Share This:
https://ntp.niehs.nih.gov/go/1148

TDMS Study 05123-06 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                            NICKEL OXIDE


NTP Experiment-Test: 05123-06                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04


                                                       2 YEAR CORE STUDY


       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  1313-99-1

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25026 Other
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Merge     002   002,004                  0 MG/M3
                               Merge     006   006,008                  1.25MGM3
                               Merge     010   010,012                  2.5MG/M3
                               Merge     014   014,016                  5.0MG/M3
                               Merge     001   001,003                  0 MG/M3
                               Merge     005   005,007                  1.25MGM3
                               Merge     009   009,011                  2.5MG/M3
                               Merge     013   013,015                  5.0MG/M3
























                                                             Page   1
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|             
                             DAY ON TEST   | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|             
                                           | 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Basophilic Focus                     |    X                                                                     |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic                |    1                                                                     |             
      Hepatocyte, Vacuolization Cytoplasmic| 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
      Vacuolization Cytoplasmic            |                                                                      3   |             
      Spindle Cell, Hyperplasia            |                3  2  2                       1                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  M  +  +  +  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|             
                             DAY ON TEST   | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|             
                                           | 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Angiectasis           |                      1                                               2   |             
      Pars Distalis, Hyperplasia           |                                  2                 2                 3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    1  1              1  2  2                 3     2                 3  2|             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  M  +  +  M  +  I  +  +  I  +  +  M  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                              X  X              X        X|             
      Inflammation, Suppurative            |                                                                          |             
      Rete Ovarii, Thrombosis              |                   4                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  4  1        3     3     3        2     1     3  3                 2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                   1                                                      |             
      Myeloid Cell, Hyperplasia            |                4                                                  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +           +                                      +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  I  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                    4        2  4        2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  A  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  M  M  +  +  +  M  M  M  +  +  +  +  +  +  +  M  M  M  M  M  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          3                       3                                       |             
      Hyperplasia, Lymphoid                |                   3                    2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|             
                             DAY ON TEST   | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|             
                                           | 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +                                                     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Edema           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
      Hyperostosis                         |                                     1              1                 1   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                    2                 2                              |             
      Pigmentation, Hemosiderin            |                         1                 2                              |             
      Alveolus, Hyperplasia, Macrophage    |                                           3                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Capillary, Thrombosis                |                   4                                                      |             
      Olfactory Epithelium, Degeneration   |             1              1              2     1                        |             
      Respiratory Epithelium, Degeneration |    2  1                 1  1              2                              |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                   3  1  1                          1              2     1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                   2                       1        1              1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                        1                                 |             
      Nephropathy                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|             
                             DAY ON TEST   | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|             
                                           | 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulus, Thrombosis               |                   2                                                      |             
      Renal Tubule, Hyperplasia            |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|             
                                           | 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    4                                                                     |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                X     X   |             
      Eosinophilic Focus                   |             X                                      X                     |             
      Inflammation, Chronic, Focal         |       2                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                       2                  |             
      Inflammation, Chronic                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                 +|             
      Developmental Malformation           |       X                                                                  |             
      Inflammation                         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Degeneration                         | 3                                                                        |             
      Hyperplasia                          |                                                                2         |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  I  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|             
                                           | 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                3           3                             4           4  4|             
      Pars Distalis, Hyperplasia           | 4           2                 3                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     1  1                    4  2           1        2  1  3     1      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |       4                                                                  |             
      Pigmentation                         | 1              1                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Abscess                              |    4                                                                     |             
      Cyst                                 | X                                         X                              |             
      Inflammation, Suppurative            |    3                                                                     |             
      Rete Ovarii, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2           1                 3  4     1     2              1  2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    1                                                                     |             
      Myeloid Cell, Hyperplasia            |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +                    +                    +     +               |             
      Iliac, Hyperplasia, Lymphoid         |                               4                                          |             
      Renal, Hyperplasia, Lymphoid         |    4                          4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I|             
      Hyperplasia, Lymphoid                |    2                          1  2                             2  1  1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2  3              4                                   3     2     3  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                    3  3           2              2              1|             
      Inflammation, Suppurative            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  M  M  +  M  M  +  +  +  M  M  M  +  M  +  +  M  M|             
      Hyperplasia, Lymphoid                |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3                       4     2     2                                 |             
      Hyperplasia, Lymphoid                |                               4  3        2              2           1  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|             
                                           | 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                            3                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |       2  2                                2              1               |             
                                            __________________________________________________________________________|             
   Skin                                    |                         +                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
      Hyperostosis                         |             X  X              X           X  X           X              X|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                          +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1                                         1                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capillary, Thrombosis                |                                                                          |             
      Olfactory Epithelium, Degeneration   |             1        1  1                          1           1  1      |             
      Respiratory Epithelium, Degeneration |             1  2     2                    1        2              2      |             
      Respiratory Epithelium, Hyperplasia  |                                           1                              |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     | 1     2  1           2  1              1  1                             1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 1     1              2  1                          1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    3                                               2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|             
                                           | 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulus, Thrombosis               |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3|                                |            |
                                           | 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |      A     |
    0 MG/M3                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                |      L     |
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +                                 |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +                                 |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  A  +  +  +  +  +  +  +  +  +  M  +  +                                 |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +                                 |  60        |
      Hyperplasia, Lymphoid                |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +                                 |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +                                 |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +                                 |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Abscess                              |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Arteriole, Inflammation, Chronic     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Spindle Cell, Hyperplasia            |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  62        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3|                                |            |
                                           | 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |      A     |
    0 MG/M3                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                |      L     |
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration                         |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M                                 |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
      Pars Distalis, Angiectasis           |                                                                          |      7  3.0|
      Pars Distalis, Hyperplasia           |       2     4     3        1                                             |     10  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  62        |
      Hyperplasia, Cystic                  |    2  2     3  4  2     1     1                                          |     26  1.9|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +                                 |  57        |
      Ectasia                              |                            2                                             |      1  2.0|
      Inflammation, Chronic                |          1                                                               |      2  2.5|
      Pigmentation                         |             2        1     1                                             |      5  1.2|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +                                 |  61        |
      Abscess                              |             3                                                            |      2  3.5|
      Cyst                                 |                   X     X                                                |      8     |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Rete Ovarii, Thrombosis              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Inflammation, Suppurative            |             4                                                            |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                2           1        2  1                                 |     24  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Myelofibrosis                        |                               4                                          |      3  2.0|
      Myeloid Cell, Hyperplasia            | 3           2                                                            |      5  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +           +     +                                          |  15        |
      Iliac, Hyperplasia, Lymphoid         | 3           3                                                            |      3  3.3|
      Renal, Hyperplasia, Lymphoid         | 3           3                                                            |      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  I  +  +  +  +                                 |  54        |
      Hyperplasia, Lymphoid                | 3  4  2  2     1     1              1                                    |     14  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  61        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3|                                |            |
                                           | 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |      A     |
    0 MG/M3                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                |      L     |
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                | 4        3     3  2                                                      |     16  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  +  +  +  +  +  +  M  +  +  +  +                                 |  54        |
      Hyperplasia, Lymphoid                |             2  1                                                         |      8  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  M  +  +  M  +  +  M  M                                 |  35        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Hematopoietic Cell Proliferation     | 3        2                                                               |      8  2.8|
      Hyperplasia, Lymphoid                |    3        3  2                 1                                       |     12  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  59        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
      Hyperplasia, Glandular               |          1           1                                                   |      6  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   4        |
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Fracture                             |                                     X                                    |      1     |
      Hyperostosis                         |       X  X     X     X  X        X  X                                    |     17  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +                                 |  62        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Inflammation, Chronic                |    2     1                                                               |      7  1.4|
      Pigmentation, Hemosiderin            |                                                                          |      2  1.5|
      Alveolus, Hyperplasia, Macrophage    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  62        |
      Capillary, Thrombosis                |                                                                          |      1  4.0|
      Olfactory Epithelium, Degeneration   | 1           1           1     1  1  1                                    |     16  1.1|
      Respiratory Epithelium, Degeneration | 1  1              2     1     1  1  1  1                                 |     19  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3|                                |            |
                                           | 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |      A     |
    0 MG/M3                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                |      L     |
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     | 1           1                 1                                          |     17  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 1                                                                        |     10  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  64        |
      Hydronephrosis                       |                               2                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |      2  2.5|
      Glomerulus, Thrombosis               |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +                                 |  63        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  M  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  M  +  +  +  A  M  +  M  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  A  +  M  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation, Chronic, Focal         |                                                       2                 1|             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Sinusoid, Amyloid Deposition         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +              +                  |             
      Artery, Inflammation, Chronic        |                                        3              2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       | 2              2        1                                                |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2           1         |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Hyperplasia            |                               1  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2  2  1                             4        1  2         |             
      Pars Distalis, Hyperplasia           |                2  3        1  3  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       2  1  2     2  3     2     1  2              1  1           1  1  1|             
      Inflammation, Suppurative            |                1                 1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Pigmentation                         |                      2                                1                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Cyst                                 |    X  X                 X     X  X     X                       X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                              2                           |             
      Bilateral, Dilatation                |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     | 2  4  2           1  2  2     4  2  3  2  1              2        2  4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 3                                         2                              |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                  3                    3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                       +  +        +                        |             
      Iliac, Hyperplasia, Lymphoid         |                                     3  3                                 |             
      Iliac, Pigmentation                  |                                        1                                 |             
      Renal, Hyperplasia, Lymphoid         |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2     3        2  2  2     2     2  2     2  2     3     2  2     1  2|             
      Pigmentation                         | 1  2  1  2  1  2  2  1  1     2  1  1  2     1  2     2  1  1  2  1  2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |       4        3                 4           3           2  2  2        2|             
      Hyperplasia, Macrophage              |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3     2  2                                          |             
      Ectasia                              |                                                                   3      |             
      Hyperplasia, Lymphoid                |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  I  +  +  M  +  +  M  M  M  +  +  M  I  M  +  +  +  M  +  M  +  +  M|             
      Hyperplasia, Lymphoid                |                                     4                 1                  |             
      Pigmentation                         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    2                             2                       3               |             
      Hyperplasia, Lymphoid                | 2        2           4                 2  3  4  2     2        2         |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |             3                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                                                     +               |             
      Alopecia                             |                                                                          |             
      Pinna, Cyst Epithelial Inclusion     |    X                                                                     |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2  1     2  4  1     2                    X              X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
