     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +        +  +  +     +                                                |   6        |
      Follicular Cell, Adenoma             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Penis                                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 4| 2| 3| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 4| 6| 3| 7| 3|                                            |            |
                                           | 9| 4| 8| 9| 2| 5| 8| 7| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5MG/M3                               | 2| 3| 4| 6| 6| 7| 7| 7| 8| 9|                                            |     L      |
      LUNGTX                               | 3| 9| 1| 4| 9| 2| 3| 6| 1| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +           +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +        +  M  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +        +  M  M     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +        M  M  M     M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M        +  +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +        +     +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                       +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +  +  +     +                                                |   6        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +        +  +  +     +                                                |   6        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 0| 6| 6| 5| 4| 7| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1|                                            |            |
                                           | 8| 1| 5| 0| 0| 1| 7| 1| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    5.0MG/M3                               | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5|                                            |     L      |
      LUNGTX                               | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +     M  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     M  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +                                             |   9        |
      Hepatocellular Adenoma               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +     +  M  M                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +           +                                             |   2        |
      Sarcoma                              |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +        +              +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +     +  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 0| 6| 6| 5| 4| 7| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1|                                            |            |
                                           | 8| 1| 5| 0| 0| 1| 7| 1| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    5.0MG/M3                               | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5|                                            |     L      |
      LUNGTX                               | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +     +                                                         |   4        |
      Iliac, Lymphoma Malignant            |       X                                                                  |          1 |
      Inguinal, Lymphoma Malignant         |       X                                                                  |          1 |
      Renal, Lymphoma Malignant            |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +     +  +  M                                             |   7        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M     +  +  +                                             |   8        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  +  M     +  +  M                                             |   5        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     M  M  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +              +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
      Alveolar/Bronchiolar Adenoma         |       X  X                                                               |          2 |
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |          1 |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  19                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 0| 6| 6| 5| 4| 7| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1|                                            |            |
                                           | 8| 1| 5| 0| 0| 1| 7| 1| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    5.0MG/M3                               | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5|                                            |     L      |
      LUNGTX                               | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  20                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------