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TDMS Study 05123-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: LITRI                                                    NICKEL OXIDE                                     DATE: 05/20/95       
EXPERIMENT: 05123 TEST: 06                                                                                     TIME: 05:42:06       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: Y0-ES-30108                               ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C00862       
PATHOLOGIST: P. HALEY                                                                                          CAS: 1313-99-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: LITRI                                                    NICKEL OXIDE                                     DATE: 05/20/95      
EXPERIMENT: 05123 TEST: 06                                                                                     TIME: 05:42:06      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: Y0-ES-30108                               ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C00862      
PATHOLOGIST: P. HALEY                                                                                          CAS: 1313-99-1      

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 36     CENSORED DEATHS 4    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      4     162   162   162   290   341   392   430   470   508                 |
 |      510   512   559   559   559   584   590   599   601   602                 |
 |      603   607   629   629   643   643   653   660   666   675                 |
 |      689   694   697   713   713   732                                         |
 |  CENSORED DEATHS                                                               |
 |      77    77    77    78                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = O MG/M3   LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 16   TERMINAL 2         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      593   637                                                                 |
 |  CENSORED DEATHS                                                               |
 |      77    77    77    77    77    77    199   199   199   199                 |
 |      199   458   458   458   458   458                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.25MGM3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      24    105   135   157   226   290   298   341   442   445                 |
 |      471   480   493   508   512   539   593   604   610   612                 |
 |      612   616   626   637   643   644   649   669   675   679                 |
 |      683   692   694   706   717   726   726                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1.25MGM3  LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 7      CENSORED DEATHS 10   TERMINAL 3         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      501   539   557   567   676   717   728                                   |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      155   356   463   483   483   489   516   539   539   540                 |
 |      552   580   603   605   629   648   649   660   660   665                 |
 |      665   676   676   677   684   696   704   709   712   718                 |
 |      730                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2.5MG/M3  LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 6      CENSORED DEATHS 10   TERMINAL 4         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      245   368   482   539   679   694                                         |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   458   458   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 5.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      137   194   224   241   271   422   428   459   489   499                 |
 |      501   527   538   543   559   574   580   597   601   612                 |
 |      616   635   641   659   659   670   697   698   698   704                 |
 |      706   713   714   716   726   726   736                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 5.0MG/M3  LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 9      CENSORED DEATHS 10   TERMINAL 1         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      21    317   431   571   580   615   670   676   698                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   458   458   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/M3    |    98.3  92.8  92.8  89.2  87.4  83.7  78.3  61.9  49.2  34.6      |
 |           |                                                                    |
 |           |                                                                    |
 |O          |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  75.0  50.0  50.0      |
 |MG/M3   LUN|TX                                                                  |
 |           |                                                                    |
 |1.25MGM3   |    98.3  93.3  91.7  86.7  86.7  80.0  73.3  70.0  55.0  38.3      |
 |           |                                                                    |
 |           |                                                                    |
 |1.25MGM3   |   100.0 100.0 100.0 100.0 100.0 100.0  80.0  60.0  60.0  30.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |   100.0  98.3  98.3  96.7  96.7  91.7  83.3  76.7  65.0  48.3      |
 |           |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |   100.0 100.0  93.3  93.3  86.7  75.8  65.0  65.0  65.0  43.3      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |5.0MG/M3   |   100.0  98.3  93.3  91.7  90.0  86.7  76.7  68.3  58.3  38.3      |
 |           |                                                                    |
 |           |                                                                    |
 |5.0MG/M3   |    95.0  95.0  95.0  88.2  88.2  81.4  81.4  58.2  46.5  11.6      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 MG/M3     O           1.25MGM3    1.25MGM3    2.5MG/M3    2.5MG/M3    5.0MG/M3    5.0MG/M3 |
 |                                            MG/M3   LUNG X          LUNGTX                  LUNGTX                  LUNGTX   |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       34.6%       50.0%       38.3%       30.0%       48.3%       43.3%       38.3%       11.6%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.986N     -----      P=0.768N    P=0.950N    P=0.097N    P=0.762N    P=0.601N    P=0.357  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       534.5       615.0       521.1       612.1       595.5       501.2       559.7       508.8    |
 |NATURAL DEATHS (C)      |       (30.2)      (22.0)      (32.1)      (34.9)      (22.2)      (71.6)      (27.1)      (73.7)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       568.7       322.6       603.8       489.1       663.9       462.0       627.7       430.1    |
 |(STANDARD ERROR)        |       (28.1)      (52.5)      (24.0)      (44.9)      (14.6)      (46.2)      (20.1)      (46.2)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      29    117   132   357   510   549   559   586   599   618                 |
 |      622   638   642   688   694   695   728   728                             |
 |  CENSORED DEATHS                                                               |
 |      14                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 MG/M3   LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 4      CENSORED DEATHS 10   TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      11    24    92    229                                                     |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.25MGM3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      203   317   469   510   566   583   603   609   640   644                 |
 |      652   676   683   683   690   692   695   711   720   726                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1.25MGM3  LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 6      CENSORED DEATHS 10   TERMINAL 4         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      46    162   593   597   626   657                                         |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 16     CENSORED DEATHS 1    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      16    19    58    321   326   451   538   570   584   587                 |
 |      630   640   659   669   670   681                                         |
 |  CENSORED DEATHS                                                               |
 |      315                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2.5MG/M3  LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 4      CENSORED DEATHS 10   TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      36    566   670   676                                                     |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 5.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      70    141   293   426   495   510   533   584   595   602                 |
 |      619   640   644   670   673   675   684   699   713   720                 |
 |      726                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 5.0MG/M3  LUNGTX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 5      CENSORED DEATHS 10   TERMINAL 5         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      469   498   644   658   696                                               |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/M3    |    98.3  94.9  94.9  93.2  93.2  93.2  91.5  84.7  78.0  69.5      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |    90.0  85.0  77.9  77.9  77.9  77.9  77.9  77.9  77.9  77.9      |
 |MG/M3   LUN|TX                                                                  |
 |           |                                                                    |
 |1.25MGM3   |   100.0 100.0  98.3  96.7  96.7  95.0  93.3  88.3  81.7  66.7      |
 |           |                                                                    |
 |           |                                                                    |
 |1.25MGM3   |    95.0  90.0  90.0  90.0  90.0  90.0  90.0  67.5  45.0  45.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |    94.9  94.9  94.9  91.5  91.5  89.7  88.0  82.8  77.7  72.5      |
 |           |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |    95.0  95.0  95.0  95.0  95.0  95.0  95.0  84.4  84.4  63.3      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |5.0MG/M3   |    98.3  96.6  96.6  94.9  94.9  93.2  88.1  83.1  78.0  64.4      |
 |           |                                                                    |
 |           |                                                                    |
 |5.0MG/M3   |   100.0 100.0 100.0 100.0 100.0  90.0  80.0  80.0  60.0  50.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 MG/M3     0           1.25MGM3    1.25MGM3    2.5MG/M3    2.5MG/M3    5.0MG/M3    5.0MG/M3 |
 |                                            MG/M3   LUNG X          LUNGTX                  LUNGTX                  LUNGTX   |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       69.5%       77.9%       66.7%       45.0%       72.5%       63.3%       64.4%       50.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.747      -----      P=0.956     P=0.201     P=0.943N    P=0.998     P=0.696     P=0.541  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       527.3        89.0       603.6       446.8       463.7       487.0       557.7       593.0    |
 |NATURAL DEATHS (C)      |       (51.7)      (49.9)      (30.7)      ( 110)      (60.5)      ( 152)      (40.3)      (45.7)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       656.6       401.3       687.2       444.6       650.0       480.9       668.0       495.3    |
 |(STANDARD ERROR)        |       (22.2)      (58.1)      (12.7)      (50.9)      (23.0)      (52.4)      (17.8)      (46.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            NICKEL OXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/M3          = 1
                                                        O MG/M3   LUNGTX = 2
                                                        1.25MGM3         = 3
                                                        1.25MGM3  LUNGTX = 4
                                                        2.5MG/M3         = 5
                                                        2.5MG/M3  LUNGTX = 6
                                                        5.0MG/M3         = 7
                                                        5.0MG/M3  LUNGTX = 8