      Pons, Compression                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 1  1  1  1  2     1  2     1  2  1  2              1  2  1  1  1     2  2|             
      Alveolar Epithelium, Hyperplasia     | 1     1  1     1  1  1        1                 1  1  1  1  1  1  1  1  1|             
      Alveolus, Hyperplasia, Macrophage    |                               3              2                           |             
      Alveolus, Pigmentation               | 2  1  2  2  2  1  1  2  1  2  1  2  1  2  1  1  2  2  1  1  2  1  1  2  1|             
      Alveolus, Proteinosis                |                   1  2        2     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Degeneration   |       1                          1  2                    1               |             
      Respiratory Epithelium, Degeneration |       1                       2  1              1        1        1  2   |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     | 1                 1  1           1                    2        1         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Squamous                        |                            1                          2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
      External Ear, Hyperkeratosis         |                                                                         2|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       2                  |             
      Nephropathy                          |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |    3                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|             
                                           | 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  M  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              X                           |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                        2                                 |             
      Sinusoid, Amyloid Deposition         |                                                             3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                      2                          1  2                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
      Developmental Malformation           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Spindle Cell, Hyperplasia            |    4                                2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                      4   |             
      Pars Distalis, Hyperplasia           |                2                                               2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|             
                                           | 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2  3     2        1  1        2     3        1                        |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Ectasia                              | 2                                                                        |             
      Pigmentation                         | 2                 3                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 | X                    X     X           X                    X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Bilateral, Dilatation                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2  3  2     3  3  3                 2  1  1              3  1     3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
      Necrosis                             |                                           4                              |             
      Myeloid Cell, Hyperplasia            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +        +           +                             +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Pigmentation                  |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Congestion                           |          1                                                               |             
      Hyperplasia, Lymphoid                | 2  2  2     2     1     3              2     2           2        1  2  1|             
      Pigmentation                         | 2  1  2  1  2     1  1  2  2     1  1  1  1  2  1  1     2  1  1  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                       2                  |             
      Hyperplasia, Lymphoid                |                3  4        2                                2            |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  M  +  M  I  M  I  I  +  +  +  M  +  M  M  I  +  M  M  M|             
      Hyperplasia, Lymphoid                |                4                                                         |             
      Pigmentation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|             
                                           | 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     4           2           3            |             
      Hyperplasia, Lymphoid                |    2     4  4  2     2  2                                                |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  I  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                            1                                             |             
                                            __________________________________________________________________________|             
   Skin                                    |          +              +           +                          +         |             
      Alopecia                             |                                                                1         |             
      Pinna, Cyst Epithelial Inclusion     |                                                                          |             
      Subcutaneous Tissue, Edema           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Hyperostosis                         |       X        2        X  X                    X                 X  X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                               4                                          |             
      Pons, Compression                    |                               4                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
      Hemorrhage                           |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            1                 3                           |             
      Inflammation, Chronic                |    1  1     3  2  1  1  2        1  1  1     3           1        1  1   |             
      Alveolar Epithelium, Hyperplasia     |    1     1     1        1     1  1           1  1        1        1  1  1|             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
      Alveolus, Pigmentation               | 1  1  1  2  2  2  1  1  1  1  2  1  1  2  1  2  1  1  1     1  1  1  1  1|             
      Alveolus, Proteinosis                |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
      Olfactory Epithelium, Degeneration   |    1                 1                             1              1  1   |             
      Respiratory Epithelium, Degeneration |          2           1  1                       1                 2      |             
      Respiratory Epithelium, Hyperplasia  |                                              1                           |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |             1  1  2        1  3  1  1           2                 2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|             
                                           | 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Squamous                        |          2  1     1              1           1  3                 3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      External Ear, Hyperkeratosis         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          |             1                                               4            |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1|                          |            |
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6|                          |            |
                                           | 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    1.25MGM3                               | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                          |      L     |
                                           | 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +                           |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  A  +  M  +  +  +  +  +  +  +                           |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Basophilic Focus                     |                                                                          |      1     |
      Inflammation, Chronic, Focal         |                               2                                          |      3  1.7|
      Hepatocyte, Hyperplasia              |             2                                                            |      1  2.0|
      Hepatocyte, Necrosis                 |                                  2                                       |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Sinusoid, Amyloid Deposition         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  63        |
      Hyperkeratosis                       |                      2              2                                    |      8  1.8|
      Inflammation, Suppurative            |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +                           |  63        |
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Spindle Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Spindle Cell, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1|                          |            |
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6|                          |            |
                                           | 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    1.25MGM3                               | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                          |      L     |
                                           | 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M                           |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Pars Distalis, Angiectasis           | 1                          3     4                                       |     10  2.4|
      Pars Distalis, Hyperplasia           |    3                                                                     |      9  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hyperplasia, Cystic                  |       1              1  2     2           2                              |     26  1.7|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  62        |
      Ectasia                              |             2                                                            |      2  2.0|
      Pigmentation                         |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                      X  X                                                |     14     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Dilatation                           |                                                                          |      1  2.0|
      Bilateral, Dilatation                |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2     2     4        3  3        3        3                              |     34  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Myelofibrosis                        |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                  3                                       |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |   9        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
      Iliac, Pigmentation                  |                                                                          |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                           |  63        |
      Congestion                           |          2                                                               |      2  1.5|
      Hyperplasia, Lymphoid                | 2  1  3  2  3  2           3  2        2  1                              |     37  2.0|
      Pigmentation                         | 1  2  2  2  2  2     2  2  1  1  2  1  2  1                              |     58  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  M                           |  63        |
      Congestion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1|                          |            |
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6|                          |            |
                                           | 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    1.25MGM3                               | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                          |      L     |
                                           | 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |       3           3     4  4  4  3                                       |     18  3.0|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                           |  63        |
      Congestion                           |             4                                                            |      4  2.8|
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |          4                                                               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  I  M  M  I  M  M  +  I  M  +  M  M  +  M                           |  28        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
      Pigmentation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hematopoietic Cell Proliferation     |                                                                          |      6  2.7|
      Hyperplasia, Lymphoid                |                         3              2                                 |     17  2.6|
      Hyperplasia, Macrophage              |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  61        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hyperplasia, Glandular               |                            1  1                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                +                                       |   8        |
      Alopecia                             |                                                                          |      1  1.0|
      Pinna, Cyst Epithelial Inclusion     |                                                                          |      1     |
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Hyperostosis                         | X  X  X        X              X        X  X                              |     25  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hypothalamus, Compression            |          2                                                               |      2  3.0|
      Pons, Compression                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  63        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hemorrhage                           |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1|                          |            |
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6|                          |            |
                                           | 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    1.25MGM3                               | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                          |      L     |
                                           | 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                | 1  1  1  2  4  1        2  2  1        1  1                              |     43  1.4|
      Alveolar Epithelium, Hyperplasia     | 1  1  1        1     1  1              1                                 |     35  1.0|
      Alveolus, Hyperplasia, Macrophage    |                                                                          |      2  2.5|
      Alveolus, Pigmentation               | 1  1  1  1  1  1     2  2  1  2  1  1  1  1  1                           |     64  1.3|
      Alveolus, Proteinosis                |                                  1     1  1                              |      8  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   |                                           1                              |     10  1.1|
      Respiratory Epithelium, Degeneration |          1                             1  1                              |     15  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Chronic                         |                                  1                                       |      1  1.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                   2  2        1                                          |     18  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      9  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      External Ear, Hyperkeratosis         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          |       1                                                                  |      3  2.0|
      Pelvis, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +                           |  62        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|             
                                           | 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                          2                 2         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                   X                                                      |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic, Focal         |    1                                   1                                 |             
      Mixed Cell Focus                     |                                                                          |             
      Hepatocyte, Fatty Change             |                                                 2                        |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                       2                  |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            2                                             |             
      Inflammation, Suppurative            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1                                 |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|             
                                           | 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  +  M  M  M  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          1        3                                                  3   |             
      Pars Distalis, Hyperplasia           |             4                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2  2  1  1              1           3     1                 4  1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |             1                                                           1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                   X        X              X     X              X         |             
      Inflammation, Suppurative            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  3  2  2           2     2  2  2  3  1     4  1  4     3     1     3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                   2      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                         +  +           +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                       3                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Hyperplasia, Lymphoid                | 2  2  1              3     2     3        1     2        2     1  2  2   |             
      Pigmentation                         | 1  2  1  2  2  2     1     1  2  2  2  2  1     2  1  1  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Hyperplasia, Lymphoid                |    3  4           1  2        3  3     4                                4|             
      Inflammation, Suppurative            |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |       4     2                             2  2                           |             
      Inflammation, Chronic Active         |                                                                         3|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  I  +  +  +  M  M  +  +  +  +  M  M  +  I  +  +  +  M  +  +  M  +|             
      Hyperplasia, Lymphoid                |                   4                          3        3                  |             
      Pigmentation                         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|             
                                           | 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                3                       4     2                 2     2   |             
      Hyperplasia, Lymphoid                |    2              2           2  3        4                       2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                       +        +        +|             
      Alopecia                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2  1                                X  X                 X     X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                            2                                      X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                | 1  1  1  2  2     2        2  1  1  1  1  2  2        1  2     2  2  1  1|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia     | 1        1     1           1  1              1  1        1     1  1  1  1|             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Pigmentation               | 2  2  2  2  1  1  1  2     2  2  2  2  2  2  2  2  2  1  2  1  2  1  2  2|             
      Alveolus, Proteinosis                |       1  1  1                       1                 1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |          2                                               2               |             
      Respiratory Epithelium, Degeneration |                               1  1                                       |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     | 1                 1                          1           1     2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                              1           1     2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|             
                                           | 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
      Inflammation, Chronic                |                                                       3                  |             
      Nephropathy                          |                                                                          |             
      Medulla, Cyst                        | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  M  M  +  +  +  A  +  +  +  +  +  +  +  +  M  +  M  A  M  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                    X           X         |             
      Inflammation, Chronic, Focal         |                                        2                                 |             
      Mixed Cell Focus                     |                                                                          |             
      Hepatocyte, Fatty Change             |                                                                          |             
      Hepatocyte, Necrosis                 |                                                    1                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                     X                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2           3                          1           2                     |             
      Pars Distalis, Hyperplasia           | 4                                4              3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     1  2  2              2  2  1     1  4     1  1     1     3        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Pigmentation                         |                   2  1                                   2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                      X                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2  1                       2        2     2        2  3     2  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |       3              4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +  +                                            +     +   |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                2                                                         |             
      Renal, Hyperplasia, Lymphoid         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |          3  2        2     2  2  1  2  3  3  1  1  2  2  2        2  1  2|             
      Pigmentation                         | 2  2  1  2  2  1  1  2     2  2  2  2  2  2  2  2  2  2  2     2  2  1  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2     2              3     4     2     2              4        3         |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Hyperplasia, Lymphoid                |             2        3                                                  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  M  +  +  M  M  M  M  +  M  M  M  M  I  +  M  M  +  +  M  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       4              3                                2                  |             
      Hyperplasia, Lymphoid                | 3        2  2                 1  2     2     3     1     2     3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               | 2                                1  1     2                              |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +                                   +                  |             
      Alopecia                             |                   X                                                      |             
      Inflammation, Suppurative            |                                                       4                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         | X        X  X  2     X        X     X  X     X  X  X     X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |          X                          X                                X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                             2            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                | 3  2  2  3     1     1     1  2  2  2  1  3  2  1  2  2  1     1  2  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1  1  1  1  1  1     1     1     1  2     1  1  1  1  1  1     1  1     1|             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Pigmentation               | 2  2  3  2  1  2  1  2     1  1  2  2  2  2  2  2  2  2  2  1  2  2  2  2|             
      Alveolus, Proteinosis                |                   1              2  2  1  1  2                          1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Respiratory Epithelium, Degeneration | 1        2                    1                          2        1  1   |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     | 1     2  1           3           1                    2  1              1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2        1           2                                1  1           1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                              2                           |             
      Inflammation, Chronic                |                3                                                         |             
      Nephropathy                          |          1                                         1                     |             
      Medulla, Cyst                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2|                                |            |
                                           | 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                |      A     |
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8|                                |      L     |
                                           | 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  57        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  M  +     A  +  +  +  M  M  M  M                                 |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  56        |
      Hyperplasia, Lymphoid                |             4                    4                                       |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Basophilic Focus                     |                            1                                             |      1  1.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Inflammation, Chronic, Focal         |                                                                          |      3  1.3|
      Mixed Cell Focus                     |                      X                                                   |      1     |
      Hepatocyte, Fatty Change             |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  62        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  62        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  62        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   1        |
      Inflammation                         |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2|                                |            |
                                           | 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                |      A     |
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8|                                |      L     |
                                           | 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  62        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +     +  +  +  +  +  +  +  +                                 |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  61        |
      Pars Distalis, Angiectasis           |       2     2           1     3                                          |     11  2.1|
      Pars Distalis, Hyperplasia           |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Hyperplasia, Cystic                  |    1  1     1           3     1  1     1                                 |     32  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  57        |
      Pigmentation                         |                                                                          |      5  1.4|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     M  +  +  +  +  +  +  +                                 |  60        |
      Cyst                                 |       X     X                                                            |      9     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  62        |
      Cyst                                 |                         X                                                |      1     |
      Endometrium, Hyperplasia, Cystic     |    2     3                 2                                             |     30  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  62        |
      Necrosis                             |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |             2                                                            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  10        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  59        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2     1  3  2        2  1  2  3  1  1  3                                 |     40  1.9|
      Pigmentation                         | 2  2  2  2  2        3  2  1  2  2  2  1                                 |     56  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     A  +  +  M  +  +  +  +                                 |  59        |
      Congestion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2|                                |            |
                                           | 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                |      A     |
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8|                                |      L     |
                                           | 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                         4              3                                 |     18  2.9|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     A  +  +  +  +  +  M  +                                 |  54        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |             1                                                            |      8  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +     +  I  +  M  +  +  M  M                                 |  33        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Hematopoietic Cell Proliferation     |                                                                          |      8  2.8|
      Hyperplasia, Lymphoid                |          1  2           2  2  2  3                                       |     22  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  M  +  +                                 |  60        |
      Atrophy                              |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Hyperplasia, Glandular               |       1     2                       2                                    |      8  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    |             +                                                            |   6        |
      Alopecia                             |                                                                          |      1     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Hyperostosis                         | X     X  X  X        X  X        X  X                                    |     26  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Hypothalamus, Compression            |                                     X                                    |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  62        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Fibrosis                             |          2                                                               |      1  2.0|
      Inflammation, Chronic                | 2  1  1  2  2     1  1  2  1  2  2  2  1                                 |     53  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7|                                |            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2|                                |            |
                                           | 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                |      A     |
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8|                                |      L     |
                                           | 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0|                                |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1  1  1  1              1     1  1  1                                    |     39  1.0|
      Alveolus, Hemorrhage                 |                            2                                             |      1  2.0|
      Alveolus, Pigmentation               | 2  2  2  2  2     2  2  2  2  3  2  2  2                                 |     61  1.9|
      Alveolus, Proteinosis                |    1  1  1  3           1                                                |     17  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  62        |
      Olfactory Epithelium, Degeneration   |                                                                          |      2  2.0|
      Respiratory Epithelium, Degeneration |       1                 2           1                                    |     11  1.3|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |          1  1              1        1  1                                 |     18  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             2           1  1        1                                    |     14  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +                                 |  63        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Nephropathy                          |             3                                                            |      3  1.7|
      Medulla, Cyst                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     A  +  +  +  +  +  +  +                                 |  60        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  M  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                     X                                    |             
      Hepatocyte, Necrosis                 |                                           3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Spindle Cell, Hyperplasia            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                3                                               4  2      |             
      Pars Distalis, Hyperplasia           |                                        3        2                    4   |             
      Pars Distalis, Necrosis              |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  1  1  1     3        1        1  3  2     1  3  1                 2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +|             
      Ectasia                              |                                  2                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                   2                                            2        2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                             2                  |             
      Cyst                                 |       X        X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       4           3  2  2  2        3     2  2           2  2           3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +     +  +                                   +               |             
      Iliac, Hyperplasia, Lymphoid         |                   3                                                      |             
      Iliac, Hyperplasia, Macrophage       |       2                                                                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |             3     4                                                      |             
      Renal, Inflammation, Chronic Active  |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Hyperplasia, Lymphoid                | 3  1  2  2  2  2        3  1        3  2        1  2  1     2  2  2  1  1|             
      Pigmentation                         | 2  2  2  2  2  2  1  1  2  1  1  2  2  2  2  1  2  2  3  1  2  3  2  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1                 3        1     3              4                 4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                                                |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Hyperplasia, Lymphoid                | 2           2  1           1        3                             2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  M  +  I  +  +  M  M  +  M  +  +  M  M  +  I  +  M  M  M  +  I|             
      Hyperplasia, Lymphoid                |                                                                      4   |             
      Pigmentation                         |                                                    1                 2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               4                                          |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia, Lymphoid                | 2     2     3  3  3     2                                      2         |             
      Hyperplasia, Macrophage              |                                     4                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  I  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |    2        3  1                       1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +           +     +           +     +      |             
      Alopecia                             |                                                             2            |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Inflammation, Chronic                |                                                                   4      |             
      Epidermis, Inflammation, Suppurative |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         | X        X                          X        X  X     X        X  X      |             
      Pelvis, Fracture                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |    X        X           3                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              1                           |             
      Inflammation, Chronic                | 2  1  1  2  1  3  1     2  1  4  1  3  3     2  2  3  1        2  3  2  3|             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1     1     1  1  1  1  1  1     1  1        1     1  1     1  1  1      |             
      Alveolus, Pigmentation               | 3  2  2  3  3  2  3  2  2  3  1  2  2  2  2  2  2  2  3  1  2  3  2  3  3|             
      Alveolus, Proteinosis                |    1  2     2  2     2     1  2     1        3  2  2              2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |             1     1  1        2                                          |             
      Respiratory Epithelium, Degeneration | 1     1  1           1     1  1           1           1     1           1|             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |    2              1     1  2  1     1                    1        1  1  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2  1                 2  3  2                                   1  1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation                 |                                              2                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Nephropathy                          |    1                                                                     |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|             
                                           | 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  M  +  +  +  +  +  +  +  +  M  A  +     +  +  A  M  M  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                    X                     |             
      Clear Cell Focus                     |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                            +        +      |             
      Inflammation, Chronic Active         |                                                                   4      |             
      Fat, Necrosis                        |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Developmental Malformation           |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                                    |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  M  +  +     +  M  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                              2                           |             
      Pars Distalis, Hyperplasia           |       2                       2              2              1            |             
      Pars Distalis, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2                 1     2  2  1           1        2        1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|             
                                           | 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              1           2               |             
      Inflammation, Chronic                |                                                                   2      |             
      Inflammation, Chronic Active         |                            4                                             |             
      Pigmentation                         |                         2           1        2  2  2     2              1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    1     3        3           2           3  2     3  3  1  3  2     4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                   2                                                      |             
      Myeloid Cell, Hyperplasia            |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                                            |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Macrophage       |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                 3                        |             
      Hyperplasia, Lymphoid                | 2     3  2     4        3  2  2           2  2     2  2     3  1     2  3|             
      Pigmentation                         | 3  2  2  1  2  1        2  2  2     2     2  1  2  3  2     2  3  2  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3        3           4                 3        4                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  M  M     +  +  M  +  +  +  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                   2                       2                             3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  M  M  +  M  M  M     I  M  M  +  M  +  +  M  +  +  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 4                        |             
      Hematopoietic Cell Proliferation     |                                                    2  2                  |             
      Hyperplasia, Lymphoid                |       2     3                 3              2                          3|             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|             
                                           | 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               | 3                       2  3                                             |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +                    +     +                 +      |             
      Alopecia                             |                                                                          |             
      Edema                                |                                                 3                        |             
      Hemorrhage                           |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Epidermis, Inflammation, Suppurative |                                                                   4      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                   3      |             
      Subcutaneous Tissue, Necrosis        |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  I  +  +  +  +  +|             
      Hyperostosis                         |                         X                 X  2        X        X     4   |             
      Pelvis, Fracture                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                            +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               1           1                              |             
      Inflammation, Chronic                | 3     2  2     2  2     2  2  2     2     2  2  2  2  2     2  3  1  1  2|             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1  1  1  1  1     1     1                    1     1        1  1     1  1|             
      Alveolus, Pigmentation               | 2  3  3  3  2  2  2  1  3  2  3  2  2     3  2  2  3  3  2  2  4  2  1  3|             
      Alveolus, Proteinosis                | 1  2     3     2  1           3     2     1        1  2                 1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |                1           1        3                                    |             
      Respiratory Epithelium, Degeneration | 1        1     1                                               2         |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     | 2                          3     3  1                    2     3         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2                                   3                          3        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|             
                                           | 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation                 |                                                                2         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                          3               |             
      Nephropathy                          |    2                                                                     |             
      Cortex, Cyst                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                   +      |             
      Concretion                           |                                                                   4      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7|                             |            |
                             DAY ON TEST   | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2|                             |            |
                                           | 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    5.0MG/M3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                             |      L     |
                                           | 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  A  +  +  M  +  +  +  +                              |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  A  +  +  A  +  +  +  +                              |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  A  +  M  A  +  +  M  M                              |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  +  A  +  +  +  +                              |  56        |
      Hyperplasia, Lymphoid                |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  A  +  +  A  +  +  +  +                              |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +  A  +  +  +  +                              |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  A  A  +  +  A  +  +  +  +                              |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Hepatocyte, Necrosis                 |       3           3                                                      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  62        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  60        |