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 11 83                 7  5             6                                       4              2
      |  1  3            3    3  51    7   7                    5                 5
      |    8                  3  3         7   7           8                      5 5
      |                          31         3  6   7  1           6        7        55
   90 +                                               13      1       1    77        5 4 5   4
      |                                                3   8  3   6   1     1 3  7  67   5   5
      |                                                                     1      1 7 7     55
      |                                                                     8 3    13  71   7 55  85
   80 +                                                                             3 3 11  74  4  5    5
      |                                                                               3 31   77 1       5  5
P     |                                                                             6    3   3  7 7   2    52 5
E     |                                                                                      3  1 771 373     5  5
R  70 +                                                                                         44881 1133
C     |                                                                                                7 7
E     |                                                                                      6           7  7    5 5
N     |                                                                                                113 337   7
T  60 +                                                                                          4      1  133     45
      |                                                                                            8     8 1 13  77 5 55
S     |                                                                                                       3   36  655
U     |                                                                                                      1 1  33  7755
R  50 +                                                                                                     2  1 1133    4  52
V     |                                                                                                  8        1133377   55
I     |                                                                                                            1 13377
V     |                                                                                                              113 33  6
A  40 +                                                                                                               1 144  7
L     |                                                                                                                 1 3 13
      |                                                                                                           88        11
      |
   30 +                                                                                                                   4  4
      |
      |
      |                                                                                                            8  8
   20 +
      |
      |
      |                                                                                                               8      8
   10 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 53 obs hidden.

                                                            NICKEL OXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/M3          = 1
                                                        0 MG/M3   LUNGTX = 2
                                                        1.25MGM3         = 3
                                                        1.25MGM3  LUNGTX = 4
                                                        2.5MG/M3         = 5
                                                        2.5MG/M3  LUNGTX = 6
                                                        5.0MG/M3         = 7
                                                        5.0MG/M3  LUNGTX = 8

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 25  164  7                    3                                         8
      |    5  1   57       1 1 7        3             7    3                      3
      |   2 2  64 5          1    4                   7    5    1          7      3     3        6
      |                                                    55   1          7    5     7 1      1 3  3
P  90 +     2          2          4                                             5 8    87    5 11   3 4 3
E     |                                                                                      5  1 5 1 713    3
R     |                2                    2                                                    6    71  1       6
C     |                                                                                             5  7  15 1 3   3
E  80 +                                                                                8              44   5 5   5 33
N     |                                     2                                                                1   557311     2
T     |                                                                                                           565
      |                                                                                                            7531 3 1 5
S  70 +                                                                                                      8 8    7 7 331 1
U     |                                                                                                4   4            733 3
R     |                                                                                                                  77 7
V     |                                                                                                            6        6
I  60 +                                                                                                        8      8
V     |                                                                                                    4   4
A     |
L     |
   50 +                                                                                                               8     8
      |
      |                                                                                                        4            4
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 45 obs hidden.