      Hyperkeratosis                       |                                  3                                       |      1  3.0|
      Hyperplasia, Squamous                |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  60        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  62        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Spindle Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  62        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  62        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                              |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  62        |
      Pars Distalis, Angiectasis           |                3                    3     1                              |      7  2.6|
      Pars Distalis, Hyperplasia           |                                  2     2                                 |      9  2.2|
      Pars Distalis, Necrosis              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7|                             |            |
                             DAY ON TEST   | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2|                             |            |
                                           | 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    5.0MG/M3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                             |      L     |
                                           | 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Hyperplasia, Cystic                  |                   4        3     2        1                              |     26  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  M  M  A  +  +  +  +  +  +  +                              |  55        |
      Ectasia                              |                                                                          |      3  1.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Pigmentation                         |                                     1  2                                 |     12  1.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cyst                                 |       X        X        X                                                |      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Inflammation, Suppurative            |       3                                                                  |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 3        2                 1     1     2                                 |     29  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Myelofibrosis                        | 3                                                                        |      2  2.5|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                 +  +                                             |   9        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Macrophage       |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  3.5|
      Renal, Inflammation, Chronic Active  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  62        |
      Congestion                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                | 4  3     2  2  2  3        2     3  2  3  2                              |     44  2.2|
      Pigmentation                         | 2  2  2  3  2  2  2  3  1  3  2  3  2  3  3                              |     60  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  A  +  +  M  +  +  +  +                              |  58        |
      Hyperplasia, Lymphoid                |    4           4  4                                                      |     14  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  M  +  +  M  +  +  +  +                              |  55        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |             2              2        2  2                                 |     13  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7|                             |            |
                             DAY ON TEST   | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2|                             |            |
                                           | 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    5.0MG/M3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                             |      L     |
                                           | 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  M  M  M  M  +  +  +  M  +  M  M                              |  29        |
      Hyperplasia, Lymphoid                |                            2                                             |      2  3.0|
      Pigmentation                         |    1                    2                                                |      5  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Congestion                           |                                                                          |      2  4.0|
      Hematopoietic Cell Proliferation     |                   3              2                                       |      5  2.2|
      Hyperplasia, Lymphoid                |    2        1              2        3     2                              |     17  2.4|
      Hyperplasia, Macrophage              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +                              |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Hyperplasia, Glandular               |                         3                                                |      8  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +                    +                                             |  12        |
      Alopecia                             |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Epidermis, Inflammation, Suppurative |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  63        |
      Hyperostosis                         | X  X     X  X  X        X        X  X  X  X                              |     24  3.0|
      Pelvis, Fracture                     | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Hypothalamus, Compression            |                                                                          |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Fibrosis                             |                                                                          |      3  1.0|
      Inflammation, Chronic                | 3  2  1  2  1  2  1        1     2  1  2  2                              |     52  1.9|
      Metaplasia, Squamous                 |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7|                             |            |
                             DAY ON TEST   | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2|                             |            |
                                           | 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    5.0MG/M3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                             |      L     |
                                           | 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     | 1  1     1  1  1  2     1  1     1  1  1                                 |     40  1.0|
      Alveolus, Pigmentation               | 2  2  2  3  3  2  2  3  3  2  2  4  2  3  3                              |     64  2.4|
      Alveolus, Proteinosis                |          1              1  2              1                              |     29  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  62        |
      Olfactory Epithelium, Degeneration   |                                                                          |      7  1.4|
      Respiratory Epithelium, Degeneration |          1        1                       1                              |     17  1.1|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                         1  1        1  1  2                              |     21  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                         1  1        1     3                              |     15  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  63        |
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          |                                                                          |      2  1.5|
      Cortex, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Concretion                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  A  +  +  A  +  +  +  +                              |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|             
                             DAY ON TEST   | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|             
                                           | 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +     +  M  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                X                                                         |             
      Hyperplasia, Macrophage              |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                               2                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                           1        1           1         |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  A  +  +  M  M  M  +  +  M  M  +  +  +  +  M  +     M  M  +  M|             
      Cyst                                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M|             
      Pars Distalis, Hyperplasia           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Cystic                  |                   1                       1                    1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|             
                             DAY ON TEST   | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|             
                                           | 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |          +              +        +  +        +           +           +   |             
      Concretion                           |                                  2                                       |             
      Inflammation, Chronic                |                                     3                                    |             
      Inflammation, Suppurative            |          3              4                    4           4           2   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Ectasia                              |             2              1     2           3                    2  2  2|             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            | 4     4  4              4        4  4        1  2                        |             
      Bilateral, Ectasia                   |    2           4  3  3        2        3  3        3  3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  M  M  +|             
      Inflammation, Suppurative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Suppurative            | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +           +  +  +     +     +     +                       +  +|             
      Iliac, Hyperplasia, Histiocytic      |                                  2                                       |             
      Iliac, Hyperplasia, Lymphoid         | 3        2           2     2                 2                           |             
      Inguinal, Hyperplasia, Lymphoid      |          2              2              2     2                       2   |             
      Inguinal, Hyperplasia                |                                  2                                       |             
      Inguinal, Pigmentation               |                                                                         1|             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                  2                                       |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  I  +  +  M  +  +  +  +  +  +  +  +  +     +  +  I  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           1                              |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M     +  +  +  +|             
      Hyperplasia, Lymphoid                |       1        2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  M|             
      Congestion                           |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|             
                             DAY ON TEST   | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|             
                                           | 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                  2           3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  M  M  +  +  M  M  M  M  M  M  +  I  M  M  M  +  M     M  M  +  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2        2           2  1  1           3     3  2        2           1   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +     +  +  +  +|             
      Atrophy                              |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |          +           +  +  +     +  +  +     +  +                    +   |             
      Alopecia                             |                                                                      X   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |          4           4  4  4     3  4  4     3  3                    2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Fracture Healed                      |                                                                          |             
      Hyperostosis                         |                                                                1         |             
      Vertebra, Inflammation, Suppurative  |                      4                                                   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                           4                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Respiratory Epithelium, Degeneration |                         1                                                |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |       1                                                        2     1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  I|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|             
                             DAY ON TEST   | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|             
                                           | 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                                                    2                     |             
      Bilateral, Inflammation, Suppurative |                                                                          |             
      Bilateral, Papilla, Inflammation,    |                                                                          |             
           Suppurative                     |                                                                          |             
      Bilateral, Pelvis, Dilatation        |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Fibrosis                     |                                                                          |             
      Pelvis, Dilatation                   |                      2     2     2  2        1                           |             
      Pelvis, Inflammation, Suppurative    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Calculus Micro Observation Only      |                                                                X         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            | 4                                                                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|             
                                           | 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  A  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  A  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  A  A  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +|             
      Inflammation, Suppurative            |                                  4                                       |             
      Ulcer                                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  1                                       |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |             
      Hepatocyte, Necrosis                 |                      2        1     4              3           4         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Dysplasia                            |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                  2   |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          2  1              1                    2                    2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|             
                                           | 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         2     4  3                       3        2  4  1|             
      Inflammation, Chronic                |                                                                      3   |             
      Inflammation, Chronic Active         |          4        4     4                       4  3  3                 3|             
      Inflammation, Suppurative            |             3                                4                    4      |             
      Bilateral, Ectasia                   |    1  2     3  4     4     3        2  3  3     2           3  3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                         3                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |    2              2                                               3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +  +           +           +        +  +           +  +   |             
      Iliac, Hyperplasia, Histiocytic      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                       2                  |             
      Inguinal, Hyperplasia, Lymphoid      |                1  2                       3           2           3  4   |             
      Inguinal, Hyperplasia                |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |    4                                                                     |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                               1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  I  +  I  +  +  +  M  +  +  M  +  +  +  I  +  +  +  +|             
      Congestion                           |                                                                4         |             
      Hyperplasia, Lymphoid                |    4  2                             1                                    |             
      Inflammation, Granulomatous          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  M  +  +|             
      Congestion                           |                               4                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|             
                                           | 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           4                          3   |             
      Inflammation, Suppurative            |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  M  M  +  +  M  +  +  M  M  M  +  M  I  M  M  M  M  +  M  M  +|             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       4                       2  2        2           2           1      |             
      Hyperplasia, Lymphoid                |    2                             4                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  I  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                         +                 +           +  +     +         |             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Inflammation, Suppurative            |                                           3              4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |    X                                                                     |             
      Hyperostosis                         |          2                                                               |             
      Vertebra, Inflammation, Suppurative  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Inflammation, Suppurative            |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Respiratory Epithelium, Degeneration |                            1                                             |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                     1                    1               |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                     1                    1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|             
                                           | 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               4                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                                                                          |             
      Bilateral, Inflammation, Suppurative |                               4                                          |             
      Bilateral, Papilla, Inflammation,    |                                                                          |             
           Suppurative                     |                                           2                              |             
      Bilateral, Pelvis, Dilatation        |                                        1                                 |             
      Cortex, Cyst                         |                                                                      X   |             
      Cortex, Fibrosis                     |                                        1                                 |             
      Pelvis, Dilatation                   |                               3           2           2                  |             
      Pelvis, Inflammation, Suppurative    |                2                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                           4                              |             
      Inflammation, Suppurative            |                4                                                         |             
      Transitional Epithelium, Hyperplasia |                               2                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |            |
                             DAY ON TEST   | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |            |
                                           | 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      A     |
    0 MG/M3                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                    |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  A  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  A  +  +  +  +                                                   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  A  +  A  +  +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  +                                                   |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  M  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +                                                   |  51        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Basophilic Focus                     |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Macrophage              |    2                                                                     |      1  2.0|
      Hepatocyte, Cytomegaly               |                1                                                         |      1  1.0|
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | M  +  +  M  +  +  +  +                                                   |  54        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   2        |
      Dysplasia                            |                3                                                         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  57        |
      Hyperplasia                          |                1                                                         |      6  1.3|
      Spindle Cell, Hyperplasia            |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +  M  +  +  +  +                                                   |  54        |
      Hyperplasia                          |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  +  +                                                   |  37        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |            |
                             DAY ON TEST   | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |            |
                                           | 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      A     |
    0 MG/M3                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                    |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                    |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +                                                   |  55        |
      Hyperplasia, Cystic                  | 2     2        2  2  1                                                   |     13  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   2        |
      Abscess                              |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +                                                   |  56        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   7        |
      Concretion                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +                                                   |  57        |
      Ectasia                              |    3        3                                                            |     16  2.4|
      Inflammation, Chronic                |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |       4     2                                                            |      9  3.4|
      Inflammation, Suppurative            |    4              3  4                                                   |     14  3.5|
      Bilateral, Ectasia                   | 2              4                                                         |     23  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +                                                   |  53        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +                                                   |  55        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  56        |
      Myeloid Cell, Hyperplasia            |    3              3                                                      |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +              +  +                                                   |  22        |
      Iliac, Hyperplasia, Histiocytic      |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |    3                 3                                                   |      8  2.4|
      Inguinal, Hyperplasia, Lymphoid      |                   2                                                      |     12  2.3|
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
      Inguinal, Pigmentation               |                                                                          |      1  1.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |            |
                             DAY ON TEST   | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |            |
                                           | 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      A     |
    0 MG/M3                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                    |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hyperplasia, Histiocytic      |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |    3                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  I  +  +                                                   |  45        |
      Congestion                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |             2                                                            |      5  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +                                                   |  47        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  M  M  +  +                                                   |  45        |
      Congestion                           | 3                                                                        |      4  2.5|
      Hyperplasia, Lymphoid                |    3                                                                     |      3  3.3|
      Inflammation, Suppurative            |                   3                                                      |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  M  +  +  M                                                   |  18        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  56        |
      Hematopoietic Cell Proliferation     |    4                                                                     |     17  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +                                                   |  45        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                   +                                                      |  16        |
      Alopecia                             |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                   4                                                      |     13  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Fracture Healed                      |                X                                                         |      2     |
      Hyperostosis                         |                                                                          |      2  1.5|
      Vertebra, Inflammation, Suppurative  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |            |
                             DAY ON TEST   | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |            |
                                           | 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7|                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                    |      A     |
    0 MG/M3                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                    |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                    |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +  +  +  +                                                   |  55        |
      Respiratory Epithelium, Degeneration |                                                                          |      2  1.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |       1                                                                  |      6  1.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |    3                                                                     |      1  3.0|
      Mineralization                       | 1                                                                        |      1  1.0|
      Nephropathy                          |                                                                          |      1  2.0|
      Bilateral, Inflammation, Suppurative |                                                                          |      1  4.0|
      Bilateral, Papilla, Inflammation,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Bilateral, Pelvis, Dilatation        |                                                                          |      1  1.0|
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Fibrosis                     |                                                                          |      1  1.0|
      Pelvis, Dilatation                   |                   2                                                      |      9  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +              +                                                         |   2        |
      Calculus Micro Observation Only      | X                                                                        |      1     |
      Concretion                           |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +                                                   |  54        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation, Chronic                |    4                                                                     |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|             
                                           | 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  M  A  +  +  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  A  +  +  M  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     |    X                                                                     |             
      Eosinophilic Focus                   |                                        X                                 |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Infarct                              |       3                                                                  |             
      Mixed Cell Focus                     |                                                                      X   |             
      Thrombosis                           |                   X                                                      |             
      Hepatocyte, Hyperplasia              |                                                       2                  |             
      Hepatocyte, Necrosis                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Hemorrhage                           |                3                                                         |             
      Thrombosis                           |                X                                                         |             
      Vein, Inflammation, Chronic          |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperkeratosis                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                    +               |             
      Dysplasia                            |                                     3                    3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1  2                                 |             
      Bilateral, Hyperplasia               |                                                          2               |             
      Spindle Cell, Hyperplasia            |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|             
                                           | 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  M  M  +  M  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3                       1  2     1     2  2  2        1        2     3  2|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                 +                    +|             
      Concretion                           |                                                    4                    4|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                  4                                       |             
      Mineralization                       |                                                                          |             
      Necrosis, Chronic                    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                      1                                                   |             
      Ectasia                              |    2  2     2                 3     3     2  3                           |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                  3     2     4                           |             
      Inflammation, Chronic Active         |    4                                4                                   2|             
      Inflammation, Suppurative            |                               3                                          |             
      Bilateral, Ectasia                   |          4     3  4     3        3     3           3  3  3  4  3  4     3|             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active                           |                                           3                          3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                               3                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                  4                 3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|             
                                           | 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                   4              3                          4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +           +  +                          +            |             
      Iliac, Hyperplasia, Lymphoid         |                               2                                          |             
      Iliac, Inflammation, Suppurative     |                                                                          |             
      Iliac, Pigmentation                  |                   1           1                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                               3  2                                       |             
      Inguinal, Pigmentation               |                   1              1                                       |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  M  +  +  +  +  +  M  M|             
      Atrophy                              |                   4                                                      |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |             1  2     2              1        2                 1  3      |             
      Pigmentation                         | 2  1  1  2  2  1  1  2  2  1     2  1  2  2  1        2  1  1  1  2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Congestion                           | 2     2     3           3              2                 2        3  2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  M  M  M  +  M  +  +  +  M  M  +  M  M  M  +  I  M  M  M  M  +|             
      Pigmentation                         |                      1     1  1                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                   4              1  2                                    |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +                    +  +     +  +  +              +                    +|             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                      2        4  3                 4                    4|             
      Necrosis                             |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                  4  4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|             
                                           | 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                         3                                                |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                                          |             
      Hemorrhage                           |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pons, Demyelination                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Chronic                |    1        1  2  1  2           1  1     1  2                    3  1  1|             
      Thrombosis                           |    2                          1                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |       1  1  1  1                 2  1  1  1           1        1     1   |             
      Alveolus, Pigmentation               | 1  1  1  2  1  1  1  2  1  1  1  1  1  2  1  1     1  1  2  1  1  2  1  1|             
      Alveolus, Proteinosis                | 1                 1        1     2                 1           1        2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                              2           1        2      |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Suppurative                     |                                                          3        1      |             
      Respiratory Epithelium, Degeneration |                                                          1               |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                              1     1     3        1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                              2     1     3        1      |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                   1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|             
                                           | 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                   4                                                      |             
      Inflammation, Chronic Active         |                               1                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                                                                          |             
      Cortex, Cyst                         | X                                                                        |             
      Pelvis, Dilatation                   |                               2  1                 1                     |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      | X                                                                        |             
      Crystals                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                   4                                                      |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|             
                                           | 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  A  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  A  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                                    4     4               |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                X                             X                           |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vein, Inflammation, Chronic          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Suppurative            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                +                    +      |             
      Dysplasia                            |                                              4                    3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                             1                              |             
      Bilateral, Hyperplasia               |                                                                          |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|             
                                           | 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  +  M  +  +  +  +  +  M  M  +  M  M  +  M  M  +  +  +  +  M|             
      Cyst                                 |                                  X                                       |             
      Hyperplasia, Cystic                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         1     2  1  2     2        1        2     1      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |             4                                                            |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                             +  +     +                       +|             
      Concretion                           |                                           3                              |             
      Hemorrhage                           |                                                                         4|             
      Inflammation                         |                                        3                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                 3                        |             
      Necrosis, Chronic                    |                                                                         3|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Ectasia                              |       2  3  2                 3        1                             3  2|             
      Hemorrhage                           |                                        3                                 |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Chronic Active         |          2              2                          4           4  4      |             
      Inflammation, Suppurative            |             4                          2  2     2                        |             
      Bilateral, Ectasia                   |                      4     2     3  3     3  3        3  3  3            |             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                         2|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       4                                2  3                    2        2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                   3        3                  |             
      Congestion                           |          2                                                               |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|             
                                           | 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                         3                 2  3     3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +           +                    +        +  +     +           +|             
      Iliac, Hyperplasia, Lymphoid         |          2                                         2  2                  |             
      Iliac, Inflammation, Suppurative     |                                                                         3|             
      Iliac, Pigmentation                  |          1                                1                              |             
      Inguinal, Hyperplasia, Lymphoid      |                      2                    3        2  2     2            |             
      Inguinal, Pigmentation               |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Pigmentation                  |       1                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |          1                          2        2                       4   |             
      Pigmentation                         |       1  2  2  2     2  1  1  2  2  1  1  1  3     2  2  1  2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                       3                  |             
      Hyperplasia, Lymphoid                |             3                                   3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  +  +  M  M  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                            2                                         2   |             
      Hematopoietic Cell Proliferation     |                                              4                           |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |                                                                1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  M  +  M  +  M  M  M  M  M  M  M  +  M  M  M  M  I  M  M  +  M|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                         3                 2     2  2           3        3|             
      Hyperplasia, Lymphoid                |             2                                3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  I  M  I  +  +  +  +  M  +  I  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4                                                         |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +           +  +              +  +  +  +           +            |             
      Alopecia                             |                                                 2                        |             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Chronic Active         |                         4                                                |             
      Inflammation, Suppurative            |       3  4           4                    4                              |             
      Necrosis                             |                                                 4                        |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|             
                                           | 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                                        3                                 |             
      Subcutaneous Tissue, Fibrosis        |                                              3                           |             
      Subcutaneous Tissue, Hemorrhage      |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                    X                     |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pons, Demyelination                  |    2                                                     2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                                 |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Chronic                |          1  2           1        1  1                                    |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       1     1           1  1     1           1                    1      |             
      Alveolus, Pigmentation               |    1  1  1  1  1  1  2  1  1  1  2  2  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolus, Proteinosis                |                1                    1                 1              1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1  2                                                      |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                       2                  |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |             4              1              1           1              1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 1           2                                                        1   |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|             
                                           | 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                       1                  |             
      Inflammation, Chronic                |                            2                                             |             
      Inflammation, Chronic Active         |                         3                                      2         |             
      Inflammation, Suppurative            |                                                                         3|             
      Mineralization                       |                                                       1                  |             
      Nephropathy                          |             1                                                            |             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Dilatation                   |       2                                                     3            |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                               +                                      +  +|             
      Calculus Micro Observation Only      |                               X                                      X  X|             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                      X   |             
      Crystals                             |                                        1                                 |             
      Hemorrhage                           |                            3                                             |             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                         3                                                |             
      Inflammation, Suppurative            |                            4                                            4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4|                       |            |
                             DAY ON TEST   | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4|                       |            |
                                           | 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2|                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                       |      A     |
    1.25MGM3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                       |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0|                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +                        |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A                        |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  M  +  +  +  +  +  +  +  A  +  +  +  +  A  A                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  A                        |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  A  A                        |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  A  A                        |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  A  +  +  +  A  +  +  +  +  A  +  +  +  +  A  A                        |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                           2                              |      2  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infarct                              |                4        4                       4                        |      6  3.8|
      Mixed Cell Focus                     |                                                                          |      1     |
      Thrombosis                           |                                                                          |      3     |
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1     |
      Vein, Inflammation, Chronic          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                        |  65        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A                        |  63        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A                        |  63        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   5        |
      Dysplasia                            |                                                                          |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4|                       |            |
                             DAY ON TEST   | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4|                       |            |
                                           | 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2|                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                       |      A     |
    1.25MGM3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                       |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0|                       |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                        2                                 |      5  1.4|
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                        |  64        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                        |  48        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Cystic                  | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                        |  62        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Hyperplasia, Cystic                  | 1           1     1     2  2  1        1  1                              |     27  1.6|
      Inflammation, Chronic                |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +  +  +                                          |  11        |
      Concretion                           |                         2     4                                          |      5  3.4|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis, Chronic                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  66        |
      Concretion                           |                                                                          |      1  1.0|
      Ectasia                              |       3                 2                       3                        |     17  2.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                         2  3           2                                 |      7  2.4|
      Inflammation, Chronic Active         |    2  4     4        2                                                   |     12  3.2|
      Inflammation, Suppurative            |                                  4  3     2                              |      8  2.8|
      Bilateral, Ectasia                   | 2  2     3  3  2  3  3        3     2  3  3  2                           |     34  3.0|
      Bilateral, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                        |  61        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4|                       |            |
                             DAY ON TEST   | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4|                       |            |
                                           | 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2|                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                       |      A     |
    1.25MGM3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                       |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0|                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                        |  66        |
      Dilatation                           |    2                                                                     |      8  2.8|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  66        |
      Atrophy                              |                                                                          |      3  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  66        |
      Myeloid Cell, Hyperplasia            |             4        4  3  3     3              3                        |     13  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +        +     +     +                                       |  18        |
      Iliac, Hyperplasia, Lymphoid         |             4        3     3     3                                       |      8  2.6|
      Iliac, Inflammation, Suppurative     |                                                                          |      1  3.0|
      Iliac, Pigmentation                  |                                                                          |      4  1.0|
      Inguinal, Hyperplasia, Lymphoid      |    3                 3                                                   |      9  2.4|
      Inguinal, Pigmentation               |                                                                          |      2  1.0|
      Renal, Hyperplasia, Lymphoid         |             3        2                                                   |      2  2.5|
      Renal, Pigmentation                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +                        |  56        |
      Atrophy                              |                                                                          |      1  4.0|
      Edema                                |                2                                                         |      1  2.0|
      Hyperplasia, Lymphoid                | 2  1              2              2  1  2  2                              |     18  1.8|
      Pigmentation                         | 2  1     1  1  2  2  1     1     2  2  2  2  1  2                        |     55  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +                        |  57        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M                        |  55        |
      Congestion                           |       2        3                 3                                       |     13  2.4|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                  3        2                              |      4  2.3|
      Inflammation, Suppurative            |             4                                                            |      1  4.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  +  M  M  M  +  M  M  M  M  M  +  M  M  M                        |  19        |
      Pigmentation                         |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Angiectasis                          |                                        2                                 |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4|                       |            |
                             DAY ON TEST   | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4|                       |            |
                                           | 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2|                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                       |      A     |
    1.25MGM3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                       |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0|                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |    3        3        2  2  2                                             |     14  2.4|
      Hyperplasia, Lymphoid                |                                  2              3                        |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  +  +  I  +  I  +  +  M  +  M                        |  53        |
      Atrophy                              |                                                                          |      1  4.0|
      Pigmentation                         |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +        +  +  +  +  +                                       |  23        |
      Alopecia                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |             3                                                            |      2  3.5|
      Inflammation, Suppurative            |                      2  2                                                |     11  3.3|
      Necrosis                             |                                  4                                       |      2  4.0|
      Prepuce, Inflammation, Suppurative   |                         3  4     3                                       |      5  3.6|
      Subcutaneous Tissue, Edema           |                                                                          |      2  3.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Fracture Healed                      |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Pons, Demyelination                  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  64        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Macrophage              |                               4                                          |      1  4.0|
      Inflammation, Chronic                |       2                       2        1     1                           |     21  1.4|
      Thrombosis                           |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1     1           1              1  1  1                                 |     24  1.0|
      Alveolus, Pigmentation               | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1                        |     65  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4|                       |            |
                             DAY ON TEST   | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4|                       |            |
                                           | 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2|                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                       |      A     |
    1.25MGM3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                       |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0|                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Proteinosis                |                                           1                              |     12  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +                        |  66        |
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Olfactory Epithelium, Degeneration   |                                  2                                       |      4  1.8|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Respiratory Epithelium, Degeneration |                                  2                                       |      3  1.7|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                                                                          |      9  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      7  1.6|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  67        |
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |    3        4                                   4                        |      6  2.8|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |      1  1.0|
      Cortex, Cyst                         |                                                                          |      1     |
      Pelvis, Dilatation                   |             2                                                            |      6  1.8|
      Pelvis, Inflammation, Chronic Active |                      2                                                   |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                                                                        |   4        |
      Calculus Micro Observation Only      |                                                                          |      3     |
      Concretion                           | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A                        |  63        |
      Calculus Micro Observation Only      |                                     X                                    |      3     |
      Crystals                             |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |             4                                                            |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4|                       |            |
                             DAY ON TEST   | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4|                       |            |
                                           | 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2|                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                       |      A     |
    1.25MGM3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                       |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0|                       |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    3                 4                                                   |      5  3.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|             
                                           | 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +|             
      Necrosis                             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  1                 1                     |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                        2                                 |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |       2                                                                  |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                                                          X               |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                         1|             
      Hepatocyte, Necrosis                 | 4                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                    +                                       |             
      Dysplasia                            |             4                                                            |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ventricle, Thrombosis                |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             1  3                    2                                    |             
      Bilateral, Spindle Cell, Hyperplasia |                                                                          |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|             
                                           | 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |             1  2        2  1     1     3              1  2  2        1   |             
      Inflammation, Suppurative            |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +     +                                             |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Chronic                    |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +     +        +                    +|             
      Concretion                           |                                     4     4        1                    2|             
      Hemorrhage                           |                                           3                              |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Chronic                    |                                           4                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1  2            |             
      Ectasia                              | 3     3  3        3     2        3  3  3        3     4  4               |             
      Inflammation, Chronic                |             2  2  4                             2              4         |             
      Inflammation, Chronic Active         |       2                          3                                   3   |             
      Inflammation, Suppurative            | 3        3                          4                    2               |             
      Bilateral, Ectasia                   |    3        3  3     3     1  3           2  3     2        3     4  3  3|             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Bilateral, Inflammation, Suppurative |                                                    3                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           4              2           2  3|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |    3  3        2  3                 3                    3     3        2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +              +     +                    +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|             
                                           | 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |    2  4              3              4     3                    3     3   |             
      Iliac, Pigmentation                  |    2                                                                     |             
      Inguinal, Hyperplasia, Lymphoid      |       4        2  3                                                  3   |             
      Pancreatic, Hyperplasia, Lymphoid    |       4                                                                  |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    | 4                                                                        |             
      Renal, Hyperplasia, Lymphoid         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |          2  1  1     2  3  2     3  3  2     2        2     1     3  1  2|             
      Inflammation, Chronic Active         |       3                                                                  |             
      Pigmentation                         | 2  2  1  2  2  2  2  2  1  2  1  2  2  1  2  2  2  2  2  1  2  2  1  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       4  2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2        2  3              2        4        1        1      |             
      Hyperplasia, Lymphoid                |       4                                      3     2                     |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  M  +  M  M  +  M  M  +  M  I  M  I  +  +  M  +  M  +  M  M  M|             
      Inflammation, Chronic                |       3                                                                  |             
      Pigmentation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  4           2  2              2                    3              1|             
      Hyperplasia, Lymphoid                |                                                 1              3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  I  +  +  M  +  +  +  +  I  M  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Granulomatous          |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +  +  +  +              +                          +     +  +|             
      Inflammation, Suppurative            |       4        3  4  4              4                                4  4|             
      Necrosis                             |                                                                4         |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                                         4|             
      Prepuce, Necrosis                    |                                                                4         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                3                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|             
                                           | 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hyperostosis                         |                         2     1                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             1            |             
      Inflammation, Chronic                |    1  3  1  2  2        2  1     1     2              2     1     2  1   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1        1  1     1        1     1  1  1     1  1  1  1     1     2     1|             
      Alveolus, Pigmentation               | 2  2  1  2  2  2  2  1  2  2  1  2  2  2  1  2  2  2  2  1  2  2  2  2  2|             
      Alveolus, Proteinosis                |       3              1        1        1                       1        1|             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  3                                       |             
      Olfactory Epithelium, Degeneration   |       2                                                                  |             
      Respiratory Epithelium, Degeneration |       3                                                           1      |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |             3  2  1     1           1                       1            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             2  1  1     2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    4  4                                   2              4               |             
      Necrosis                             |                                                                          |             
      Nephropathy                          |             1                                                     3      |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Inflammation, Chronic        |                                                                         1|             
      Pelvis, Dilatation                   |                                           2                    2         |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Mineralization         | 1                                                                    1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +     +         |             
      Inflammation, Suppurative            |                                                          4               |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +     +                                            +         |             
      Calculus Micro Observation Only      |                   X                                            X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|             
                                           | 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Concretion                           |             4                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                            X                                             |             
      Inflammation, Chronic                |    3                                                                     |             
      Inflammation, Chronic Active         |       3                                                                  |             
      Inflammation, Suppurative            |                                           3              4               |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|             
                                           | 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  M  +  A  +  +  +  +  +  +  +  +  I  M  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  A  +  A  +  +  +  M  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                 1                        |             
      Clear Cell Focus                     |                         1                                                |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Infarct                              |                4                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Cyst                      |                                  X                                       |             
      Hepatocyte, Cytomegaly               |                                                                          |             
      Hepatocyte, Necrosis                 |                                                 1                 2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |                2                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Dysplasia                            |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                   1                    1                                 |             
      Bilateral, Spindle Cell, Hyperplasia |                         2                                                |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|             
                                           | 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1        3  2              2        1  1        2  2              1      |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
      Inflammation, Suppurative            |                                  2                                       |             
      Necrosis, Chronic                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                            +                                             |             
      Concretion                           |                            4                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Chronic                    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                               3                        |             
      Ectasia                              |          3  2                          4     4  4  3        2  4        2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                            2                             3               |             
      Inflammation, Suppurative            |          4        4                 3  3           4  4           4      |             
      Bilateral, Ectasia                   | 3  3  3        3  3  4  3  3  3  3  3     4           3              2   |             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active                           |             2                                                            |             
      Bilateral, Inflammation, Suppurative |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                    2  3     2     2  4   |             
      Inflammation, Chronic                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |    2     2                 3                       3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +           +           +              +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|             
                                           | 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                            3                          3                  |             
      Iliac, Pigmentation                  |                                        1              1                  |             
      Inguinal, Hyperplasia, Lymphoid      |          4     1           2                                      3      |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Hyperplasia, Lymphoid                | 2                       2     2        3  2  1                       3  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         | 2  2     2  2  2     2  2  2  2  2  2  2  2  2  2     2  2     1  2  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2              3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +|             
      Congestion                           |                         3                                2               |             
      Hyperplasia, Lymphoid                | 4                                                                        |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  +  +  M  M  M  M  +  M  +  M  +  M  M  M  +  M  +  M  M  M  +  M|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     2                 2           1      |             
      Hyperplasia, Lymphoid                |                3                                            2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +              +  +                 +  +              +      |             
      Inflammation, Suppurative            |    4     4                 4                                      4      |             
      Necrosis                             |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                 4  4                     |             
      Prepuce, Necrosis                    |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|             
                                           | 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                    X                     |             
      Hyperostosis                         |          1                                                     3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
      Inflammation, Chronic                | 1  1     2        1  2     1  2  1     2  1     1     1  1              1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2           4                                                            |             
      Alveolar Epithelium, Hyperplasia     | 1  1     1        1     1  1  1  1  1  1  1  1     1  1  1              1|             
      Alveolus, Pigmentation               | 2  2  1  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2  1  1  1  2  2|             
      Alveolus, Proteinosis                |       1  1     2           2        1           1     1     1     3      |             
      Pleura, Fibrosis                     |                                                                3         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                                                         1|             
      Respiratory Epithelium, Degeneration |             1                                                            |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                        1        1                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             1                          2        1                       1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Nephropathy                          |                                                                4         |             
      Cortex, Cyst                         | X                                      X                                 |             
      Cortex, Inflammation, Chronic        |                                                                          |             
      Pelvis, Dilatation                   |                            3                       1  4        3  2      |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +              +      |             
      Calculus Micro Observation Only      |                                                    X              X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|             
                                           | 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         X                                                |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4|                          |            |
                             DAY ON TEST   | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8|                          |            |
                                           | 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                          |      A     |
    2.5MG/M3                               | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                          |      L     |
                                           | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A                           |  57        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +                           |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  M  +  M  +  +  +  +  +  +  I  +  +  +                           |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  60        |
      Inflammation, Chronic                |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A                           |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A                           |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A                           |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Basophilic Focus                     |                                                                          |      3  1.0|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                            X                                             |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                               X                                          |      1     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Cyst                      |                                                                          |      1     |
      Hepatocyte, Cytomegaly               |                                                                          |      1  1.0|
      Hepatocyte, Necrosis                 |                            1                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Hyperkeratosis                       |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                     +                                    |   4        |
      Dysplasia                            |                                                                          |      1  4.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Ventricle, Thrombosis                |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4|                          |            |
                             DAY ON TEST   | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8|                          |            |
                                           | 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                          |      A     |
    2.5MG/M3                               | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                          |      L     |
                                           | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |       X                                                                  |      1     |
      Hyperplasia                          |                               1                                          |      6  1.5|
      Bilateral, Spindle Cell, Hyperplasia |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +                           |  63        |
      Pars Distalis, Cyst                  |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hyperplasia, Cystic                  |    2              1        1  1     1  2                                 |     25  1.6|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Necrosis, Chronic                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Granuloma Sperm                      |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                +        +                                                |   7        |
      Concretion                           |                                                                          |      5  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                         4                                                |      1  4.0|
      Necrosis, Chronic                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Atrophy                              |                                                                          |      4  2.3|
      Ectasia                              |    4                          3  4     2     3                           |     25  3.1|
      Inflammation, Chronic                |                                                                          |      5  2.8|
      Inflammation, Chronic Active         |                               4  4                                       |      7  3.0|
      Inflammation, Suppurative            |    4                    3                                                |     13  3.5|
      Bilateral, Ectasia                   | 3     3  4  3  3  3  3  3  2              3                              |     37  2.9|
      Bilateral, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Bilateral, Inflammation, Suppurative |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  63        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4|                          |            |
                             DAY ON TEST   | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8|                          |            |
                                           | 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                          |      A     |
    2.5MG/M3                               | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                          |      L     |
                                           | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Dilatation                           | 3                                            3                           |     11  2.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Myeloid Cell, Hyperplasia            |       3        4           2                                             |     15  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        +        +  +                                             |  20        |
      Iliac, Hyperplasia, Lymphoid         |                4           3                                             |     11  3.2|
      Iliac, Pigmentation                  |                                                                          |      3  1.3|
      Inguinal, Hyperplasia, Lymphoid      |       3                 3  2                                             |     11  2.7|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +                           |  61        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2           2     2           2           2                              |     28  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Pigmentation                         | 2  2  2  2  2  2  2  2  2  1  2  1  1     2  1                           |     61  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                           |  63        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  I  +  +  +  +                           |  56        |
      Congestion                           |                      3        2        2                                 |     12  2.3|
      Hyperplasia, Lymphoid                |                                        3                                 |      5  3.2|
      Hyperplasia, Macrophage              |                                        3                                 |      1  3.0|
      Inflammation, Suppurative            |                2     2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  +  M  +  +  M  +  M  M  I  M  M  M                           |  21        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hematopoietic Cell Proliferation     |                4     2     1                                             |     13  2.2|
      Hyperplasia, Lymphoid                |          2  2                                                            |      6  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +                           |  52        |
      Cyst                                 |                                        X                                 |      1     |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4|                          |            |
                             DAY ON TEST   | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8|                          |            |
                                           | 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                          |      A     |
    2.5MG/M3                               | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                          |      L     |
                                           | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  63        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +     +  +  +  +           +                              |  24        |
      Inflammation, Suppurative            |       4        4     4  4                 4                              |     16  3.9|
      Necrosis                             |                                                                          |      1  4.0|
      Prepuce, Inflammation, Chronic Active|                            3                                             |      1  3.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      3  4.0|
      Prepuce, Necrosis                    |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Developmental Malformation           |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +                           |  64        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Inflammation, Chronic                | 1  1        1              1        1  3  1                              |     34  1.4|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia     | 1     1     1     1  1        1     1  1  1                              |     40  1.0|
      Alveolus, Pigmentation               | 2  1  1  1  2  1  2  2  1  2  2  1  2  2  2  1                           |     66  1.7|
      Alveolus, Proteinosis                |    2           2     2     1     2        1  1                           |     22  1.5|
      Pleura, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Olfactory Epithelium, Degeneration   |                                                                          |      2  1.5|
      Respiratory Epithelium, Degeneration |                         1                                                |      4  1.5|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                                        1                                 |      9  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4|                          |            |
                             DAY ON TEST   | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8|                          |            |
                                           | 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3|                          |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                          |      A     |
    2.5MG/M3                               | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                          |      L     |
                                           | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Squamous                        |                                                                          |      8  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                             +                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation, Suppurative            |                                                                          |      4  3.5|
      Necrosis                             |          1                                                               |      1  1.0|
      Nephropathy                          |                                                                          |      3  2.7|
      Cortex, Cyst                         |                                                                          |      2     |
      Cortex, Inflammation, Chronic        |                                                                          |      1  1.0|
      Pelvis, Dilatation                   |                3                          3                              |      9  2.6|
      Pelvis, Inflammation, Chronic        |                3                                                         |      1  3.0|
      Renal Tubule, Mineralization         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   5        |
      Calculus Micro Observation Only      |                                                                          |      4     |
      Concretion                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Calculus Micro Observation Only      |                               X                                          |      3     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                4                                                         |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                4                                                         |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|             
                                           | 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  M  +  A  +  M  M  +  +  M  +  M  +  M  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Basophilic Focus                     |                   X                                                      |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |       X                                                                  |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                   4                                                      |             
      Hepatocyte, Hyperplasia              |    1                                                  1                  |             
      Hepatocyte, Necrosis                 |          4                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|             
                                           | 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     1  2                       1     1                    1        1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    1                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                            +                        |             
      Concretion                           |    2                                                                     |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4                     |             
      Ectasia                              | 2                 4     3     3  3  2                       2            |             
      Inflammation, Chronic                |                   2     3        2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    3                                            2     2              4  4|             
      Bilateral, Ectasia                   |    3  3  3  3  4     4     3           2  3     3  4  3  3     2  3  4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Bilateral, Atrophy                   |          3                                                               |             
      Germinal Epithelium, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                         3|             
      Myeloid Cell, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                            +     +           +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                 2                    3  4|             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |    2                                                  3              3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|             
                                           | 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                | 1     2     1     2  2  3     2  1     2  2                 2  1     1   |             
      Pigmentation                         | 2  2  2  2  2     2  3  2     2  2     3  3     2     2  2  2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  4                    2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                       1              3  2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  +  +  +  +  M  M  M  M  +  M  M  M  M  I  M  M  +  +  M  M  M  +  M  +|             
      Congestion                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2        3                 2                       1                  |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +     +           +        +        +        +        +     +|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                                                                   4      |             
      Inflammation, Suppurative            |    4     4  4                                   2                        |             
      Necrosis                             |                                                          4               |             
      Prepuce, Inflammation                |                                                                         4|             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|             
                                           | 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                              1                           |             
      Fibrosis                             |                               1                                          |             
      Inflammation, Chronic                | 2  1  1     1  1  1  1  2     3  1     1  2     1     1  2  3  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     | 1  1  1           1  1  1     1  1     1  1           1  1  1  1     1  1|             
      Alveolus, Pigmentation               | 3  2  3  2  2  1  2  3  2  2  3  3  1  2  3     2  1  2  2  2  3  1  2  3|             
      Alveolus, Proteinosis                |             1  1     1     1  2  3  2  1        2     2  1     1  1  3  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                 1           1  1        1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |       1                                                                  |             
      Pelvis, Dilatation                   |                                                 1                    1   |             
      Pelvis, Hyperplasia, Squamous        |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                       +                  |             
      Concretion                           |                                                       2                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +     +                 +           +  +|             
      Calculus Micro Observation Only      |                                                                      X  X|             
      Concretion                           |                                  4     4                 4               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                           X                              |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|             
                                           | 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  A  +  +  M  +  +  A  A  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic                |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  M  +  +  +  +  +  M  A  A  A  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  A  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  M  +  A  +  +  A  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  +  +  A  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  +  A  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                            4                                             |             
      Basophilic Focus                     |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                            3                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                     4                          4  3      |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |             1                                                           2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|             
                                           | 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     3  2        1        2                    2  2     1     2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             4  3                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         3                                                |             
                                            __________________________________________________________________________|             
   Penis                                   |             +           +        +     +     +     +           +  +      |             
      Concretion                           |             4                    1     3                          1      |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                         4                          3           3         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                                                                     |             
      Ectasia                              |       3  3                             3  2     4     2  3     2  2      |             
      Inflammation, Chronic                |                                                 4     3        3         |             
      Inflammation, Chronic Active         |                         3                                         4      |             
      Inflammation, Suppurative            |       4  4  4                                      4                     |             
      Bilateral, Ectasia                   | 3  4           3  4  3     3  4  4           3              4        3  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Dilatation                           |       2     3           2              3           2  2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Bilateral, Atrophy                   |                                                                          |             
      Germinal Epithelium, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |       3  2              3  3                       2        4           3|             
      Myeloid Cell, Inflammation           |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +           +                          +        +  +        +|             
      Iliac, Hyperplasia, Lymphoid         |             4           4                                      3        2|             
      Iliac, Pigmentation                  |                                                                1        1|             
      Inguinal, Hyperplasia, Lymphoid      |          2  2                                      4        3           2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|             
                                           | 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Edema                                |                                                                         2|             
      Hyperplasia, Lymphoid                | 2     3     2  2  2  1        1     1           1        1           2   |             
      Pigmentation                         | 2  1  2  2  2  2  2  2     2  2  1  1  2     3  3  2  1  2  2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M|             
      Congestion                           |    3                       3                                             |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia, Lymphoid                |                                                          2           1   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  I  M  +  +  M  +  +  +  M  M  M  +  M  M  M  +  M  M  +  M  M  M|             
      Congestion                           |    2                                                                     |             
      Pigmentation                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2              2  2                                2  2        3|             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Thrombosis                           |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  M  +  M|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |       +        +     +     +           +     +  +  +  +           +     +|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                4                       4        4     4           4     4|             
      Necrosis                             |                                                                          |             
      Prepuce, Inflammation                |                                                                          |             
      Prepuce, Inflammation, Suppurative   |       4                    4                       4                     |             
      Subcutaneous Tissue, Fibrosis        |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|             
                                           | 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0MG/M3                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                | 2  2  2  2     1  2     1  2  2  3     1     1  1  1  2  2  1  1  1  1   |             
      Alveolar Epithelium, Hyperplasia     | 1     1  1        1           1              1     1  1  1        1  1   |             
      Alveolus, Pigmentation               | 3  2  3  3  1  2  2  2  1  3  3  3  2  2  2  2  2  2  2  3  1  2  2  2  2|             
      Alveolus, Proteinosis                | 1        4     3  1  1  2  3           1  4     1  1     1  2  3  2     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration   |                   1                                                      |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                   2                                               1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                   2                                               2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Hyperplasia                          |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Chronic Active         |                         2                                                |             
      Inflammation, Suppurative            |             3                                                           4|             
      Nephropathy                          |                                                                          |             
      Pelvis, Dilatation                   |                2        2                                                |             
      Pelvis, Hyperplasia, Squamous        | 2                                                                        |             
      Pelvis, Inflammation, Chronic Active |          2                                                               |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                         +|             
      Concretion                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                         4|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +        +           +        +                          +         |             
      Calculus Micro Observation Only      |       X        X           X        X                          X         |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                      X   |             
      Inflammation, Chronic Active         |                                                                         2|             
      Inflammation, Suppurative            |          4  4                                                            |             
      Transitional Epithelium, Hyperplasia |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6|                 |            |
                             DAY ON TEST   | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1|                 |            |
                                           | 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2|                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                 |      A     |
    5.0MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                 |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +                  |  58        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +                  |  62        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  +  A  M  +  M  +  +  +  +  M  +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                  |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +                  |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +                  |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +                  |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Abscess                              |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                                          |      1     |
      Developmental Malformation           |          X                                                               |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                   1                                                      |      1  1.0|
      Infarct                              |                                                                          |      4  3.8|
      Hepatocyte, Hyperplasia              |                                                                          |      2  1.0|
      Hepatocyte, Necrosis                 |                1                                                         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
      Hyperkeratosis                       |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                        +                                 |   1        |
      Dysplasia                            |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Cyst                                 |                                     X                                    |      1     |
      Hyperplasia                          |                3                                                         |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6|                 |            |
                             DAY ON TEST   | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1|                 |            |
                                           | 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2|                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                 |      A     |
    5.0MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                 |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                  |  68        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  +  M                  |  57        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                  |  66        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Hyperplasia, Cystic                  |    2  2     1        1  2                       1  1  4                  |     27  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +           +                           |   4        |
      Hemorrhage                           |                                  3                                       |      1  3.0|
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Inflammation, Chronic                |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |             +           +                          +                     |  13        |
      Concretion                           |                                                                          |      5  2.2|
      Inflammation                         |                         2                                                |      1  2.0|
      Inflammation, Suppurative            |             3                                      3                     |      6  3.2|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Atrophy                              |                                                                          |      2  3.5|
      Ectasia                              |          3     3           3                       2                     |     20  2.7|
      Inflammation, Chronic                | 1     2              3                                                   |      9  2.6|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Inflammation, Suppurative            |          4                                         4                     |     11  3.5|
      Bilateral, Ectasia                   | 3  3  2     3     4     3     4  4  3  3  3     2     3                  |     41  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +                  |  65        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Cyst                                 |    X                                                                     |      1     |
      Dilatation                           | 3           3                                                            |     10  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Atrophy                              |                            3                                             |      1  3.0|
      Bilateral, Atrophy                   |                                                                          |      1  3.0|
      Germinal Epithelium, Degeneration    |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6|                 |            |
                             DAY ON TEST   | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1|                 |            |
                                           | 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2|                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                 |      A     |
    5.0MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                 |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Erythroid Cell, Hyperplasia          |                   4                                                      |      1  4.0|
      Myeloid Cell, Hyperplasia            | 3              3        3           2              3                     |     13  2.8|
      Myeloid Cell, Inflammation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +           +                    +                  |  16        |
      Iliac, Hyperplasia, Lymphoid         |                                                       3                  |      8  3.1|
      Iliac, Pigmentation                  |                                                                          |      2  1.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                       4                  |      9  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I                  |  62        |
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2  2  3                       3     2  1  2     3  1                     |     33  1.8|
      Pigmentation                         | 2  2  2  2  3  1  2  2  2  2  2  2  2  2  3     2  3                     |     60  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                  |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  63        |
      Congestion                           |       3                                                                  |      6  2.5|
      Hematopoietic Cell Proliferation     | 2                                                  1                     |      3  1.7|
      Hyperplasia, Lymphoid                |    2                                                                     |      3  1.7|
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  I  +  M  +  M  +  +  M  I  I  M  M  M  +  M  M  +  M                  |  25        |
      Congestion                           |                                                    2                     |      2  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Hematopoietic Cell Proliferation     | 4              3  3     3        3           4     2                     |     17  2.5|
      Hyperplasia, Lymphoid                |          3                    2                                          |      4  2.3|
      Thrombosis                           |                                  X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  M  M  M  +  +  I  +  +  +  +  +  +  +  +  M  +                  |  58        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +  +           +        +     +  +                  |  27        |
      Alopecia                             |                                              2                           |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                         4           4              4                     |     13  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6|                 |            |
                             DAY ON TEST   | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1|                 |            |
                                           | 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2|                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                 |      A     |
    5.0MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                 |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  4.0|
      Prepuce, Inflammation                |                                                                          |      1  4.0|
      Prepuce, Inflammation, Suppurative   |                                                       3                  |      4  3.8|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I                  |  68        |
      Fracture Healed                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  66        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Congestion                           |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic                | 2  2  2     1  1  1  1     1  1  1     1  1     2  1  1                  |     55  1.4|
      Alveolar Epithelium, Hyperplasia     | 1  1  1  1  1        1     1  1     1  1  1     1  1                     |     40  1.0|
      Alveolus, Pigmentation               | 2  2  2  1  2  2  2  2  2  2  3  2  3  2  3  1  2  2  3                  |     68  2.1|
      Alveolus, Proteinosis                | 3  1     2  2  1     1  1           2     1  2     1  3                  |     43  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
      Olfactory Epithelium, Degeneration   |                                                                          |      1  1.0|
      Respiratory Epithelium, Degeneration |                               1                                          |      1  1.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                            1                                             |      7  1.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                  |  68        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                    +                        |   3        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 4              2  3     1                                                |      6  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05123-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:50:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6|                 |            |
                             DAY ON TEST   | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1|                 |            |
                                           | 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2|                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                 |      A     |
    5.0MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                 |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          |                                                                          |      1  1.0|
      Pelvis, Dilatation                   |             2                                                            |      5  1.6|
      Pelvis, Hyperplasia, Squamous        |                                                                          |      1  2.0|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Pelvis, Inflammation, Suppurative    | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +                       +                                                |   4        |
      Concretion                           |                         3                                                |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                                                  +                     |  12        |
      Calculus Micro Observation Only      | X                                                                        |      8     |
      Concretion                           |                                                    4                     |      4  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +                  |  66        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 4                       4                                                |      4  4.0|
      Transitional Epithelium, Hyperplasia |                2                                                         |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------